| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pinar Mesci, Sakina Zaïdi, Christian S Lobsiger, Stéphanie Millecamps, Carole Escartin, Danielle Seilhean, Hideyo Sato, Michel Mallat, Séverine Boillé. System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Brain : a journal of neurology. vol 138. issue Pt 1. 2015-03-02. PMID:25384799. |
with excitotoxicity being a major mechanism proposed to cause motor neuron death in amyotrophic lateral sclerosis, our hypothesis was that excessive glutamate release by activated microglia through their system [formula: see text] (a cystine/glutamate antiporter with the specific subunit xct/slc7a11) could contribute to neurodegeneration. |
2015-03-02 |
2023-08-13 |
mouse |
| Pinar Mesci, Sakina Zaïdi, Christian S Lobsiger, Stéphanie Millecamps, Carole Escartin, Danielle Seilhean, Hideyo Sato, Michel Mallat, Séverine Boillé. System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Brain : a journal of neurology. vol 138. issue Pt 1. 2015-03-02. PMID:25384799. |
genetic deletion of xct in mice demonstrated that activated microglia released glutamate mainly through system [formula: see text]. |
2015-03-02 |
2023-08-13 |
mouse |
| A Y Lai, C D Dibal, G A Armitage, I R Winship, K G Tod. Distinct activation profiles in microglia of different ages: a systematic study in isolated embryonic to aged microglial cultures. Neuroscience. vol 254. 2015-02-23. PMID:24042036. |
microglial morphology, glutamate (glu) uptake, and release of trophic and inflammatory factors were assessed under basal conditions and in microglia activated with adenosine 5'-triphosphate (atp) or lipopolysaccharide. |
2015-02-23 |
2023-08-12 |
rat |
| Fengtian Xue, Bogdan A Stoica, Marie Hanscom, Shruti V Kabadi, Alan I Fade. Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) attenuate microglial activation. CNS & neurological disorders drug targets. vol 13. issue 4. 2015-02-23. PMID:24168364. |
recent studies show that neurodegeneration and neuroinflammation after traumatic brain injury can be inhibited as late as one month in animals by the activation of the metabotropic glutamate receptor 5 in microglia using (rs)-2-chloro-5- hydroxy-phenylglycine. |
2015-02-23 |
2023-08-12 |
Not clear |
| Zhen Zhao Luo, Yan Gao, Ning Sun, Yin Zhao, Jing Wang, Bo Tian, Jing Sh. Enhancing the interaction between annexin-1 and formyl peptide receptors regulates microglial activation to protect neurons from ischemia-like injury. Journal of neuroimmunology. vol 276. issue 1-2. 2015-02-02. PMID:25115219. |
we found that annexin-1 could polarize microglia to a beneficial phenotype and promote microglial migration to protect neurons from ischemia-like injury, and the annexin-1-mediated neuroprotective effect was dependent on the release of glutamate and atp from the injured neurons. |
2015-02-02 |
2023-08-13 |
Not clear |
| Philip G Nijland, Iliana Michailidou, Maarten E Witte, Mark R Mizee, Susanne M A van der Pol, Bert van Het Hof, Arie Reijerkerk, Luc Pellerin, Paul van der Valk, Helga E de Vries, Jack van Horsse. Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions. Glia. vol 62. issue 7. 2015-01-02. PMID:24692237. |
we show that in control brain tissue glut and mct proteins were abundantly expressed in a variety of central nervous system cells, particularly in microglia and endothelial cells. |
2015-01-02 |
2023-08-13 |
human |
| Tomoya Terashima, Hideto Kojima, Hiroshi Urabe, Isamu Yamakawa, Nobuhiro Ogawa, Hiromichi Kawai, Lawrence Chan, Hiroshi Maegaw. Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration. Journal of neuroscience research. vol 92. issue 7. 2015-01-02. PMID:24936617. |
moreover, after scf activation, but not flt3 activation or no activation, the migrating microglia expressed glutamate transporter-1 (glt-1). |
2015-01-02 |
2023-08-13 |
mouse |
| Aarti Nagayach, Nisha Patro, Ishan Patr. Experimentally induced diabetes causes glial activation, glutamate toxicity and cellular damage leading to changes in motor function. Frontiers in cellular neuroscience. vol 8. 2014-11-17. PMID:25400546. |
scenario of glial (astroglia and microglia) activation, cell death and glutamate transportation was gaged using immunohistochemistry, histological study and image analysis. |
2014-11-17 |
2023-08-13 |
rat |
| N Morioka, M Tokuhara, Y Nakamura, Y Idenoshita, S Harano, F F Zhang, K Hisaoka-Nakashima, Y Nakat. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor. Neuroscience. vol 258. 2014-09-29. PMID:24300109. |
microglia glutamate transporters, however, might serve as a back-up system when astrocytic glutamate uptake is impaired, and could have a prominent neuroprotective function under pathological conditions. |
2014-09-29 |
2023-08-12 |
rat |
| N Morioka, M Tokuhara, Y Nakamura, Y Idenoshita, S Harano, F F Zhang, K Hisaoka-Nakashima, Y Nakat. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor. Neuroscience. vol 258. 2014-09-29. PMID:24300109. |
in the current study, the effect of nicotine, well known as a neuroprotective molecule, on the function of glutamate transporters in cultured rat cortical microglia was examined. |
2014-09-29 |
2023-08-12 |
rat |
| N Morioka, M Tokuhara, Y Nakamura, Y Idenoshita, S Harano, F F Zhang, K Hisaoka-Nakashima, Y Nakat. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor. Neuroscience. vol 258. 2014-09-29. PMID:24300109. |
reverse transcription polymerase chain reaction and pharmacological approaches demonstrated that, glutamate/aspartate transporter (glast), not glutamate transporter 1 (glt-1), is the major functional glutamate transporter in cultured cortical microglia. |
2014-09-29 |
2023-08-12 |
rat |
| Hideyuki Takeuchi, Akio Suzumur. Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases. Frontiers in cellular neuroscience. vol 8. 2014-09-17. PMID:25228858. |
activated microglia secrete high levels of glutamate, which damages cns cells and has been implicated as a major cause of neurodegeneration in these conditions. |
2014-09-17 |
2023-08-13 |
Not clear |
| Hideyuki Takeuchi, Akio Suzumur. Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases. Frontiers in cellular neuroscience. vol 8. 2014-09-17. PMID:25228858. |
glutamate-receptor blockers and microglia inhibitors (e.g., minocycline) have been examined as therapeutic candidates for several neurodegenerative diseases; however, these compounds exerted little therapeutic benefit because they either perturbed physiological glutamate signals or suppressed the actions of protective microglia. |
2014-09-17 |
2023-08-13 |
Not clear |
| Hideyuki Takeuchi, Akio Suzumur. Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases. Frontiers in cellular neuroscience. vol 8. 2014-09-17. PMID:25228858. |
we recently found that abnormally activated microglia secrete glutamate via gap-junction hemichannels on the cell surface. |
2014-09-17 |
2023-08-13 |
Not clear |
| Olga Ciccarelli, Frederik Barkhof, Benedetta Bodini, Nicola De Stefano, Xavier Golay, Klaas Nicolay, Daniel Pelletier, Petra J W Pouwels, Seth A Smith, Claudia A M Wheeler-Kingshott, Bruno Stankoff, Tarek Yousry, David H Mille. Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging. The Lancet. Neurology. vol 13. issue 8. 2014-09-15. PMID:25008549. |
many insights have been gained from such imaging studies: persisting inflammation in the absence of a damaged blood-brain barrier, activated microglia within and beyond lesions, increased mitochondrial activity after acute lesions, raised sodium concentrations in the brain, increased glutamate in acute lesions and normal-appearing white matter, different degrees of demyelination in different patients and lesions, early neuronal damage in grey matter, and early astrocytic proliferation and activation in lesions and white matter. |
2014-09-15 |
2023-08-13 |
Not clear |
| Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barge. Metabotropic glutamate receptors inhibit microglial glutamate release. ASN neuro. vol 4. issue 5. 2014-09-02. PMID:22770428. |
pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. |
2014-09-02 |
2023-08-12 |
rat |
| Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barge. Metabotropic glutamate receptors inhibit microglial glutamate release. ASN neuro. vol 4. issue 5. 2014-09-02. PMID:22770428. |
since microglia also express various glutamate receptors themselves, we were interested in the potential feedback of glutamate on this system. |
2014-09-02 |
2023-08-12 |
rat |
| Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barge. Metabotropic glutamate receptors inhibit microglial glutamate release. ASN neuro. vol 4. issue 5. 2014-09-02. PMID:22770428. |
several agonists of mglurs (metabotropic glutamate receptors) were applied to primary rat microglia, and the export of glutamate into their culture medium was evoked by lps (lipopolysaccharide). |
2014-09-02 |
2023-08-12 |
rat |
| Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barge. Metabotropic glutamate receptors inhibit microglial glutamate release. ASN neuro. vol 4. issue 5. 2014-09-02. PMID:22770428. |
these data indicate that mglur activation attenuates a potentially neurotoxic export of glutamate from activated microglia and implicate camp as a contributor to this aspect of microglial action. |
2014-09-02 |
2023-08-12 |
rat |
| Munehisa Shimamura, Hironori Nakagami, Mariana K Osako, Hitomi Kurinami, Hiroshi Koriyama, Pang Zhengda, Hideki Tomioka, Akiko Tenma, Kouji Wakayama, Ryuichi Morishit. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 22. 2014-08-20. PMID:24847069. |
although enhanced rankl/rank signaling had no effects in glutamate, cocl2, or h2o2-stimulated neuronal culture, enhanced rankl/rank signaling showed neuroprotective effects with reduced expression in inflammatory cytokines in lps-stimulated neuron-glia mixed culture, suggesting that rankl/rank signaling can attenuate inflammation through a toll-like receptor signaling pathway in microglia. |
2014-08-20 |
2023-08-13 |
mouse |