| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jastrow Canlas, Phillip Holt, Alexander Carroll, Shane Rix, Paul Ryan, Lorena Davies, Dusan Matusica, Stuart M Pitson, Claire F Jessup, Ian L Gibbins, Rainer V Haberberge. Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in molecular neuroscience. vol 8. 2015-08-18. PMID:26283908. |
similarly, sphk2(-/-) mice showed in contrast to wild-type no cpi-dependent increase in areas of the dorsal horn immunoreactive for the microglia marker iba-1 and the astrocyte marker glial fibrillary acidic protein (gfap). |
2015-08-18 |
2023-08-13 |
mouse |
| Nemat Khan, Richard Gordon, Trent M Woodruff, Maree T Smit. Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord. Pharmacology research & perspectives. vol 3. issue 3. 2015-07-14. PMID:26171221. |
fully developed mechanical allodynia in the bilateral hindpaws of vehicle-treated rr-eae mice was accompanied by marked cd3(+) t-cell infiltration, microglia activation, and increased brain-derived neurotrophic factor (bdnf)-tyrosine kinase b (trkb) signaling in the dorsal horn of the lumbar spinal cord. |
2015-07-14 |
2023-08-13 |
mouse |
| Young Chan Jeong, Kihyun Pyun, Young Bae Kwo. Inhibition of mitogen-activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model. Biological & pharmaceutical bulletin. vol 37. issue 10. 2015-06-22. PMID:25099229. |
pregabalin dramatically inhibited zymosan-induced fos expression (a marker for neuronal activation) and microglia activation (using markers cd11b and ed1) in the spinal dorsal horn. |
2015-06-22 |
2023-08-13 |
Not clear |
| Young Chan Jeong, Kihyun Pyun, Young Bae Kwo. Inhibition of mitogen-activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model. Biological & pharmaceutical bulletin. vol 37. issue 10. 2015-06-22. PMID:25099229. |
moreover, zymosan significantly increased phosphorylation of extracellular signal-regulated protein kinase (erk) 1/2 (double labeling with neuron), erk5 (double labelling with neuron and microglia) and p38 mapk (double labeling with microglia) in the spinal dorsal horn, which overall elevations were reversed by pregabalin. |
2015-06-22 |
2023-08-13 |
Not clear |
| Xiao-Hong Jin, Li-Na Wang, Jian-Ling Zuo, Jian-Ping Yang, Si-Lan Li. P2X4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:24984884. |
although p2x4r is also localized within spinal microglia in the dorsal horn, little is known about its role in cancer-induced bone pain (cibp), which is in some ways unique. |
2015-06-19 |
2023-08-13 |
rat |
| Anna K Clark, Doris Gruber-Schoffnegger, Ruth Drdla-Schutting, Katharina J Gerhold, Marzia Malcangio, Jürgen Sandkühle. Selective activation of microglia facilitates synaptic strength. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 11. 2015-06-15. PMID:25788673. |
the present data thus suggest that, under chronic pain states, cx3cr1-mediated activation of microglia drives the facilitation of excitatory synaptic transmission in the dorsal horn, which contributes to pain hypersensitivity in chronic pain states. |
2015-06-15 |
2023-08-13 |
rat |
| Shigeru Ebisawa, Tsugunobu Andoh, Yutaka Shimada, Yasushi Kuraish. Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-04-13. PMID:25866544. |
il-6 immunoreactivity was detected in microglia and astrocytes in the spinal dorsal horn. |
2015-04-13 |
2023-08-13 |
mouse |
| Masaya Yasui, Takashi Yoshimura, So Takeuchi, Kyohei Tokizane, Makoto Tsuda, Kazuhide Inoue, Hiroshi Kiyam. A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation. Glia. vol 62. issue 9. 2015-03-13. PMID:24852223. |
quantification analysis revealed a higher accumulation of microglia in the medial part of layers i-iv of the dorsal horn. |
2015-03-13 |
2023-08-13 |
rat |
| Ming Liu, Kaijun Liao, Changxi Yu, Xuejun Li, Suhuan Liu, Shuyu Yan. Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. Mediators of inflammation. vol 2014. 2015-02-12. PMID:25089076. |
meanwhile, in both models puerarin inhibited the activation of microglia and astroglia in the spinal dorsal horn. |
2015-02-12 |
2023-08-13 |
Not clear |
| Samar Ghorbanpoor, Luis Miguel Garcia-Segura, Ali Haeri-Rohani, Fariba Khodagholi, Masoumeh Jorjan. Aromatase inhibition exacerbates pain and reactive gliosis in the dorsal horn of the spinal cord of female rats caused by spinothalamic tract injury. Endocrinology. vol 155. issue 11. 2014-12-31. PMID:25105782. |
the proportion of microglia with a reactive phenotype and the number of glial fibrillary acidic protein-immunoreactive astrocytes were increased by the injury in the dorsal horn. |
2014-12-31 |
2023-08-13 |
rat |
| Wenling Chen, Wendy Walwyn, Helena S Ennes, Hyeyoung Kim, James A McRoberts, Juan Carlos G Marvizó. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. The European journal of neuroscience. vol 39. issue 9. 2014-12-17. PMID:24611998. |
nmda-induced nk1r internalization was also enabled in a neuropathic pain model or by activating dorsal horn microglia with lipopolysaccharide. |
2014-12-17 |
2023-08-12 |
mouse |
| Yan-Lu Ying, Xu-Hong Wei, Xue-Bing Xu, Shou-Zhang She, Li-Jun Zhou, Jing Lv, Dai Li, Bin Zheng, Xian-Guo Li. Over-expression of P2X7 receptors in spinal glial cells contributes to the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR) in rats. Experimental neurology. vol 261. 2014-12-17. PMID:25242211. |
the results of immunofluorescence showed that both microglia and astrocytes were activated in the spinal dorsal horn following smir. |
2014-12-17 |
2023-08-13 |
rat |
| Byung-Soo Ahn, Seong-Kyu Kim, Ha Neul Kim, Ji-Hye Lee, Ji-Hwan Lee, Deog Sang Hwang, Hyunsu Bae, Byung-Il Min, Sun Kwang Ki. Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-12-16. PMID:25505922. |
immunoreactivities of glial fibrillary acidic protein (gfap, astrocyte marker) and ox-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by gbt administration. |
2014-12-16 |
2023-08-13 |
rat |
| Shuang-Shuang Li, Wei-Shi Zhang, Dong Ji, Ya-Lan Zhou, Hui Li, Jia-Le Yang, Yuan-Chang Xiong, Yu-Qiu Zhang, Hua X. Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI. Neuroscience letters. vol 560. 2014-09-08. PMID:24345418. |
western blotting revealed that dexmedetomidine reduced the activation of microglia and the upregulation of interleukin-18 (il-18) protein expression in the ipsilateral lumbar spinal dorsal horn, while brl44408 pretreatment significantly blocked these effects of dexmedetomidine. |
2014-09-08 |
2023-08-12 |
rat |
| Shuang-Shuang Li, Wei-Shi Zhang, Dong Ji, Ya-Lan Zhou, Hui Li, Jia-Le Yang, Yuan-Chang Xiong, Yu-Qiu Zhang, Hua X. Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI. Neuroscience letters. vol 560. 2014-09-08. PMID:24345418. |
immunocytochemistry/immunohistochemistry indicated that the α2a-adrenoceptor was localised to microglia in primary culture, and il-18 predominantly colocalised with the microglial marker iba-1 in the dorsal horn of the spinal cord. |
2014-09-08 |
2023-08-12 |
rat |
| K-I Cheng, H-C Wang, Y-T Chuang, C-W Chou, H-P Tu, Y-C Yu, L-L Chang, C-S La. Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic rats. European journal of pain (London, England). vol 18. issue 2. 2014-09-04. PMID:23868758. |
in experimental early painful diabetic neuropathy, persistent hyperglycaemia induces dys-regulated sodium channel (navs) expression in the dorsal root ganglion (drg) and activates microglia in the spinal dorsal horn (sdh). |
2014-09-04 |
2023-08-12 |
rat |
| Knut Biber, Erik Boddek. Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Frontiers in cellular neuroscience. vol 8. 2014-08-22. PMID:25147499. |
the development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord. |
2014-08-22 |
2023-08-13 |
Not clear |
| Knut Biber, Erik Boddek. Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Frontiers in cellular neuroscience. vol 8. 2014-08-22. PMID:25147499. |
for long it remained obscure how a nerve injury in the periphery would initiate a microglia response in the dorsal horn of the spinal cord. |
2014-08-22 |
2023-08-13 |
Not clear |
| Yoki Nakamura, Norimitsu Morioka, Hiromi Abe, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakat. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. PloS one. vol 8. issue 8. 2014-06-15. PMID:23991202. |
also, the injury-induced translocation of hmgb1 from the nucleus to the cytosol occurred mainly in dorsal horn neurons and not in astrocytes and microglia, indicating a neuronal source of hmgb1. |
2014-06-15 |
2023-08-12 |
rat |
| Yoki Nakamura, Norimitsu Morioka, Hiromi Abe, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakat. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. PloS one. vol 8. issue 8. 2014-06-15. PMID:23991202. |
markers of astrocyte (glial fibrillary acidic protein (gfap)), microglia (ionized calcium binding adaptor molecule 1 (iba1)) and spinal neuron (cfos) activity were greatly increased in the ipsilateral dorsal horn side compared to the sham-operated side 21 days after psnl. |
2014-06-15 |
2023-08-12 |
rat |