| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Björn Bluhm, Björn Laffer, Daniela Hirnet, Matthias Rothermundt, Oliver Ambree, Christian Loh. Normal cerebellar development in S100B-deficient mice. Cerebellum (London, England). vol 14. issue 2. 2015-12-01. PMID:25342137. |
this time range covers important developmental steps in the cerebellum such as granule cell proliferation and migration, as well as dendritic growth of purkinje cells. |
2015-12-01 |
2023-08-13 |
mouse |
| Haibo Zhou, Zhanmin Lin, Kai Voges, Chiheng Ju, Zhenyu Gao, Laurens W J Bosman, Tom J H Ruigrok, Freek E Hoebeek, Chris I De Zeeuw, Martijn Schonewill. Cerebellar modules operate at different frequencies. eLife. vol 3. 2015-11-23. PMID:24843004. |
in this study, we show in awake mice at rest that spiking activity of purkinje cells, the sole output cells of the cerebellar cortex, differs between cerebellar modules and correlates with their expression of the glycolytic enzyme aldolase c or zebrin. |
2015-11-23 |
2023-08-13 |
mouse |
| Dar-Shong Lin, Chung-Der Hsiao, Allan Yueh-Luen Lee, Che-Sheng Ho, Hsuan-Liang Liu, Tuen-Jen Wang, Yuan-Ren Jian, Jui-Cheng Hsu, Zon-Darr Huang, Tsung-Han Lee, Ming-Fu Chian. Mitigation of cerebellar neuropathy in globoid cell leukodystrophy mice by AAV-mediated gene therapy. Gene. vol 571. issue 1. 2015-11-23. PMID:26115766. |
we observed degeneration of purkinje cells, bergmann glia, and granule cells in addition to astrocytosis and demyelination in the cerebellum of the twitcher mice. |
2015-11-23 |
2023-08-13 |
mouse |
| Dar-Shong Lin, Chung-Der Hsiao, Allan Yueh-Luen Lee, Che-Sheng Ho, Hsuan-Liang Liu, Tuen-Jen Wang, Yuan-Ren Jian, Jui-Cheng Hsu, Zon-Darr Huang, Tsung-Han Lee, Ming-Fu Chian. Mitigation of cerebellar neuropathy in globoid cell leukodystrophy mice by AAV-mediated gene therapy. Gene. vol 571. issue 1. 2015-11-23. PMID:26115766. |
intracerebellar-mediated gene therapy efficiently corrected enzymatic deficiency by direct transduction to purkinje cells and cross-correction in other cell types in the cerebellum, leading to the amelioration of both neuroinflammation and demyelination. |
2015-11-23 |
2023-08-13 |
mouse |
| Dar-Shong Lin, Chung-Der Hsiao, Allan Yueh-Luen Lee, Che-Sheng Ho, Hsuan-Liang Liu, Tuen-Jen Wang, Yuan-Ren Jian, Jui-Cheng Hsu, Zon-Darr Huang, Tsung-Han Lee, Ming-Fu Chian. Mitigation of cerebellar neuropathy in globoid cell leukodystrophy mice by AAV-mediated gene therapy. Gene. vol 571. issue 1. 2015-11-23. PMID:26115766. |
the population, dendritic territory, and axonal processes of purkinje cells remained normal in the cerebellum of treated twitcher mice, where radial fibers of bergmann glia spanned the molecular layer and collateral branches ensheathed the dendritic processes of purkinje cells. |
2015-11-23 |
2023-08-13 |
mouse |
| Dar-Shong Lin, Chung-Der Hsiao, Allan Yueh-Luen Lee, Che-Sheng Ho, Hsuan-Liang Liu, Tuen-Jen Wang, Yuan-Ren Jian, Jui-Cheng Hsu, Zon-Darr Huang, Tsung-Han Lee, Ming-Fu Chian. Mitigation of cerebellar neuropathy in globoid cell leukodystrophy mice by AAV-mediated gene therapy. Gene. vol 571. issue 1. 2015-11-23. PMID:26115766. |
taken together, our findings underscore the complexity of cerebellar neurodegeneration in gld and highlight the potential effectiveness of gene therapy in mitigating neuropathological deficits in gld and other neurodegenerative disorders in which purkinje cells are involved. |
2015-11-23 |
2023-08-13 |
mouse |
| David R Hampson, Gene J Blat. Autism spectrum disorders and neuropathology of the cerebellum. Frontiers in neuroscience. vol 9. 2015-11-23. PMID:26594141. |
postmortem studies have revealed neuropathological abnormalities in cerebellar cellular architecture while studies on mouse lines with cell loss or mutations in single genes restricted to cerebellar purkinje cells have also strongly implicated this brain structure in contributing to the autistic phenotype. |
2015-11-23 |
2023-08-13 |
mouse |
| Yara Dadalti Fragoso, Patrick N Stoney, Kirsty D Shearer, Angelo Sementilli, Sonia E Nanescu, Pietro Sementilli, Peter McCaffer. Expression in the human brain of retinoic acid induced 1, a protein associated with neurobehavioural disorders. Brain structure & function. vol 220. issue 2. 2015-11-17. PMID:24519454. |
in the cerebellum, a second region of high expression, rai1 was present in purkinje cells, but not granule cells. |
2015-11-17 |
2023-08-12 |
mouse |
| Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Shyamali Saha, Satya Prakas. Intranasal, siRNA Delivery to the Brain by TAT/MGF Tagged PEGylated Chitosan Nanoparticles. Journal of pharmaceutics. vol 2013. 2015-11-11. PMID:26555995. |
the results indicate that 0.5 mg/kg of sirna is delivered successfully to the hippocampus, thalamus, hypothalamus, and purkinje cells in the cerebellum after 4 hrs of post intranasal delivery. |
2015-11-11 |
2023-08-13 |
Not clear |
| Robert S Raike, Carolyn E Pizoli, Catherine Weisz, Arn M J M van den Maagdenberg, H A Jinnah, Ellen J Hes. Limited regional cerebellar dysfunction induces focal dystonia in mice. Neurobiology of disease. vol 49. 2015-11-10. PMID:22850483. |
by using conditional genetics to regionally limit cerebellar dysfunction, we found that abnormalities restricted to purkinje cells were sufficient to cause dystonia. |
2015-11-10 |
2023-08-12 |
mouse |
| Takahiro Ishikawa, Shinji Kakei, Hiroshi Mitom. Overlooked Holmes' clinical signs: reevaluation by recent physiological findings. Cerebellum & ataxias. vol 2. 2015-11-09. PMID:26550482. |
recent physiological studies have shown that cerebellar outputs are modified by release or facilitation of purkinje cell-mediated inhibition on dentate neurons. |
2015-11-09 |
2023-08-13 |
Not clear |
| James M Dell'Orco, Aaron H Wasserman, Ravi Chopra, Melissa A C Ingram, Yuan-Shih Hu, Vikrant Singh, Heike Wulff, Puneet Opal, Harry T Orr, Vikram G Shakkotta. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269637. |
cerebellar perfusion of flufenamic acid, an agent that restores the depolarized membrane potential of sca1 purkinje neurons by activating potassium channels, prevents purkinje neuron dendritic atrophy. |
2015-11-05 |
2023-08-13 |
mouse |
| Kohei Matsushita, Yukari Kohara, Yuko Ito, Tsuyoshi Yoshikawa, Makoto Sato, Keisuke Kitaura, Satoshi Matsumot. A case of spontaneous myocardial necrosis and cerebral ischemic lesions in a laboratory beagle dog. Journal of toxicologic pathology. vol 28. issue 4. 2015-11-05. PMID:26538814. |
in the brain, necrosis was observed in neurons and glia of the cerebral cortex, hippocampal pyramidal cells, glial cells of the rostral commissure and purkinje cells of the cerebellar vermis. |
2015-11-05 |
2023-08-13 |
dog |
| J Hordeaux, L Dubreil, J Deniaud, F Iacobelli, S Moreau, M Ledevin, C Le Guiner, V Blouin, J Le Duff, A Mendes-Madeira, F Rolling, Y Cherel, P Moullier, M-A Coll. Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate rats. Gene therapy. vol 22. issue 4. 2015-10-29. PMID:25588740. |
iv delivery is more efficient in neonates and targets predominantly purkinje cells of the cerebellum and sensory neurons of the spinal cord and dorsal root ganglia. |
2015-10-29 |
2023-08-13 |
rat |
| Michelle Lee, Melody M Cheng, Chi-Ying Lin, Elan D Louis, Phyllis L Faust, Sheng-Han Ku. Decreased EAAT2 protein expression in the essential tremor cerebellar cortex. Acta neuropathologica communications. vol 2. 2015-10-26. PMID:25391854. |
our main finding, a significant reduction in cerebellar cortical eaat2 protein levels in essential tremor, suggests that purkinje cells in essential tremor might be more vulnerable to excitotoxic damage than those of controls. |
2015-10-26 |
2023-08-13 |
Not clear |
| A Brobeil, M Viard, M K Petri, K Steger, C Tag, M Wimme. Memory and PTPIP51--a new protein in hippocampus and cerebellum. Molecular and cellular neurosciences. vol 64. 2015-10-26. PMID:25496818. |
in the cerebellum ptpip51 was traced in purkinje cells, the cells of the molecular layer and the granular layer. |
2015-10-26 |
2023-08-13 |
mouse |
| Hiroshi Nishiyam. Dendritic translocation of climbing fibers: a new face of old phenomenon. Cerebellum (London, England). vol 14. issue 1. 2015-10-23. PMID:25331540. |
during postnatal development of the cerebellum, the number of climbing fibers that innervate individual purkinje cells decreases from many to one. |
2015-10-23 |
2023-08-13 |
Not clear |
| M Oostland, J A van Hoof. The role of serotonin in cerebellar development. Neuroscience. vol 248. 2015-10-20. PMID:23721821. |
last, activation of 5-ht₂ receptors expressed by granule cells and purkinje cells both during late postnatal development and in the mature cerebellum promotes the stability of synaptic activity. |
2015-10-20 |
2023-08-12 |
Not clear |
| Conor Houghto. Supervised learning with complex spikes and spike-timing-dependent plasticity. PloS one. vol 9. issue 6. 2015-10-19. PMID:24945786. |
these complex spikes have an initial rapid burst of spikes and spikelets followed by a sustained depolarization; in some models of cerebellar function this climbing fiber input supervises learning in purkinje cells. |
2015-10-19 |
2023-08-13 |
Not clear |
| Kris S Chaisanguanthum, Mati Joshua, Javier F Medina, William Bialek, Stephen G Lisberge. The Neural Code for Motor Control in the Cerebellum and Oculomotor Brainstem. eNeuro. vol 1. issue 1. 2015-10-14. PMID:26464956. |
we analyzed the discharge of purkinje cells in the floccular complex of the cerebellum, floccular target neurons in the brainstem, other vestibular neurons, and abducens neurons. |
2015-10-14 |
2023-08-13 |
Not clear |