| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo Jun Liu, Rajini Nagarajah, Richard B Banati, Max R Bennet. Glutamate induces directed chemotaxis of microglia. The European journal of neuroscience. vol 29. issue 6. 2009-06-09. PMID:19302147. |
this chemotaxis is meditated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (ampa) and metabotropic glutamate receptors on the microglia. |
2009-06-09 |
2023-08-12 |
Not clear |
| Nathan Erdmann, Changhai Tian, Yunlong Huang, Jianxing Zhao, Shelley Herek, Norman Curthoys, Jialin Zhen. In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage. Journal of neurochemistry. vol 109. issue 2. 2009-04-24. PMID:19222703. |
mononuclear phagocyte (mp, macrophages and microglia) dysfunction plays a significant role in the pathogenesis of hiv-1-associated dementia (had) through the production and release of soluble neurotoxic factors including glutamate. |
2009-04-24 |
2023-08-12 |
human |
| Simona Eleuteri, Elisabetta Polazzi, Antonio Contestabil. Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18950681. |
neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells. |
2009-04-16 |
2023-08-12 |
rat |
| Simona Eleuteri, Elisabetta Polazzi, Antonio Contestabil. Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18950681. |
we have tested the efficacy of media directly conditioned by microglia or conditioned by microglia after having been exposed to apoptotic neurons, towards neuroprotection of rat cerebellar granule cells (cgcs) challenged with staurosporine or glutamate. |
2009-04-16 |
2023-08-12 |
rat |
| Simona Eleuteri, Elisabetta Polazzi, Antonio Contestabil. Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18950681. |
apoptotic death of cgc caused by staurosporine, as well as by a mild excitotoxic stimulus delivered through sub-chronic glutamate treatment, was significantly counteracted by microglia conditioned media. |
2009-04-16 |
2023-08-12 |
rat |
| Simona Eleuteri, Elisabetta Polazzi, Antonio Contestabil. Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18950681. |
on the other hand, an acute excitotoxic insult delivered through a short pulse of glutamate exposure in the absence of magnesium and resulting in a mix of apoptotic and necrotic death was only marginally counteracted by microglia conditioned media. |
2009-04-16 |
2023-08-12 |
rat |
| Hui Qin Xing, Hitoshi Hayakawa, Ellen Gelpi, Ryuji Kubota, Herbert Budka, Shuji Izum. Reduced expression of excitatory amino acid transporter 2 and diffuse microglial activation in the cerebral cortex in AIDS cases with or without HIV encephalitis. Journal of neuropathology and experimental neurology. vol 68. issue 2. 2009-04-09. PMID:19151621. |
the expression of eaat-2 by activated microglia suggests that they might exert a compensatory effect that protects neurons from glutamate neurotoxicity. |
2009-04-09 |
2023-08-12 |
human |
| Akio Suzumur. [Therapeutic strategy against multiple sclerosis]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 11. 2009-04-08. PMID:19198124. |
another important strategy against ms is to suppress axonal degeneration which reportedly occurs from an early stage of ms. we have found that the most toxic agent from activated macrophages and microglia is glutamate that was produced by glutaminase and released through gap-junction. |
2009-04-08 |
2023-08-12 |
Not clear |
| Simona D'Antoni, Antonio Berretta, Carmela Maria Bonaccorso, Valeria Bruno, Eleonora Aronica, Ferdinando Nicoletti, Maria Vincenza Catani. Metabotropic glutamate receptors in glial cells. Neurochemical research. vol 33. issue 12. 2009-02-19. PMID:18438710. |
in addition to being expressed in neurons, glutamate receptors are expressed in different types of glial cells including astrocytes, oligodendrocytes, and microglia. |
2009-02-19 |
2023-08-12 |
Not clear |
| Russell L Blayloc. A possible central mechanism in autism spectrum disorders, part 1. Alternative therapies in health and medicine. vol 14. issue 6. 2009-01-02. PMID:19043938. |
it is also known that one phenotypic form of microglia activation can result in an outpouring of neurotoxic levels of the excitotoxins, glutamate and quinolinic acid. |
2009-01-02 |
2023-08-12 |
Not clear |
| Anna De Simoni, Nicola J Allen, David Attwel. Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current. The European journal of neuroscience. vol 28. issue 6. 2008-12-15. PMID:18783372. |
this implies that the membrane properties of microglia in their normal cellular environment differ from those of cultured microglia (similarly, microglia generated a current in response to atp but, unlike in culture, not to glutamate or gaba). |
2008-12-15 |
2023-08-12 |
rat |
| Timothy J Harrigan, Iskandar F Abdullaev, David Jourd'heuil, Alexander A Mongi. Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18624925. |
stimulation of microglia with zymosan triggered production of endogenous ros and strongly enhanced glutamate release via vrac in swollen cells. |
2008-11-07 |
2023-08-12 |
rat |
| Jia-Yong Wu, Feng-nan Niu, Rong Huang, Yun X. Enhancement of glutamate uptake in 1-methyl-4-phenylpyridinium-treated astrocytes by trichostatin A. Neuroreport. vol 19. issue 12. 2008-09-16. PMID:18628666. |
enhancement of glutamate uptake in 1-methyl-4-phenylpyridinium-treated astrocytes by trichostatin a. histone deacetylases (hdac) inhibitors have been emerging as neuroprotective agents by acting on neurons and microglia. |
2008-09-16 |
2023-08-12 |
Not clear |
| Jianfeng Liang, Hideyuki Takeuchi, Yukiko Doi, Jun Kawanokuchi, Yoshifumi Sonobe, Shijie Jin, Izumi Yawata, Hua Li, Satoko Yasuoka, Tetsuya Mizuno, Akio Suzumur. Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity. Brain research. vol 1210. 2008-08-26. PMID:18410911. |
astrocytes prevented excito-neurotoxicity by the reduction of exogenous glutamate whereas microglia did not. |
2008-08-26 |
2023-08-12 |
Not clear |
| Jianfeng Liang, Hideyuki Takeuchi, Yukiko Doi, Jun Kawanokuchi, Yoshifumi Sonobe, Shijie Jin, Izumi Yawata, Hua Li, Satoko Yasuoka, Tetsuya Mizuno, Akio Suzumur. Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity. Brain research. vol 1210. 2008-08-26. PMID:18410911. |
conversely, activated microglia released an excess of glutamate that induced excitotoxic neuronal death. |
2008-08-26 |
2023-08-12 |
Not clear |
| Kazuyuki Nakajima, Shinichi Yamamoto, Shinichi Kohsaka, Tadashi Kurihar. Neuronal stimulation leading to upregulation of glutamate transporter-1 (GLT-1) in rat microglia in vitro. Neuroscience letters. vol 436. issue 3. 2008-08-25. PMID:18406522. |
neuronal stimulation leading to upregulation of glutamate transporter-1 (glt-1) in rat microglia in vitro. |
2008-08-25 |
2023-08-12 |
rat |
| Kazuyuki Nakajima, Shinichi Yamamoto, Shinichi Kohsaka, Tadashi Kurihar. Neuronal stimulation leading to upregulation of glutamate transporter-1 (GLT-1) in rat microglia in vitro. Neuroscience letters. vol 436. issue 3. 2008-08-25. PMID:18406522. |
as previously reported, activated microglia facilitate the expression of a glial cell-type glutamate transporter, glutamate transporter-1 (glt-1; eaat2), around injured motoneurons in axotomized rat facial nucleus. |
2008-08-25 |
2023-08-12 |
rat |
| Kazuyuki Nakajima, Shinichi Yamamoto, Shinichi Kohsaka, Tadashi Kurihar. Neuronal stimulation leading to upregulation of glutamate transporter-1 (GLT-1) in rat microglia in vitro. Neuroscience letters. vol 436. issue 3. 2008-08-25. PMID:18406522. |
in the present study, we investigated the effects of neuronal stimulus on the uptake of glutamate (glu) by microglia and on the expression of glt-1 protein in microglia in vitro. |
2008-08-25 |
2023-08-12 |
rat |
| Kazuyuki Nakajima, Shinichi Yamamoto, Shinichi Kohsaka, Tadashi Kurihar. Neuronal stimulation leading to upregulation of glutamate transporter-1 (GLT-1) in rat microglia in vitro. Neuroscience letters. vol 436. issue 3. 2008-08-25. PMID:18406522. |
furthermore, immunoblotting analysis revealed that the amounts of glt-1, but not another glial cell-type glutamate transporter glutamate-aspartate transporter (glast: eaat1), increased significantly in microglia by treatment with ncm. |
2008-08-25 |
2023-08-12 |
rat |
| Fleur Pinteaux-Jones, Ioanna G Sevastou, Victoria A H Fry, Simon Heales, David Baker, Jennifer M Pococ. Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors. Journal of neurochemistry. vol 106. issue 1. 2008-08-19. PMID:18419765. |
incubation of primary cultured rat microglia with rat-brain derived myelin (0.1-1 microg/ml) for 24 h induced microglial activation; cells displayed enhanced ed1 staining, expression of inducible nitric oxide synthase, production and release of the cytokine tumour necrosis factor-alpha and glutamate release. |
2008-08-19 |
2023-08-12 |
rat |