| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adam L Halberstadt, Virginia D Lehmann-Masten, Mark A Geyer, Susan B Powel. Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice. Psychopharmacology. vol 215. issue 1. 2011-08-15. PMID:21153406. |
because serotonergic hallucinogens increase glutamate release and mglu receptors modulate the response to serotonin (5-ht)(2a) activation, the interactions between serotonin 5-ht(2a) receptors and mglu receptors may prove to be important for our understanding of these diseases. |
2011-08-15 |
2023-08-12 |
mouse |
| Yukihiro Ohno, Nobumasa Sofue, Takuji Imaoku, Eri Morishita, Kenta Kumafuji, Masashi Sasa, Tadao Serikaw. Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy. Journal of pharmacological sciences. vol 114. issue 1. 2011-08-11. PMID:20736508. |
to explore the role of the serotonergic system in modulating absence seizures, we examined the effects of 5-ht(1a) and 5-ht(2) agonists on the incidence of spike-and-wave discharges (swd) in groggy (gry) rats, a novel rat model of absence-like epilepsy. |
2011-08-11 |
2023-08-12 |
rat |
| Yukihiro Ohno, Nobumasa Sofue, Takuji Imaoku, Eri Morishita, Kenta Kumafuji, Masashi Sasa, Tadao Serikaw. Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy. Journal of pharmacological sciences. vol 114. issue 1. 2011-08-11. PMID:20736508. |
the present results suggest that the serotonergic system negatively regulates the incidence of absence seizures by stimulation of 5-ht(1a) and 5-ht(2) receptors. |
2011-08-11 |
2023-08-12 |
rat |
| Antonio Ortega-Alvaro, Auxiliadora Aracil-Fernández, María S García-Gutiérrez, Francisco Navarrete, Jorge Manzanare. Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 7. 2011-08-10. PMID:21430651. |
gene expression of dopamine d(2) (d(2)r), adrenergic-α(2c) (α(2c)r), serotonergic 5-ht(2a) and 5-ht(2c) receptors (5-ht(2a)r and 5-ht(2c)r) were studied by rt-pcr in brain regions related to schizophrenia. |
2011-08-10 |
2023-08-12 |
mouse |
| Emmanuelle Simon O'Brien, Rémi Legastelois, Hakim Houchi, Catherine Vilpoux, Stéphanie Alaux-Cantin, Olivier Pierrefiche, Etienne André, Mickaël Naassil. Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 7. 2011-08-10. PMID:21430652. |
a few clinical studies have shown that dual antidepressants (serotonergic (5-ht) and noradrenergic (ne) transporter inhibitors, snris) may be effective in alcoholism treatment. |
2011-08-10 |
2023-08-12 |
mouse |
| Joseph J Normandin, Anne Z Murph. Serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats. Pharmacology, biochemistry, and behavior. vol 98. issue 3. 2011-07-28. PMID:21296106. |
serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats. |
2011-07-28 |
2023-08-12 |
rat |
| Joseph J Normandin, Anne Z Murph. Serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats. Pharmacology, biochemistry, and behavior. vol 98. issue 3. 2011-07-28. PMID:21296106. |
the ventrolateral periaqueductal gray (vlpag) provides serotonin to this region, thus providing an anatomical and neurochemical basis for serotonergic regulation of the npgi. |
2011-07-28 |
2023-08-12 |
rat |
| Youssef Sari, Verity R Johnson, Jason M Weedma. Role of the serotonergic system in alcohol dependence: from animal models to clinics. Progress in molecular biology and translational science. vol 98. 2011-07-27. PMID:21199778. |
we emphasize the serotonin transporter and its possible role in alcoholism, then present several serotonergic receptors and discuss their contribution to alcoholism, and finally assess the serotonin system as a target for pharmacotherapy, with an emphasis on current and potential treatments. |
2011-07-27 |
2023-08-12 |
Not clear |
| Florent G Revel, Jean-Luc Moreau, Raul R Gainetdinov, Amyaouch Bradaia, Tatyana D Sotnikova, Roland Mory, Sean Durkin, Katrin Groebke Zbinden, Roger Norcross, Claas A Meyer, Veit Metzler, Sylvie Chaboz, Laurence Ozmen, Gerhard Trube, Bruno Pouzet, Bernhard Bettler, Marc G Caron, Joseph G Wettstein, Marius C Hoene. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 20. 2011-07-26. PMID:21525407. |
furthermore, modulation of taar1 activity altered the desensitization rate and agonist potency at 5-ht(1a) receptors in the dorsal raphe, suggesting that taar1 modulates not only dopaminergic but also serotonergic neurotransmission. |
2011-07-26 |
2023-08-12 |
mouse |
| Charles P Mercado, Endrit Ziu, Fusun Kili. Communication between 5-HT and small GTPases. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21320798. |
advances over the past decade have improved our understanding of the serotonin (5-ht) biology outside the central nervous system specifically the molecular mechanisms of serotonergic signaling in association with small gtpases. |
2011-07-25 |
2023-08-12 |
Not clear |
| Mark J Milla. MicroRNA in the regulation and expression of serotonergic transmission in the brain and other tissues. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21345728. |
fluoxetine promotes the biogenesis of mir-16, leading to translational repression of 5-ht transporters in mouse serotonergic neurones. |
2011-07-25 |
2023-08-12 |
human |
| H Y Meltzer, B W Masse. The role of serotonin receptors in the action of atypical antipsychotic drugs. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21420906. |
the serotonergic actions of the atypical apds, especially 5-ht(2a) receptor antagonism, are particularly important to the differential effects of typical and atypical apds to overcome the effects of acute or subchronic administration of n-methyl-d-aspartate (nmda) receptor antagonists, such as phencyclidine, ketamine, and dizocipline (mk-801). |
2011-07-25 |
2023-08-12 |
Not clear |
| Kyu-Sang Park, Pyo-Jin Sin, Dong Hyeon Lee, Seung-Kuy Cha, Min-Jeong Kim, Na-Hyun Kim, Soon-Koo Baik, Seong-Woo Jeong, In Deok Kon. Switching-on of serotonergic calcium signaling in activated hepatic stellate cells. World journal of gastroenterology. vol 17. issue 2. 2011-07-22. PMID:21245988. |
to investigate serotonergic ca²+ signaling and the expression of 5-hydroxytryptamine (5-ht) receptors, as well as ca²+ transporting proteins, in hepatic stellate cells (hscs). |
2011-07-22 |
2023-08-12 |
Not clear |
| Nirupa Goel, Kimberly S Plyler, Derek Daniels, Tracy L Bal. Androgenic influence on serotonergic activation of the HPA stress axis. Endocrinology. vol 152. issue 5. 2011-07-22. PMID:21385938. |
the paraventricular nucleus of the hypothalamus (pvn) receives serotonergic innervation, and selective serotonin reuptake inhibitors such as citalopram activate the hpa axis independent of stress. |
2011-07-22 |
2023-08-12 |
mouse |
| Jacek Wójcikowski, Wadysawa Anna Danie. The role of the nervous system in the regulation of liver cytochrome p450. Current drug metabolism. vol 12. issue 2. 2011-07-22. PMID:21401511. |
recent preliminary studies with selective noradrenaline or serotonin neurotoxins suggest also involvement of the brain noradrenergic and serotonergic systems in the regulation of liver cyp. |
2011-07-22 |
2023-08-12 |
Not clear |
| Brian N Mathur, Nicole A Capik, Veronica A Alvarez, David M Lovinge. Serotonin induces long-term depression at corticostriatal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 20. 2011-07-21. PMID:21593324. |
we have examined serotonergic modulation of rat and mouse corticostriatal neurotransmission and find that serotonin (5-ht) activates 5-ht(1b) receptors resulting in a long-term depression (ltd) of glutamate release and striatal output that we have termed 5-ht-ltd. 5-ht-ltd is presynaptically mediated, camp pathway dependent, and inducible by endogenous striatal 5-ht, as revealed by application of a selective 5-ht reuptake inhibitor. |
2011-07-21 |
2023-08-12 |
mouse |
| Ian M Anderson, Gabriella Juhasz, Emma Thomas, Darragh Downey, Shane McKie, J F William Deakin, Rebecca Elliot. The effect of acute citalopram on face emotion processing in remitted depression: a pharmacoMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:20599362. |
both reduced serotonergic (5-ht) function and negative emotional biases have been associated with vulnerability to depression. |
2011-07-20 |
2023-08-12 |
human |
| Krisztina Mekli, Antony Payton, Fabio Miyajima, Hazel Platt, Emma Thomas, Darragh Downey, Kathryn Lloyd-Williams, Diana Chase, Zoltan G Toth, Rebecca Elliott, William E Ollier, Ian M Anderson, J F William Deakin, Gyorgy Bagdy, Gabriella Juhas. The HTR1A and HTR1B receptor genes influence stress-related information processing. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:20638825. |
our results extend previous findings of an interaction between stressful life events and the serotonin transporter gene to two other genes in the serotonergic pathway and emphasise the possible role of increased threat-related information processing as an intermediate phenotype. |
2011-07-20 |
2023-08-12 |
human |
| Raffaella Morini, Boris Mlinar, Gilda Baccini, Renato Corradett. Enhanced hippocampal long-term potentiation following repeated MDMA treatment in Dark-Agouti rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:20727723. |
one week after neurotoxic mdma treatment in vivo (12.5mg/kg i.p., once a week, per three weeks), serotonergic deficit was evident in hippocampal slices as 56.3% reduction in 5-ht content (p=0.04) and as 68.4% reduction in the effect of endogenous 5-ht release on synaptic neurotransmission (p<0.01). |
2011-07-20 |
2023-08-12 |
rat |
| John Dunlop, Stephanie W Watts, James E Barrett, Joseph Coupet, Boyd Harrison, Hossein Mazandarani, Stanley Nawoschik, Menelas N Pangalos, Siva Ramamoorthy, Lee Schechter, Deborah Smith, Gary Stack, Jean Zhang, Guoming Zhang, Sharon Rosenzweig-Lipso. Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist. The Journal of pharmacology and experimental therapeutics. vol 337. issue 3. 2011-07-19. PMID:21402690. |
vabicaserin displaced (125)i-(2,5-dimethoxy)phenylisopropylamine binding from human 5-ht(2c) receptor sites in chinese hamster ovary cell membranes with a k(i) value of 3 nm and was >50-fold selective over a number of serotonergic, noradrenergic, and dopaminergic receptors. |
2011-07-19 |
2023-08-12 |
human |