| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Izumi Maezawa, Lee-Way Ji. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392956. |
we further identified that increased levels of glutaminase and connexin 32 in mecp2-null microglia are responsible for increased glutamate production and release, respectively. |
2010-05-14 |
2023-08-12 |
Not clear |
| Izumi Maezawa, Lee-Way Ji. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392956. |
our results suggest that microglia may influence the onset and progression of rtt and that microglia glutamate synthesis or release could be a therapeutic target for rtt. |
2010-05-14 |
2023-08-12 |
Not clear |
| Yukiko Doi, Tetsuya Mizuno, Yuki Maki, Shijie Jin, Hiroyuki Mizoguchi, Masayoshi Ikeyama, Minoru Doi, Makoto Michikawa, Hideyuki Takeuchi, Akio Suzumur. Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19834064. |
cpg enhanced microglial clearance of oabeta1-42 and induced higher levels of the antioxidant enzyme heme oxygenase-1 in microglia without producing neurotoxic molecules such as nitric oxide and glutamate. |
2010-01-11 |
2023-08-12 |
mouse |
| Carlos Matut. Interaction between glutamate signalling and immune attack in damaging oligodendrocytes. Neuron glia biology. vol 3. issue 4. 2009-12-14. PMID:18634560. |
in turn, activated, but not resting microglia, can compromise glutamate homeostasis and induce oligodendrocyte excitotoxicity, which is attenuated either by ampa/kainate antagonists or by the blockade of the system x(c)- antiporter present in microglia. |
2009-12-14 |
2023-08-12 |
Not clear |
| Claudie Hooper, Victoria A H Fry, Ioanna G Sevastou, Jennifer M Pococ. Scavenger receptor control of chromogranin A-induced microglial stress and neurotoxic cascades. FEBS letters. vol 583. issue 21. 2009-12-03. PMID:19800883. |
here we show that cga-dependent inducible nitric oxide synthase (inos) expression and stress responses in microglia involved signalling via scavenger receptors (sr), since sr class-a (sr-a) ligands blocked inos expression, mitochondrial depolarisation, apoptosis and glutamate release. |
2009-12-03 |
2023-08-12 |
Not clear |
| Adelaide Fernandes, Dora Brite. Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents. Current pharmaceutical design. vol 15. issue 25. 2009-11-24. PMID:19754368. |
exposure of astrocytes and microglia to ucb initiates an inflammatory response with the release of proinflammatory cytokines, such as tnf-alpha, il-1beta and il-6, accumulation of extracellular glutamate and a time-dependent cell death. |
2009-11-24 |
2023-08-12 |
Not clear |
| Sébastien Tilleux, Stéphanie Goursaud, Emmanuel Herman. Selective up-regulation of GLT-1 in cultured astrocytes exposed to soluble mediators released by activated microglia. Neurochemistry international. vol 55. issue 1-3. 2009-07-15. PMID:19428805. |
as nervous insults are frequently associated with local inflammation involving microglia, this study aims at exploring the link between activated microglia and altered glutamate uptake in astrocytes. |
2009-07-15 |
2023-08-12 |
rat |
| Sébastien Tilleux, Stéphanie Goursaud, Emmanuel Herman. Selective up-regulation of GLT-1 in cultured astrocytes exposed to soluble mediators released by activated microglia. Neurochemistry international. vol 55. issue 1-3. 2009-07-15. PMID:19428805. |
the regulation of the expression and activity of type 1 glutamate transporter (glt-1) was examined after exposing cultures of rat astrocytes to conditioned medium from lipopolysaccharide-activated microglia cultures. |
2009-07-15 |
2023-08-12 |
rat |
| David J Loane, Bogdan A Stoica, Ahdeah Pajoohesh-Ganji, Kimberly R Byrnes, Alan I Fade. Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. The Journal of biological chemistry. vol 284. issue 23. 2009-07-13. PMID:19364772. |
group ii and iii metabotropic glutamate receptors (mglurs) are expressed in microglia and can modulate microglial activity in primary cell cultures. |
2009-07-13 |
2023-08-12 |
Not clear |
| Jin Shijie, Hideyuki Takeuchi, Izumi Yawata, Yohei Harada, Yoshifumi Sonobe, Yukiko Doi, Jianfeng Liang, Li Hua, Satoko Yasuoka, Yan Zhou, Mariko Noda, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumur. Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice. The Tohoku journal of experimental medicine. vol 217. issue 2. 2009-06-15. PMID:19212100. |
blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice. |
2009-06-15 |
2023-08-12 |
mouse |
| Jin Shijie, Hideyuki Takeuchi, Izumi Yawata, Yohei Harada, Yoshifumi Sonobe, Yukiko Doi, Jianfeng Liang, Li Hua, Satoko Yasuoka, Yan Zhou, Mariko Noda, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumur. Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice. The Tohoku journal of experimental medicine. vol 217. issue 2. 2009-06-15. PMID:19212100. |
especially, glutamate released by activated microglia induces excito-neurotoxicity and may contribute to neurodegeneration in ms. gap junction is a major cell-to-cell channel and is composed of paired hemichannels on coupled cells. |
2009-06-15 |
2023-08-12 |
mouse |
| Jin Shijie, Hideyuki Takeuchi, Izumi Yawata, Yohei Harada, Yoshifumi Sonobe, Yukiko Doi, Jianfeng Liang, Li Hua, Satoko Yasuoka, Yan Zhou, Mariko Noda, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumur. Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice. The Tohoku journal of experimental medicine. vol 217. issue 2. 2009-06-15. PMID:19212100. |
we have previously revealed that activated microglia produce glutamate via glutaminase and release it through hemichannels of gap junctions. |
2009-06-15 |
2023-08-12 |
mouse |
| Jin Shijie, Hideyuki Takeuchi, Izumi Yawata, Yohei Harada, Yoshifumi Sonobe, Yukiko Doi, Jianfeng Liang, Li Hua, Satoko Yasuoka, Yan Zhou, Mariko Noda, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumur. Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice. The Tohoku journal of experimental medicine. vol 217. issue 2. 2009-06-15. PMID:19212100. |
here we show that the gap junction blocker carbenoxolone (cbx) and the glutaminase inhibitor 6-diazo-5-oxo-l-norleucine (don) decreased glutamate release from activated microglia and rescued neuronal death in a dose-dependent manner in vitro. |
2009-06-15 |
2023-08-12 |
mouse |
| Jin Shijie, Hideyuki Takeuchi, Izumi Yawata, Yohei Harada, Yoshifumi Sonobe, Yukiko Doi, Jianfeng Liang, Li Hua, Satoko Yasuoka, Yan Zhou, Mariko Noda, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumur. Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice. The Tohoku journal of experimental medicine. vol 217. issue 2. 2009-06-15. PMID:19212100. |
thus, blockade of glutamate release from activated microglia with cbx or don may be an effective therapeutic strategy against neurodegeneration in ms. |
2009-06-15 |
2023-08-12 |
mouse |
| Mikael Persson, Marcela Pekna, Elisabeth Hansson, Lars Rönnbäc. The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner. The European journal of neuroscience. vol 29. issue 2. 2009-06-12. PMID:19200233. |
microglia can express na+-dependent high-affinity glutamate transporters during pathological conditions in the cns. |
2009-06-12 |
2023-08-12 |
Not clear |
| Mikael Persson, Marcela Pekna, Elisabeth Hansson, Lars Rönnbäc. The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner. The European journal of neuroscience. vol 29. issue 2. 2009-06-12. PMID:19200233. |
this suggests that c5a-stimulated microglia can be self- and neuroprotective by removing extracellular glutamate. |
2009-06-12 |
2023-08-12 |
Not clear |
| Claudie Hooper, Fleur Pinteaux-Jones, Victoria A H Fry, Ioanna G Sevastou, David Baker, Simon J Heales, Jennifer M Pococ. Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19187440. |
exposure of primary cultured rat brain microglia to pure, fatty acid- and lipid-deficient rat serum albumin or fraction v, (fatty acid and lipid-containing rat serum albumin), caused inducible nitric oxide synthase (inos) expression, glutamate release, tumour necrosis factor alpha (tnfalpha) and transforming growth factor-beta1 release. |
2009-06-09 |
2023-08-12 |
rat |
| Claudie Hooper, Fleur Pinteaux-Jones, Victoria A H Fry, Ioanna G Sevastou, David Baker, Simon J Heales, Jennifer M Pococ. Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19187440. |
inos expression was attenuated by the mapk/extracellular signal-regulated kinase pathway inhibitor u0126 and the phosphorylated forms of extracellular signal-regulated kinase 1 and 2 were detectable in microglia treated with albumin or fraction v. glutamate release was prevented by l-alpha-aminoadipate and glutathione levels in microglia rose on exposure to albumin. |
2009-06-09 |
2023-08-12 |
rat |
| Guo Jun Liu, Rajini Nagarajah, Richard B Banati, Max R Bennet. Glutamate induces directed chemotaxis of microglia. The European journal of neuroscience. vol 29. issue 6. 2009-06-09. PMID:19302147. |
glutamate induces directed chemotaxis of microglia. |
2009-06-09 |
2023-08-12 |
Not clear |
| Guo Jun Liu, Rajini Nagarajah, Richard B Banati, Max R Bennet. Glutamate induces directed chemotaxis of microglia. The European journal of neuroscience. vol 29. issue 6. 2009-06-09. PMID:19302147. |
microglia exposed to glutamate increase their cell membrane ruffling and migrate to a source of glutamate in cell culture and in spinal cord slices. |
2009-06-09 |
2023-08-12 |
Not clear |