| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tingting Yu, Xin Zhang, Haosong Shi, Jinge Tian, Lingling Sun, Xueming Hu, Wenqiang Cui, Dongping D. P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents. Cell death & disease. vol 10. issue 3. 2020-04-20. PMID:30778044. |
p2y12 receptors on microglia are thought to be a key player in the surveillance of the local environment, but whether or how these receptors are engaged in the cross-talk between microglia and neurons of the dorsal horn remain ambiguous. |
2020-04-20 |
2023-08-13 |
mouse |
| Tingting Yu, Xin Zhang, Haosong Shi, Jinge Tian, Lingling Sun, Xueming Hu, Wenqiang Cui, Dongping D. P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents. Cell death & disease. vol 10. issue 3. 2020-04-20. PMID:30778044. |
we found that spinal nerve ligation (snl) significantly increased the level of p2y12 receptors specifically in the microglia of the ipsilateral dorsal horn. |
2020-04-20 |
2023-08-13 |
mouse |
| Ágnes Hunyady, Zsófia Hajna, Tímea Gubányi, Bálint Scheich, Ágnes Kemény, Balázs Gaszner, Éva Borbély, Zsuzsanna Helye. Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms. Brain research bulletin. vol 147. 2020-04-06. PMID:30664920. |
microglia, but not astrocyte activation was observed 14 days after psl in the ipsilateral spinal dorsal horn of wildtype, but not hk-1-deficient mice. |
2020-04-06 |
2023-08-13 |
mouse |
| Zsuzsanna Helyes, Valéria Tékus, Nikolett Szentes, Krisztina Pohóczky, Bálint Botz, Tamás Kiss, Ágnes Kemény, Zsuzsanna Környei, Krisztina Tóth, Nikolett Lénárt, Hajnalka Ábrahám, Emmanuel Pinteaux, Sheila Francis, Serena Sensi, Ádám Dénes, Andreas Goebe. Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 26. 2020-04-06. PMID:31182576. |
after a short-lasting paw inflammatory response in all groups, crps igg-injected mice displayed sustained, profound microglia and astrocyte activation in the dorsal horn of the spinal cord and pain-related brain regions, indicating central sensitization. |
2020-04-06 |
2023-08-13 |
mouse |
| Wei Wang, Xiongxiong Zhong, Yongyong Li, Ruixian Guo, Sujuan Du, Lili Wen, Yanlu Ying, Tao Yang, Xu-Hong We. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic post-operative pain. Journal of neurochemistry. vol 149. issue 6. 2020-03-13. PMID:30570747. |
the microinjection of the p2x7r agonist bzatp, the nadph oxidase activator phorbol-12-myristate-13-acetate, or il-1β into the rvm induced bilateral mechanical allodynia, microglia activation, and 5-ht release in the l3 spinal dorsal horn. |
2020-03-13 |
2023-08-13 |
rat |
| Ana Carolina Pinheiro Campos, Miriã Benatti Berzuino, Marina Sorrentino Hernandes, Erich Talamoni Fonoff, Rosana Lima Pagan. Monoaminergic regulation of nociceptive circuitry in a Parkinson's disease rat model. Experimental neurology. vol 318. 2020-03-02. PMID:31028827. |
through immunohistochemistry, the number and activation of neurons, and the staining for astrocytes, microglia and enkephalin were evaluated in specific brain structures and the dorsal horn of the spinal cord. |
2020-03-02 |
2023-08-13 |
rat |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Analgesic Effect of Duloxetine on an Animal Model of Monosodium Iodoacetate-Induced Hip Osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 38. issue 2. 2020-02-10. PMID:31538672. |
a single injection of duloxetine significantly attenuated it in induced hip oa (p < 0.05) and suppressed the number of iba1-ir microglia of the ipsilateral dorsal horn (p < 0.05). |
2020-02-10 |
2023-08-13 |
rat |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Analgesic Effect of Duloxetine on an Animal Model of Monosodium Iodoacetate-Induced Hip Osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 38. issue 2. 2020-02-10. PMID:31538672. |
these results suggest that a single injection of duloxetine suppressed mechanical hyperalgesia and may influence the expression of iba1 in the microglia of the ipsilateral dorsal horn in the mia-induced hip oa. |
2020-02-10 |
2023-08-13 |
rat |
| Yuhua Yin, Jinpyo Hong, Thuỳ Linh Phạm, Juhee Shin, Do Hyeong Gwon, Hyeok Hee Kwon, Nara Shin, Hyo Jung Shin, Sun Yeul Lee, Won-Hyung Lee, Dong Woon Ki. Evans Blue Reduces Neuropathic Pain Behavior by Inhibiting Spinal ATP Release. International journal of molecular sciences. vol 20. issue 18. 2020-01-30. PMID:31505901. |
taken together, these data demonstrate that eb prevents atp release in the spinal dorsal horn and reduces the atp/purinergic receptor-induced activation of spinal microglia followed by a decline in algogenic substances, thereby relieving neuropathic pain in rats with snl. |
2020-01-30 |
2023-08-13 |
rat |
| Coralie Brifault, HyoJun Kwon, Wendy M Campana, Steven L Gonia. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. vol 67. issue 6. 2019-12-30. PMID:30746765. |
lrp1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. |
2019-12-30 |
2023-08-13 |
mouse |
| Coralie Brifault, HyoJun Kwon, Wendy M Campana, Steven L Gonia. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. vol 67. issue 6. 2019-12-30. PMID:30746765. |
following injury to the peripheral nervous system (pns), microglia in the spinal dorsal horn (sdh) become activated and contribute to the development of local neuro-inflammation, which may regulate neuropathic pain processing. |
2019-12-30 |
2023-08-13 |
mouse |
| Hou-Sheng Deng, Long-Sheng Xu, Hua-Dong Ni, Ting-Ting Wang, Ming-Juan Liu, Mao-Xian Yang, Hui Shen, Huan Pan, Ming Ya. Proteomic profiling reveals Arl6ip-1 as a candidate target in cancer-induced bone pain rat model after oxycodone treatment. Neuroscience letters. vol 699. 2019-12-17. PMID:30708128. |
fluorescent staining revealed that arl6ip-1 co-localized with spinal dorsal horn neurons, but not with astrocytes or microglia. |
2019-12-17 |
2023-08-13 |
rat |
| Ryota Yamagata, Wataru Nemoto, Osamu Nakagawasai, Wan-Yi Hung, Kazuhiro Shima, Yasuo Endo, Koichi Tan-N. Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 3. 2019-12-06. PMID:30515539. |
in mice subjected to psnl, slc17a9 was present in neurons and microglia, but not in astrocytes of the lumbar superficial dorsal horn. |
2019-12-06 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Yu-Chen Lee, Chien-Hsin Tseng, Dai-Yin Chen, Chieh-Yun Shih, Iona MacDonald, Shih-Ya Hung, Yi-Hung Che. Electroacupuncture inhibits pruritogen-induced spinal microglial activation in mice. Brain research. vol 1649. issue Pt A. 2019-11-20. PMID:27396909. |
ea application (2hz) to li4 and li11 attenuated gnti-induced scratching behavior and repressed gnti-induced iba1 expression and iba1 (+) microglia in the dorsal horn. |
2019-11-20 |
2023-08-13 |
mouse |
| Yangyang Chen, Yiqian Shi, Guoxiang Wang, Yimei Li, Longzhen Cheng, Yun Wan. Memantine selectively prevented the induction of dynamic allodynia by blocking Kir2.1 channel and inhibiting the activation of microglia in spinal dorsal horn of mice in spared nerve injury model. Molecular pain. vol 15. 2019-08-12. PMID:30845882. |
memantine selectively prevented the induction of dynamic allodynia by blocking kir2.1 channel and inhibiting the activation of microglia in spinal dorsal horn of mice in spared nerve injury model. |
2019-08-12 |
2023-08-13 |
mouse |
| Akira Sayo, Hiroyuki Konishi, Masaaki Kobayashi, Kuniyuki Kano, Hiroki Kobayashi, Hideharu Hibi, Junken Aoki, Hiroshi Kiyam. GPR34 in spinal microglia exacerbates neuropathic pain in mice. Journal of neuroinflammation. vol 16. issue 1. 2019-08-12. PMID:30975169. |
microglia are activated in the spinal dorsal horn after sensory nerve injury and contribute to neuropathic pain. |
2019-08-12 |
2023-08-13 |
mouse |
| Kuang-Yi Tseng, Hung-Chen Wang, Lin-Li Chang, Kuang-I Chen. Advances in Experimental Medicine and Biology: Intrafascicular Local Anesthetic Injection Damages Peripheral Nerve-Induced Neuropathic Pain. Advances in experimental medicine and biology. vol 1099. 2019-07-26. PMID:30306515. |
in spinal dorsal horn (sdh), the microglia and astrocytes located in sdh were activated and proliferated after intrafascicular la injection and returned to baseline gradually at the end of the month. |
2019-07-26 |
2023-08-13 |
Not clear |
| Hiroai Okutani, Hiroki Yamanaka, Kimiko Kobayashi, Masamichi Okubo, Koichi Noguch. Recombinant interleukin-4 alleviates mechanical allodynia via injury-induced interleukin-4 receptor alpha in spinal microglia in a rat model of neuropathic pain. Glia. vol 66. issue 8. 2019-07-18. PMID:29693281. |
in particular, activated microglia in the spinal cord facilitate the hyper-excitability of dorsal horn neurons after peripheral nerve injury via pro-inflammatory molecules. |
2019-07-18 |
2023-08-13 |
rat |
| Bo-Jun Xiong, Ying Xu, Gui-Lin Jin, Ming Liu, Jian Yang, Chang-Xi Y. Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain. Scientific reports. vol 7. issue 1. 2019-07-16. PMID:29079733. |
our results showed that microglia and astroglia were activated in the spinal dorsal horn post-incision, along with an increase of proinflammatory cytokines (interleukin 1β, interleukin 6, and tumor necrosis factor α). |
2019-07-16 |
2023-08-13 |
rat |
| Xisheng Yan, Fen Li, Dylan W Maixner, Ruchi Yadav, Mei Gao, Mourad Wagdy Ali, Shelley B Hooks, Han-Rong Wen. Interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome. Glia. vol 67. issue 3. 2019-06-13. PMID:30578561. |
interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome. |
2019-06-13 |
2023-08-13 |
mouse |