| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heinz H Pertz, Jochen Lehmann, René Roth-Ehrang, Sigurd El. Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. Planta medica. vol 77. issue 10. 2011-10-20. PMID:21305447. |
in these conditions, cholinergic m (3) receptors and serotonergic 5-ht (3) and 5-ht (4) receptors are involved. |
2011-10-20 |
2023-08-12 |
rat |
| Benjamin N Greenwood, Monika Fleshne. Exercise, stress resistance, and central serotonergic systems. Exercise and sport sciences reviews. vol 39. issue 3. 2011-10-19. PMID:21508844. |
evidence reviewed herein is consistent with the hypothesis that exercise increases stress resistance by producing neuroplasticity at multiple sites of the central serotonergic system, which all help to limit the behavioral impact of acute increases in serotonin during stressor exposure. |
2011-10-19 |
2023-08-12 |
Not clear |
| Michael R Bruchas, Abigail G Schindler, Haripriya Shankar, Daniel I Messinger, Mayumi Miyatake, Benjamin B Land, Julia C Lemos, Catherine E Hagan, John F Neumaier, Albert Quintana, Richard D Palmiter, Charles Chavki. Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron. vol 71. issue 3. 2011-10-18. PMID:21835346. |
stress-induced activation of p38α mapk translocated the serotonin transporter to the plasma membrane and increased the rate of transmitter uptake at serotonergic nerve terminals. |
2011-10-18 |
2023-08-12 |
mouse |
| Sonny K H Tan, Henrike Hartung, Trevor Sharp, Yasin Teme. Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus? Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21251918. |
the biological mechanism may involve changes in monoamine systems, in particular the serotonergic (5-hydroxytryptamine, 5-ht) system. |
2011-10-14 |
2023-08-12 |
Not clear |
| Silvina Laura Diaz, Luc Maroteau. Implication of 5-HT(2B) receptors in the serotonin syndrome. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21277875. |
the 5-ht(2b) receptor has been proposed as a positive modulator of serotonergic activity, but whether it is involved in 5-ht syndrome has not yet been studied. |
2011-10-14 |
2023-08-12 |
mouse |
| Bryan L Rot. Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21288474. |
5-hydroxytryptamine(2a) (5-ht(2a)) serotonin receptors are important pharmacological targets for a large number of central nervous system and peripheral serotonergic medications. |
2011-10-14 |
2023-08-12 |
Not clear |
| Jean-Philippe Guilloux, Denis J P David, Lin Xia, Hai Thanh Nguyen, Quentin Rainer, Bruno P Guiard, Christelle Repérant, Thierry Deltheil, Miklos Toth, René Hen, Alain M Gardie. Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21333660. |
it is known that single deletion of either 5-ht(1a) or 5-ht(1b) receptor induces behavioral changes that are not correlated with differences in brain serotonergic tone. |
2011-10-14 |
2023-08-12 |
mouse |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
neither type of serotonergic lesion altered the densities of 5-ht(1a) or 5-ht(2a) receptors in the hippocampus; serotonin transporters or 5-ht(1a) autoreceptors on raphe cell bodies; or dopamine transporters, d(1) or d(2) receptors in forebrain regions efferent to the hippocampus and implicated in schizophrenia, such as the nucleus accumbens. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
selective upregulation of 5-ht(2c) receptors in the dorsal, but not ventral, hippocampus of these lesioned rats suggests that hippocampal 5-ht(2c) receptors vary in their adaptability to changes in serotonergic tone along the dorsoventral axis. |
2011-10-14 |
2023-08-12 |
rat |
| Kevin G Broadbelt, David S Paterson, Richard A Belliveau, Felicia L Trachtenberg, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hannah C Kinne. Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome. Journal of neuropathology and experimental neurology. vol 70. issue 9. 2011-10-14. PMID:21865888. |
γ-aminobutyric acid (gaba) neurons in the medulla oblongata help regulate homeostasis, in part through interactions with the medullary serotonergic (5-ht) system. |
2011-10-14 |
2023-08-12 |
Not clear |
| Lynette C Daws, Georgianna G Goul. Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacology & therapeutics. vol 131. issue 1. 2011-10-05. PMID:21447358. |
sert is the high-affinity uptake mechanism for 5-ht and exerts tight control over the strength and duration of serotonergic neurotransmission. |
2011-10-05 |
2023-08-12 |
human |
| Tanya L Wallace, Theresa M Ballard, Bruno Pouzet, Wim J Riedel, Joseph G Wettstei. Drug targets for cognitive enhancement in neuropsychiatric disorders. Pharmacology, biochemistry, and behavior. vol 99. issue 2. 2011-09-29. PMID:21463652. |
both glutamatergic and serotonergic (5-ht) agonists and antagonists have profound effects on neurotransmission and improve cognitive function in preclinical experiments with animals; some of these compounds are now in proof-of-concept studies in humans. |
2011-09-29 |
2023-08-12 |
Not clear |
| Brian D Poeschla, Pauline Bartle, Karen P Hanse. Serotonin syndrome associated with polypharmacy in the elderly. General hospital psychiatry. vol 33. issue 3. 2011-09-29. PMID:21601732. |
the increasing use of serotonergic agents, alone and in combination, across multiple disciplines, makes it likely that the prevalence of serotonin syndrome will rise. |
2011-09-29 |
2023-08-12 |
Not clear |
| Brian D Poeschla, Pauline Bartle, Karen P Hanse. Serotonin syndrome associated with polypharmacy in the elderly. General hospital psychiatry. vol 33. issue 3. 2011-09-29. PMID:21601732. |
as this case illustrates, serotonin syndrome can be caused by combinations of direct serotonin agonists (e.g., serotonergic antidepressants) and indirect serotonin agonists (e.g., atypical antipsychotics). |
2011-09-29 |
2023-08-12 |
Not clear |
| Camila Marroni Roncon, Camila Biesdorf de Almeida, Traudi Klein, João Carlos Palazzo de Mello, Elisabeth Aparecida Aud. Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test. Planta medica. vol 77. issue 3. 2011-09-26. PMID:20845263. |
to evaluate possible serotonergic and dopaminergic neurotransmission involvement in the action of pea during the etm test, ineffective doses of metergoline (met; 5-ht (2a/2c) antagonist receptor) or sulpiride (sul; dopaminergic receptor antagonist) were acutely administered together with the pea. |
2011-09-26 |
2023-08-12 |
rat |
| Jon K Slettedal, Dag Olav V Nilssen, Morten Magelssen, Else Marit Løberg, Jan Maehle. Brain pathology in fatal serotonin syndrome: presentation of two cases. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 3. 2011-09-22. PMID:20880320. |
excess serotonergic activity in the cns and peripheral serotonin receptors results in neuromuscular hyperactivity, mental changes and autonomic symptoms. |
2011-09-22 |
2023-08-12 |
Not clear |
| Whorra P Chander, Navdeep Singh, Gulshan K Mukhiy. Serotonin syndrome in maintenance haemodialysis patients following sertraline treatment for depression. Journal of the Indian Medical Association. vol 109. issue 1. 2011-09-22. PMID:21888157. |
in our experience the use of ssri, sertraline for depression in esrd patients on maintenance haemodalysis was associated with a high incidence of serotonergic side-effects and toxic serotonin syndrome. |
2011-09-22 |
2023-08-12 |
Not clear |
| Saydur Rahman, Izhar A Khan, Peter Thoma. Tryptophan hydroxylase: a target for neuroendocrine disruption. Journal of toxicology and environmental health. Part B, Critical reviews. vol 14. issue 5-7. 2011-09-21. PMID:21790322. |
tryptophan hydroxylase (tph), the rate-limiting enzyme in serotonin (5-ht) synthesis, performs an essential role in the maintenance of serotonergic functions in the central nervous system (cns), including regulation of the neuroendocrine system controlling reproduction. |
2011-09-21 |
2023-08-12 |
Not clear |
| Saydur Rahman, Izhar A Khan, Peter Thoma. Tryptophan hydroxylase: a target for neuroendocrine disruption. Journal of toxicology and environmental health. Part B, Critical reviews. vol 14. issue 5-7. 2011-09-21. PMID:21790322. |
pharmacological restoration of hypothalamic 5-ht levels after exposure to both stressors also restored neuroendocrine and reproductive functions, indicating that the serotonergic system is an important site for hypoxia- and aroclor 1254-induced inhibition of reproductive neuroendocrine functions. |
2011-09-21 |
2023-08-12 |
Not clear |
| Ryo Kawai, Suguru Kobayashi, Yutaka Fujito, Etsuro It. Multiple subtypes of serotonin receptors in the feeding circuit of a pond snail. Zoological science. vol 28. issue 7. 2011-09-20. PMID:21728800. |
recent electrophysiological studies have claimed that only metabotropic serotonin (5-ht(2)) receptors, and not ionotropic (5-ht(3)) receptors, are used in synapses between serotonergic neurons (the cerebral giant cells, cgcs) and the follower buccal motoneurons (the b1 cells). |
2011-09-20 |
2023-08-12 |
Not clear |