| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yukiko Hagino, Yukihiro Kariura, Yoshimasa Manago, Taiju Amano, Bing Wang, Masayuki Sekiguchi, Kaori Nishikawa, Shunsuke Aoki, Keiji Wada, Mami Nod. Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia. Glia. vol 47. issue 1. 2004-09-01. PMID:15139014. |
glutamate (glu)- or kainite (ka)-induced currents were completely inhibited by a specific blocker of ampa receptor, ly300164, indicating that functional glu-receptors in cultured microglia are mostly ampa receptor but not ka receptor in many cells. |
2004-09-01 |
2023-08-12 |
rat |
| Julie Wieseler-Frank, Steven F Maier, Linda R Watkin. Glial activation and pathological pain. Neurochemistry international. vol 45. issue 2-3. 2004-07-26. PMID:15145553. |
in exaggerated pain, astrocytes, and microglia are activated by neuronal signals including substance p, glutamate, and fractalkine. |
2004-07-26 |
2023-08-12 |
Not clear |
| Tomohisa Suzuki, Izumi Hide, Katsutoshi Ido, Shinichi Kohsaka, Kazuhide Inoue, Yoshihiro Nakat. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 1. 2004-01-30. PMID:14715932. |
finally, our data suggest that p2x7 receptor-activated microglia protect neurons against glutamate toxicity primarily because they are able to release tnf. |
2004-01-30 |
2023-08-12 |
Not clear |
| Guy C Brown, Anna Bal-Pric. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Molecular neurobiology. vol 27. issue 3. 2003-09-16. PMID:12845153. |
activated astrocytes or microglia cause a potent inhibition of respiration in cocultured neurons due to glial no inhibiting cytochrome oxidase within the neurons, resulting in atp depletion and glutamate release. |
2003-09-16 |
2023-08-12 |
Not clear |
| Françoise Lazarini, To Nam Tham, Philippe Casanova, Fernando Arenzana-Seisdedos, Monique Dubois-Dalc. Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia. vol 42. issue 2. 2003-06-10. PMID:12655598. |
it enhances migration and proliferation of cerebellar granule cells, chemoattracts microglia, and stimulates cytokine production and glutamate release by astrocytes. |
2003-06-10 |
2023-08-12 |
Not clear |
| Jennifer L Takahashi, Fabrizio Giuliani, Christopher Power, Yoshinori Imai, V Wee Yon. Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity. Annals of neurology. vol 53. issue 5. 2003-06-04. PMID:12730992. |
because there is microglia activation in all stages of multiple sclerosis, we determined whether a microglia product, interleukin-1beta, could provide the mechanism for glutamate excitotoxicity. |
2003-06-04 |
2023-08-12 |
Not clear |
| Jennifer L Takahashi, Fabrizio Giuliani, Christopher Power, Yoshinori Imai, V Wee Yon. Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity. Annals of neurology. vol 53. issue 5. 2003-06-04. PMID:12730992. |
these results provide a mechanistic link between the persistent and insidious microglia activation that is evident in all stages of multiple sclerosis, with the recent appreciation that glutamate excitotoxicity leads to the destruction of oligodendrocytes in the disease. |
2003-06-04 |
2023-08-12 |
Not clear |
| Gabriel Gras, Fabrice Chrétien, Anne-Valérie Vallat-Decouvelaere, Gwenaelle Le Pavec, Fabrice Porcheray, Christophe Bossuet, Cathie Léone, Patricia Mialocq, Nathalie Dereuddre-Bosquet, Pascal Clayette, Roger Le Grand, Christophe Créminon, Dominique Dormont, Anne-Cécile Rimaniol, Françoise Gra. Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain pathology (Zurich, Switzerland). vol 13. issue 2. 2003-06-04. PMID:12744474. |
regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in hiv infection? |
2003-06-04 |
2023-08-12 |
Not clear |
| Gabriel Gras, Fabrice Chrétien, Anne-Valérie Vallat-Decouvelaere, Gwenaelle Le Pavec, Fabrice Porcheray, Christophe Bossuet, Cathie Léone, Patricia Mialocq, Nathalie Dereuddre-Bosquet, Pascal Clayette, Roger Le Grand, Christophe Créminon, Dominique Dormont, Anne-Cécile Rimaniol, Françoise Gra. Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain pathology (Zurich, Switzerland). vol 13. issue 2. 2003-06-04. PMID:12744474. |
other in vitro studies as well as in vivo experiments in rodents following mechanical stimulation, show that activated microglia and brain macrophages express high affinity glutamate transporters. |
2003-06-04 |
2023-08-12 |
Not clear |
| Gabriel Gras, Fabrice Chrétien, Anne-Valérie Vallat-Decouvelaere, Gwenaelle Le Pavec, Fabrice Porcheray, Christophe Bossuet, Cathie Léone, Patricia Mialocq, Nathalie Dereuddre-Bosquet, Pascal Clayette, Roger Le Grand, Christophe Créminon, Dominique Dormont, Anne-Cécile Rimaniol, Françoise Gra. Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain pathology (Zurich, Switzerland). vol 13. issue 2. 2003-06-04. PMID:12744474. |
recent studies in humans with hiv infection show that activated microglia and brain macrophages express the glutamate transporter eaat-1 and that expression varies according to the disease stage. |
2003-06-04 |
2023-08-12 |
Not clear |
| Gabriel Gras, Fabrice Chrétien, Anne-Valérie Vallat-Decouvelaere, Gwenaelle Le Pavec, Fabrice Porcheray, Christophe Bossuet, Cathie Léone, Patricia Mialocq, Nathalie Dereuddre-Bosquet, Pascal Clayette, Roger Le Grand, Christophe Créminon, Dominique Dormont, Anne-Cécile Rimaniol, Françoise Gra. Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain pathology (Zurich, Switzerland). vol 13. issue 2. 2003-06-04. PMID:12744474. |
in this review article, we discuss the possible neuroprotective and neurotrophic roles of activated microglia and macrophages that may be generated by the expression of high affinity glutamate transporters and glutamine synthetase, 2 major effectors of glial glutamate metabolism, and the implications for hiv-induced neuronal dysfunction, the underlying cause of hiv dementia. |
2003-06-04 |
2023-08-12 |
Not clear |
| Deanna L Taylor, Lara T Diemel, Jennifer M Pococ. Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 6. 2003-04-17. PMID:12657674. |
we examined the expression and functionality of group iii metabotropic glutamate (mglu) receptors on microglia. |
2003-04-17 |
2023-08-12 |
rat |
| Yoichi Nakamura, Miho Ohmaki, Koji Murakami, Yukio Yoned. Involvement of protein kinase C in glutamate release from cultured microglia. Brain research. vol 962. issue 1-2. 2003-04-01. PMID:12543462. |
involvement of protein kinase c in glutamate release from cultured microglia. |
2003-04-01 |
2023-08-12 |
rat |
| Yoichi Nakamura, Miho Ohmaki, Koji Murakami, Yukio Yoned. Involvement of protein kinase C in glutamate release from cultured microglia. Brain research. vol 962. issue 1-2. 2003-04-01. PMID:12543462. |
to elucidate the mechanism of glutamate release, we examined the possible regulation by nitric oxide and protein kinase c. cultured microglia prepared from the whole brains of newborn rats released glutamate by the stimulation with lipopolysaccharide (lps) dose dependently. |
2003-04-01 |
2023-08-12 |
rat |
| F Chrétien, A-V Vallat-Decouvelaere, C Bossuet, A-C Rimaniol, R Le Grand, G Le Pavec, C Créminon, D Dormont, F Gray, G Gra. Expression of excitatory amino acid transporter-2 (EAAT-2) and glutamine synthetase (GS) in brain macrophages and microglia of SIVmac251-infected macaques. Neuropathology and applied neurobiology. vol 28. issue 5. 2003-03-12. PMID:12366822. |
this observation might modify our current understanding of brain inflammation, which considers activated microglia and brain macrophages as the main neurotoxic cells through their production of a variety of neurotoxins, including glutamate. |
2003-03-12 |
2023-08-12 |
human |
| F Chrétien, A-V Vallat-Decouvelaere, C Bossuet, A-C Rimaniol, R Le Grand, G Le Pavec, C Créminon, D Dormont, F Gray, G Gra. Expression of excitatory amino acid transporter-2 (EAAT-2) and glutamine synthetase (GS) in brain macrophages and microglia of SIVmac251-infected macaques. Neuropathology and applied neurobiology. vol 28. issue 5. 2003-03-12. PMID:12366822. |
we found that both microglia and brain macrophages expressed eaat-2 and gs in infected primates, suggesting that these cells might, like astrocytes, clear extracellular glutamate and provide glutamine to neurones. |
2003-03-12 |
2023-08-12 |
human |
| D L Taylor, L T Diemel, M L Cuzner, J M Pococ. Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease. Journal of neurochemistry. vol 82. issue 5. 2002-10-18. PMID:12358765. |
here we report that microglia possess functional group ii metabotropic glutamate receptors, expressing mrna and receptor protein for mglu2 and mglu3, negatively coupled to adenylate cyclase. |
2002-10-18 |
2023-08-12 |
Not clear |
| A Martínez-Contreras, M Huerta, S Lopez-Perez, J García-Estrada, S Luquín, C Beas Zárat. Astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. Journal of neuroscience research. vol 67. issue 2. 2002-02-21. PMID:11782964. |
astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. |
2002-02-21 |
2023-08-12 |
rat |
| D R Brow. Microglia and prion disease. Microscopy research and technique. vol 54. issue 2. 2001-10-04. PMID:11455614. |
first, there is a reduction in neuronal resistance to toxic insults and, second, there is an increase in the production of toxic substances such as reactive oxygen species by microglia and a decrease in glutamate clearance by astrocytes. |
2001-10-04 |
2023-08-12 |
cattle |
| F K van Landeghem, J F Stover, I Bechmann, W Brück, A Unterberg, C Bührer, A von Deimlin. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia. vol 35. issue 3. 2001-10-04. PMID:11494408. |
early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. |
2001-10-04 |
2023-08-12 |
rat |