| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew Barszczyk, Hong-Shuo Sun, Yi Quan, Wenhua Zheng, Milton P Charlton, Zhong-Ping Fen. Differential roles of the mevalonate pathway in the development and survival of mouse Purkinje cells in culture. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24973985. |
the cerebellum is an important locus for motor learning and higher cognitive functions, and purkinje cells constitute a key component of its circuit. |
2016-02-12 |
2023-08-13 |
mouse |
| Christian D Wilms, Michael Häusse. Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo. Nature communications. vol 6. 2016-02-09. PMID:25751648. |
the clustered parallel fibre input we observe is ideally suited for driving dendritic spikes, postsynaptic calcium signalling, and synaptic plasticity in downstream purkinje cells, and is thus likely to be a major feature of cerebellar function during sensory processing. |
2016-02-09 |
2023-08-13 |
mouse |
| João Couto, Daniele Linaro, E De Schutter, Michele Giuglian. On the firing rate dependency of the phase response curve of rat Purkinje neurons in vitro. PLoS computational biology. vol 11. issue 3. 2016-02-01. PMID:25775448. |
synchronous spiking during cerebellar tasks has been observed across purkinje cells: however, little is known about the intrinsic cellular mechanisms responsible for its initiation, cessation and stability. |
2016-02-01 |
2023-08-13 |
rat |
| João Couto, Daniele Linaro, E De Schutter, Michele Giuglian. On the firing rate dependency of the phase response curve of rat Purkinje neurons in vitro. PLoS computational biology. vol 11. issue 3. 2016-02-01. PMID:25775448. |
given the implications for computation and information processing in the cerebellum and the possible role of synchrony in the communication with its post-synaptic targets, we further explored the firing rate dependency of the prc in purkinje cells. |
2016-02-01 |
2023-08-13 |
rat |
| Keiko Muguruma, Ayaka Nishiyama, Hideshi Kawakami, Kouichi Hashimoto, Yoshiki Sasa. Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell reports. vol 10. issue 4. 2016-01-28. PMID:25640179. |
during cerebellar development, the main portion of the cerebellar plate neuroepithelium gives birth to purkinje cells and interneurons, whereas the rhombic lip, the germinal zone at its dorsal edge, generates granule cells and cerebellar nuclei neurons. |
2016-01-28 |
2023-08-13 |
human |
| Praveen Kumar, Vishwa Mohan, Rohit Anthony Sinha, Megha Chagtoo, Madan M Godbol. Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats. The Journal of endocrinology. vol 227. issue 2. 2016-01-26. PMID:26427529. |
using valproate, an hdac inhibitor, we show that hdac inhibition significantly blocks the deleterious effects of hypothyroidism on rat cerebellum, evident by recovery of th target genes like bdnf, pcp2 and mbp as well as improved dendritic structure of cerebellar purkinje neurons. |
2016-01-26 |
2023-08-13 |
mouse |
| Joel W Aspden, Carol L Armstrong, Cristian I Gutierrez-Ibanez, Richard Hawkes, Andrew N Iwaniuk, Tobias Kohl, David J Graham, Douglas R Wyli. Zebrin II / aldolase C expression in the cerebellum of the western diamondback rattlesnake (Crotalus atrox). PloS one. vol 10. issue 2. 2016-01-25. PMID:25692946. |
aldolase c, also known as zebrin ii (zii), is a glycolytic enzyme that is expressed in cerebellar purkinje cells of the vertebrate cerebellum. |
2016-01-25 |
2023-08-13 |
Not clear |
| José Manuel Verdes, Mercedes Márquez, Aldo Calliari, Daniel Battes, José Antonio Moraña, Eduardo Juan Gimeno, Ernesto Odriozola, Federico Giannitti, Florentina Guerrero, Luis Eusebio Fidalgo, Martí Pumarol. A novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 27. issue 3. 2016-01-25. PMID:25901005. |
intoxication with solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. |
2016-01-25 |
2023-08-13 |
cattle |
| Björn Kowalewski, Peter Heimann, Theresa Ortkras, Renate Lüllmann-Rauch, Tomo Sawada, Steven U Walkley, Thomas Dierks, Markus Damm. Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III). Human molecular genetics. vol 24. issue 7. 2016-01-13. PMID:25452429. |
this study revealed massive loss of purkinje cells and gliosis in the cerebellum, and secondary accumulation of glycolipids like gm2 and gm3 gangliosides and unesterified cholesterol in surviving purkinje cells, as well as neurons of some other brain regions. |
2016-01-13 |
2023-08-13 |
mouse |
| Johannes Hradsky, Hans-Gert Bernstein, Monika Marunde, Marina Mikhaylova, Michael R Kreut. Alternative splicing, expression and cellular localization of Calneuron-1 in the rat and human brain. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 63. issue 10. 2016-01-11. PMID:26116628. |
the protein is most abundant in purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent. |
2016-01-11 |
2023-08-13 |
human |
| Haibo Zhou, Kai Voges, Zhanmin Lin, Chiheng Ju, Martijn Schonewill. Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules. Journal of neurophysiology. vol 113. issue 7. 2016-01-01. PMID:25717166. |
the massive computational capacity of the cerebellar cortex is conveyed by purkinje cells onto cerebellar and vestibular nuclei neurons through their gabaergic, inhibitory output. |
2016-01-01 |
2023-08-13 |
mouse |
| Haibo Zhou, Kai Voges, Zhanmin Lin, Chiheng Ju, Martijn Schonewill. Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules. Journal of neurophysiology. vol 113. issue 7. 2016-01-01. PMID:25717166. |
cerebellar modules with distinct anatomical connectivity and gene expression have been described, and purkinje cells in these modules also differ in firing rate of simple and complex spikes. |
2016-01-01 |
2023-08-13 |
mouse |
| Haibo Zhou, Kai Voges, Zhanmin Lin, Chiheng Ju, Martijn Schonewill. Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules. Journal of neurophysiology. vol 113. issue 7. 2016-01-01. PMID:25717166. |
in this study we systematically correlate, in awake mice, the pausing in simple spike activity of purkinje cells recorded throughout the entire cerebellum, with their location in terms of lobule, transverse zone, and zebrin-identified cerebellar module. |
2016-01-01 |
2023-08-13 |
mouse |
| Haibo Zhou, Kai Voges, Zhanmin Lin, Chiheng Ju, Martijn Schonewill. Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules. Journal of neurophysiology. vol 113. issue 7. 2016-01-01. PMID:25717166. |
in contrast to long pauses, short pauses (<500 ms) and the shape of the interspike interval (isi) distributions can differ between purkinje cells of different lobules and cerebellar modules. |
2016-01-01 |
2023-08-13 |
mouse |
| Danuta Maslinska, Milena Laure-Kamionowska, Sławomir Maslinsk. Methyl-CpG binding protein 2, receptors of innate immunity and receptor for advanced glycation end-products in human viral meningoencephalitis. Folia neuropathologica. vol 52. issue 4. 2015-12-30. PMID:25574748. |
moreover, in the early period of viral meningoencephalitis, we found that purkinje cells of the cerebellum contain tlr3 or tlr9 receptors that can recognize viral pathogens and may activate a self-destructive mechanism in these neurons. |
2015-12-30 |
2023-08-13 |
human |
| Shanshan Wang, Yunliang Wang, Qingshan Lu, Xinshan Liu, Fuyu Wang, Xiaodong Ma, Chunping Cui, Chenghe Shi, Jinfeng Li, Dajin Zhan. The expression and distributions of ANP32A in the developing brain. BioMed research international. vol 2015. 2015-12-28. PMID:25866766. |
however, anp32a was abundant in the granular layer of the cerebellum and the cerebral cortex when the mice were growing up, as well as in the purkinje cells of the cerebellum. |
2015-12-28 |
2023-08-13 |
mouse |
| Jun-Dal Kim, Kyung-Eui Park, Junji Ishida, Koichiro Kako, Juri Hamada, Shuichi Kani, Miki Takeuchi, Kana Namiki, Hajime Fukui, Shigetomo Fukuhara, Masahiko Hibi, Makoto Kobayashi, Yasunori Kanaho, Yoshitoshi Kasuya, Naoki Mochizuki, Akiyoshi Fukamiz. PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination. Science advances. vol 1. issue 11. 2015-12-15. PMID:26665171. |
moreover, prmt8 (-/-) mice and talen-induced zebrafish prmt8 mutants and morphants showed abnormal phenotypes, including the development of dendritic trees in purkinje cells and altered cerebellar structure. |
2015-12-15 |
2023-08-13 |
mouse |
| Shuyan Wang, Bin Wang, Na Pan, Linlin Fu, Chaodong Wang, Gongru Song, Jing An, Zhongfeng Liu, Wanwan Zhu, Yunqian Guan, Zhi-Qing David Xu, Piu Chan, Zhiguo Chen, Y Alex Zhan. Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons. Scientific reports. vol 5. 2015-12-14. PMID:25782665. |
by co-culturing human purkinje progenitors with rat cerebellar slices, we observed mature purkinje-like cells with right morphology and marker expression patterns, which yet showed no appropriate membrane properties. |
2015-12-14 |
2023-08-13 |
mouse |
| Shuyan Wang, Bin Wang, Na Pan, Linlin Fu, Chaodong Wang, Gongru Song, Jing An, Zhongfeng Liu, Wanwan Zhu, Yunqian Guan, Zhi-Qing David Xu, Piu Chan, Zhiguo Chen, Y Alex Zhan. Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons. Scientific reports. vol 5. 2015-12-14. PMID:25782665. |
co-culture with human fetal cerebellar slices drove the progenitors to not only morphologically correct but also electrophysiologically functional purkinje neurons. |
2015-12-14 |
2023-08-13 |
mouse |
| D E Korzhevskiy, Ye G Sukhorukova, V V Gusel'nikova, O V Kirik, I P Grigoriye. [INTRANUCLEAR IRON DISTRIBUTION IN THE PURKINJE CELLS OF HUMAN CEREBELLUM]. Morfologiia (Saint Petersburg, Russia). vol 148. issue 4. 2015-12-14. PMID:26601473. |
[intranuclear iron distribution in the purkinje cells of human cerebellum]. |
2015-12-14 |
2023-08-13 |
human |