| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valeria Pibiri, Clara Gerosa, Laura Vinci, Gavino Faa, Rossano Amb. Immunoreactivity pattern of calretinin in the developing human cerebellar cortex. Acta histochemica. vol 119. issue 3. 2017-07-13. PMID:28174028. |
whereas at 11 weeks of gestation calretinin immunoreactivity was not detected in the developing cerebellum, from the 18th to the 24th week, calretinin expression was found in purkinje cells migrating from the ventricular neuroepithelium and in migrating cerebellar interneurons. |
2017-07-13 |
2023-08-13 |
human |
| Valeria Pibiri, Clara Gerosa, Laura Vinci, Gavino Faa, Rossano Amb. Immunoreactivity pattern of calretinin in the developing human cerebellar cortex. Acta histochemica. vol 119. issue 3. 2017-07-13. PMID:28174028. |
from the 30th to the 38th week, calretinin was expressed by most of purkinje cells and by migrating cerebellar interneurons. |
2017-07-13 |
2023-08-13 |
human |
| Valeria Pibiri, Clara Gerosa, Laura Vinci, Gavino Faa, Rossano Amb. Immunoreactivity pattern of calretinin in the developing human cerebellar cortex. Acta histochemica. vol 119. issue 3. 2017-07-13. PMID:28174028. |
our data show that calretinin, other than for developing purkinje cells, is a useful marker also for migrating cerebellar interneurons and for some neuronal elements related to the granular layer. |
2017-07-13 |
2023-08-13 |
human |
| Derek Dc Ireland, Cecilia Tami, Joao Pedras-Vasconcelos, Daniela Verthely. CD4 and CD8 T cells mediate distinct lethal meningoencephalitis in mice challenged with Tacaribe arenavirus. Cellular & molecular immunology. vol 14. issue 1. 2017-07-10. PMID:27569560. |
we show that infection leads to inflammation, t cell and monocyte infiltration into the cerebellar parenchyma, apoptosis of astrocytes, neuronal degeneration and loss of purkinje cells. |
2017-07-10 |
2023-08-13 |
mouse |
| Derek Dc Ireland, Cecilia Tami, Joao Pedras-Vasconcelos, Daniela Verthely. CD4 and CD8 T cells mediate distinct lethal meningoencephalitis in mice challenged with Tacaribe arenavirus. Cellular & molecular immunology. vol 14. issue 1. 2017-07-10. PMID:27569560. |
cd8+ t cells drive the pathology, which even in the absence of cd4+ t-cell help, infiltrate the parenchyma and mediate the apoptotic loss of cerebellar astrocytes, neurodegeneration and loss of purkinje cells resulting in loss of balance, paralysis and death. |
2017-07-10 |
2023-08-13 |
mouse |
| Nélio Gonçalves, Ana T Simões, Rui D Prediger, Hirokazu Hirai, Rodrigo A Cunha, Luís Pereira de Almeid. Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia. Annals of neurology. vol 81. issue 3. 2017-06-30. PMID:28032667. |
here we investigated the ability of caffeine to alleviate behavioral deficits and cerebellar neuropathology in transgenic mice with a severe ataxia resulting from expression of a truncated fragment of polyglutamine-expanded ataxin-3 in purkinje cells. |
2017-06-30 |
2023-08-13 |
mouse |
| Shouqiang Cheng, Alpay B Seven, Jing Wang, Georgios Skiniotis, Engin Özka. Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex. Structure (London, England : 1993). vol 24. issue 12. 2017-06-28. PMID:27926833. |
in the cerebellum, synapses between parallel fiber neurons and purkinje cells are specified by the simultaneous interactions of secreted protein cerebellin with pre-synaptic neurexin and post-synaptic delta-type glutamate receptors (glud). |
2017-06-28 |
2023-08-13 |
rat |
| Hitomi Matsuno, Moeko Kudoh, Akiya Watakabe, Tetsuo Yamamori, Ryuichi Shigemoto, Soichi Naga. Distribution and Structure of Synapses on Medial Vestibular Nuclear Neurons Targeted by Cerebellar Flocculus Purkinje Cells and Vestibular Nerve in Mice: Light and Electron Microscopy Studies. PloS one. vol 11. issue 10. 2017-06-26. PMID:27711146. |
distribution and structure of synapses on medial vestibular nuclear neurons targeted by cerebellar flocculus purkinje cells and vestibular nerve in mice: light and electron microscopy studies. |
2017-06-26 |
2023-08-13 |
mouse |
| Hitomi Matsuno, Moeko Kudoh, Akiya Watakabe, Tetsuo Yamamori, Ryuichi Shigemoto, Soichi Naga. Distribution and Structure of Synapses on Medial Vestibular Nuclear Neurons Targeted by Cerebellar Flocculus Purkinje Cells and Vestibular Nerve in Mice: Light and Electron Microscopy Studies. PloS one. vol 11. issue 10. 2017-06-26. PMID:27711146. |
several previous physiological and pharmacological studies have consistently suggested that the cerebellar flocculus (fl) purkinje cells (p-cells) and the medial vestibular nucleus (mvn) neurons targeted by fl (fl-targeted mvn neurons) may respectively maintain the memory traces of short- and long-term adaptation. |
2017-06-26 |
2023-08-13 |
mouse |
| Anatoly Buchin, Sarah Rieubland, Michael Häusser, Boris S Gutkin, Arnd Rot. Inverse Stochastic Resonance in Cerebellar Purkinje Cells. PLoS computational biology. vol 12. issue 8. 2017-06-20. PMID:27541958. |
purkinje neurons play an important role in cerebellar computation since their axons are the only projection from the cerebellar cortex to deeper cerebellar structures. |
2017-06-20 |
2023-08-13 |
Not clear |
| Genri Kawahara, Yukiko K Hayash. Characterization of Zebrafish Models of Marinesco-Sjögren Syndrome. PloS one. vol 11. issue 10. 2017-06-19. PMID:27792754. |
moreover, they showed smaller-sized eyes and loss of purkinje cells in cerebellar area compared to controls. |
2017-06-19 |
2023-08-13 |
human |
| Yasser A Khadrawy, Iman M Mourad, Haitham S Mohammed, Neveen A Noor, Heba S Aboul Ez. Cerebellar neurochemical and histopathological changes in rat model of Parkinson's disease induced by intrastriatal injection of rotenone. General physiology and biophysics. vol 36. issue 1. 2017-06-16. PMID:27901474. |
in addition the cerebellar sections from rat model of pd showed marked necrosis of purkinje cells, irregular damaged cells, cytoplasmic shrinkage, necrosis and perineuronal vacuolation. |
2017-06-16 |
2023-08-13 |
rat |
| Charles A Oyinbo, Patrick S Igbigbi, Godwin O Avwior. Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells. Folia medica. vol 58. issue 4. 2017-06-15. PMID:28068280. |
landolphia owariensis attenuates alcohol-induced cerebellar neurodegeneration: significance of neurofilament protein alteration in the purkinje cells. |
2017-06-15 |
2023-08-13 |
Not clear |
| Joke Delbaere, Pieter Vancamp, Stijn L J Van Herck, Nele M A Bourgeois, Mary J Green, Richard J T Wingate, Veerle M Darra. MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development. The Journal of endocrinology. vol 232. issue 2. 2017-06-14. PMID:27879339. |
mct8 deficiency in purkinje cells disrupts embryonic chicken cerebellar development. |
2017-06-14 |
2023-08-13 |
human |
| Joke Delbaere, Pieter Vancamp, Stijn L J Van Herck, Nele M A Bourgeois, Mary J Green, Richard J T Wingate, Veerle M Darra. MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development. The Journal of endocrinology. vol 232. issue 2. 2017-06-14. PMID:27879339. |
in conclusion, early mct8 deficiency in purkinje cells results in both cell-autonomous and non-autonomous effects on cerebellar development and indicates that mct8 expression is essential from very early stages of development, providing a novel insight into the ontogenesis of the allan-herndon-dudley syndrome. |
2017-06-14 |
2023-08-13 |
human |
| Anna Nolte, Aimara Bello, Michaela Drögemüller, Tosso Leeb, Eva Brockhaus, Wolfgang Baumgärtner, Peter Wohlsei. Neuronal ceroid lipofuscinosis in an adult American Staffordshire Terrier. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere. vol 44. issue 6. 2017-06-06. PMID:27778018. |
in addition, the cerebellum revealed marked degeneration and loss of purkinje and inner granule cells. |
2017-06-06 |
2023-08-13 |
human |
| Noriko Miyake, Ryoko Fukai, Chihiro Ohba, Takahiro Chihara, Masayuki Miura, Hiroshi Shimizu, Akiyoshi Kakita, Eri Imagawa, Masaaki Shiina, Kazuhiro Ogata, Jiu Okuno-Yuguchi, Noboru Fueki, Yoshifumi Ogiso, Hiroshi Suzumura, Yoshiyuki Watabe, George Imataka, Huey Yin Leong, Aviva Fattal-Valevski, Uri Kramer, Satoko Miyatake, Mitsuhiro Kato, Nobuhiko Okamoto, Yoshinori Sato, Satomi Mitsuhashi, Ichizo Nishino, Naofumi Kaneko, Akira Nishiyama, Tomohiko Tamura, Takeshi Mizuguchi, Mitsuko Nakashima, Fumiaki Tanaka, Hirotomo Saitsu, Naomichi Matsumot. Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy. American journal of human genetics. vol 99. issue 4. 2017-05-24. PMID:27666374. |
furthermore, the autopsied brain from one deceased individual showed characteristic neurodegenerative findings: cactus and somatic sprout formations in the residual purkinje cells in the cerebellum, which are also seen in some diseases associated with mitochondrial impairment. |
2017-05-24 |
2023-08-13 |
drosophila_melanogaster |
| Meriel McEntagart, Kathleen A Williamson, Jacqueline K Rainger, Ann Wheeler, Anne Seawright, Elfride De Baere, Hannah Verdin, L Therese Bergendahl, Alan Quigley, Joe Rainger, Abhijit Dixit, Ajoy Sarkar, Eduardo López Laso, Rocio Sanchez-Carpintero, Jesus Barrio, Pierre Bitoun, Trine Prescott, Ruth Riise, Shane McKee, Jackie Cook, Lisa McKie, Berten Ceulemans, Françoise Meire, I Karen Temple, Fabienne Prieur, Jonathan Williams, Penny Clouston, Andrea H Németh, Siddharth Banka, Hemant Bengani, Mark Handley, Elisabeth Freyer, Allyson Ross, Veronica van Heyningen, Joseph A Marsh, Frances Elmslie, David R FitzPatric. A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect. American journal of human genetics. vol 98. issue 5. 2017-05-15. PMID:27108798. |
purkinje cells of the cerebellum appear to be the most sensitive to impaired itpr1 function in humans. |
2017-05-15 |
2023-08-13 |
mouse |
| Chan Chung, Matthew J Elrick, James M Dell'Orco, Zhaohui S Qin, Shanker Kalyana-Sundaram, Arul M Chinnaiyan, Vikram G Shakkottai, Andrew P Lieberma. Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease. PLoS genetics. vol 12. issue 5. 2017-05-12. PMID:27152617. |
here, we sought to identify candidate genes underlying vulnerability of purkinje cells in anterior cerebellar lobules using data freely available in the allen brain atlas. |
2017-05-12 |
2023-08-13 |
mouse |
| Chenghua Wu, Guoguang Fan, Chunli Wu, Guibo Yu, Zixuan L. Morphologic changes within the cerebellar cortex in the unilateral 6-hydroxydopamine lesioned rat model for Parkinson disease. Histology and histopathology. vol 31. issue 12. 2017-04-14. PMID:26996233. |
however, expression of neurofilament h in the cortex within bilateral paramedian lobule (pml) and crus 2 of the ansiform lobule (c2al) in cerebellum posterior lobe of parkinsonian rats was decreased compared with controls (p<0.05), especially in the loss of purkinje cells and the presence of morphologic abnormalities in the cell nucleus. |
2017-04-14 |
2023-08-13 |
rat |