| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vicki M Tysseling, Vibhu Sahni, Eugene T Pashuck, Derin Birch, Amy Hebert, Catherine Czeisler, Samuel I Stupp, John A Kessle. Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury. Journal of neuroscience research. vol 88. issue 14. 2011-06-24. PMID:20818775. |
serotonin can promote stepping even in complete transection models, so the improved function produced by the ikvav pa treatment may reflect the increased serotonergic innervation caudal to the lesion in addition to the previously demonstrated regeneration of motor and sensory axons through the lesion. |
2011-06-24 |
2023-08-12 |
mouse |
| Eelke Snoeren, Johnny Chan, Astrid Bovens, Edwin Cuppen, Marcel Waldinger, Berend Olivier, Ronald Oostin. Serotonin transporter null mutation and sexual behavior in female rats: 5-HT1A receptor desensitization. The journal of sexual medicine. vol 7. issue 7. 2011-06-22. PMID:20456632. |
in serotonin transporter (sert) knockout rats (-/-), basal extracellular 5-ht levels are considerably increased, indicating a serotonergic disturbance. |
2011-06-22 |
2023-08-12 |
human |
| Ulrich Schmitt, Dianne E Lee, Matthias M Herth, Markus Piel, Hans-Georg Buchholz, Frank Roesch, Christoph Hiemke, Hartmut Lueddens, Fabian Debu. P-glycoprotein influence on the brain uptake of a 5-HT(2A) ligand: [(18)F]MH.MZ. Neuropsychobiology. vol 63. issue 3. 2011-06-21. PMID:21304228. |
the serotonergic system, especially the 5-ht(2a) receptor, is involved in various diseases and conditions. |
2011-06-21 |
2023-08-12 |
Not clear |
| Vera Kiyasova, Sebastian P Fernandez, Jeanne Laine, Lea Stankovski, Aude Muzerelle, Stephane Doly, Patricia Gaspa. A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 8. 2011-06-21. PMID:21414898. |
overall, our findings lead us to propose the existence of pet1-dependent and pet1-resistant 5-ht neurons targeting different brain centers that might delineate the anatomical basis for a dual serotonergic control on stress responses. |
2011-06-21 |
2023-08-12 |
mouse |
| P Ken Gillma. CNS toxicity involving methylene blue: the exemplar for understanding and predicting drug interactions that precipitate serotonin toxicity. Journal of psychopharmacology (Oxford, England). vol 25. issue 3. 2011-06-20. PMID:20142303. |
serotonin toxicity is reviewed, using the lessons inherent in the methylene blue story and experience, to illustrate how the mechanisms and potency of serotonergic drugs interact to determine severity. |
2011-06-20 |
2023-08-12 |
human |
| Maria J Barnes, Richard C Rogers, Montina J Van Meter, Gerlinda E Herman. Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat. Brain research. vol 1355. 2011-06-20. PMID:20691166. |
fibers in the nst and rp that possess trhr1 receptors were phenotypically identified as serotonergic [i.e., immunopositive for the serotonin transporter; sert]. |
2011-06-20 |
2023-08-12 |
rat |
| Ivan Skelin, Tomislav Kovačević, Hiroki Sato, Mirko Diksi. Upregulated arachidonic acid signalling in the olfactory bulbectomized rat model of depression. Neurochemistry international. vol 58. issue 4. 2011-06-17. PMID:21211542. |
taken together with the previous measurements, one can conclude that this elevation is likely related to upregulation in the brain serotonergic system because of the elevated 5-ht synthesis of the obx rats. |
2011-06-17 |
2023-08-12 |
human |
| Katherine C Murray, Marilee J Stephens, Edmund W Ballou, Charles J Heckman, David J Bennet. Motoneuron excitability and muscle spasms are regulated by 5-HT2B and 5-HT2C receptor activity. Journal of neurophysiology. vol 105. issue 2. 2011-06-16. PMID:20980537. |
immediately after spinal cord injury (sci), a devastating paralysis results from the loss of brain stem and cortical innervation of spinal neurons that control movement, including a loss of serotonergic (5-ht) innervation of motoneurons. |
2011-06-16 |
2023-08-12 |
rat |
| Roger L H Pobbe, Helio Zangrossi, D Caroline Blanchard, Robert J Blanchar. Involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-HT receptors in the modulation of mouse defensive behaviors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 4. 2011-06-15. PMID:20570114. |
male cd-1 mice were tested in the mdtb after intra-drn administration of the 5-ht(1a) receptor antagonist way-100635 or after intra-dpag injection of two serotonergic agonists, the 5-ht(1a) receptor agonist 8-oh-dpat and the 5-ht(2a/2c) receptor agonist doi. |
2011-06-15 |
2023-08-12 |
mouse |
| Thomas Mueggler, Florence Razoux, Holger Russig, Anna Buehler, Tamara B Franklin, Christof Baltes, Isabelle M Mansuy, Markus Rudi. Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 4. 2011-06-15. PMID:20656461. |
here, we investigated brain activity in serotonergic pathways in the adult mouse brain by using acute pharmacological challenge of 5-hydroxytryptamine (5-ht) 1a receptors. |
2011-06-15 |
2023-08-12 |
mouse |
| Thomas Mueggler, Florence Razoux, Holger Russig, Anna Buehler, Tamara B Franklin, Christof Baltes, Isabelle M Mansuy, Markus Rudi. Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 4. 2011-06-15. PMID:20656461. |
the method opens novel perspectives for investigating 5-ht(1a) receptor functions in mouse models of human pathologies resulting from a dysfunction of the 5-ht(1a) receptor or the serotonergic system, including depression and anxiety. |
2011-06-15 |
2023-08-12 |
mouse |
| L M Redman, E Ravussi. Lorcaserin for the treatment of obesity. Drugs of today (Barcelona, Spain : 1998). vol 46. issue 12. 2011-06-09. PMID:21589947. |
serotonin (5-ht) has been implicated as a critical factor in the short-term (meal-by-meal) regulation of food intake and pharmaceutical companies have invested millions of dollars to discover and develop drug targets for the serotonergic pathway. |
2011-06-09 |
2023-08-12 |
Not clear |
| Morvarid Karimi, Stephen M Moerlein, Tom O Videen, Robert R Luedtke, Michelle Taylor, Robert H Mach, Joel S Perlmutte. Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect? Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 1. 2011-06-06. PMID:20960437. |
we have demonstrated with positron emission tomography that patients with primary focal cranial or hand dystonia have reduced putamenal specific binding of [(18)f]spiperone, a nonselective d2-like radioligand with nearly equal affinity for serotonergic 5-ht(2a) sites. |
2011-06-06 |
2023-08-12 |
human |
| Martin Sjögren, Per R Jonsson, Mia Dahlström, Tomas Lundälv, Robert Burman, Ulf Göransson, Lars Bohli. Two brominated cyclic dipeptides released by the coldwater marine sponge Geodia barretti act in synergy as chemical defense. Journal of natural products. vol 74. issue 3. 2011-06-02. PMID:21338120. |
previously, 1 and 2 were demonstrated to bind specifically to serotonergic 5-ht receptors. |
2011-06-02 |
2023-08-12 |
Not clear |
| P Bloms-Funke, E Dremencov, T I F H Cremers, T M Tzschentk. Tramadol increases extracellular levels of serotonin and noradrenaline as measured by in vivo microdialysis in the ventral hippocampus of freely-moving rats. Neuroscience letters. vol 490. issue 3. 2011-06-01. PMID:21195741. |
it can be concluded that, albeit less efficacious, the effects of tramadol on serotonergic and noradrenergic neurotransmission resemble those of the dual 5-ht and na re-uptake inhibitors duloxetine, venlafaxine, and clomipramine, and are different from those of the ssri citalopram and the nri reboxetine. |
2011-06-01 |
2023-08-12 |
rat |
| Yan Liu, Yun'ai Jiang, Yunxia Si, Ji-Young Kim, Zhou-Feng Chen, Yi Ra. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. vol 472. issue 7341. 2011-05-31. PMID:21441904. |
these results indicate that 5-ht and serotonergic neurons in the adult brain regulate mammalian sexual preference. |
2011-05-31 |
2023-08-12 |
mouse |
| Anniek K D Visser, Aren van Waarde, Antoon T M Willemsen, Fokko J Bosker, Paul G M Luiten, Johan A den Boer, Ido P Kema, Rudi A J O Dierck. Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications. European journal of nuclear medicine and molecular imaging. vol 38. issue 3. 2011-05-26. PMID:21113591. |
in this review we give an overview of the conventional methods of measuring serotonin synthesis and methods using positron emission tomography (pet) tracers, more specifically with respect to serotonergic function in affective disorders. |
2011-05-26 |
2023-08-12 |
Not clear |
| Anniek K D Visser, Aren van Waarde, Antoon T M Willemsen, Fokko J Bosker, Paul G M Luiten, Johan A den Boer, Ido P Kema, Rudi A J O Dierck. Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications. European journal of nuclear medicine and molecular imaging. vol 38. issue 3. 2011-05-26. PMID:21113591. |
in conclusion, pet with radiolabelled substrates for the serotonergic pathway is the only direct way to detect changes of serotonin synthesis in the living brain. |
2011-05-26 |
2023-08-12 |
Not clear |
| Kota Nakaya, Osamu Nakagawasai, Yuichiro Arai, Hiroshi Onogi, Atsushi Sato, Fukie Niijima, Koichi Tan-No, Takeshi Tadan. Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: involvement of dopamine D2 and 5-HT2A receptors. Behavioural brain research. vol 218. issue 1. 2011-05-25. PMID:21130810. |
these results suggest that involvement of dopaminergic and/or serotonergic neurotransmission may play a crucial role in memantine-induced ppi disruption, and additionally, indicate that blockade of either the d(2) or 5-ht(2a) receptor may prevent disruption of ppi induced by memantine in mice. |
2011-05-25 |
2023-08-12 |
mouse |
| Shigeo Miyata, Shoko Hirano, Masahiro Ohsawa, Junzo Kame. Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:19823805. |
since chlorpheniramine inhibits the reuptake of serotonin (5-ht), the anxiolytic-like effect of chlorpheniramine may be produced by an increase in serotonergic function. |
2011-05-24 |
2023-08-12 |
mouse |