| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abris Gilvesy, Evelina Husen, Zsofia Magloczky, Orsolya Mihaly, Tibor Hortobágyi, Shigeaki Kanatani, Helmut Heinsen, Nicolas Renier, Tomas Hökfelt, Jan Mulder, Mathias Uhlen, Gabor G Kovacs, Csaba Ador. Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging. Acta neuropathologica. 2022-08-30. PMID:36040521. |
tau pathology of the noradrenergic locus coeruleus (lc) is a hallmark of several age-related neurodegenerative disorders, including alzheimer's disease. |
2022-08-30 |
2023-08-14 |
human |
| Wojciech B Solecki, Michał Kielbinski, Michał Wilczkowski, Katarzyna Zajda, Karolina Karwowska, Bernacka Joanna, Zenon Rajfur, Ryszard Przewłock. Regulation of cocaine seeking behavior by locus coeruleus noradrenergic activity in the ventral tegmental area is time- and contingency-dependent. Frontiers in neuroscience. vol 16. 2022-08-22. PMID:35992934. |
noradrenergic (na) inputs from locus coeruleus (lc) into vta have been shown to modulate vta neuronal activity, and are implicated in psychostimulant effects. |
2022-08-22 |
2023-08-14 |
rat |
| Sara Bagnoli, Baldassare Fronte, Carlo Bibbiani, Eva Terzibasi Tozzini, Alessandro Cellerin. Quantification of noradrenergic-, dopaminergic-, and tectal-neurons during aging in the short-lived killifish Nothobranchius furzeri. Aging cell. 2022-08-20. PMID:35986561. |
parkinson's disease (pd) is characterized by phosphorylation and aggregation of the protein α-synuclein and ensuing neuronal death progressing from the noradrenergic locus coeruleus to midbrain dopaminergic neurons. |
2022-08-20 |
2023-08-14 |
Not clear |
| Natale R Sciolino, Madeline Hsiang, Christopher M Mazzone, Leslie R Wilson, Nicholas W Plummer, Jaisal Amin, Kathleen G Smith, Christopher A McGee, Sydney A Fry, Cindy X Yang, Jeanne M Powell, Michael R Bruchas, Alexxai V Kravitz, Jesse D Cushman, Michael J Krashes, Guohong Cui, Patricia Jense. Natural locus coeruleus dynamics during feeding. Science advances. vol 8. issue 33. 2022-08-19. PMID:35984878. |
recent data demonstrate that noradrenergic neurons of the locus coeruleus (lc-ne) are required for fear-induced suppression of feeding, but the role of endogenous lc-ne activity in natural, homeostatic feeding remains unclear. |
2022-08-19 |
2023-08-14 |
mouse |
| Lidia Bravo, Patricia Mariscal, Meritxell Llorca-Torralba, Jose María López-Cepero, Juan Nacher, Esther Berrocos. Altered expression of vesicular glutamate transporter-2 and cleaved caspase-3 in the locus coeruleus of nerve-injured rats. Frontiers in molecular neuroscience. vol 15. 2022-08-15. PMID:35966012. |
neuropathic pain is a debilitating chronic condition provoked by a lesion in the nervous system and it induces functional alterations to the noradrenergic locus coeruleus (lc), affecting distinct dimensions of pain, like sensorial hypersensitivity, pain-induced depression, and anxiety. |
2022-08-15 |
2023-08-14 |
rat |
| Karen Hoang, Hilary Watt, Mara Golemme, Richard J Perry, Craig Ritchie, Danielle Wilson, James Pickett, Chris Fox, Robert Howard, Paresh A Malhotr. Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer's Disease (NorAD): study protocol for a randomised clinical trial and COVID-19 amendments. Trials. vol 23. issue 1. 2022-08-01. PMID:35915506. |
attention is affected early in alzheimer's disease (ad), and this may relate to pathological changes within the locus coeruleus, the main source of noradrenergic pathways within the brain. |
2022-08-01 |
2023-08-14 |
human |
| Kazuhiko Baba, Makoto Kawasaki, Haruki Nishimura, Hitoshi Suzuki, Takanori Matsuura, Naofumi Ikeda, Teruaki Fujitani, Yoshiaki Yamanaka, Manabu Tsukamoto, Hideo Ohnishi, Mitsuhiro Yoshimura, Takashi Maruyama, Kenya Sanada, Satomi Sonoda, Kazuaki Nishimura, Kentaro Tanaka, Tatsushi Onaka, Yoichi Ueta, Akinori Saka. Upregulation of the hypothalamo-neurohypophysial system and activation of vasopressin neurones attenuates hyperalgesia in a neuropathic pain model rat. Scientific reports. vol 12. issue 1. 2022-07-29. PMID:35906406. |
avp neurones increased the neuronal activity of serotonergic dorsal raphe, noradrenergic locus coeruleus, and inhibitory interneurones in the spinal dorsal horn. |
2022-07-29 |
2023-08-14 |
rat |
| John A Tkaczynski, Olga Borodovitsyna, Daniel J Chandle. Delta Opioid Receptors and Enkephalinergic Signaling within Locus Coeruleus Promote Stress Resilience. Brain sciences. vol 12. issue 7. 2022-07-27. PMID:35884666. |
the noradrenergic nucleus locus coeruleus is a key component of the stress circuitry of the brain. |
2022-07-27 |
2023-08-14 |
Not clear |
| N L Taylor, A D'Souza, B R Munn, J Lv, L Zaborszky, E J Müller, G Wainstein, F Calamante, J M Shin. Structural connections between the noradrenergic and cholinergic system shape the dynamics of functional brain networks. NeuroImage. 2022-07-09. PMID:35809888. |
to test this hypothesis, we estimated the strength of structural connectivity between key hubs of the noradrenergic and cholinergic arousal systems (the locus coeruleus [lc] and nucleus basalis of meynert [nbm], respectively). |
2022-07-09 |
2023-08-14 |
Not clear |
| Roy Moyal, Hamid B Turker, Wen-Ming Luh, Khena M Swallo. Auditory Target Detection Enhances Visual Processing and Hippocampal Functional Connectivity. Frontiers in psychology. vol 13. 2022-06-30. PMID:35769754. |
in agreement with accounts suggesting that subcortical noradrenergic influences play a role in the attentional boost effect, auditory target detection also caused an increase in locus coeruleus activity and phasic pupil responses. |
2022-06-30 |
2023-08-14 |
human |
| Shristi Baral, Hassan Hosseini, Kaushik More, Thomaz M C Fabrin, Jochen Braun, Matthias Prigg. Spike-Dependent Dynamic Partitioning of the Locus Coeruleus Network through Noradrenergic Volume Release in a Simulation of the Nucleus Core. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741613. |
spike-dependent dynamic partitioning of the locus coeruleus network through noradrenergic volume release in a simulation of the nucleus core. |
2022-06-24 |
2023-08-14 |
mouse |
| Jing Wang, Yingzi Wang, Xiaona Du, Hailin Zhan. Potassium Channel Conductance Is Involved in Phenylephrine-Induced Spontaneous Firing of Serotonergic Neurons in the Dorsal Raphe Nucleus. Frontiers in cellular neuroscience. vol 16. 2022-06-23. PMID:35734219. |
the activity of 5-ht neurons is regulated by norepinephrine (ne) released from the projection terminals of noradrenergic input from the locus coeruleus (lc) |
2022-06-23 |
2023-08-14 |
Not clear |
| Irene L Gutiérrez, Cinzia Dello Russo, Fabiana Novellino, Javier R Caso, Borja García-Bueno, Juan C Leza, José L M Madriga. Noradrenaline in Alzheimer's Disease: A New Potential Therapeutic Target. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682822. |
noradrenaline involvement in this disease was first proposed after finding deficits of noradrenergic neurons in the locus coeruleus from alzheimer's disease patients. |
2022-06-10 |
2023-08-14 |
Not clear |
| Elham Alaee, Fatemeh Farahani, Saeed Semnanian, Hossein Aziz. Prenatal exposure to morphine enhances excitability in locus coeruleus neurons. Journal of neural transmission (Vienna, Austria : 1996). 2022-06-08. PMID:35674919. |
in this study, we assessed the effect of prenatal exposure to morphine on electrophysiological features of locus coeruleus (lc) noradrenergic neurons which is involved in modulating cognitive performance. |
2022-06-08 |
2023-08-14 |
Not clear |
| Yutaka Nakagawa, Shizuo Yamad. The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications. Cellular and molecular neurobiology. 2022-05-31. PMID:35635600. |
it is possible that the overactive noradrenergic system stimulates the apoptosis signaling pathway and pathogenic protein formation, leading to further pathological changes which can occur in the presence or absence of locus coeruleus hypoactivation. |
2022-05-31 |
2023-08-13 |
Not clear |
| Sijia Zhao, Yajie Liu, Kunlin We. Pupil-Linked Arousal Response Reveals Aberrant Attention Regulation among Children with Autism Spectrum Disorder. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-31. PMID:35641188. |
notably, the locus ceruleus (lc) and its noradrenergic projections throughout the brain modulate attentional function, but the extent to which this locus ceruleus-norepinephrine (lc-ne) system influences attention in individuals with asd, who frequently exhibit dysregulated alerting and attention orienting, is unknown. |
2022-05-31 |
2023-08-13 |
human |
| Yoo Hyun Um, Sheng-Min Wang, Dong Woo Kang, Nak-Young Kim, Hyun Kook Li. Alterations of Resting-State Locus Coeruleus Functional Connectivity After Transdermal Trigeminal Electrical Neuromodulation in Insomnia. Frontiers in psychiatry. vol 13. 2022-05-27. PMID:35619611. |
transdermal trigeminal electrical neuromodulation (tten) is a novel treatment modality that is known for noradrenergic modulation through the trigeminal nerve and locus coeruleus (lc). |
2022-05-27 |
2023-08-13 |
Not clear |
| Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu, Song Ca. Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn. Journal of neuroinflammation. vol 19. issue 1. 2022-05-27. PMID:35624514. |
the noradrenergic neurons of locus coeruleus (lc) project to the spinal dorsal horn (sdh), and release norepinephrine (ne) to inhibit pain transmission. |
2022-05-27 |
2023-08-13 |
mouse |
| Tatiana Bezdudnaya, Moin Vahora, David Giacobbo, Vitaliy Marchenk. Anatomical Basis of Interactions Between Locomotor and Respiratory Systems. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555670. |
in the brainstem, the double-labeled neurons were seen in the following structures: 1) midbrain - in all parts of periaqueductal gray substance (pag), dorsal raphe (dr) and deep mesncephalic (dme) nuclei; 2) pons - in kölliker-fuse and parabrachial nuclei (pb/kf), in areas of noradrenergic groups of cells (locus coeruleus and a5) and sub-coeruleus areas, in oral and caudal pontine nuclei (pno and pnc); 3) medulla - in all parts of raphe (obscurus, magnus and pallidus), gigantocellular reticular (gi), internal reticular (irt), and lateral paragigantocellular (lpgi) nuclei, in para-fascial/retrotrapezoid area (pf/rtn), and in bötzinger and pre-bötzinger complexes (bc and pbc). |
2022-05-13 |
2023-08-13 |
rat |
| Zhe Yu, Paul Marva. Role of locus coeruleus expressing angiotensin type 1 receptors (AT1R) neurons in fear learning and stress-induced anxiety. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556117. |
the locus coeruleus (lc), a major noradrenergic nucleus of the brain, plays a critical role in modulating anxiety-like behaviors. |
2022-05-13 |
2023-08-13 |
Not clear |