| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maxwell R Bennet. Synaptic P2X7 receptor regenerative-loop hypothesis for depression. The Australian and New Zealand journal of psychiatry. vol 41. issue 7. 2007-10-04. PMID:17558618. |
this synaptic atp can also act on microglia p2x7 receptors to release the cytokine tumour necrosis factor-alpha (tnf-alpha), as can glutamate, with this tnf-alpha acting on the post-synaptic neuronal membrane to increase glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) receptors there. |
2007-10-04 |
2023-08-12 |
Not clear |
| Nathan Erdmann, Jianxing Zhao, Alicia L Lopez, Shelley Herek, Norman Curthoys, Terry D Hexum, Takashi Tsukamoto, Dana Ferraris, Jialin Zhen. Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17596215. |
mononuclear phagocyte (macrophages and microglia) dysfunction plays a significant role in the pathogenesis of human immunodeficiency virus (hiv) associated dementia (had) through the production and release of soluble neurotoxic factors including glutamate. |
2007-09-07 |
2023-08-12 |
human |
| Steven W Barger, Mary E Goodwin, Mandy M Porter, Marjorie L Begg. Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation. Journal of neurochemistry. vol 101. issue 5. 2007-08-06. PMID:17403030. |
glutamate release from activated microglia requires the oxidative burst and lipid peroxidation. |
2007-08-06 |
2023-08-12 |
Not clear |
| Steven W Barger, Mary E Goodwin, Mandy M Porter, Marjorie L Begg. Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation. Journal of neurochemistry. vol 101. issue 5. 2007-08-06. PMID:17403030. |
when activated by proinflammatory stimuli, microglia release substantial levels of glutamate, and mounting evidence suggests this contributes to neuronal damage during neuroinflammation. |
2007-08-06 |
2023-08-12 |
Not clear |
| María Domercq, María Victoria Sánchez-Gómez, Catherine Sherwin, Estibaliz Etxebarria, Robert Fern, Carlos Matut. System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 10. 2007-06-13. PMID:17475885. |
our results reveal a novel mechanism by which reactive microglia can contribute to altering glutamate homeostasis and to the pathogenesis of white matter disorders. |
2007-06-13 |
2023-08-12 |
rat |
| Mikael Persson, Mats Sandberg, Elisabeth Hansson, Lars Rönnbäc. Microglial glutamate uptake is coupled to glutathione synthesis and glutamate release. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16925588. |
this study addresses how glutamate, taken up from the extracellular space, is utilized by microglia. |
2007-03-06 |
2023-08-12 |
rat |
| Mikael Persson, Mats Sandberg, Elisabeth Hansson, Lars Rönnbäc. Microglial glutamate uptake is coupled to glutathione synthesis and glutamate release. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16925588. |
additionally, the increased glutathione contents after lps or tnf-alpha treatment were able to reduce microglial cell death after h(2)o(2) challenge, showing a potential (self)-protective function for microglial glutamate transporter expression and glutathione synthesis. |
2007-03-06 |
2023-08-12 |
rat |
| S Rosi, A Vazdarjanova, V Ramirez-Amaya, P F Worley, C A Barnes, G L Wen. Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience. vol 142. issue 4. 2007-02-27. PMID:16989956. |
lps is known to activate microglia directly, leading to increased glutamate release, and in enhanced n-methyl-d-aspartate (nmda) -dependent signaling. |
2007-02-27 |
2023-08-12 |
human |
| Guo Jun Liu, Adrianna Kalous, Eryn L Werry, Max R Bennet. Purine release from spinal cord microglia after elevation of calcium by glutamate. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16760362. |
purine release from spinal cord microglia after elevation of calcium by glutamate. |
2006-09-28 |
2023-08-12 |
mouse |
| Guo Jun Liu, Adrianna Kalous, Eryn L Werry, Max R Bennet. Purine release from spinal cord microglia after elevation of calcium by glutamate. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16760362. |
in this study, we investigated the mechanisms by which glutamate releases atp from cultured spinal cord microglia. |
2006-09-28 |
2023-08-12 |
mouse |
| Guo Jun Liu, Adrianna Kalous, Eryn L Werry, Max R Bennet. Purine release from spinal cord microglia after elevation of calcium by glutamate. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16760362. |
the 4-fold increase in atp release from microglia in response to glutamate (0.5 mm) was blocked by alpha-aminohydroxy-5-methyl-isoxazole-4-proprionate (ampa)/kainate receptor antagonist 6-cyano-7-nitroguinoxaline-2,3-dione and specific ampa receptor antagonist 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5h-2,3-benzodiazepine hydrochloride (gyki 52466) but not by n-methyl-d-aspartic acid or metabotropic glutamate receptor antagonists. |
2006-09-28 |
2023-08-12 |
mouse |
| Guo Jun Liu, Adrianna Kalous, Eryn L Werry, Max R Bennet. Purine release from spinal cord microglia after elevation of calcium by glutamate. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16760362. |
a role for the cftr was further confirmed using microglia from cftr knockout mice, which released significantly less atp than microglia from control wild-type mice in response to glutamate. |
2006-09-28 |
2023-08-12 |
mouse |
| Hideyuki Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. The Journal of biological chemistry. vol 281. issue 30. 2006-09-18. PMID:16720574. |
tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. |
2006-09-18 |
2023-08-12 |
Not clear |
| Hideyuki Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. The Journal of biological chemistry. vol 281. issue 30. 2006-09-18. PMID:16720574. |
glutamate released by activated microglia induces excitoneurotoxicity and may contribute to neuronal damage in neurodegenerative diseases, including alzheimer disease, parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
2006-09-18 |
2023-08-12 |
Not clear |
| Hideyuki Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. The Journal of biological chemistry. vol 281. issue 30. 2006-09-18. PMID:16720574. |
further, we have demonstrated that the connexin 32 hemichannel of the gap junction is another main source of glutamate release from microglia besides glutamate transporters. |
2006-09-18 |
2023-08-12 |
Not clear |
| Randolph N Christensen, Byeong Keun Ha, Fang Sun, Jacqueline C Bresnahan, Michael S Beatti. Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia. Journal of neuroscience research. vol 84. issue 1. 2006-09-08. PMID:16625662. |
this study describes the microglial response to the glutamate receptor agonist kainate (ka) and shows via immunochemistry that the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa)-type glutamate receptor subunit glur1 is present on cultured microglia. |
2006-09-08 |
2023-08-12 |
Not clear |
| Mark F McCart. Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. Medical hypotheses. vol 67. issue 2. 2006-08-23. PMID:16513287. |
peroxynitrite, prostanoids, and cytokines generated by these microglia can potentiate the excitotoxicity that contributes to neuronal death and dysfunction in these disorders--both by direct effects on neurons, and by impairing the capacity of astrocytes to sequester and metabolize glutamate. |
2006-08-23 |
2023-08-12 |
Not clear |
| Si Qin, Catherine Colin, Ina Hinners, Annie Gervais, Cyril Cheret, Michel Malla. System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 12. 2006-04-14. PMID:16554485. |
microglia enhanced the toxicity of abeta by releasing glutamate through the cystine-glutamate antiporter system xc-. |
2006-04-14 |
2023-08-12 |
mouse |
| Daniela Rossi, Liliana Brambilla, Chiara F Valori, Andrea Crugnola, Giorgio Giaccone, Raffaella Capobianco, Michela Mangieri, Ann E Kingston, Alain Bloc, Paola Bezzi, Andrea Volterr. Defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of Alzheimer disease. The Journal of biological chemistry. vol 280. issue 51. 2006-04-04. PMID:16253995. |
acute inflammation in vitro, induced by adding reactive microglia to astrocyte cultures, enhances tnfalpha production and amplifies glutamate release, switching the pathway into a neurodamaging cascade (bezzi, p., domercq, m., brambilla, l., galli, r., schols, d., de clercq, e., vescovi, a., bagetta, g., kollias, g., meldolesi, j., and volterra, a. |
2006-04-04 |
2023-08-12 |
mouse |
| Deanna L Taylor, Fleur Jones, Eva S F Chen Seho Kubota, Jennifer M Pococ. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 11. 2006-03-13. PMID:15772355. |
stimulation of group ii metabotropic glutamate (mglu) receptors on rat primary microglia with the specific group ii agonist 2s,2'r,3'r-2-(2',3'-dicarboxy-cyclopropyl)glycine for 24 h induced microglial activation and resulted in a neurotoxic microglial phenotype. |
2006-03-13 |
2023-08-12 |
rat |