| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonnathan Singh Alvarado, Jordan Hatfield, Richard Moone. Divergent projections from locus coeruleus to the corticobasal ganglia system and ventral tegmental area of the adult male zebra finch. The Journal of comparative neurology. 2023-03-28. PMID:36976533. |
the locus coeruleus (lc) is a small noradrenergic brainstem nucleus that plays a central role in regulating arousal, attention, and performance. |
2023-03-28 |
2023-08-14 |
Not clear |
| XiTing Lian, Qing Xu, YuLing Wang, LeYuan Gu, Qian Yu, WeiHui Shao, HaiXiang Ma, Yue Shen, Lu Liu, JiaXuan Gu, HongHai Zhan. Noradrenergic pathway from the locus coeruleus to heart is implicated in modulating SUDEP. iScience. vol 26. issue 4. 2023-03-27. PMID:36968083. |
noradrenergic pathway from the locus coeruleus to heart is implicated in modulating sudep. |
2023-03-27 |
2023-08-14 |
Not clear |
| XiTing Lian, Qing Xu, YuLing Wang, LeYuan Gu, Qian Yu, WeiHui Shao, HaiXiang Ma, Yue Shen, Lu Liu, JiaXuan Gu, HongHai Zhan. Noradrenergic pathway from the locus coeruleus to heart is implicated in modulating SUDEP. iScience. vol 26. issue 4. 2023-03-27. PMID:36968083. |
here, we found that both the locus coeruleus (lc) and peripheral noradrenergic neurotransmission were involved in s-ira and the protective effect of atomoxetine in reducing the occurrence of s-ira and sudep could be reversed by esmolol hydrochloride. |
2023-03-27 |
2023-08-14 |
Not clear |
| Anouk Tosserams, Bastiaan R Bloem, Kaylena A Ehgoetz Martens, Rick C Helmich, Roy P C Kessels, James M Shine, Natasha L Taylor, Gabriel Wainstein, Simon J G Lewis, Jorik Nonneke. Modulating arousal to overcome gait impairments in Parkinson's disease: how the noradrenergic system may act as a double-edged sword. Translational neurodegeneration. vol 12. issue 1. 2023-03-26. PMID:36967402. |
we propose that the noradrenergic locus coeruleus plays an important role in modulating pd symptom severity and expression, by regulating arousal and by mediating network-level functional integration across the brain. |
2023-03-26 |
2023-08-14 |
Not clear |
| Ariana Farrand, Vincent Jacquemet, Ryan Verner, Misty Owens, Eric Beaumon. Vagus nerve stimulation parameters evoke differential neuronal responses in the locus coeruleus. Physiological reports. vol 11. issue 5. 2023-03-11. PMID:36905173. |
the noradrenergic center locus coeruleus (lc) is vital for vns effects; however, the impact of varying stimulation parameters on lc activation is poorly understood. |
2023-03-11 |
2023-08-14 |
rat |
| Mihwa Choi, Marc Schneeberger, Wei Fan, Abhijit Bugde, Laurent Gautron, Kevin Vale, Robert E Hammer, Yuan Zhang, Jeffrey M Friedman, David J Mangelsdorf, Steven A Kliewe. FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system. Cell metabolism. vol 35. issue 3. 2023-03-08. PMID:36889282. |
fgf21 mediates its anti-intoxicant effects by directly activating noradrenergic neurons in the locus coeruleus region, which regulates arousal and alertness. |
2023-03-08 |
2023-08-14 |
mouse |
| Daniel Torrente, Enming J Su, Gerald P Schielke, Mark Warnock, Kris Mann, Daniel A Lawrenc. Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity. Journal of neuroinflammation. vol 20. issue 1. 2023-03-02. PMID:36864439. |
noradrenergic neurons in the locus coeruleus (lc) are the primary source of norepinephrine (ne) in the brain and degeneration of these neurons is reported in the early stages of parkinson's disease (pd), even prior to dopaminergic neuron degeneration in the substantia nigra (sn), which is a hallmark of pd pathology. |
2023-03-02 |
2023-08-14 |
human |
| Shaomin L. The β-adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease. Journal of neurochemistry. 2023-02-17. PMID:36799441. |
as damaging of noradrenergic neurons in the locus coeruleus (lc) occurs at the prodromal stage of ad, activation of adrenergic receptors could serve as the first line of defense against the onset of the disease. |
2023-02-17 |
2023-08-14 |
Not clear |
| Andrew McKinney, Ming Hu, Amber Hoskins, Arian Mohammadyar, Nabeeha Naeem, Junzhan Jing, Saumil S Patel, Bhavin R Sheth, Xiaolong Jian. Cellular and circuit organization of the locus coeruleus of adult mice. eLife. vol 12. 2023-02-03. PMID:36734517. |
the locus coeruleus (lc) houses the vast majority of noradrenergic neurons in the brain and regulates many fundamental functions including fight and flight response, attention control, and sleep/wake cycles. |
2023-02-03 |
2023-08-14 |
mouse |
| Gioacchino de Leo, Rosario Gulino, Marino Coradazzi, Giampiero Leanz. Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory. Brain communications. vol 5. issue 1. 2023-01-12. PMID:36632183. |
severe loss of cholinergic neurons in the basal forebrain nuclei and of noradrenergic neurons in the locus coeruleus are almost invariant histopathological hallmarks of alzheimer's disease. |
2023-01-12 |
2023-08-14 |
human |
| Alexa F Iannitelli, Michael A Kelberman, Daniel J Lustberg, Anu Korukonda, Katharine E McCann, Bernard Mulvey, Arielle Segal, L Cameron Liles, Steven A Sloan, Joseph D Dougherty, David Weinshenke. The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease. eNeuro. 2023-01-12. PMID:36635251. |
the noradrenergic locus coeruleus (lc) is among the earliest sites of tau and alpha-synuclein pathology in alzheimer's disease (ad) and parkinson's disease (pd), respectively. |
2023-01-12 |
2023-08-14 |
mouse |
| Mateusz W Kucharczyk, Francesca Di Domenico, Kirsty Banniste. A critical brainstem relay for mediation of diffuse noxious inhibitory controls. Brain : a journal of neurology. 2023-01-10. PMID:36625030. |
the noradrenergic locus coeruleus (the a6 nucleus) originates such a descending control whose influence on pain modulation encompasses an interaction with a spinally projecting non-cerulean noradrenergic cell group. |
2023-01-10 |
2023-08-14 |
Not clear |
| Andrew K Evans, Erwin Defensor, Mehrdad Shamlo. Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration. Frontiers in pharmacology. vol 13. 2022-12-19. PMID:36532725. |
locus coeruleus (lc) noradrenergic (ne) neurons supply the main adrenergic input to the forebrain. |
2022-12-19 |
2023-08-14 |
Not clear |
| Gayane Aghakhanyan, Alessandro Galgani, Andrea Vergallo, Francesco Lombardo, Nicola Martini, Filippo Baldacci, Gloria Tognoni, Andrea Leo, Federica Guidoccio, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Duccio Volterrani, Filippo S Giorg. Brain metabolic correlates of Locus Coeruleus degeneration in Alzheimer's disease: a multimodal neuroimaging study. Neurobiology of aging. vol 122. 2022-12-04. PMID:36463849. |
locus coeruleus (lc) degeneration occurs early in alzheimer's disease (ad) and this could affect several brain regions innervated by lc noradrenergic axon terminals, as these bear neuroprotective effects and modulate neurovascular coupling/neuronal activity. |
2022-12-04 |
2023-08-14 |
Not clear |
| Chao-Cheng Kuo, Hao Chan, Wei-Chen Hung, Ruei-Feng Chen, Hsiu-Wen Yang, Ming-Yuan Mi. Carbachol Increases Locus Coeruleus Activation by Targeting Noradrenergic Neurons, Inhibitory Interneurons, and Inhibitory Synaptic Transmission. The European journal of neuroscience. 2022-11-16. PMID:36382388. |
carbachol increases locus coeruleus activation by targeting noradrenergic neurons, inhibitory interneurons, and inhibitory synaptic transmission. |
2022-11-16 |
2023-08-14 |
Not clear |
| Chao-Cheng Kuo, Hao Chan, Wei-Chen Hung, Ruei-Feng Chen, Hsiu-Wen Yang, Ming-Yuan Mi. Carbachol Increases Locus Coeruleus Activation by Targeting Noradrenergic Neurons, Inhibitory Interneurons, and Inhibitory Synaptic Transmission. The European journal of neuroscience. 2022-11-16. PMID:36382388. |
the locus coeruleus (lc) consists of noradrenergic (na) neurons and plays an important role in controlling behaviours. |
2022-11-16 |
2023-08-14 |
Not clear |
| Hanna Antila, Iris Kwak, Ashley Choi, Alexa Pisciotti, Ivan Covarrubias, Justin Baik, Amelia Eisch, Kevin Beier, Steven Thomas, Franz Weber, Shinjae Chun. A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 45. 2022-11-04. PMID:36331996. |
this poor sleep quality was reflected in an increased number of calcium transients in the activity of noradrenergic (ne) neurons in the locus coeruleus (lc) during nrems. |
2022-11-04 |
2023-08-14 |
mouse |
| Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshah. The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease. Frontiers in neuroscience. vol 16. 2022-10-24. PMID:36278000. |
furthermore, ample preclinical and clinical evidence indicates that dbs influences neurotransmitter dynamics in pd, particularly the effects of subthalamic nucleus (stn) dbs on striatal dopaminergic and glutamatergic systems; pallidum dbs on striatal dopaminergic and gabaergic systems; pedunculopontine nucleus dbs on cholinergic systems; and stn-dbs on locus coeruleus (lc) noradrenergic system. |
2022-10-24 |
2023-08-14 |
Not clear |
| Lazaros C Triarhou, Mario Mant. The Discovery of the Monoaminergic Innervation of the Cerebellum: Convergence of Divergent and Point-to-Point Systems. Cerebellum (London, England). 2022-09-23. PMID:36149526. |
this cerebellar classic highlights the landmark discovery of the innervation of the cerebellar cortex and cerebellar nuclei by noradrenergic and serotoninergic axons emanating, respectively, from the locus coeruleus and the raphé nuclei. |
2022-09-23 |
2023-08-14 |
Not clear |
| Anthony M Downs, Christina M Catavero, Michael R Kasten, Zoé A McElligot. Tauopathy and alcohol consumption interact to alter locus coeruleus excitatory transmission and excitability in male and female mice. Alcohol (Fayetteville, N.Y.). 2022-09-23. PMID:36150608. |
the locus coeruleus (lc) is the major noradrenergic nuclei in the brain and is one of the earliest sites to be affected by tau lesions. |
2022-09-23 |
2023-08-14 |
mouse |