| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Paula S Dornellas, Todd E Thiele, Montserrat Navarr. Chemogenetic inhibition of locus coeruleus to rostromedial tegmental nucleus noradrenergic pathway increases light cycle ethanol drinking in male and female mice and blunts ethanol-induced CTA. Neuropharmacology. 2023-12-04. PMID:38048984. |
we recently showed that chemogenetic activation of the locus coeruleus (lc) to the rostromedial tegmental nucleus (rmtg) noradrenergic (ne) pathway significantly blunted binge-like ethanol drinking and induced aversive-like behaviors in mice. |
2023-12-04 |
2023-12-10 |
mouse |
| Ivana Maric, Lorena López-Ferreras, Yashaswini Bhat, Mohammed Asker, Stina Börchers, Lauren Bellfy, Suyeun Byun, Janine L Kwapis, Karolina P Skibick. From the stomach to locus coeruleus: new neural substrate for ghrelin's effects on ingestive, motivated and anxiety-like behaviors. Frontiers in pharmacology. vol 14. 2023-12-01. PMID:38026980. |
noradrenergic neurons of the locus coeruleus (lc) are known to play an important role in arousal, emotion, cognition, but recently have also been implicated in control of feeding behavior. |
2023-12-01 |
2023-12-10 |
rat |
| Tenzin Ngodup, Tomohiko Irie, Sean Elkins, Laurence O Trussel. The Na bioRxiv : the preprint server for biology. 2023-11-24. PMID:37987013. |
noradrenergic fibers from locus coeruleus project to the dcn, and α2-adrenergic receptors inhibit spontaneous spike activity but simultaneously enhance synaptic strength in cartwheel cells, a dual effect leading to enhanced signal- to-noise for inhibition. |
2023-11-24 |
2023-11-28 |
Not clear |
| Lars Emil Larsen, Sielke Caestecker, Latoya Stevens, Pieter van Mierlo, Evelien Carrette, Paul Boon, Kristl Vonck, Robrecht Raed. Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus. Neurobiology of disease. 2023-11-17. PMID:37977430. |
in this study, we performed a detailed assessment of the activity of locus coeruleus neurons and changes in noradrenergic transmission during acute hippocampal seizures evoked with perforant path stimulation, using state-of-the-art methodology. |
2023-11-17 |
2023-11-20 |
rat |
| Dorothy Tse, Lucia Privitera, Anna C Norton, Francesco Gobbo, Patrick Spooner, Tomonori Takeuchi, Stephen J Martin, Richard G M Morri. Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 46. 2023-11-06. PMID:37931094. |
despite the locus coeruleus being considered a primarily noradrenergic area, both effects of such stimulation were blocked by the dopamine d1/d5 receptor antagonist sch 23390. |
2023-11-06 |
2023-11-08 |
rat |
| Susan T Lubejko, Giulia Livrizzi, Janki Patel, Jean C Yung, Tony L Yaksh, Matthew R Banghar. Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. bioRxiv : the preprint server for biology. 2023-10-24. PMID:37873091. |
here, we establish that noradrenergic neurons of the locus coeruleus (lc) are essential for supraspinal opioid antinociception. |
2023-10-24 |
2023-11-08 |
Not clear |
| Chloé Laurencin, Sophie Lancelot, Sarah Brosse, Inés Mérida, Jérôme Redouté, Elise Greusard, Ludovic Lamberet, Véronique Liotier, Didier Le Bars, Nicolas Costes, Stéphane Thobois, Philippe Boulinguez, Bénédicte Ballange. Noradrenergic alterations in Parkinson's disease: a combined 11C-yohimbine PET/neuromelanin MRI study. Brain : a journal of neurology. 2023-10-03. PMID:37787503. |
here, we evaluate two aspects of the noradrenergic system using multimodal in vivo imaging in patients with parkinson's disease and healthy controls: the pigmented cell bodies of the locus coeruleus with neuromelanin sensitive mri and the density of α2-adrenergic receptors (ars) with pet using [11c]yohimbine. |
2023-10-03 |
2023-10-07 |
human |
| Chloé Laurencin, Sophie Lancelot, Sarah Brosse, Inés Mérida, Jérôme Redouté, Elise Greusard, Ludovic Lamberet, Véronique Liotier, Didier Le Bars, Nicolas Costes, Stéphane Thobois, Philippe Boulinguez, Bénédicte Ballange. Noradrenergic alterations in Parkinson's disease: a combined 11C-yohimbine PET/neuromelanin MRI study. Brain : a journal of neurology. 2023-10-03. PMID:37787503. |
these findings highlight a multifaceted alteration of the noradrenergic system in parkinson's disease since locus coeruleus and α2-ars degenerations were found to be partly uncoupled. |
2023-10-03 |
2023-10-07 |
human |
| Patricia Mariscal, Lidia Bravo, Meritxell Llorca-Torralba, Jone Razquin, Cristina Miguelez, Irene Suárez-Pereira, Esther Berrocos. Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice. Biology of sex differences. vol 14. issue 1. 2023-09-28. PMID:37770907. |
interestingly, the locus coeruleus (lc), a noradrenergic nucleus that exhibits sexual dimorphism, integrates signals that are related to diverse activities, including emotions, cognition and pain. |
2023-09-28 |
2023-10-07 |
mouse |
| Hyun Joo Yoo, Kaoru Nashiro, Shubir Dutt, Jungwon Min, Christine Cho, Julian F Thayer, Paul Lehrer, Catie Chang, Mara Mathe. Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults. Neurobiology of aging. vol 132. 2023-09-28. PMID:37769491. |
using data from a clinical trial, we tested the hypothesis that daily sessions modulating heart rate oscillations affect older adults' volume of a region-of-interest (roi) comprised of adjacent hippocampal subregions with relatively strong locus coeruleus (lc) noradrenergic input. |
2023-09-28 |
2023-10-07 |
Not clear |
| Hyun Joo Yoo, Kaoru Nashiro, Shubir Dutt, Jungwon Min, Christine Cho, Julian F Thayer, Paul Lehrer, Catie Chang, Mara Mathe. Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults. medRxiv : the preprint server for health sciences. 2023-09-25. PMID:37745356. |
using data from a clinical trial, we tested the hypothesis that daily sessions modulating heart rate oscillations affect older adults' volume of a region-of-interest (roi) comprised of adjacent hippocampal subregions with relatively strong locus coeruleus (lc) noradrenergic input. |
2023-09-25 |
2023-10-07 |
Not clear |
| Jun-Ya Wang, Wen-Cai Weng, Ting-Qi Wang, Yue Liu, De-Lai Qiu, Mao-Cheng Wu, Chun-Ping Ch. Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice. Scientific reports. vol 13. issue 1. 2023-09-23. PMID:37741947. |
the noradrenergic fibers of the locus coeruleus, together with mossy fibers and climbing fibers, comprise the three types of cerebellar afferents that modulate the cerebellar neuronal circuit. |
2023-09-23 |
2023-10-07 |
mouse |
| b' Yasutaka Mukai \\xe5\\x90\\x91\\xe4\\xba\\x95\\xe5\\xba\\xb7\\xe6\\x95\\xac, Tatsuo Okubo \\xe5\\xa4\\xa7\\xe4\\xb9\\x85\\xe4\\xbf\\x9d\\xe9\\x81\\x94\\xe5\\xa4\\xab, Michael Lazarus, Daisuke Ono \\xe5\\xb0\\x8f\\xe9\\x87\\x8e\\xe5\\xa4\\xa7\\xe8\\xbc\\x94, Kenji F Tanaka \\xe7\\x94\\xb0\\xe4\\xb8\\xad\\xe8\\xac\\x99\\xe4\\xba\\x8c, Akihiro Yamanaka \\xe5\\xb1\\xb1\\xe4\\xb8\\xad\\xe7\\xab\\xa0\\xe5\\xbc\\x9. Prostaglandin E The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-09-21. PMID:37734949.' |
noradrenergic neurons in the locus coeruleus (lc-na neurons) are involved in diverse physiological functions, including sleep/wakefulness and stress responses. |
2023-09-21 |
2023-10-07 |
Not clear |
| Alessandra Gargano, Bolanle Fatimat Olabiyi, Michela Palmisano, Andreas Zimmer, Andras Bilkei-Gorz. Possible role of locus coeruleus neuronal loss in age-related memory and attention deficits. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694113. |
noradrenergic neurons in the locus coeruleus (lc) undergo an approximately 20 % loss during ageing both in humans and mice, but whether this change contributes to cognitive deficits is not known. |
2023-09-11 |
2023-10-07 |
mouse |
| Joseph M Villarin, Christoph Kellendon. Locus of control: How the brain gives up when failure is taken for granted. Neuron. vol 111. issue 17. 2023-09-07. PMID:37678166. |
identify a circuit involving noradrenergic projections from the locus coeruleus to gabaergic projection neurons in the orbitofrontal cortex that participate in this adaptive behavior. |
2023-09-07 |
2023-10-07 |
mouse |
| Rong Ye, Frank H Hezemans, Claire O'Callaghan, Kamen A Tsvetanov, Catarina Rua, P Simon Jones, Negin Holland, Maura Malpetti, Alexander G Murley, Roger A Barker, Caroline H Williams-Gray, Trevor W Robbins, Luca Passamonti, James B Row. Locus coeruleus integrity is linked to response inhibition deficits in Parkinson's disease and progressive supranuclear palsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-09-05. PMID:37669861. |
motor and cognitive control are associated with noradrenergic innervation of the cortex, arising from the locus coeruleus (lc) noradrenergic system. |
2023-09-05 |
2023-10-07 |
human |
| Rachel A Matt, Frederick G Westhorpe, Rosemary F Romuar, Payal Rana, Joel R Gever, Anthony P For. Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles. Frontiers in molecular biosciences. vol 10. 2023-09-04. PMID:37664183. |
noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (ar) function across the varied brain cell types has not been extensively characterized, especially with agonists. |
2023-09-04 |
2023-09-07 |
Not clear |
| Alejandro Torrillas-de la Cal, Sonia Torres-Sanchez, Lidia Bravo, Meritxell Llorca-Torralba, Jose Antonio Garcia-Partida, Ana I Arroba, Esther Berrocos. Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis. Journal of neuroinflammation. vol 20. issue 1. 2023-09-01. PMID:37658434. |
there is evidence of reduced noradrenaline levels and alterations to locus coeruleus (lc) noradrenergic neurons in ms patients, as well as in animal models of this disease, potentially factors contributing to the pathophysiology. |
2023-09-01 |
2023-09-07 |
Not clear |
| Dániel Veréb, Mite Mijalkov, Anna Canal-Garcia, Yu-Wei Chang, Emiliano Gomez-Ruiz, Blanca Zufiria Gerboles, Miia Kivipelto, Per Svenningsson, Henrik Zetterberg, Giovanni Volpe, Matthew Betts, Heidi I L Jacobs, Joana B Pereir. Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions. eLife. vol 12. 2023-08-31. PMID:37650882. |
the locus coeruleus (lc) is an important noradrenergic nucleus that has recently attracted a lot of attention because of its emerging role in cognitive and psychiatric disorders. |
2023-08-31 |
2023-09-07 |
human |
| Martin J Dahl, Shelby L Bachman, Shubir Dutt, Sandra Düzel, Nils C Bodammer, Ulman Lindenberger, Simone Kühn, Markus Werkle-Bergner, Mara Mathe. The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance. Nature aging. 2023-08-31. PMID:37653256. |
here, combining longitudinal mri of the dopaminergic substantia nigra-ventral tegmental area (sn-vta) and noradrenergic locus coeruleus (lc) in younger (n = 69) and older (n = 251) adults, we found that dopaminergic and noradrenergic integrity are differentially associated with memory performance. |
2023-08-31 |
2023-09-07 |
Not clear |