| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gregory V Carr, Lee E Schechter, Irwin Luck. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20217056. |
although selective serotonin reuptake inhibitors (ssris) produce clinical therapeutic effects on depression and anxiety through augmentation of serotonergic neurotransmission, there is little known about the potential contributions of the 5-ht(6) receptor in the treatment of mood disorders. |
2011-05-24 |
2023-08-12 |
rat |
| Matthias Reimold, Astrid Knobel, Michael A Rapp, Anil Batra, Klaus Wiedemann, Andreas Ströhle, Anke Zimmer, Peter Schönknecht, Michael N Smolka, Daniel R Weinberger, David Goldman, Hans-Jürgen Machulla, Roland Bares, Andreas Hein. Central serotonin transporter levels are associated with stress hormone response and anxiety. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20585760. |
negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-htt) levels. |
2011-05-24 |
2023-08-12 |
Not clear |
| Christina Hackl, Anna Papazoglou, Claudia Ganser, Alexander Klein, Nilima Prakash, Wolfgang Wurst, Guido Nikkha. Ectopic dopaminergic progenitor cells from En1(+/Otx2lacZ) transgenic mice survive and functionally reinnervate the striatum following transplantation in a rat model of Parkinson's disease. Cell transplantation. vol 19. issue 9. 2011-05-20. PMID:20447348. |
morphological analyses revealed equivalent numbers of surviving da neurons from both homotopic vm- and ectopic rh-derived grafts from transgenic donors with low numbers of surviving serotonergic (5-ht) neurons. |
2011-05-20 |
2023-08-12 |
mouse |
| A Sanchez-Bahillo, V Bautista-Hernandez, Carlos Barcia Gonzalez, R Bañon, A Luna, E C Hirsch, Maria-Trinidad Herrer. Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims. Neuropsychiatric disease and treatment. vol 4. issue 2. 2011-05-17. PMID:18728743. |
the serotonergic and noradrenergic systems have frequently been, implicated in suicidal behavior and the amount of serotonin in the brain and csf of suicide victims has been found to be low compared with normal subjects. |
2011-05-17 |
2023-08-12 |
human |
| Michael Riedel, Norbert Müller, Martin Strassnig, Ilja Spellmann, Emanuel Severus, Hans-Jürgen Mölle. Quetiapine in the treatment of schizophrenia and related disorders. Neuropsychiatric disease and treatment. vol 3. issue 2. 2011-05-17. PMID:19300555. |
it has major affinity to cerebral serotonergic (5ht(2a)), histaminergic (h1), and dopaminergic d(1) and d(2) receptors, moderate affinity to alpha(1)- und alpha(2)-adrenergic receptors, and minor affinity to muscarinergic m1 receptors; it demonstrates a substantial selectivity for the limbic system. |
2011-05-17 |
2023-08-12 |
Not clear |
| Marios Politis, Kit Wu, Clare Loane, Lorenzo Kiferle, Sophie Molloy, David J Brooks, Paola Piccin. Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study. Neurobiology of disease. vol 40. issue 1. 2011-05-16. PMID:20594979. |
striatal and extrastriatal serotonergic function was studied with (11)c-dasb pet, a marker of serotonin transporter availability. |
2011-05-16 |
2023-08-12 |
human |
| Ying Liu, Michael K Lee, Maria M James, Donald L Price, David R Borchelt, Juan C Troncoso, Esther S O. Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice. Journal of Alzheimer's disease : JAD. vol 23. issue 2. 2011-05-12. PMID:20966549. |
for example, 7b6 treated mice showed almost 2-fold greater densities of serotonergic (5-ht) axons in the cortex compared to saline treated mice. |
2011-05-12 |
2023-08-12 |
mouse |
| Johnny S W Chan, Eelke M S Snoeren, Edwin Cuppen, Marcel D Waldinger, Berend Olivier, Ronald S Oostin. The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. The journal of sexual medicine. vol 8. issue 1. 2011-05-06. PMID:20704641. |
heterozygous (+/-) serotonin transporter (sert) rats and sert knockout rats (-/-) have serotonergic disturbances with significant elevations of basal extracellular 5-ht levels. |
2011-05-06 |
2023-08-12 |
rat |
| Daniel G Miller, Elise O Lovel. Antibiotic-induced serotonin syndrome. The Journal of emergency medicine. vol 40. issue 1. 2011-05-05. PMID:18455905. |
due to its broad spectrum of clinical presentations and to the large number of available serotonergic medications, serotonin syndrome (ss) remains an elusive diagnosis to many clinicians. |
2011-05-05 |
2023-08-12 |
Not clear |
| Albert Adel. Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154150. |
lu-aa21004 belongs to a novel chemical class of antidepressant agents, the bisarylsulfanyl amines, and possesses a novel pharmacological profile, with activity at serotonergic receptors 5-ht3, 5-ht7 and 5-ht1a, and also at the 5-ht transporter. |
2011-05-02 |
2023-08-12 |
rat |
| Delia Bishara, David Taylo. Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder. Neuropsychiatric disease and treatment. vol 5. 2011-04-26. PMID:19851515. |
it has high affinity for various receptors including antagonism at 5ht(2a), 5ht(2b), 5ht(2c), 5ht(6) and 5ht(7) serotonergic receptor subtypes, alpha(1a), alpha(2a), alpha(2b) and alpha(2c) adrenergic and d(3) and d(4) dopaminergic receptors. |
2011-04-26 |
2023-08-12 |
Not clear |
| Aaron Ettenberg, Oren A Ofer, Carl L Mueller, Stephanie Waldroup, Ami Cohen, Osnat Ben-Shaha. Inactivation of the dorsal raphé nucleus reduces the anxiogenic response of rats running an alley for intravenous cocaine. Pharmacology, biochemistry, and behavior. vol 97. issue 4. 2011-04-25. PMID:21108959. |
cocaine blocks reuptake of the serotonergic (5-ht) transporter and serotonin has been implicated in the modulation of anxiety. |
2011-04-25 |
2023-08-12 |
human |
| Domenico De Berardis, Nicola Serroni, Alessandro Carano, Marco Scali, Alessandro Valchera, Daniela Campanella, Alessandro D'Albenzio, Berardo Di Giuseppe, Francesco Saverio Moschetta, Rosa Maria Salerno, Filippo Maria Ferr. The role of duloxetine in the treatment of anxiety disorders. Neuropsychiatric disease and treatment. vol 4. issue 5. 2011-04-21. PMID:19183783. |
pharmacologic options studied for treating ads may include benzodiazepines, tricyclic antidepressants (tca), selective serotonin reuptake inhibitors (ssris), noradrenergic and specific serotonergic drug (nassa) and dual-reuptake inhibitors of serotonin and norepinephrine (snris). |
2011-04-21 |
2023-08-12 |
Not clear |
| Nicole A Northrop, Laura P Smith, Bryan K Yamamoto, David J Eyerma. Regulation of glutamate release by α7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21159748. |
in addition, the subsequent long-term decreases in markers of dopaminergic and serotonergic terminals, including da reuptake transporter (dat), serotonin reuptake transporter (sert), vesicular monoamine transporter-2, vesicular da, and vesicular 5-ht content in the rat striatum, were measured. |
2011-04-21 |
2023-08-12 |
rat |
| Ashish P Bharne, Manoj A Upadhya, Dadasaheb M Kokare, Nishikant K Subheda. Effect of alpha-melanocyte stimulating hormone on locomotor recovery following spinal cord injury in mice: Role of serotonergic system. Neuropeptides. vol 45. issue 1. 2011-04-18. PMID:21036396. |
we suggest that early antagonism of serotonergic 5-ht(2a/2c) receptors may potentiate the neurotropic and locomotor recovery activity of α-msh. |
2011-04-18 |
2023-08-12 |
mouse |
| Kirsten X Jacobsen, Margaret Czesak, Mariam Deria, Brice Le François, Paul R Alber. Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21182526. |
pet-1/fev is an ets transcription factor expressed exclusively in serotonergic neurons and is essential for serotonergic differentiation, although its regulation of 5-ht receptors has not yet been studied. |
2011-04-15 |
2023-08-12 |
mouse |
| Hong-Wu Shen, Xi-Ling Jiang, Jerrold C Winter, Ai-Ming Y. Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Current drug metabolism. vol 11. issue 8. 2011-04-11. PMID:20942780. |
harmaline, 5-meo-dmt and bufotenine act agonistically on serotonergic systems and may result in hyperserotonergic effects or serotonin toxicity. |
2011-04-11 |
2023-08-12 |
Not clear |
| Marios Politis, Kit Wu, Clare Loane, Niall P Quinn, David J Brooks, Stig Rehncrona, Anders Bjorklund, Olle Lindvall, Paola Piccin. Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants. Science translational medicine. vol 2. issue 38. 2011-04-05. PMID:20592420. |
the dyskinesias were markedly attenuated by systemic administration of a serotonin [5-hydroxytryptamine (5-ht)] receptor (5-ht(1a)) agonist, which dampens transmitter release from serotonergic neurons, indicating that the dyskinesias were caused by the serotonergic hyperinnervation. |
2011-04-05 |
2023-08-12 |
Not clear |
| Anders Ettrup, Birgitte R Kornum, Pia Weikop, Gitte M Knudse. An approach for serotonin depletion in pigs: effects on serotonin receptor binding. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20560131. |
depletion of central serotonin (5-ht) levels and dysfunction in serotonergic transmission are implicated in a variety of human cns disorders. |
2011-04-01 |
2023-08-12 |
human |
| Anders Ettrup, Birgitte R Kornum, Pia Weikop, Gitte M Knudse. An approach for serotonin depletion in pigs: effects on serotonin receptor binding. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20560131. |
this porcine model of serotonin depletion will be useful in future studies of cerebral serotonergic dysfunction. |
2011-04-01 |
2023-08-12 |
human |