| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Flavia Antonucci, Alán Alpár, Johannes Kacza, Matteo Caleo, Claudia Verderio, Alice Giani, Henrik Martens, Farrukh A Chaudhry, Manuela Allegra, Jens Grosche, Dominik Michalski, Christian Erck, Anke Hoffmann, Tibor Harkany, Michela Matteoli, Wolfgang Härti. Cracking down on inhibition: selective removal of GABAergic interneurons from hippocampal networks. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323713. |
we also show the focal and indiscriminate loss of calbindin(+), calretinin(+), parvalbumin/system a transporter 1(+), somatostatin(+), vesicular glutamate transporter 3 (vglut3)/cholecystokinin/cb(1) cannabinoid receptor(+) and neuropeptide y(+) local-circuit interneurons upon sava microlesions to the ca1 subfield of the rodent hippocampus, with interneuron debris phagocytosed by infiltrating microglia. |
2012-03-27 |
2023-08-12 |
mouse |
| Kristina A Kigerl, Daniel P Ankeny, Sanjay K Garg, Ping Wei, Zhen Guan, Wenmin Lai, Dana M McTigue, Ruma Banerjee, Phillip G Popovic. System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22079587. |
system x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo. |
2012-03-25 |
2023-08-12 |
Not clear |
| Shiping Zou, Sylvia Fitting, Yun-Kyung Hahn, Sandra P Welch, Nazira El-Hage, Kurt F Hauser, Pamela E Knap. Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia. Brain : a journal of neurology. vol 134. issue Pt 12. 2012-02-09. PMID:22102648. |
morphine enhanced transactivator of transcription-induced inflammatory effectors released by glia, elevating reactive oxygen species, increasing 3-nitrotyrosine production by microglia, and reducing the ability of glia to buffer glutamate. |
2012-02-09 |
2023-08-12 |
human |
| Juan A Orellana, Xavier F Figueroa, Helmuth A Sánchez, Susana Contreras-Duarte, Victoria Velarde, Juan C Sáe. Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions. CNS & neurological disorders drug targets. vol 10. issue 3. 2012-01-11. PMID:21288190. |
however, if the stimulus is deleterious, microglia and the endothelium become overactivated, both releasing bioactive molecules (e.g., glutamate, cytokines, prostaglandins and atp) that increase the activity of astroglial hemichannels, reducing the astrocyte neuroprotective functions, and further reducing neuronal cell viability. |
2012-01-11 |
2023-08-12 |
Not clear |
| Ji Woon Kim, Sung Hoon Lee, Hyun Myung Ko, Kyoung Ja Kwon, Kyu Suk Cho, Chang Soon Choi, Jin-Hee Park, Hahn Young Kim, Jongmin Lee, Seol-Heui Han, Louis J Ignarro, Jae Hoon Cheong, Won-Ki Kim, Chan Young Shi. Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: essential role of astrocyte-derived plasminogen activator inhibitor-1. Neurochemistry international. vol 58. issue 3. 2011-12-27. PMID:21193004. |
in cultured primary cells, glutamate stimulation increased tpa activity in neurons but not in other cells such as microglia and astrocytes. |
2011-12-27 |
2023-08-12 |
rat |
| Alicia Guemez-Gamboa, Ana María Estrada-Sánchez, Teresa Montiel, Blanca Páramo, Lourdes Massieu, Julio Morá. Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation. Journal of neuropathology and experimental neurology. vol 70. issue 11. 2011-12-08. PMID:22002428. |
in wild-type mice, nox2 immunoreactivity in neurons and microglia was stimulated by glutamate administration, and it progressively increased as microglia became activated; calpain activity was also induced. |
2011-12-08 |
2023-08-12 |
mouse |
| Alicia Guemez-Gamboa, Ana María Estrada-Sánchez, Teresa Montiel, Blanca Páramo, Lourdes Massieu, Julio Morá. Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation. Journal of neuropathology and experimental neurology. vol 70. issue 11. 2011-12-08. PMID:22002428. |
these results suggest that nox2 is stimulated by glutamate in neurons and reactive microglia through the activation of ionotropic and metabotropic receptors. |
2011-12-08 |
2023-08-12 |
mouse |
| Yunlong Huang, Lixia Zhao, Beibei Jia, Li Wu, Yuju Li, Norman Curthoys, Jialin C Zhen. Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 42. 2011-12-08. PMID:22016553. |
using a human microglia primary culture system and macrophage-tropic hiv-1 strains, we have now demonstrated that hiv-1 infection of microglia resulted in a significant increase in extracellular glutamate concentrations and elevated levels of neurotoxicity. |
2011-12-08 |
2023-08-12 |
human |
| Hideyuki Takeuchi, Hiroyuki Mizoguchi, Yukiko Doi, Shijie Jin, Mariko Noda, Jianfeng Liang, Hua Li, Yan Zhou, Rarami Mori, Satoko Yasuoka, Endong Li, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Jun Sato, Koji Yamanaka, Gen Sobue, Tetsuya Mizuno, Akio Suzumur. Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. PloS one. vol 6. issue 6. 2011-11-21. PMID:21712989. |
glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and alzheimer's disease. |
2011-11-21 |
2023-08-12 |
mouse |
| Hideyuki Takeuchi, Hiroyuki Mizoguchi, Yukiko Doi, Shijie Jin, Mariko Noda, Jianfeng Liang, Hua Li, Yan Zhou, Rarami Mori, Satoko Yasuoka, Endong Li, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Jun Sato, Koji Yamanaka, Gen Sobue, Tetsuya Mizuno, Akio Suzumur. Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. PloS one. vol 6. issue 6. 2011-11-21. PMID:21712989. |
although both blockade of glutamate receptors and inhibition of microglial activation are the therapeutic candidates for these neurodegenerative diseases, glutamate receptor blockers also perturbed physiological and essential glutamate signals, and inhibitors of microglial activation suppressed both neurotoxic/neuroprotective roles of microglia and hardly affected disease progression. |
2011-11-21 |
2023-08-12 |
mouse |
| Hideyuki Takeuchi, Hiroyuki Mizoguchi, Yukiko Doi, Shijie Jin, Mariko Noda, Jianfeng Liang, Hua Li, Yan Zhou, Rarami Mori, Satoko Yasuoka, Endong Li, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Jun Sato, Koji Yamanaka, Gen Sobue, Tetsuya Mizuno, Akio Suzumur. Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. PloS one. vol 6. issue 6. 2011-11-21. PMID:21712989. |
we previously demonstrated that activated microglia release a large amount of glutamate specifically through gap junction hemichannel. |
2011-11-21 |
2023-08-12 |
mouse |
| Hedy Folkersma, Jessica C Foster Dingley, Bart N M van Berckel, Annemieke Rozemuller, Ronald Boellaard, Marc C Huisman, Adriaan A Lammertsma, W Peter Vandertop, Carla F M Molthof. Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study. Journal of neuroinflammation. vol 8. 2011-10-03. PMID:21672189. |
the aim of the present study was to investigate microglia activation over time following traumatic brain injury (tbi) and to relate these findings to glutamate release. |
2011-10-03 |
2023-08-12 |
rat |
| Yoshihiro Seki, Satoshi O Suzuki, Kenta Masui, Shiori Harada, Seiji Nakamura, Shigenobu Kanba, Toru Iwak. A simple and high-yield method for preparation of rat microglial cultures utilizing Aclar plastic film. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 3. 2011-09-22. PMID:21092060. |
the smk cells exhibited markers specific for the microglia lineage, including iba-1, cd11b, cd45, cd68, major histocompatibility complex (mhc) class i and mhc class ii, but not for the astrocyte-specific markers, gfap and glutamate aspartate transporter. |
2011-09-22 |
2023-08-12 |
rat |
| Carlos Matut. Glutamate and ATP signalling in white matter pathology. Journal of anatomy. vol 219. issue 1. 2011-08-24. PMID:21250988. |
thus, inhibition of glutamate uptake by activated microglia can compromise glutamate homeostasis and induce oligodendrocyte excitotoxicity. |
2011-08-24 |
2023-08-12 |
Not clear |
| Shuang-Shuang Dai, Yuan-Guo Zho. Adenosine 2A receptor: a crucial neuromodulator with bidirectional effect in neuroinflammation and brain injury. Reviews in the neurosciences. vol 22. issue 2. 2011-08-23. PMID:21476942. |
the main conclusions are: (1) pharmacological, neurochemical and molecular/genetic approaches to the complex actions of a2ar in different cellular elements suggest that a2ar activation exerts bidirectional effect (detrimental or protective) after brain insults; (2) modulation of glutamate excitotoxicity and neuroinflammation are involved in the protection of a2ar agonists or antagonists, but the bidirectional effect of a2ar is largely due to the bidirectional regulation of neuroinflammation (anti-inflammation or proinflammation) by a2ar on immune cells such as microglia cells and peripheral bone marrow cells; and (3) the bidirectional effect of a2ar on neuroinflammation and brain injury depends on the distinct and sometimes opposite actions of a2ar in various cellular elements and on different injury models and associated pathological conditions. |
2011-08-23 |
2023-08-12 |
Not clear |
| Lyanne C Schlichter, Timothy Mertens, Baosong Li. Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release. Channels (Austin, Tex.). vol 5. issue 2. 2011-07-15. PMID:21150294. |
swelling activated cl- channels in microglia: biophysics, pharmacology and role in glutamate release. |
2011-07-15 |
2023-08-12 |
rat |
| Lyanne C Schlichter, Timothy Mertens, Baosong Li. Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release. Channels (Austin, Tex.). vol 5. issue 2. 2011-07-15. PMID:21150294. |
cell swelling evoked glutamate release from primary microglia and mls-9 cells, and this was inhibited by the blockers (above), and by iaa-94, but not by tamoxifen or the na+/k+/cl- symport inhibitor, bumetanide. |
2011-07-15 |
2023-08-12 |
rat |
| Kuan-Min Fang, Jen-Kun Chen, Shih-Chieh Hung, Mei-Chun Chen, Yi-Ting Wu, Tsung-Jung Wu, Hsin-I Lin, Chia-Hua Chen, Henrich Cheng, Chung-Shi Yang, Shun-Fen Tzen. Effects of combinatorial treatment with pituitary adenylate cyclase activating peptide and human mesenchymal stem cells on spinal cord tissue repair. PloS one. vol 5. issue 12. 2011-07-05. PMID:21187959. |
furthermore, in vitro studies showed that co-culture with hmscs in the presence of pacap not only increased a subpopulation of microglia expressing galectin-3, but also enhanced the ability of astrocytes to uptake extracellular glutamate. |
2011-07-05 |
2023-08-12 |
human |
| Juan A Orellana, Kenji F Shoji, Verónica Abudara, Pascal Ezan, Edwige Amigou, Pablo J Sáez, Jean X Jiang, Christian C Naus, Juan C Sáez, Christian Giaum. Amyloid β-induced death in neurons involves glial and neuronal hemichannels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 13. 2011-05-30. PMID:21451035. |
thus, aβ leads to a cascade of hemichannel activation in which microglia promote the release of glutamate and atp through glial (microglia and astrocytes) hemichannels that induces neuronal death by triggering hemichannels in neurons. |
2011-05-30 |
2023-08-12 |
mouse |
| Janelle Drouin-Ouellet, Anna-Liisa Brownell, Martine Saint-Pierre, Caroline Fasano, Vincent Emond, Louis-Eric Trudeau, Daniel Lévesque, Francesca Cicchett. Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions. Glia. vol 59. issue 2. 2011-04-14. PMID:21125661. |
this response was accompanied by a significant increase in metabotropic glutamate receptor type 5 (mglur5) expression within two distinct neuroinflammatory cell types; astrocytes and microglia. |
2011-04-14 |
2023-08-12 |
rat |