| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel D Lam, Alastair S Garfield, Oliver J Marston, Jill Shaw, Lora K Heisle. Brain serotonin system in the coordination of food intake and body weight. Pharmacology, biochemistry, and behavior. vol 97. issue 1. 2011-09-15. PMID:20837046. |
through the decades, serotonin receptors have been identified and their function in the serotonergic regulation of food intake clarified. |
2011-09-15 |
2023-08-12 |
Not clear |
| P C McHugh, P R Joyce, X Deng, M A Kenned. A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. The pharmacogenomics journal. vol 11. issue 3. 2011-09-14. PMID:20351752. |
given the pivotal role of the serotonergic system in mood disorders and selective serotonin reuptake inhibitors (ssris) antidepressant function, we tested the hypothesis that gfrp gene (gchfr) variants would modify response to antidepressants in subjects with major depression. |
2011-09-14 |
2023-08-12 |
human |
| Christian M Nefzger, John M Haynes, Colin W Pouto. Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells. Stem cells (Dayton, Ohio). vol 29. issue 6. 2011-09-13. PMID:21472823. |
combined directed expression of gata2, proneural gene mash1, and forkhead transcription factor foxa2 further enhanced serotonergic neural differentiation, resulting in a 10-fold increase in serotonin content. |
2011-09-13 |
2023-08-12 |
Not clear |
| Qing-Qiu Mao, Yan-Fang Xian, Siu-Po Ip, Chun-Tao Ch. Involvement of serotonergic system in the antidepressant-like effect of piperine. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21477634. |
taken together, these results clearly suggest that the antidepressant-like effect of piperine is mediated via the serotonergic system by enhancing 5-ht content in mouse brain. |
2011-09-13 |
2023-08-12 |
mouse |
| Tien-Wen Lee, Younger W Y Yu, Chen-Jee Hong, Shih-Jen Tsai, Hung-Chi Wu, Tai-Jui Che. The influence of serotonin transporter polymorphisms on cortical activity: a resting EEG study. BMC neuroscience. vol 12. 2011-09-12. PMID:21507249. |
the serotonin transporter gene (5-htt) is a key regulator of serotonergic neurotransmission and has been linked to various psychiatric disorders. |
2011-09-12 |
2023-08-12 |
Not clear |
| Angela Shuyi Chen, Young Mee Kim, Shovanlal Gayen, Qiwei Huang, Manfred Raida, Congbao Kan. NMR structural study of the intracellular loop 3 of the serotonin 5-HT(1A) receptor and its interaction with calmodulin. Biochimica et biophysica acta. vol 1808. issue 9. 2011-09-12. PMID:21640070. |
the serotonin (5-ht(1a)) receptor, a g-protein-coupled receptor (gpcr), plays important roles in serotonergic signaling in the central nervous system. |
2011-09-12 |
2023-08-12 |
Not clear |
| Thomas Giang, Yvonne Ritze, Steffen Rauchfuss, Maite Ogueta, Henrike Schol. The serotonin transporter expression in Drosophila melanogaster. Journal of neurogenetics. vol 25. issue 1-2. 2011-09-08. PMID:21314480. |
the serotonin transporter is an important regulator of serotonergic signaling. |
2011-09-08 |
2023-08-12 |
drosophila_melanogaster |
| Thomas Giang, Yvonne Ritze, Steffen Rauchfuss, Maite Ogueta, Henrike Schol. The serotonin transporter expression in Drosophila melanogaster. Journal of neurogenetics. vol 25. issue 1-2. 2011-09-08. PMID:21314480. |
in contrast to this, there are other areas in serotonergic neurons where dsert expression and/or function are uncoupled from synaptic neurotransmitter recycling and serotonin release. |
2011-09-08 |
2023-08-12 |
drosophila_melanogaster |
| Shih-Ching Chen, Chen-Li Cheng, Wen-Jia Fan, Jia-Jin Jason Chen, Chien-Hung Lai, Chih-Wei Pen. Effect of a 5-HT1A receptor agonist (8-OH-DPAT) on external urethral sphincter activity in a rat model of pudendal nerve injury. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 1. 2011-09-08. PMID:21490366. |
although serotonergic agents have been used to treat patients with stress urinary incontinence, the characteristics of the external urethral sphincter (eus) activity activated by 5-ht receptors have not been extensively studied. |
2011-09-08 |
2023-08-12 |
rat |
| Soo-Hyun Park, Yun-Beom Sim, Jin-Koo Lee, Seon-Mi Kim, Yu-Jung Kang, Jun-Sub Jung, Hong-Won Su. The analgesic effects and mechanisms of orally administered eugenol. Archives of pharmacal research. vol 34. issue 3. 2011-09-07. PMID:21547684. |
however, methysergide (5-ht serotonergic receptor antagonist) did not affect antinociception induced by eugenol in the writhing test. |
2011-09-07 |
2023-08-12 |
mouse |
| Jochen Winterer, A Vanessa Stempel, Tamar Dugladze, Csaba Földy, Nino Maziashvili, Aleksandar R Zivkovic, Josef Priller, Ivan Soltesz, Tengis Gloveli, Dietmar Schmit. Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 23. 2011-09-01. PMID:21653851. |
midbrain raphe nuclei provide strong serotonergic projections to the hippocampus, in which serotonin (5-ht) exerts differential effects mediated by multiple 5-ht receptor subtypes. |
2011-09-01 |
2023-08-12 |
rat |
| J B Fregoneze, E F Oliveira, V F Ribeiro, H S Ferreira, E De Castro E Silv. Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation. Neuropeptides. vol 45. issue 3. 2011-08-29. PMID:21514668. |
it is shown that a 5-ht(3) receptor-dependent mechanism seems to be part of the brain serotonergic system that contributes to cardiovascular regulation since the hypertensive response observed after ondansetron administration indicates that central 5-ht(3) receptors exert a tonic inhibitory drive on blood pressure. |
2011-08-29 |
2023-08-12 |
rat |
| J B Fregoneze, E F Oliveira, V F Ribeiro, H S Ferreira, E De Castro E Silv. Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation. Neuropeptides. vol 45. issue 3. 2011-08-29. PMID:21514668. |
furthermore, the data obtained here clearly indicate that the hypotensive response observed after pharmacological stimulation of central 5-ht(3) receptors depends on the functional integrity of brain μ, κ and δ opioid receptors, suggesting that a functional interaction between serotonergic and opiatergic pathways in the brain is part of the complex, multifactorial system that regulates blood pressure in the central nervous system. |
2011-08-29 |
2023-08-12 |
rat |
| Ian B Hickie, Naomi L Roger. Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet (London, England). vol 378. issue 9791. 2011-08-29. PMID:21596429. |
in particular, we highlight agomelatine, a melatonin-receptor agonist and selective serotonergic receptor subtype (ie, 5-ht(2c)) antagonist that has chronobiotic, antidepressant, and anxiolytic effects. |
2011-08-29 |
2023-08-12 |
Not clear |
| Nadja Osterberg, Michael Wiehle, Oliver Oehlke, Stefanie Heidrich, Cheng Xu, Chen-Ming Fan, Kerstin Krieglstein, Eleni Rouss. Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons. PloS one. vol 6. issue 4. 2011-08-23. PMID:21541283. |
mesencephalic dopaminergic neurons (mda) and serotonergic (5-ht) neurons are clinically important ventral neuronal populations. |
2011-08-23 |
2023-08-12 |
mouse |
| Robert F Wideman, Krishna R Hama. Idiopathic pulmonary arterial hypertension: an avian model for plexogenic arteriopathy and serotonergic vasoconstriction. Journal of pharmacological and toxicological methods. vol 63. issue 3. 2011-08-22. PMID:21277983. |
serotonin has been directly linked to the pathogenesis of ipah in humans, including ipah linked to serotonergic anorexigens that trigger the formation of plexiform lesions indistinguishable from those observed in primary ipah triggered by other causes. |
2011-08-22 |
2023-08-12 |
Not clear |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
observations suggest that constitutive gastrointestinal motility depends more on neuronal than ec cell serotonin; moreover, serotonergic neurons promote development/survival of some classes of late-born enteric neurons, including dopaminergic neurons, which appear to innervate and activate in the adult ens. |
2011-08-22 |
2023-08-12 |
mouse |
| Elisabeth M Dykens, Elizabeth Roof, Douglas Bittel, Merlin G Butle. TPH2 G/T polymorphism is associated with hyperphagia, IQ, and internalizing problems in Prader-Willi syndrome. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 5. 2011-08-18. PMID:21418060. |
as aberrant serotonergic functioning is strongly implicated in pws, we examined associations between the pws phenotype and polymorphisms in tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in the biosynthesis of serotonin in the brain. |
2011-08-18 |
2023-08-12 |
Not clear |
| Oguz Mutlu, Guner Ulak, Ipek Komsuoglu Celikyurt, Firuzan Yildiz Akar, Faruk Erde. Effects of citalopram on cognitive performance in passive avoidance, elevated plus-maze and three-panel runway tasks in naïve rats. The Chinese journal of physiology. vol 54. issue 1. 2011-08-18. PMID:21786537. |
citalopram, a selective serotonin reuptake inhibitor (ssri), is one of the most widely used drugs for the treatment of disorders related to serotonergic dysfunction like depression and anxiety. |
2011-08-18 |
2023-08-12 |
rat |
| Harumasa Takano, Hiroshi Ito, Hidehiko Takahashi, Ryosuke Arakawa, Masaki Okumura, Fumitoshi Kodaka, Tatsui Otsuka, Motoichiro Kato, Tetsuya Suhar. Serotonergic neurotransmission in the living human brain: a positron emission tomography study using [¹¹C]dasb and [¹¹C]WAY100635 in young healthy men. Synapse (New York, N.Y.). vol 65. issue 7. 2011-08-16. PMID:21484882. |
the central serotonergic (5-ht) system is closely involved in regulating various mental functions such as mood and emotion. |
2011-08-16 |
2023-08-12 |
human |