| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Jung Chen, Yen-Chuan Ou, Cheng-Yi Chang, Hung-Chuan Pan, Su-Lan Liao, Shih-Yun Chen, Shue-Ling Raung, Ching-Yi La. Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal death. Glia. vol 60. issue 3. 2013-11-01. PMID:22144112. |
infection with jev was found to elicit the extracellular glutamate accumulation from microglia but not from neuron and astrocyte cultures. |
2013-11-01 |
2023-08-12 |
Not clear |
| Chun-Jung Chen, Yen-Chuan Ou, Cheng-Yi Chang, Hung-Chuan Pan, Su-Lan Liao, Shih-Yun Chen, Shue-Ling Raung, Ching-Yi La. Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal death. Glia. vol 60. issue 3. 2013-11-01. PMID:22144112. |
the link between neuroinflammation and excitotoxic death may involve a mechanism in which tnf-α released by microglia plays a facilitory role in glutamate excitoneurotoxicity via up-regulation of glutamate synthesis and down-regulation of glutamate uptake. |
2013-11-01 |
2023-08-12 |
Not clear |
| George Anderson, Michael Mae. Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression. Progress in neuro-psychopharmacology & biological psychiatry. vol 42. 2013-10-29. PMID:22800757. |
in 1995, the macrophage-t lymphocyte theory of schizophrenia (smith and maes, 1995) considered that activated immuno-inflammatory pathways may account for the higher neurodevelopmental pathology linked with gestational infections through the detrimental effects of activated microglia, oxidative and nitrosative stress (o&ns), cytokine-induced activation of the tryptophan catabolite (trycat) pathway and consequent modulation of the n-methyl d-aspartate receptor (nmdar) and glutamate production. |
2013-10-29 |
2023-08-12 |
Not clear |
| Kaoru Beppu, Yuki Kosai, Mizuho A Kido, Nozomi Akimoto, Yuki Mori, Yuichiro Kojima, Kyota Fujita, Yuko Okuno, Yukiko Yamakawa, Masataka Ifuku, Rika Shinagawa, Junichi Nabekura, Rolf Sprengel, Mami Nod. Expression, subunit composition, and function of AMPA-type glutamate receptors are changed in activated microglia; possible contribution of GluA2 (GluR-B)-deficiency under pathological conditions. Glia. vol 61. issue 6. 2013-10-29. PMID:23468421. |
expression, subunit composition, and function of ampa-type glutamate receptors are changed in activated microglia; possible contribution of glua2 (glur-b)-deficiency under pathological conditions. |
2013-10-29 |
2023-08-12 |
mouse |
| Kaoru Beppu, Yuki Kosai, Mizuho A Kido, Nozomi Akimoto, Yuki Mori, Yuichiro Kojima, Kyota Fujita, Yuko Okuno, Yukiko Yamakawa, Masataka Ifuku, Rika Shinagawa, Junichi Nabekura, Rolf Sprengel, Mami Nod. Expression, subunit composition, and function of AMPA-type glutamate receptors are changed in activated microglia; possible contribution of GluA2 (GluR-B)-deficiency under pathological conditions. Glia. vol 61. issue 6. 2013-10-29. PMID:23468421. |
microglia express ampa (α-amino-hydroxy-5-methyl-isoxazole-4-propionate)-type of glutamate (glu) receptors (ampar), which are highly ca(2+) impermeable due to the expression of glua2. |
2013-10-29 |
2023-08-12 |
mouse |
| Moonhee Le. Neurotransmitters and microglial-mediated neuroinflammation. Current protein & peptide science. vol 14. issue 1. 2013-09-13. PMID:23441898. |
microglia express receptors for neurotransmitters such as atp, adenosine, glutamate, gaba, acetylcholine, dopamine and adrenaline. |
2013-09-13 |
2023-08-12 |
Not clear |
| Moonhee Le. Neurotransmitters and microglial-mediated neuroinflammation. Current protein & peptide science. vol 14. issue 1. 2013-09-13. PMID:23441898. |
however, glutamate and dopamine are both pro- and anti-inflammatory depending on the receptor subtypes expressed in microglia. |
2013-09-13 |
2023-08-12 |
Not clear |
| Akio Suzumur. Neuron-microglia interaction in neuroinflammation. Current protein & peptide science. vol 14. issue 1. 2013-09-13. PMID:23544747. |
we have shown previously that the most neurotoxic factor from activated microglia is glutamate, and that the suppression of glutamate release from microglia results in amelioration of disease progression in animal models of neurodegenerative disorders. |
2013-09-13 |
2023-08-12 |
Not clear |
| Valentina L Savchenk. Regulation of NADPH oxidase gene expression with PKA and cytokine IL-4 in neurons and microglia. Neurotoxicity research. vol 23. issue 3. 2013-08-29. PMID:22565378. |
il-4 prevents glutamate release from microglia suppressing xct expression induced by ab. |
2013-08-29 |
2023-08-12 |
rat |
| B-S Liu, R Ferreira, S Lively, L C Schlichte. Microglial SK3 and SK4 currents and activation state are modulated by the neuroprotective drug, riluzole. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 1. 2013-08-16. PMID:22527636. |
classical activation of microglia can produce neurotoxic levels of glutamate and immune mediators (e.g., pro-inflammatory cytokines, reactive oxygen and nitrogen species), while alternative activation up-regulates anti-inflammatory molecules and is thought to resolve inflammation and protect the brain. |
2013-08-16 |
2023-08-12 |
rat |
| Milos Kostic, Nikola Zivkovic, Ivana Stojanovi. Multiple sclerosis and glutamate excitotoxicity. Reviews in the neurosciences. vol 24. issue 1. 2013-08-06. PMID:23152401. |
glutamate is the major excitatory neurotransmitter of the central nervous system, which has been proven to have a central role in a complex communication network established between all residential brain cells, including neurons, astrocytes, oligodendrocytes and microglia. |
2013-08-06 |
2023-08-12 |
Not clear |
| Jia-Wei Wang, Han-Dong Wang, Zi-Xiang Cong, Xiang-Sheng Zhang, Xiao-Ming Zhou, Ding-Ding Zhan. Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats. Biochemical and biophysical research communications. vol 430. issue 3. 2013-07-22. PMID:23261470. |
in vitro studies were reported that activation of metabotropic glutamate receptor 5 (mglur5) could inhibit the microglia-associated inflammation in response to lipopolysaccharide and our previous study indicated that mglur5 was expressed in activated microglia following tbi. |
2013-07-22 |
2023-08-12 |
rat |
| B Amin, V Hajhashemi, H Hosseinzadeh, Kh Abnou. Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat. Neuroscience. vol 224. 2013-06-17. PMID:22871519. |
glutamate homeostasis and microglia activation play an important role in the development and maintenance of neuropathic pain. |
2013-06-17 |
2023-08-12 |
rat |
| María Domercq, Nuria Vázquez-Villoldo, Carlos Matut. Neurotransmitter signaling in the pathophysiology of microglia. Frontiers in cellular neuroscience. vol 7. 2013-04-30. PMID:23626522. |
in particular, microglia express receptors for atp and glutamate, which regulate microglial motility. |
2013-04-30 |
2023-08-12 |
Not clear |
| María Domercq, Nuria Vázquez-Villoldo, Carlos Matut. Neurotransmitter signaling in the pathophysiology of microglia. Frontiers in cellular neuroscience. vol 7. 2013-04-30. PMID:23626522. |
microglia have the capacity to release a large number of substances that can be detrimental to the surrounding neurons, including glutamate, atp, and reactive oxygen species. |
2013-04-30 |
2023-08-12 |
Not clear |
| Thomas Mika, Nora Prochno. Functions of connexins and large pore channels on microglial cells: the gates to environment. Brain research. vol 1487. 2013-04-23. PMID:22842527. |
ligands including glutamate, tumor necrosis factor alpha (tnf-α), cytokines, superoxide radicals and neurotrophins released by microglia have in turn effects on neuronal function and cell death. |
2013-04-23 |
2023-08-12 |
Not clear |
| Katarzyna Starowicz, Barbara Przewlock. Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1607. 2013-04-08. PMID:23108547. |
the development of innovative pharmacological strategies has led to the identification of new promising pharmacological targets, including glutamate antagonists, microglia inhibitors and, interestingly, endogenous ligands of cannabinoids and the transient receptor potential vanilloid type 1 (trpv1). |
2013-04-08 |
2023-08-12 |
Not clear |
| Aaron Y Lai, Kamaldeep S Dhami, Comfort D Dibal, Kathryn G Tod. Neonatal rat microglia derived from different brain regions have distinct activation responses. Neuron glia biology. vol 7. issue 1. 2013-01-14. PMID:22857737. |
here, we show that microglia, the resident immune cells of the brain, display region-specific responses for activating agents including glutamate (glu), lipopolysaccharide (lps) and adenosine 5'-triphosphate (atp). |
2013-01-14 |
2023-08-12 |
rat |
| Sandra L Silva, Ana R Vaz, Maria J Diógenes, Nico van Rooijen, Ana M Sebastião, Adelaide Fernandes, Rui F M Silva, Dora Brite. Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22361233. |
neuritic growth impairment and cell death by unconjugated bilirubin is mediated by no and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10. |
2012-12-20 |
2023-08-12 |
Not clear |
| Sandra L Silva, Ana R Vaz, Maria J Diógenes, Nico van Rooijen, Ana M Sebastião, Adelaide Fernandes, Rui F M Silva, Dora Brite. Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22361233. |
microglia, a crucial mediator of cns inflammation, evidenced to react to ucb by releasing glutamate and no before becoming senescent. |
2012-12-20 |
2023-08-12 |
Not clear |