| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F López-Redondo, K Nakajima, S Honda, S Kohsak. Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762723. |
to our knowledge, this is the first direct demonstration of the expression of glt-1 protein in activated microglial cells, suggesting a neuroprotective role of microglia against glutamate excitotoxicity following nerve axotomy. |
2000-06-05 |
2023-08-12 |
human |
| M Noda, H Nakanishi, J Nabekura, N Akaik. AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 1. 2000-01-27. PMID:10627602. |
ampa-kainate subtypes of glutamate receptor in rat cerebral microglia. |
2000-01-27 |
2023-08-12 |
rat |
| M Noda, H Nakanishi, N Akaik. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426500. |
glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. |
1999-10-08 |
2023-08-12 |
rat |
| M Noda, H Nakanishi, N Akaik. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426500. |
in the present study, we found that amyloid-beta peptide enhanced glutamate release from primary cultured rat microglia via the na+-dependent glutamate transporter, which was activated by extracellular k+. |
1999-10-08 |
2023-08-12 |
rat |
| M Noda, H Nakanishi, N Akaik. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426500. |
both these reverse and forward glutamate transport currents were three-fold greater in microglia incubated with a relatively low concentration of amyloid-beta peptide (25-35) (5 microm) for four days. |
1999-10-08 |
2023-08-12 |
rat |
| M Noda, H Nakanishi, N Akaik. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426500. |
the glutamate concentration released from microglia upon high-k+ stimulation was also significantly increased (up to 170 microm) after treatment with amyloid-beta peptide (25-35). |
1999-10-08 |
2023-08-12 |
rat |
| M Noda, H Nakanishi, N Akaik. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426500. |
these results suggest that, at the pathological sites where extracellular k+ concentration may increase, the activation of microglia by amyloid-beta peptide causes an increase in extracellular glutamate concentration via reverse glutamate transporter, and therefore this mechanism may contribute to the pathogenesis of neuronal dysfunction and death in alzheimer's disease. |
1999-10-08 |
2023-08-12 |
rat |
| E Koutsilieri, S Sopper, T Heinemann, C Scheller, J Lan, C Stahl-Hennig, V ter Meulen, P Riederer, M Gerlac. Involvement of microglia in cerebrospinal fluid glutamate increase in SIV-infected rhesus monkeys (Macaca mulatta). AIDS research and human retroviruses. vol 15. issue 5. 1999-07-16. PMID:10195757. |
involvement of microglia in cerebrospinal fluid glutamate increase in siv-infected rhesus monkeys (macaca mulatta). |
1999-07-16 |
2023-08-12 |
monkey |
| K Biber, D J Laurie, A Berthele, B Sommer, T R Tölle, P J Gebicke-Härter, D van Calker, H W Boddek. Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098876. |
expression and signaling of group i metabotropic glutamate receptors in astrocytes and microglia. |
1999-04-13 |
2023-08-12 |
rat |
| P L McGeer, E G McGee. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer disease and associated disorders. vol 12 Suppl 2. 1999-02-02. PMID:9769023. |
accumulations of amyloid, extracellular tangles, or lewy bodies apparently act as irritants, causing the activation of complement, the initiation of reactive changes in microglia, and the release of potentially neurotoxic products such as the membrane attack complex, oxygen free radicals, and excess glutamate. |
1999-02-02 |
2023-08-12 |
human |
| D R Brown, H A Kretzschma. The glio-toxic mechanism of alpha-aminoadipic acid on cultured astrocytes. Journal of neurocytology. vol 27. issue 2. 1999-01-05. PMID:9609401. |
this inhibition may be due to glutamate release by microglia. |
1999-01-05 |
2023-08-12 |
Not clear |
| H Neumann, T Misgeld, K Matsumuro, H Wekerl. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 10. 1998-06-19. PMID:9576961. |
interferon-gamma (ifn-gamma)-dependent mhc class ii inducibility in microglia cells was very low, but strongly increased in the hippocampal slices after the blockade of neuronal activity by neurotoxins [tetrodotoxin (ttx), omega-conotoxin] or glutamate antagonists. |
1998-06-19 |
2023-08-12 |
rat |
| K Inoue, K Nakajima, T Morimoto, Y Kikuchi, S Koizumi, P Illes, S Kohsak. ATP stimulation of Ca2+ -dependent plasminogen release from cultured microglia. British journal of pharmacology. vol 123. issue 7. 1998-06-11. PMID:9579723. |
atp (10-100 microm), but not glutamate (100 microm), stimulated the release of plasminogen from microglia in a concentration-dependent manner during a 10 min stimulation. |
1998-06-11 |
2023-08-12 |
Not clear |
| Y P Wu, E A Lin. Induction of microglial and astrocytic response in the adult rat lumbar spinal cord following middle cerebral artery occlusion. Experimental brain research. vol 118. issue 2. 1998-04-15. PMID:9547093. |
present results suggest that following mca occlusion, the vigorous response of microglia, and subsequently astrocytes, in the spinal cord in extra-focal areas far removed from the primary site of ischaemia may be mediated by glutamate released from the ischaemic corticospinal neurons through nmda receptors on the postsynaptic spinal cord neurons. |
1998-04-15 |
2023-08-12 |
rat |
| I E Mazzoni, R L Kenigsber. Microglia from the developing rat medial septal area can affect cholinergic and GABAergic neuronal differentiation in vitro. Neuroscience. vol 76. issue 1. 1997-03-18. PMID:8971767. |
furthermore, in the absence or presence of other glial cell types, microglia also influence septal gabaergic neurons by significantly increasing glutamate decarboxylase activity. |
1997-03-18 |
2023-08-12 |
rat |
| I E Mazzoni, R L Kenigsber. Microglia from the developing rat medial septal area can affect cholinergic and GABAergic neuronal differentiation in vitro. Neuroscience. vol 76. issue 1. 1997-03-18. PMID:8971767. |
finally, although basic fibroblast growth factor and interleukin-3 significantly increase septal glutamate decarboxylase activity, neither appears to be implicated in the gabaergic cell response to the microglia. |
1997-03-18 |
2023-08-12 |
rat |
| F Alliot, M C Marty, D Cambier, B Pessa. A spontaneously immortalized mouse microglial cell line expressing CD4. Brain research. Developmental brain research. vol 95. issue 1. 1997-01-14. PMID:8873987. |
this microglial clone expresses two characteristics not previously reported for microglial cell lines: it synthesizes the cd4 molecule and produces and releases large amounts of glutamate. |
1997-01-14 |
2023-08-12 |
mouse |
| S M Fine, R A Angel, S W Perry, L G Epstein, J D Rothstein, S Dewhurst, H A Gelbar. Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. The Journal of biological chemistry. vol 271. issue 26. 1996-08-20. PMID:8663435. |
to test this hypothesis, we examined the effect of the pro-inflammatory cytokine, tumor necrosis factor alpha (tnfalpha), produced by hiv-1-infected macrophages and microglia, on glutamate transport by primary human fetal astrocytes (phfas). |
1996-08-20 |
2023-08-12 |
human |
| K Kondo, H Hashimoto, J Kitanaka, M Sawada, A Suzumura, T Marunouchi, A Bab. Expression of glutamate transporters in cultured glial cells. Neuroscience letters. vol 188. issue 2. 1995-07-27. PMID:7792059. |
oligodendrocytes and microglia expressed mrnas for both glt-1 and glast equally, but the expression in microglia was not prominent, suggesting glutamate uptake is not essential in microglia. |
1995-07-27 |
2023-08-12 |
Not clear |
| J M Rosenstein, N S More, J M Kru. Immunocytochemical distribution of the brain glucose transporter (GLUT 1) in experimental gliosis. Brain research. vol 659. issue 1-2. 1995-02-13. PMID:7820675. |
this report suggests that glut 1 protein may be upregulated in non-endothelial components, such as reactive astroglia or possibly microglia, that are associated with injured or angiogenic vessels. |
1995-02-13 |
2023-08-12 |
Not clear |