| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fleur Pinteaux-Jones, Ioanna G Sevastou, Victoria A H Fry, Simon Heales, David Baker, Jennifer M Pococ. Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors. Journal of neurochemistry. vol 106. issue 1. 2008-08-19. PMID:18419765. |
co-incubation of microglia with agonists or antagonists of different metabotropic glutamate receptor (mglur) subtypes ameliorated microglial neurotoxicity by inhibiting soluble neurotoxin production. |
2008-08-19 |
2023-08-12 |
rat |
| Leah McNally, Zubin Bhagwagar, Jonas Hannesta. Inflammation, glutamate, and glia in depression: a literature review. CNS spectrums. vol 13. issue 6. 2008-08-18. PMID:18567974. |
microglia activated by excess inflammation, astroglial loss, and inappropriate glutamate receptor activation ultimately disrupt the delicate balance of neuroprotective versus neurotoxic effects in the brain, potentially leading to depression. |
2008-08-18 |
2023-08-12 |
Not clear |
| Izumi Yawata, Hideyuki Takeuchi, Yukiko Doi, Jianfeng Liang, Tetsuya Mizuno, Akio Suzumur. Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors. Life sciences. vol 82. issue 21-22. 2008-06-30. PMID:18452953. |
we have shown previously, that the most neurotoxic factor from activated microglia is glutamate that is produced by glutaminase utilizing extracellular glutamine as a substrate. |
2008-06-30 |
2023-08-12 |
Not clear |
| Izumi Yawata, Hideyuki Takeuchi, Yukiko Doi, Jianfeng Liang, Tetsuya Mizuno, Akio Suzumur. Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors. Life sciences. vol 82. issue 21-22. 2008-06-30. PMID:18452953. |
drugs that inhibit glutaminase or gap junction through which the glutamate is released were effective in reducing neurotoxic activity of microglia. |
2008-06-30 |
2023-08-12 |
Not clear |
| Norimitsu Morioka, Md Joynal Abdin, Tomoya Kitayama, Katsuya Morita, Yoshihiro Nakata, Toshihiro Doh. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport. Glia. vol 56. issue 5. 2008-06-12. PMID:18240314. |
p2x(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport. |
2008-06-12 |
2023-08-12 |
rat |
| Norimitsu Morioka, Md Joynal Abdin, Tomoya Kitayama, Katsuya Morita, Yoshihiro Nakata, Toshihiro Doh. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport. Glia. vol 56. issue 5. 2008-06-12. PMID:18240314. |
it has been shown that spinal microglia expressing certain types of glutamate transporters function in the modulation of neuropathogenesis. |
2008-06-12 |
2023-08-12 |
rat |
| Norimitsu Morioka, Md Joynal Abdin, Tomoya Kitayama, Katsuya Morita, Yoshihiro Nakata, Toshihiro Doh. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport. Glia. vol 56. issue 5. 2008-06-12. PMID:18240314. |
in this study, the effect of atp, potentially able to mediate the communication between neurons and glial cells in the spinal cord on the transport of glutamate in cultured spinal microglia, was investigated. |
2008-06-12 |
2023-08-12 |
rat |
| Norimitsu Morioka, Md Joynal Abdin, Tomoya Kitayama, Katsuya Morita, Yoshihiro Nakata, Toshihiro Doh. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport. Glia. vol 56. issue 5. 2008-06-12. PMID:18240314. |
these results suggest that the activation of p2x(7) receptors in spinal microglia is important in the regulation of glutamate transport via activation of the extracellular signal-regulated kinase cascade and production of oxidants. |
2008-06-12 |
2023-08-12 |
rat |
| Vikas Kaushal, Lyanne C Schlichte. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 9. 2008-04-08. PMID:18305255. |
we found that oxygen-glucose deprivation (ogd)-stressed neurons released glutamate, which activated microglia through their group ii metabotropic glutamate receptors (mglurs). |
2008-04-08 |
2023-08-12 |
Not clear |
| Vikas Kaushal, Lyanne C Schlichte. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 9. 2008-04-08. PMID:18305255. |
the same microglia neurotoxic behavior was evoked without exposure to ogd-stressed neurons, by directly activating microglial group ii mglurs with (2s,2'r,3'r)-2-(2'3'-dicarboxycyclopropyl) glycine or glutamate, which stimulated production of tnf-alpha (not nitric oxide) and mediated tnf-alpha-dependent neurotoxicity through activation of nf-kappab (not p38 mapk). |
2008-04-08 |
2023-08-12 |
Not clear |
| Falko Meisner, Eva Neuen-Jacob, Sieghart Sopper, Michaela Schmidt, Serge Schlammes, Carsten Scheller, Daniel Vosswinkel, Volker Ter Meulen, Peter Riederer, Eleni Koutsilier. Disruption of excitatory amino acid transporters in brains of SIV-infected rhesus macaques is associated with microglia activation. Journal of neurochemistry. vol 104. issue 1. 2008-02-18. PMID:17986224. |
our data support the glutamate hypothesis for the development of hiv dementia and suggest that the pathogenetic mechanism for the neurodysfunction is the impairment of glutamate clearing which occurs in the stage of aids and which is associated with activated microglia. |
2008-02-18 |
2023-08-12 |
human |
| Shijie Jin, Jun Kawanokuchi, Tetsuya Mizuno, Jinyan Wang, Yoshifumi Sonobe, Hideyuki Takeuchi, Akio Suzumur. Interferon-beta is neuroprotective against the toxicity induced by activated microglia. Brain research. vol 1179. 2008-01-17. PMID:17905201. |
ifn-beta suppressed the production of glutamate and superoxide by activated microglia to 70% and 75% of lipopolysaccharide stimulation, respectively, and prevented microglial-induced neuronal cell death. |
2008-01-17 |
2023-08-12 |
Not clear |
| Mikael Persson, Mona Brantefjord, Jan-Ake Liljeqvist, Tomas Bergström, Elisabeth Hansson, Lars Rönnbäc. Microglial GLT-1 is upregulated in response to herpes simplex virus infection to provide an antiviral defence via glutathione. Glia. vol 55. issue 14. 2007-12-20. PMID:17680651. |
microglia have been shown to express the glutamate transporter glt-1 during pathological events, leading to increased microglial glutamate uptake and glutathione synthesis. |
2007-12-20 |
2023-08-12 |
rat |
| Sébastien Tilleux, Julie Berger, Emmanuel Herman. Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5. Journal of neuroimmunology. vol 189. issue 1-2. 2007-11-28. PMID:17628702. |
induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5. |
2007-11-28 |
2023-08-12 |
Not clear |
| Sébastien Tilleux, Julie Berger, Emmanuel Herman. Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5. Journal of neuroimmunology. vol 189. issue 1-2. 2007-11-28. PMID:17628702. |
to explore the impact of neuroinflammation on the control of glutamate transmission, we studied the metabotropic glutamate receptor 5 (mglur5) expression in cultured astrocytes exposed to conditioned medium from lipopolysaccharide-activated microglia. |
2007-11-28 |
2023-08-12 |
Not clear |
| b' Carlos Matute, Elena Alberdi, Mar\\xc3\\xada Domercq, Mar\\xc3\\xada-Victoria S\\xc3\\xa1nchez-G\\xc3\\xb3mez, Alberto P\\xc3\\xa9rez-Samart\\xc3\\xadn, Alfredo Rodr\\xc3\\xadguez-Antig\\xc3\\xbcedad, Fernando P\\xc3\\xa9rez-Cerd\\xc3\\xa. Excitotoxic damage to white matter. Journal of anatomy. vol 210. issue 6. 2007-11-13. PMID:17504270.' |
activated microglia in turn may secrete cytokines and generate radical oxygen species, which impair glutamate uptake and reduce the expression of glutamate transporters. |
2007-11-13 |
2023-08-12 |
Not clear |
| Sébastien Tilleux, Emmanuel Herman. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. Journal of neuroscience research. vol 85. issue 10. 2007-11-01. PMID:17497670. |
although several research projects have focused on the biochemical mechanisms of the regulation of glial glutamate transporters, a relationship between activation of microglia and modulation of astrocytic glutamate uptake is now suggested. |
2007-11-01 |
2023-08-12 |
Not clear |
| Marco Vercellino, Aristide Merola, Chiara Piacentino, Barbara Votta, Elisabetta Capello, Giovanni Luigi Mancardi, Roberto Mutani, Maria Teresa Giordana, Paola Cavall. Altered glutamate reuptake in relapsing-remitting and secondary progressive multiple sclerosis cortex: correlation with microglia infiltration, demyelination, and neuronal and synaptic damage. Journal of neuropathology and experimental neurology. vol 66. issue 8. 2007-10-26. PMID:17882017. |
altered glutamate reuptake in relapsing-remitting and secondary progressive multiple sclerosis cortex: correlation with microglia infiltration, demyelination, and neuronal and synaptic damage. |
2007-10-26 |
2023-08-12 |
Not clear |
| Marco Vercellino, Aristide Merola, Chiara Piacentino, Barbara Votta, Elisabetta Capello, Giovanni Luigi Mancardi, Roberto Mutani, Maria Teresa Giordana, Paola Cavall. Altered glutamate reuptake in relapsing-remitting and secondary progressive multiple sclerosis cortex: correlation with microglia infiltration, demyelination, and neuronal and synaptic damage. Journal of neuropathology and experimental neurology. vol 66. issue 8. 2007-10-26. PMID:17882017. |
alterations of the mechanisms of glutamate reuptake are found in cortical ms lesions in the presence of activated microglia and are associated with signs of neuronal and synaptic damage suggestive of excitotoxicity. |
2007-10-26 |
2023-08-12 |
Not clear |
| Gabriel Gras, Fabrice Porcheray, Boubekeur Samah, Cathie Leon. The glutamate-glutamine cycle as an inducible, protective face of macrophage activation. Journal of leukocyte biology. vol 80. issue 5. 2007-10-23. PMID:16912070. |
in vitro and in vivo studies have demonstrated that activated microglia and brain macrophages (amm) express the transporters and enzymes of the glutamate cycle. |
2007-10-23 |
2023-08-12 |
Not clear |