| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Qi, Chen Chen, Qing-Xi Meng, Yan Wu, Haitao Wu, Ting-Bao Zha. Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia. Scientific reports. vol 6. 2018-06-21. PMID:27995982. |
interestingly, inhibition of microglia activation by minocycline significantly suppressed the activation of both neurons and microglia in spinal dorsal horn. |
2018-06-21 |
2023-08-13 |
Not clear |
| Jian Qi, Chen Chen, Qing-Xi Meng, Yan Wu, Haitao Wu, Ting-Bao Zha. Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia. Scientific reports. vol 6. 2018-06-21. PMID:27995982. |
together, our data suggest that the presence of a "crosstalk" between activated microglia and neurons in the spinal dorsal horn, which might contribute to the stress-induced hyperactivated state, leading to an increased pain sensitivity. |
2018-06-21 |
2023-08-13 |
Not clear |
| Wataru Nemoto, Ryota Yamagata, Yoshiki Ogata, Osamu Nakagawasai, Takeshi Tadano, Koichi Tan-N. Inhibitory effect of angiotensin (1-7) on angiotensin III-induced nociceptive behaviour in mice. Neuropeptides. vol 65. 2018-06-14. PMID:28559062. |
furthermore, we showed that in the lumbar superficial dorsal horn, mas receptors are expressed in neurons and microglia but absent from astrocytes. |
2018-06-14 |
2023-08-13 |
mouse |
| Suzanne Doolen, Jennifer Cook, Maureen Riedl, Kelley Kitto, Shinichi Kohsaka, Christopher N Honda, Carolyn A Fairbanks, Bradley K Taylor, Lucy Vulchanov. Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling. Glia. vol 65. issue 12. 2018-06-05. PMID:28850719. |
complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling. |
2018-06-05 |
2023-08-13 |
Not clear |
| Yuangui Lin, Lian Liu, Haixia Jiang, Jieshu Zhou, Yuying Tan. Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis. European journal of pharmacology. vol 811. 2018-05-30. PMID:28663035. |
blockade of il-6 function by tocilizumab markedly suppressed the activation of astrocytes and microglia in the ipsilateral dorsal horn, reduced c-fos immunoreactivity in dorsal horn neurons, and attenuated the upregulation of glutamate receptor subunits glur1 and nr2b in dorsal horn in the rats with mia-induced oa. |
2018-05-30 |
2023-08-13 |
rat |
| Juan Niu, Dujuan Huang, Rui Zhou, MingXia Yue, Tao Xu, Junna Yang, Li He, Hong Tian, XiaoHong Liu, Junwei Zen. Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y Journal of neuroinflammation. vol 14. issue 1. 2018-05-29. PMID:28899427. |
activation of dorsal horn cannabinoid cb2 receptor suppresses the expression of p2y more evidence suggests that dorsal spinal cord microglia is an important site contributing to cb2 receptor-mediated analgesia. |
2018-05-29 |
2023-08-13 |
Not clear |
| Fang Fang Zhang, Norimitsu Morioka, Hiromi Abe, Shiori Fujii, Kazuki Miyauchi, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase. Neurochemistry international. vol 101. 2018-01-12. PMID:27840124. |
fourteen days after psnl, increased phosphorylation of both p38 mitogen-activated protein kinase (mapk) in microglia and c-jun n-terminal kinase (jnk) in astrocytes of ipsilateral spinal dorsal horn were observed. |
2018-01-12 |
2023-08-13 |
mouse |
| Nan Gu, Ukpong B Eyo, Madhuvika Murugan, Jiyun Peng, Sanjana Matta, Hailong Dong, Long-Jun W. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26576724. |
next, we characterised both the electrophysiological and morphological properties of microglia in the superficial spinal cord dorsal horn following snt injury. |
2017-12-29 |
2023-08-13 |
mouse |
| Jian Li, Xiangnan Li, Xin Jiang, Mei Yang, Rui Yang, Geoffrey Burnstock, Zhenghua Xiang, Hongbin Yua. Microvesicles shed from microglia activated by the P2X7-p38 pathway are involved in neuropathic pain induced by spinal nerve ligation in rats. Purinergic signalling. vol 13. issue 1. 2017-11-17. PMID:27683228. |
first, we found that mvs shed from microglia were increased in the cerebrospinal fluid and dorsal horn of the spinal cord after snl. |
2017-11-17 |
2023-08-13 |
rat |
| Katherine A Mifflin, Bradley J Ker. Pain in autoimmune disorders. Journal of neuroscience research. vol 95. issue 6. 2017-11-16. PMID:27448322. |
pathological pain has been linked to t-cell activation and the release of cytokines from activated microglia in the dorsal horn of the spinal cord. |
2017-11-16 |
2023-08-13 |
Not clear |
| Wenlong Huang, Margarita Calvo, Tim Pheby, David L H Bennett, Andrew S C Ric. A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. Pain. vol 158. issue 1. 2017-11-02. PMID:27682209. |
furthermore, we found a small but significant increase in microglia with the effector morphology in the lumbar spinal dorsal horn in indinavir-treated animals, coupled with significantly increased expression of phospho-p38 in microglia. |
2017-11-02 |
2023-08-13 |
rat |
| Ting Zhang, Kai Sun, Wen Shen, Le Qi, Wei Yin, Li-Wei Wan. SOCS1 regulates neuropathic pain by inhibiting neuronal sensitization and glial activation in mouse spinal cord. Brain research bulletin. vol 124. 2017-10-26. PMID:27233783. |
accumulating evidence indicates that astrocytes and microglia are activated in the spinal cord dorsal horn (scdh) after cci. |
2017-10-26 |
2023-08-13 |
mouse |
| C Richard Chapman, Charles J Vierc. The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms. The journal of pain. vol 18. issue 4. 2017-09-20. PMID:27908839. |
these propose that chronic pain results from: 1) persistent noxious signaling in the periphery; 2) enduring maladaptive neuroplastic changes at the spinal dorsal horn and/or higher central nervous system structures reflecting a multiplicity of factors, including peripherally released neurotrophic factors and interactions between neurons and microglia; 3) compromised inhibitory modulation of noxious signaling in medullary-spinal pathways; 4) descending facilitatory modulation; and 5) maladaptive brain remodeling in function, structure, and connectivity. |
2017-09-20 |
2023-08-13 |
Not clear |
| Katsuya Kami, Satoru Taguchi, Fumihiro Tajima, Emiko Senb. Histone Acetylation in Microglia Contributes to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice. The journal of pain. vol 17. issue 5. 2017-09-19. PMID:26844418. |
we intended to clarify whether histone acetylation in microglia in the spinal dorsal horn contributes to eih in npp model mice. |
2017-09-19 |
2023-08-13 |
mouse |
| Katsuya Kami, Satoru Taguchi, Fumihiro Tajima, Emiko Senb. Histone Acetylation in Microglia Contributes to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice. The journal of pain. vol 17. issue 5. 2017-09-19. PMID:26844418. |
in immunofluorescence analysis, psl surgery markedly increased the number of histone deacetylase 1-positive/cd11b-positive microglia in the ipsilateral superficial dorsal horn, and they were significantly decreased by treadmill-running. |
2017-09-19 |
2023-08-13 |
mouse |
| Katsuya Kami, Satoru Taguchi, Fumihiro Tajima, Emiko Senb. Histone Acetylation in Microglia Contributes to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice. The journal of pain. vol 17. issue 5. 2017-09-19. PMID:26844418. |
moreover, the number of microglia with nuclear expression of acetylated h3k9 in the ipsilateral superficial dorsal horn was maintained at low levels in psl-sedentary mice, but running exercise significantly increased them. |
2017-09-19 |
2023-08-13 |
mouse |
| Ying Shi, Wanxiang Qin, Fachuan Nie, Huizhong Wen, Kaizhi Lu, Jian Cu. Ulinastatin attenuates neuropathic pain via the ATP/P2Y2 receptor pathway in rat models. Gene. vol 627. 2017-09-18. PMID:28652182. |
we found that increased expression of p2y2 receptor in microglia was likely involved in the activation of microglia after nerve injury, and ulinastatin inhibited the abnormal microglia activation in the dorsal horn after nerve injury. |
2017-09-18 |
2023-08-13 |
rat |
| Martha E Zeeman, Sonia Kartha, Beth A Winkelstei. Whole-body vibration induces pain and lumbar spinal inflammation responses in the rat that vary with the vibration profile. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 8. 2017-08-31. PMID:27571442. |
similarly, increased activation of microglia, macrophages, and astrocytes in the superficial dorsal horn of the lumbar spinal cord is only evident after the painful 8 hz wbv. |
2017-08-31 |
2023-08-13 |
rat |
| Christian König, Eric Morch, Annett Eitner, Christian Möller, Brian Turnquist, Hans-Georg Schaible, Andrea Ebersberge. Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 38. 2017-08-17. PMID:27656018. |
together, these data show that the induction of hyperexcitability of nociceptive deep dorsal horn neurons by tnf-α largely depends on the formation of il-6/sil-6r complexes that are downstream of tnf-α and requires the interactions of neurons and microglia orchestrated by tnf-α. |
2017-08-17 |
2023-08-13 |
rat |
| Preet G S Makker, Samuel S Duffy, Justin G Lees, Chamini J Perera, Ryan S Tonkin, Oleg Butovsky, Susanna B Park, David Goldstein, Gila Moalem-Taylo. Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy. PloS one. vol 12. issue 1. 2017-08-10. PMID:28125674. |
in the central nervous system, ptx induced significant astrocyte activation in the spinal cord dorsal horn, and both ptx and oxa caused reduction of p2ry12+ homeostatic microglia, with no measurable changes in iba-1+ microglia/macrophages in the dorsal and ventral horns. |
2017-08-10 |
2023-08-13 |
mouse |