| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Tsuda, Kohei Koga, Tao Chen, Min Zhu. Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex. Journal of neurochemistry. vol 141. issue 4. 2017-08-07. PMID:28251660. |
nerve injury-induced pain hypersensitivity involves aberrant excitability in spinal dorsal horn (sdh) neurons as a consequence of dysfunction of inhibitory interneurons and of hyperactivity of glial cells, especially microglia, the immune cells of the central nervous system. |
2017-08-07 |
2023-08-13 |
Not clear |
| Yong Liu, Li-Jun Zhou, Jun Wang, Dai Li, Wen-Jie Ren, Jiyun Peng, Xiao Wei, Ting Xu, Wen-Jun Xin, Rui-Ping Pang, Yong-Yong Li, Zhi-Hai Qin, Madhuvika Murugan, Mark P Mattson, Long-Jun Wu, Xian-Guo Li. TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123022. |
furthermore, sni activated microglia in both spinal dorsal horn and hippocampus; pharmacological inhibition or genetic ablation of microglia prevented the region-dependent synaptic changes, neuropathic pain, and memory deficits induced by sni. |
2017-08-01 |
2023-08-13 |
mouse |
| Masaaki Kobayashi, Hiroyuki Konishi, Akira Sayo, Toshiyuki Takai, Hiroshi Kiyam. TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 43. 2017-07-14. PMID:27798193. |
the present study showed that the dnax-activating protein of 12 kda (dap12) and its associated "triggering receptor expressed on myeloid cells 2" (trem2) were predominantly expressed by microglia in the dorsal horn after spinal nerve injury, revealing a role for trem2/dap12 signaling in neuropathic pain. |
2017-07-14 |
2023-08-13 |
mouse |
| Mohammed Shaqura, Xiongjuan Li, Mahmoud Al-Khrasani, Mehdi Shakibaei, Sascha Tafelski, Susanna Fürst, Antje Beyer, Mitsuhiro Kawata, Michael Schäfer, Shaaban A Mous. Membrane-bound glucocorticoid receptors on distinct nociceptive neurons as potential targets for pain control through rapid non-genomic effects. Neuropharmacology. vol 111. 2017-07-11. PMID:27558347. |
within the spinal cord, gr predominantly localized in incoming presynaptic nociceptive neurons, in pre- and postsynaptic structures of the dorsal horn, as well as in microglia. |
2017-07-11 |
2023-08-13 |
Not clear |
| Sheu-Ran Choi, Dae-Hyun Roh, Seo-Yeon Yoon, Soon-Gu Kwon, Hoon-Seong Choi, Ho-Jae Han, Alvin J Beitz, Jang-Hern Le. Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice. Neuropharmacology. vol 111. 2017-07-11. PMID:27567941. |
sig-1rs were also increased in lumbar dorsal horn astrocytes, but not neurons or microglia. |
2017-07-11 |
2023-08-13 |
mouse |
| Li-Na Yu, Li-Hong Sun, Min Wang, Min Ya. Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain. Journal of Zhejiang University. Science. B. vol 17. issue 10. 2017-06-09. PMID:27704743. |
erk5 activation in the spinal dorsal horn occurs mainly in microglia. |
2017-06-09 |
2023-08-13 |
Not clear |
| Xiao-Qian Li, Zai-Li Zhang, Wen-Fei Tan, Xi-Jia Sun, Hong M. Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord. PloS one. vol 11. issue 10. 2017-06-06. PMID:27760212. |
double immunostaining further suggested that tlr4, which is mainly expressed on astrocytes and microglia, was closely co-localized with cxcl12 and cxcr4 in spinal dorsal horn. |
2017-06-06 |
2023-08-13 |
rat |
| Ryuji Terayama, Yuya Yamamoto, Noriko Kishimoto, Mitsuyasu Tabata, Kotaro Maruhama, Seiji Iida, Tomosada Sugimot. Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats. Neurochemical research. vol 41. issue 11. 2017-04-05. PMID:27418277. |
immunofluorescence labeling of ox-42 and gfap indicated sequential activation of microglia and astrocytes in the spinal dorsal horn. |
2017-04-05 |
2023-08-13 |
rat |
| Masayuki Miyagi, Tetsuhiro Ishikawa, Hiroto Kamoda, Miyako Suzuki, Gen Inoue, Yoshihiro Sakuma, Yasuhiro Oikawa, Kentaro Uchida, Takane Suzuki, Kazuhisa Takahashi, Masashi Takaso, Seiji Ohtor. The efficacy of nerve growth factor antibody in a mouse model of neuropathic cancer pain. Experimental animals. vol 65. issue 4. 2017-03-02. PMID:27194075. |
cgrp and atf-3-immunoreactivity in drgs and microglia expression in the spinal dorsal horn were upregulated in the saline group compared with the sham group, and they were suppressed in the anti-ngf group compared with the saline group (p<0.05). |
2017-03-02 |
2023-08-13 |
mouse |
| Peter M Grace, Keith A Strand, Erika L Galer, Daniel J Urban, Xiaohui Wang, Michael V Baratta, Timothy J Fabisiak, Nathan D Anderson, Kejun Cheng, Lisa I Greene, Debra Berkelhammer, Yingning Zhang, Amanda L Ellis, Hang Hubert Yin, Serge Campeau, Kenner C Rice, Bryan L Roth, Steven F Maier, Linda R Watkin. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 24. 2017-01-26. PMID:27247388. |
as spinal dorsal horn microglia expressed this signaling platform, these cells were selectively inhibited in vivo after transfection with a novel designer receptor exclusively activated by designer drugs (dreadd). |
2017-01-26 |
2023-08-13 |
rat |
| Liying Bai, Xinru Wang, Zhisong Li, Cunlong Kong, Yonghui Zhao, Jun-Liang Qian, Quancheng Kan, Wei Zhang, Ji-Tian X. Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats. Neuroscience bulletin. vol 32. issue 1. 2016-11-03. PMID:26781879. |
sni also induced long-lasting upregulation of cxcl12 and cxcr4 in the ipsilateral l4-5 spinal cord dorsal horn, characterized by cxcl12 expression in neurons and microglia, and cxcr4 expression in neurons and astrocytes. |
2016-11-03 |
2023-08-13 |
rat |
| Josiane C S Mapplebeck, Simon Beggs, Michael W Salte. Sex differences in pain: a tale of two immune cells. Pain. vol 157 Suppl 1. 2016-10-17. PMID:26785152. |
despite similar microglia proliferation in the dorsal horn in both sexes, females do not upregulate p2x4rs and use a microglia-independent pathway to mediate pain hypersensitivity. |
2016-10-17 |
2023-08-13 |
mouse |
| Hee Kyung Cho, Sang Ho Ahn, So-Yeon Kim, Mi-Jung Choi, Se Jin Hwang, Yun Woo Ch. Changes in the Expressions of Iba1 and Calcitonin Gene-Related Peptide in Adjacent Lumbar Spinal Segments after Lumbar Disc Herniation in a Rat Model. Journal of Korean medical science. vol 30. issue 12. 2016-10-06. PMID:26713069. |
it was found immunoreactivity for iba1-positive microglia was higher in the l5 (p=0.004) dorsal horn and in the ipsilateral l4 (p=0.009), l6 (p=0.002), and s1 (p=0.002) dorsal horns in the np-exposed group than in the sham-operated group. |
2016-10-06 |
2023-08-13 |
rat |
| J Jung, N Uesugi, N Y Jeong, B S Park, H Konishi, H Kiyam. Increase of transcription factor EB (TFEB) and lysosomes in rat DRG neurons and their transportation to the central nerve terminal in dorsal horn after nerve injury. Neuroscience. vol 313. 2016-09-30. PMID:26601776. |
in the spinal dorsal horn (dh), nerve injury activates microglia and induces neuropathic pain. |
2016-09-30 |
2023-08-13 |
rat |
| Yi Liang, Yujie Qiu, Junying Du, Jin Liu, Junfan Fang, Ji Zhu, Jianqiao Fan. Inhibition of spinal microglia and astrocytes contributes to the anti-allodynic effect of electroacupuncture in neuropathic pain induced by spinal nerve ligation. Acupuncture in medicine : journal of the British Medical Acupuncture Society. vol 34. issue 1. 2016-09-23. PMID:26177687. |
besides neurons, activated microglia and astrocytes in the spinal cord dorsal horn (scdh) contribute to the pathogenesis of chronic pain. |
2016-09-23 |
2023-08-13 |
Not clear |
| Hui Fan, Teng-Fei Li, Nian Gong, Yong-Xiang Wan. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression. Neuropharmacology. vol 101. 2016-09-22. PMID:26363192. |
in the spinal dorsal horn and primary microglia, sm significantly evoked β-endorphin expression, which was completely prevented by the microglial inhibitor minocycline and p38 mitogen-activated protein kinase (mapk) inhibitor sb203580. |
2016-09-22 |
2023-08-13 |
rat |
| Young Chan Jeong, Ji Seon Son, Young Bae Kwo. The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26434709. |
zymosan also led to increased cd11b immunoreactivity (a marker of microglia) accompanied by 'phosphorylated p38 mitogen activated protein kinase' (p-p38mapk) and interleukin-1βimmunoreactivity in the spinal dorsal horn. |
2016-08-29 |
2023-08-13 |
rat |
| Sasan Gazerani, Jalal Zaringhalam, Homa Manaheji, Sahar Golab. The Role of C Fibers in Spinal Microglia Induction and Possible Relation with TRPV3 Expression During Chronic Inflammatory Arthritis in Rats. Basic and clinical neuroscience. vol 7. issue 3. 2016-08-26. PMID:27563416. |
stimulation of peptidergic fibers activates microglia in the dorsal horn. |
2016-08-26 |
2023-08-13 |
rat |
| Dongmei Wang, Yaping Xue, Yajuan Chen, Liqin Ruan, Yanguo Hon. Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats. Neuroscience letters. vol 618. 2016-08-22. PMID:26952974. |
bam8-22 (10 nmol) inhibited snl-induced microglia activation in the spinal dorsal horn on day 2 post-snl. |
2016-08-22 |
2023-08-13 |
rat |
| Dongmei Wang, Yaping Xue, Yajuan Chen, Liqin Ruan, Yanguo Hon. Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats. Neuroscience letters. vol 618. 2016-08-22. PMID:26952974. |
these results suggest that the activation of mrgc receptors can relieve pain hypersensitivity by the inhibition of nnos increase in drg neurons and microglia activation in the spinal dorsal horn in the early time following peripheral nerve injury. |
2016-08-22 |
2023-08-13 |
rat |