| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F K van Landeghem, J F Stover, I Bechmann, W Brück, A Unterberg, C Bührer, A von Deimlin. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia. vol 35. issue 3. 2001-10-04. PMID:11494408. |
by 8 h after ccii, csf glutamate levels were increased (10.5 microm vs. 2.56 microm in controls; p < 0.001), reaching maximum values by 48 h. a significant increase in de novo glast and glt-1 expressing ramified microglia was observed within 4 h, reached a stable level by 48 h, and remained high up to 72 h after ccii. |
2001-10-04 |
2023-08-12 |
rat |
| F K van Landeghem, J F Stover, I Bechmann, W Brück, A Unterberg, C Bührer, A von Deimlin. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia. vol 35. issue 3. 2001-10-04. PMID:11494408. |
furthermore, ramified microglia de novo expressed the neuronal glutamate transporter eaac1 after ccii. |
2001-10-04 |
2023-08-12 |
rat |
| F K van Landeghem, J F Stover, I Bechmann, W Brück, A Unterberg, C Bührer, A von Deimlin. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia. vol 35. issue 3. 2001-10-04. PMID:11494408. |
microglia are capable of de novo expressing glutamate transporter proteins, indicating that the expression of glial and neuronal glutamate transporters is not restricted to a specific glial or neuronal lineage. |
2001-10-04 |
2023-08-12 |
rat |
| F K van Landeghem, J F Stover, I Bechmann, W Brück, A Unterberg, C Bührer, A von Deimlin. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia. vol 35. issue 3. 2001-10-04. PMID:11494408. |
ramified microglia may play an important compensatory role in the early regulation of extracellular glutamate after ccii. |
2001-10-04 |
2023-08-12 |
rat |
| K Nakajima, Y Tohyama, S Kohsaka, T Kurihar. Ability of rat microglia to uptake extracellular glutamate. Neuroscience letters. vol 307. issue 3. 2001-08-30. PMID:11438391. |
ability of rat microglia to uptake extracellular glutamate. |
2001-08-30 |
2023-08-12 |
rat |
| K Nakajima, Y Tohyama, S Kohsaka, T Kurihar. Ability of rat microglia to uptake extracellular glutamate. Neuroscience letters. vol 307. issue 3. 2001-08-30. PMID:11438391. |
since it has been suggested that microglia in vivo act as glutamate scavengers, this possibility was investigated in primary cultured microglia. |
2001-08-30 |
2023-08-12 |
rat |
| K Nakajima, Y Tohyama, S Kohsaka, T Kurihar. Ability of rat microglia to uptake extracellular glutamate. Neuroscience letters. vol 307. issue 3. 2001-08-30. PMID:11438391. |
these results suggest that microglia uptake glutamate by means of glt-1. |
2001-08-30 |
2023-08-12 |
rat |
| K Nakajima, Y Tohyama, S Kohsaka, T Kurihar. Ability of rat microglia to uptake extracellular glutamate. Neuroscience letters. vol 307. issue 3. 2001-08-30. PMID:11438391. |
all together, these results indicate that microglia can act as glutamate scavengers in vivo by expressing the glutamate transporter glt-1. |
2001-08-30 |
2023-08-12 |
rat |
| P Bezzi, M Domercq, L Brambilla, R Galli, D Schols, E De Clercq, A Vescovi, G Bagetta, G Kollias, J Meldolesi, A Volterr. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nature neuroscience. vol 4. issue 7. 2001-07-19. PMID:11426226. |
cxcr4-activated astrocyte glutamate release via tnfalpha: amplification by microglia triggers neurotoxicity. |
2001-07-19 |
2023-08-12 |
Not clear |
| P Bezzi, M Domercq, L Brambilla, R Galli, D Schols, E De Clercq, A Vescovi, G Bagetta, G Kollias, J Meldolesi, A Volterr. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nature neuroscience. vol 4. issue 7. 2001-07-19. PMID:11426226. |
autocrine/paracrine tnfalpha-dependent signaling leading to prostaglandin (pg) formation not only controls glutamate release and astrocyte communication, but also causes their derangement when activated microglia cooperate to dramatically enhance release of the cytokine in response to cxcr4 stimulation. |
2001-07-19 |
2023-08-12 |
Not clear |
| M Hirayama, M Kuriyam. MK-801 is cytotoxic to microglia in vitro and its cytotoxicity is attenuated by glutamate, other excitotoxic agents and atropine. Possible presence of glutamate receptor and muscarinic receptor on microglia. Brain research. vol 897. issue 1-2. 2001-06-21. PMID:11282378. |
mk-801 is cytotoxic to microglia in vitro and its cytotoxicity is attenuated by glutamate, other excitotoxic agents and atropine. |
2001-06-21 |
2023-08-12 |
Not clear |
| M Hirayama, M Kuriyam. MK-801 is cytotoxic to microglia in vitro and its cytotoxicity is attenuated by glutamate, other excitotoxic agents and atropine. Possible presence of glutamate receptor and muscarinic receptor on microglia. Brain research. vol 897. issue 1-2. 2001-06-21. PMID:11282378. |
possible presence of glutamate receptor and muscarinic receptor on microglia. |
2001-06-21 |
2023-08-12 |
Not clear |
| M Hirayama, M Kuriyam. MK-801 is cytotoxic to microglia in vitro and its cytotoxicity is attenuated by glutamate, other excitotoxic agents and atropine. Possible presence of glutamate receptor and muscarinic receptor on microglia. Brain research. vol 897. issue 1-2. 2001-06-21. PMID:11282378. |
it suggested the existence of glutamate receptor in microglia. |
2001-06-21 |
2023-08-12 |
Not clear |
| T Tikka, B L Fiebich, G Goldsteins, R Keinanen, J Koistinah. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306611. |
in pure microglia cultures, glutamate induced transient activation of p38 mapk, and this was inhibited by minocycline. |
2001-06-07 |
2023-08-12 |
human |
| S W Barger, A S Basil. Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. Journal of neurochemistry. vol 76. issue 3. 2001-03-15. PMID:11158256. |
activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. |
2001-03-15 |
2023-08-12 |
rat |
| S W Barger, A S Basil. Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. Journal of neurochemistry. vol 76. issue 3. 2001-03-15. PMID:11158256. |
together, these data indicate a scenario by which microglia activated by sapp release excitotoxic levels of glutamate, probably as a consequence of autoprotective antioxidant glutathione production within the microglia, ultimately causing synaptic degeneration and neuronal death. |
2001-03-15 |
2023-08-12 |
rat |
| H Watanabe, H Abe, S Takeuchi, R Tanak. Protective effect of microglial conditioning medium on neuronal damage induced by glutamate. Neuroscience letters. vol 289. issue 1. 2000-10-06. PMID:10899407. |
more neurons survived in these groups, particularly in the case of glutamate stimulation of microglia. |
2000-10-06 |
2023-08-12 |
Not clear |
| H Watanabe, H Abe, S Takeuchi, R Tanak. Protective effect of microglial conditioning medium on neuronal damage induced by glutamate. Neuroscience letters. vol 289. issue 1. 2000-10-06. PMID:10899407. |
these results indicate that the neuroprotective effect of microglia appears only in the early phase after treatment of glutamate and disappears in the late phase. |
2000-10-06 |
2023-08-12 |
Not clear |
| A C Rimaniol, S Haïk, M Martin, R Le Grand, F D Boussin, N Dereuddre-Bosquet, G Gras, D Dormon. Na+-dependent high-affinity glutamate transport in macrophages. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 10. 2000-06-07. PMID:10799909. |
this suggests that brain-infiltrated macrophages and resident microglia may acquire eaats and, along with astrocytes, regulate extracellular glutamate concentration. |
2000-06-07 |
2023-08-12 |
human |
| F López-Redondo, K Nakajima, S Honda, S Kohsak. Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762723. |
glutamate transporter glt-1 is highly expressed in activated microglia following facial nerve axotomy. |
2000-06-05 |
2023-08-12 |
human |