| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| An-Hsun Chou, Ying-Ling Chen, Su-Huei Hu, Ya-Ming Chang, Hung-Li Wan. Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation. Brain research. vol 1583. 2015-06-05. PMID:25139423. |
downregulated mrna expression of calcineurin b, ip3-r1, myosin va and plc β4, which are required for the induction of cerebellar ltd, led to an impairment of ltd induction in purkinje neurons of sca3 transgenic mouse. |
2015-06-05 |
2023-08-13 |
mouse |
| Shalini S Nayak, Rajagopal Kadavigere, Mary Mathew, Pratap Kumar, Judith G Hall, Katta M Girish. Fetal akinesia deformation sequence: expanding the phenotypic spectrum. American journal of medical genetics. Part A. vol 164A. issue 10. 2015-06-04. PMID:25045026. |
both had loss/absence of purkinje cells in cerebellum. |
2015-06-04 |
2023-08-13 |
Not clear |
| Junko Sato, Naoaki Yamada, Ryosuke Kobayashi, Minoru Tsuchitani, Yoshiyasu Kobayash. Morphometric analysis of progressive changes in hereditary cerebellar cortical degenerative disease (abiotrophy) in rabbits caused by abnormal synaptogenesis. Journal of toxicologic pathology. vol 28. issue 2. 2015-06-01. PMID:26028816. |
we previously investigated rabbit hereditary cerebellar cortical degenerative disease, called cerebellar cortical abiotrophy in the veterinary field, and determined that the pathogenesis of this disease is the result of failed synaptogenesis between parallel fibers and purkinje cells. |
2015-06-01 |
2023-08-13 |
rabbit |
| Hideo Kubota, Soichi Nagao, Kunihiko Obata, Moritoshi Hiron. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PloS one. vol 9. issue 9. 2015-05-28. PMID:25181481. |
gabaergic cerebellar molecular layer interneurons (mlis) modulate firing patterns of purkinje cells (pcs), which play a key role in cerebellar information processing. |
2015-05-28 |
2023-08-13 |
mouse |
| V V Iasnetsov, V G Motin, V V Jasnecov, S K Karsanova, Ju V Ivanov, N A Chel'naj. [Effects of vestibuloprotectors mexidol and melatonin on animal cerebellum]. Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine. vol 48. issue 6. 2015-05-26. PMID:25928981. |
investigation of rat's cerebellum slices with prolonged survival showed that 5 mm of mexidol inhibited reliably purkinje cells population responses by 93 +/- 4%; the presence of mk-801 (100 micromm) weakened this effect by 82 +/- 3%. |
2015-05-26 |
2023-08-13 |
rat |
| V V Iasnetsov, V G Motin, V V Jasnecov, S K Karsanova, Ju V Ivanov, N A Chel'naj. [Effects of vestibuloprotectors mexidol and melatonin on animal cerebellum]. Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine. vol 48. issue 6. 2015-05-26. PMID:25928981. |
consequently, mexidol is capable to inhibit strongly the parallel fibers--purkinje cells synaptic transmission in the rat's cerebellum, whereas mk- 801 abates this effect appreciably. |
2015-05-26 |
2023-08-13 |
rat |
| X-Y Chen, F Lu, Y-M Wang, Y Yang, G-Q Wei, D Wu, L-F Wang, Y-M W. PTEN inactivation by germline/somatic c.950_953delTACT mutation in patients with Lhermitte-Duclos disease manifesting progressive phenotypes. Clinical genetics. vol 86. issue 4. 2015-05-25. PMID:24102544. |
lhermitte-duclos disease (ldd), a neurological manifestation of cowden syndrome (cs), is a rare and benign cerebellar disorder, featured by dysplastic cerebellar ganglion cells which replace granular and purkinje cells. |
2015-05-25 |
2023-08-12 |
Not clear |
| Xiaohong Song, Miwako Yamasaki, Taisuke Miyazaki, Kohtarou Konno, Motokazu Uchigashima, Masahiko Watanab. Neuron type- and input pathway-dependent expression of Slc4a10 in adult mouse brains. The European journal of neuroscience. vol 40. issue 5. 2015-05-25. PMID:24905082. |
slc4a10 mrna was widely expressed, with higher levels in pyramidal cells in the hippocampus and cerebral cortex, parvalbumin-positive interneurons in the hippocampus, and purkinje cells (pcs) in the cerebellum. |
2015-05-25 |
2023-08-13 |
mouse |
| Guo-Jen Huang, Andrew Edwards, Cheng-Yu Tsai, Yi-Shin Lee, Lei Peng, Takumi Era, Yoshio Hirabayashi, Ching-Yen Tsai, Shin-Ichi Nishikawa, Yoichiro Iwakura, Shu-Jen Chen, Jonathan Flin. Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice. PloS one. vol 9. issue 2. 2015-05-22. PMID:24516532. |
ectopic cerebellar cell migration causes maldevelopment of purkinje cells and abnormal motor behaviour in cxcr4 null mice. |
2015-05-22 |
2023-08-12 |
mouse |
| Guo-Jen Huang, Andrew Edwards, Cheng-Yu Tsai, Yi-Shin Lee, Lei Peng, Takumi Era, Yoshio Hirabayashi, Ching-Yen Tsai, Shin-Ichi Nishikawa, Yoichiro Iwakura, Shu-Jen Chen, Jonathan Flin. Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice. PloS one. vol 9. issue 2. 2015-05-22. PMID:24516532. |
together, these results suggest ectopic the migration of granule cells impairs development of purkinje cells, causes gross cerebellar anatomical disruption and leads to behavioural motor defects in cxcr4 null mice. |
2015-05-22 |
2023-08-12 |
mouse |
| Lisa Mapelli, Martina Pagani, Jesus A Garrido, Egidio D'Angel. Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit. Frontiers in cellular neuroscience. vol 9. 2015-05-22. PMID:25999817. |
cerebellar ltp and ltd occur in all three main cerebellar subcircuits (granular layer, molecular layer, deep cerebellar nuclei) and correspondingly regulate the function of their three main neurons: granule cells (grcs), purkinje cells (pcs) and deep cerebellar nuclear (dcn) cells. |
2015-05-22 |
2023-08-13 |
mouse |
| Xin Yan, Jan Lukas, Juntang Lin, Mathias Ernst, Dirk Koczan, Martin Witt, Georg Fuellen, Andreas Wree, Arndt Rolfs, Jiankai Lu. Aberrant expressions of delta-protocadherins in the brain of Npc1 mutant mice. Histology and histopathology. vol 29. issue 9. 2015-05-12. PMID:24671883. |
furthermore, expressions of pcdhs by oligodendrocytes in the corpus callosum and by purkinje cells and granular cells in the cerebellum are strongly decreased in npc1 mutated mice at later stages. |
2015-05-12 |
2023-08-12 |
mouse |
| Mia Levit. Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 8. 2015-05-12. PMID:25081016. |
the anti-mglur1 antibodies can be very pathogenic in the brain since they can reduce the basal neuronal activity, block the induction of long-term depression of purkinje cells, and altogether cause cerebellar motor coordination deficits by a combination of rapid effects on both the acute and the plastic responses of purkinje cells, and by chronic degenerative effects. |
2015-05-12 |
2023-08-13 |
mouse |
| Neal H Barmack, Zuyuan Qian, Vadim Yakhnits. Long-term climbing fibre activity induces transcription of microRNAs in cerebellar Purkinje cells. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1652. 2015-05-12. PMID:25135969. |
since climbing fibre activity is often associated with cerebellar behavioural plasticity, we used horizontal optokinetic stimulation (hoks) to naturally increase synaptic input to floccular purkinje cells in mice for hours, not minutes, and investigated how this activity influenced the transcription of micrornas, small non-coding nucleotides that reduce transcripts of multiple, complementary mrnas. |
2015-05-12 |
2023-08-13 |
mouse |
| Nora Mecklenburg, Jesus E Martinez-Lopez, Juan Antonio Moreno-Bravo, Ariadna Perez-Balaguer, Eduardo Puelles, Salvador Martine. Growth and differentiation factor 10 (Gdf10) is involved in Bergmann glial cell development under Shh regulation. Glia. vol 62. issue 10. 2015-05-11. PMID:24963847. |
furthermore, we found gdf10 to be regulated by sonic hedgehog (shh), which is secreted by purkinje cells of the cerebellum. |
2015-05-11 |
2023-08-13 |
Not clear |
| Jessica M Rosin, Brendan B McAllister, Richard H Dyck, Christopher J Percival, Deborah M Kurrasch, John Cob. Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Developmental biology. vol 399. issue 1. 2015-05-01. PMID:25528224. |
purkinje cells of the developing cerebellum secrete the morphogen sonic hedgehog (shh), which is required to maintain the proliferative state of granule cell precursors (gcps) prior to their differentiation and migration to form the internal granule layer (igl). |
2015-05-01 |
2023-08-13 |
mouse |
| Marie K Bosch, Jeanne M Nerbonne, David M Ornit. Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo. PloS one. vol 9. issue 8. 2015-04-24. PMID:25093726. |
viral-vector mediated gene transfer to cerebellar purkinje neurons in vivo is a promising avenue for gene therapy of cerebellar ataxias and for genetic manipulation in functional studies of animal models of cerebellar disease. |
2015-04-24 |
2023-08-13 |
mouse |
| Jingmin Ji, Melanie L Hassler, Etsuko Shimobayashi, Nagendher Paka, Raphael Streit, Josef P Kapfhamme. Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14. Neurobiology of disease. vol 70. 2015-04-21. PMID:24937631. |
we find that in mice expressing the mutated pkcγ protein the morphology of purkinje cells in cerebellar slice cultures is drastically altered and mimics closely the morphology seen after pharmacological pkc activation. |
2015-04-21 |
2023-08-13 |
mouse |
| Jingmin Ji, Melanie L Hassler, Etsuko Shimobayashi, Nagendher Paka, Raphael Streit, Josef P Kapfhamme. Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14. Neurobiology of disease. vol 70. 2015-04-21. PMID:24937631. |
in adult transgenic mice there is evidence for some localized loss of purkinje cells but there is no overall cerebellar atrophy. |
2015-04-21 |
2023-08-13 |
mouse |
| Fredrick J Sei. The changeable nervous system: studies on neuroplasticity in cerebellar cultures. Neuroscience and biobehavioral reviews. vol 45. 2015-04-16. PMID:24933693. |
when cerebellar cultures derived from newborn mice were exposed at explantation to a preparation of cytosine arabinoside that destroyed granule cells and oligodendrocytes and compromised astrocytes, purkinje cells surviving in greater than usual numbers were unensheathed by astrocytic processes and received twice the control number of inhibitory axosomatic synapses. |
2015-04-16 |
2023-08-13 |
mouse |