| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Fernández-López, Ignacio Lizasoain, Maria Angeles Moro, José Martínez-Orgad. Cannabinoids: well-suited candidates for the treatment of perinatal brain injury. Brain sciences. vol 3. issue 3. 2014-06-25. PMID:24961520. |
an early responder to neuronal injury, the endocannabinoid system has been described as an endogenous neuroprotective system that once activated can prevent glutamate excitotoxicity, intracellular calcium accumulation, activation of cell death pathways, microglia activation, neurovascular reactivity and infiltration of circulating leukocytes across the blood-brain barrier. |
2014-06-25 |
2023-08-13 |
Not clear |
| Susan C Buckingham, Stefanie Robe. Glutamate and tumor-associated epilepsy: glial cell dysfunction in the peritumoral environment. Neurochemistry international. vol 63. issue 7. 2014-06-23. PMID:23385090. |
peritumoral astrocytes become reactive and lose their ability to remove glutamate, while microglia, in response to signals from glioma cells, may release glutamate. |
2014-06-23 |
2023-08-12 |
Not clear |
| K S Dhami, M A Churchward, G B Baker, K G Tod. Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult. Molecular and cellular neurosciences. vol 56. 2014-06-20. PMID:23876875. |
fluoxetine and citalopram, the ssris, decreased the release of the amino acids glutamate and d-serine from lps-activated microglia. |
2014-06-20 |
2023-08-12 |
Not clear |
| K S Dhami, M A Churchward, G B Baker, K G Tod. Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult. Molecular and cellular neurosciences. vol 56. 2014-06-20. PMID:23876875. |
to our knowledge, our results demonstrate for the first time that fluoxetine and citalopram decrease the release of glutamate and d-serine from lps-activated microglia and this causes an increase in the survival of ogd-injured cortical neurons after co-culture. |
2014-06-20 |
2023-08-12 |
Not clear |
| Lixia Zhao, Yunlong Huang, Jialin Zhen. STAT1 regulates human glutaminase 1 promoter activity through multiple binding sites in HIV-1 infected macrophages. PloS one. vol 8. issue 9. 2014-06-16. PMID:24086752. |
mononuclear phagocytes (mp, macrophages and microglia), the main targets of hiv-1 infection in the brain, play a pathogenic role in hiv-associated neurocognitive disorders (hand) through the production and release of various soluble neurotoxic factors including glutamate. |
2014-06-16 |
2023-08-12 |
human |
| Cláudia Caldeira, Ana F Oliveira, Carolina Cunha, Ana R Vaz, Ana S Falcão, Adelaide Fernandes, Dora Brite. Microglia change from a reactive to an age-like phenotype with the time in culture. Frontiers in cellular neuroscience. vol 8. 2014-06-11. PMID:24917789. |
in contrast, 16 div (aged) microglia evidenced ramified morphology and increased matrix metalloproteinase (mmp)-2 activation, as well as reduced mmp-9, glutamate release and nuclear factor kappa-b activation, in parallel with decreased expression of toll-like receptor (tlr)-2 and tlr-4, capacity to migrate and phagocytose. |
2014-06-11 |
2023-08-13 |
mouse |
| Claire J Williams, David T Dexte. Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. Journal of neurochemistry. vol 129. issue 1. 2014-05-15. PMID:24224472. |
group iii mglu receptor stimulation prevents excitotoxicity by inhibiting glutamate release from neurons and microglia and increasing glutamate uptake by astrocytes. |
2014-05-15 |
2023-08-12 |
Not clear |
| Claire J Williams, David T Dexte. Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. Journal of neurochemistry. vol 129. issue 1. 2014-05-15. PMID:24224472. |
externalization of phosphatidylserine stimulates phagocytosis of neurons by activated microglia, which contribute to damage through glutamate and pro-inflammatory factor release. |
2014-05-15 |
2023-08-12 |
Not clear |
| Claire J Williams, David T Dexte. Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. Journal of neurochemistry. vol 129. issue 1. 2014-05-15. PMID:24224472. |
activation of group iii mglu receptors by glutamate and/or mglu receptor ligands results in inhibition of glutamate release from presynaptic terminals and microglia, reducing excitotoxicity. |
2014-05-15 |
2023-08-12 |
Not clear |
| Claire J Williams, David T Dexte. Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. Journal of neurochemistry. vol 129. issue 1. 2014-05-15. PMID:24224472. |
astrocytic glutamate uptake is increased and microglia produce neurotrophic factors. |
2014-05-15 |
2023-08-12 |
Not clear |
| Madhuvika Murugan, Eng-Ang Ling, Charanjit Kau. Glutamate receptors in microglia. CNS & neurological disorders drug targets. vol 12. issue 6. 2014-05-08. PMID:24047523. |
glutamate receptors in microglia. |
2014-05-08 |
2023-08-12 |
Not clear |
| Ajit G Thomas, Cliona M O'Driscoll, Joseph Bressler, Walter Kaufmann, Camilo J Rojas, Barbara S Slushe. Small molecule glutaminase inhibitors block glutamate release from stimulated microglia. Biochemical and biophysical research communications. vol 443. issue 1. 2014-05-06. PMID:24269238. |
small molecule glutaminase inhibitors block glutamate release from stimulated microglia. |
2014-05-06 |
2023-08-12 |
Not clear |
| Ajit G Thomas, Cliona M O'Driscoll, Joseph Bressler, Walter Kaufmann, Camilo J Rojas, Barbara S Slushe. Small molecule glutaminase inhibitors block glutamate release from stimulated microglia. Biochemical and biophysical research communications. vol 443. issue 1. 2014-05-06. PMID:24269238. |
excess glutamate release from activated macrophages and microglia correlates with upregulated glutaminase suggesting a pathogenic role for glutaminase. |
2014-05-06 |
2023-08-12 |
Not clear |
| Arik Eisenkraft, Avshalom Falk, Arseny Finkelstei. The role of glutamate and the immune system in organophosphate-induced CNS damage. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23532600. |
moreover, it was demonstrated that immunomodulatory treatments, aimed at regulating the interaction between the resident immune cells of the brain (microglia) and the peripheral immune system, can support buffering of excessive levels of glutamate and restoration of the homeostasis. |
2014-03-03 |
2023-08-12 |
Not clear |
| Adam Aguirre, Carola J Maturana, Paloma A Harcha, Juan C Sáe. Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation. Mediators of inflammation. vol 2013. 2014-02-26. PMID:23935250. |
consequently, activated microglia and astrocytes release atp and glutamate, affecting myelinization, neuronal development, and survival. |
2014-02-26 |
2023-08-12 |
Not clear |
| Cliona M O'Driscoll, Walter E Kaufmann, Joseph P Bressle. MeCP2 deficiency enhances glutamate release through NF-κB signaling in myeloid derived cells. Journal of neuroimmunology. vol 265. issue 1-2. 2014-01-30. PMID:24268627. |
pam3csk and lipopolysaccharide stimulated glutamate release in neonatal mouse microglia cultures, which was attenuated by nf-κb inhibitors. |
2014-01-30 |
2023-08-12 |
mouse |
| T A Kato, Y Yamauchi, H Horikawa, A Monji, Y Mizoguchi, Y Seki, K Hayakawa, H Utsumi, S Kanb. Neurotransmitters, psychotropic drugs and microglia: clinical implications for psychiatry. Current medicinal chemistry. vol 20. issue 3. 2014-01-17. PMID:23157624. |
therefore, in this review, at first, we summarize recent findings of interaction between microglia and neurotransmitters such as dopamine, serotonin, norepinephrine, acetylcholine and glutamate. |
2014-01-17 |
2023-08-12 |
human |
| Chih-Ping Yang, Chen-Hwan Cherng, Ching-Tang Wu, Hui-Yi Huang, Pao-Luh Tao, Sing-Ong Lee, Chih-Shung Won. Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-α and tumor necrosis factor-α receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection. Anesthesia and analgesia. vol 117. issue 6. 2014-01-16. PMID:24257399. |
glutamate homeostasis and microglia activation play an important role in the development and maintenance of neuropathic pain. |
2014-01-16 |
2023-08-12 |
rat |
| Juan Xiong, Tammy Kielia. Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype. Journal of neurochemistry. vol 127. issue 2. 2013-12-02. PMID:23919525. |
cln3(Δex7/8) microglia displayed constitutive caspase-1 activity that when blocked led to increased glutamate release that coincided with hemichannel opening. |
2013-12-02 |
2023-08-12 |
mouse |
| Chun-Jung Chen, Yen-Chuan Ou, Cheng-Yi Chang, Hung-Chuan Pan, Su-Lan Liao, Shih-Yun Chen, Shue-Ling Raung, Ching-Yi La. Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal death. Glia. vol 60. issue 3. 2013-11-01. PMID:22144112. |
glutamate released by japanese encephalitis virus-infected microglia involves tnf-α signaling and contributes to neuronal death. |
2013-11-01 |
2023-08-12 |
Not clear |