| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Issam El Ghazi, Wen S Sheng, Shuxian Hu, Brian G Reilly, James R Lokensgard, R Bryan Rock, Phillip K Peterson, George L Wilcox, Ian M Armitag. Changes in the NMR metabolic profile of human microglial cells exposed to lipopolysaccharide or morphine. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 5. issue 4. 2011-02-28. PMID:20333557. |
we found that human microglia exposed to lps had increased concentrations of glutamate and lactate, whereas the cells exposed to morphine had decreased concentrations in creatinine, taurine, and thymine. |
2011-02-28 |
2023-08-12 |
human |
| Max R Bennett, Les Farnell, William G Gibso. P2X7 regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes. Journal of theoretical biology. vol 261. issue 1. 2011-02-24. PMID:19643112. |
p2x7 regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes. |
2011-02-24 |
2023-08-12 |
Not clear |
| Mariko Noda, Yukiko Doi, Jianfeng Liang, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumur. Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression. The Journal of biological chemistry. vol 286. issue 3. 2011-02-24. PMID:21071446. |
in addition, sfkn induces the expression of the antioxidant enzyme heme oxygenase-1 (ho-1) in microglia in the absence of neurotoxic molecule production, including no, tnf, and glutamate. |
2011-02-24 |
2023-08-12 |
Not clear |
| Sunita Gupta, Alecia G Knight, Shruti Gupta, Pamela E Knapp, Kurt F Hauser, Jeffrey N Keller, Annadora J Bruce-Kelle. HIV-Tat elicits microglial glutamate release: role of NAPDH oxidase and the cystine-glutamate antiporter. Neuroscience letters. vol 485. issue 3. 2011-01-28. PMID:20849923. |
data show that application of tat to cultured primary microglia caused dose-dependent increases in extracellular glutamate that were exacerbated by morphine, which is known to worsen tat cytotoxicity. |
2011-01-28 |
2023-08-12 |
Not clear |
| Gregory T Carter, Mary E Abood, Sunil K Aggarwal, Michael D Weis. Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials. The American journal of hospice & palliative care. vol 27. issue 5. 2010-11-24. PMID:20439484. |
ideally, a multidrug regimen, including glutamate antagonists, antioxidants, a centrally acting anti-inflammatory agent, microglial cell modulators (including tumor necrosis factor alpha [tnf-alpha] inhibitors), an antiapoptotic agent, 1 or more neurotrophic growth factors, and a mitochondrial function-enhancing agent would be required to comprehensively address the known pathophysiology of als. |
2010-11-24 |
2023-08-12 |
mouse |
| María-Angeles Arevalo, María Santos-Galindo, María-José Bellini, Iñigo Azcoitia, Luis M Garcia-Segur. Actions of estrogens on glial cells: Implications for neuroprotection. Biochimica et biophysica acta. vol 1800. issue 10. 2010-11-03. PMID:19818384. |
acting on oligodendrocytes, astrocytes and microglia, estrogens regulate remyelination, edema formation, extracellular glutamate levels and the inflammatory response after brain injury. |
2010-11-03 |
2023-08-12 |
Not clear |
| Holly M Brothers, Yannick Marchalant, Gary L Wen. Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neuroscience letters. vol 480. issue 2. 2010-10-19. PMID:20541589. |
chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells. |
2010-10-19 |
2023-08-12 |
rat |
| Robert D Lovchik, Fabio Bianco, Noemi Tonna, Ana Ruiz, Michela Matteoli, Emmanuel Delamarch. Overflow microfluidic networks for open and closed cell cultures on chip. Analytical chemistry. vol 82. issue 9. 2010-08-18. PMID:20392062. |
here, we use a two-chamber omfn to show the activation of purinergic receptors in microglia grown in one chamber, upon release of adenosine triphosphate (atp) from astrocytes that are grown in another chamber and challenged with glutamate. |
2010-08-18 |
2023-08-12 |
Not clear |
| Sébastien Tilleux, Emmanuel Herman. Down-regulation of astrocytic GLAST by microglia-related inflammation is abrogated in dibutyryl cAMP-differentiated cultures. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18298666. |
the influence of neuroinflammation on glutamate uptake by glial cells was examined after exposing primary cultures of rat astrocytes to conditioned culture medium from lipopolysaccharide-activated microglia. |
2010-08-13 |
2023-08-12 |
rat |
| Sébastien Tilleux, Emmanuel Herman. Down-regulation of astrocytic GLAST by microglia-related inflammation is abrogated in dibutyryl cAMP-differentiated cultures. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18298666. |
while such treatment triggered an inflammatory response in astrocytes, as revealed by the induction of cytokine expression, a significant decrease in glast expression and activity was observed after 72 h. this regulation of glutamate transporter was not observed with medium from naive microglia, but was mimicked by direct addition of tumor necrosis factor-alpha (tnf-alpha), a major cytokine released from activated microglia. |
2010-08-13 |
2023-08-12 |
rat |
| Sébastien Tilleux, Emmanuel Herman. Down-regulation of astrocytic GLAST by microglia-related inflammation is abrogated in dibutyryl cAMP-differentiated cultures. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18298666. |
in this model, the conditioned culture medium from activated microglia, as well as tnf-alpha, were found to increase glutamate uptake capacity. |
2010-08-13 |
2023-08-12 |
rat |
| Claire E Hulsebosc. Gliopathy ensures persistent inflammation and chronic pain after spinal cord injury. Experimental neurology. vol 214. issue 1. 2010-07-21. PMID:18708053. |
the term "gliopathy" is proposed to describe the dysfunctional and maladaptive response of glial cells, specifically astrocytes and microglia, to neural injury that is initiated by the sudden injury induced increase in extracellular concentrations of glutamate and concomitant production of several proinflammatory molecules. |
2010-07-21 |
2023-08-12 |
rat |
| Hideyuki Takeuchi, Shijie Jin, Hiromi Suzuki, Yukiko Doi, Jianfeng Liang, Jun Kawanokuchi, Tetsuya Mizuno, Makoto Sawada, Akio Suzumur. Blockade of microglial glutamate release protects against ischemic brain injury. Experimental neurology. vol 214. issue 1. 2010-07-21. PMID:18775425. |
glutamate released by activated microglia induces excito-neurotoxicity and may contribute to neurodegeneration in numerous neurological diseases including ischemia, inflammation, epilepsy, and neurodegenerative diseases. |
2010-07-21 |
2023-08-12 |
Not clear |
| Hideyuki Takeuchi, Shijie Jin, Hiromi Suzuki, Yukiko Doi, Jianfeng Liang, Jun Kawanokuchi, Tetsuya Mizuno, Makoto Sawada, Akio Suzumur. Blockade of microglial glutamate release protects against ischemic brain injury. Experimental neurology. vol 214. issue 1. 2010-07-21. PMID:18775425. |
we observed that the gap junction blocker carbenoxolone (cbx) or the glutaminase inhibitor 6-diazo-5-oxo-l-norleucine (don) decreased glutamate release from activated microglia and rescued neuronal death in a dose-dependent manner in vitro. |
2010-07-21 |
2023-08-12 |
Not clear |
| Deanna L Taylor, Grisha Pirianov, Samantha Holland, Colm J McGinnity, Adele L Norman, Camilla Reali, Lara T Diemel, Djordje Gveric, Davy Yeung, Huseyin Mehme. Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia. Journal of neuroscience research. vol 88. issue 8. 2010-07-12. PMID:20091773. |
the microglial-induced inhibition of opc proliferation was reversed by stimulating group iii metabotropic glutamate receptors in microglia with the agonist l-ap4. |
2010-07-12 |
2023-08-12 |
rat |
| Jianfeng Liang, Hideyuki Takeuchi, Shijie Jin, Mariko Noda, Hua Li, Yukiko Doi, Jun Kawanokuchi, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway. Brain research. vol 1322. 2010-06-15. PMID:20138844. |
glutamate induces neurotrophic factor production from microglia via protein kinase c pathway. |
2010-06-15 |
2023-08-12 |
Not clear |
| Jianfeng Liang, Hideyuki Takeuchi, Shijie Jin, Mariko Noda, Hua Li, Yukiko Doi, Jun Kawanokuchi, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway. Brain research. vol 1322. 2010-06-15. PMID:20138844. |
microglia have been shown to attack damaged neurons by secreting a variety of neurotoxic factors including inflammatory cytokines, reactive oxygen species and glutamate. |
2010-06-15 |
2023-08-12 |
Not clear |
| Neville N Osborn. Mitochondria: Their role in ganglion cell death and survival in primary open angle glaucoma. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20359479. |
other insults to the ganglion cells might come from substances such as glutamate, prostaglandins and nitric oxide released from astrocytes and microglia in the optic nerve head region. |
2010-05-27 |
2023-08-12 |
Not clear |
| Izumi Maezawa, Lee-Way Ji. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392956. |
rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. |
2010-05-14 |
2023-08-12 |
Not clear |
| Izumi Maezawa, Lee-Way Ji. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392956. |
hippocampal neurons treated with cm from mecp2-null microglia showed an abnormal stunted and beaded dendritic morphology, and signs of microtubule disruption and damage of postsynaptic glutamatergic components within 24 h. we identified that the toxic factor in the cm is glutamate, because (1) mecp2-null microglia released a fivefold higher level of glutamate, (2) blockage of microglial glutamate synthesis by a glutaminase inhibitor abolished the neurotoxic activity, (3) blockage of microglial glutamate release by gap junction hemichannel blockers abolished the neurotoxic activity, and (4) glutamate receptor antagonists blocked the neurotoxicity of the mecp2-null microglia cm. |
2010-05-14 |
2023-08-12 |
Not clear |