| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katharina Sessler, Vivian Blechschmidt, Ulrich Hoheisel, Siegfried Mense, Lucas Schirmer, Rolf-Detlef Treed. Spinal cord fractalkine (CX3CL1) signaling is critical for neuronal sensitization in experimental nonspecific, myofascial low back pain. Journal of neurophysiology. vol 125. issue 5. 2021-08-17. PMID:33596743. |
neuroactive substances released by activated microglia contribute to hyperexcitability of spinal dorsal horn neurons in many animal models of chronic pain. |
2021-08-17 |
2023-08-13 |
Not clear |
| George Sideris-Lampretsas, Marzia Malcangi. Microglial heterogeneity in chronic pain. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34139287. |
we then consider the specific scenario of peripheral nerve or tissue injury which induce expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord. |
2021-08-06 |
2023-08-13 |
mouse |
| Masatake Fujimura, Fusako Usuki, Atsushi Nakamur. Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats. Archives of toxicology. vol 95. issue 6. 2021-08-02. PMID:33847776. |
immunohistochemistry revealed the accumulation of activated microglia in the dorsal root nerve, dorsal column, and dorsal horn of the spinal cord. |
2021-08-02 |
2023-08-13 |
rat |
| Masatake Fujimura, Fusako Usuki, Atsushi Nakamur. Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats. Archives of toxicology. vol 95. issue 6. 2021-08-02. PMID:33847776. |
the results suggest that dorsal horn neuronal activation was mediated by inflammatory factors excreted by accumulated microglia. |
2021-08-02 |
2023-08-13 |
rat |
| Masatake Fujimura, Fusako Usuki, Atsushi Nakamur. Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats. Archives of toxicology. vol 95. issue 6. 2021-08-02. PMID:33847776. |
in conclusion, mehg-mediated dorsal horn neuronal activation with inflammatory microglia might induce somatosensory cortical rewiring, leading to hyperalgesia/allodynia. |
2021-08-02 |
2023-08-13 |
rat |
| Theresa H Tam, Michael W Salte. Purinergic signalling in spinal pain processing. Purinergic signalling. vol 17. issue 1. 2021-07-31. PMID:33169292. |
in terms of pathological pain, p2x4 receptors de novo expressed on dorsal horn microglia are implicated in pain hypersensitivity following peripheral nerve injury. |
2021-07-31 |
2023-08-13 |
Not clear |
| Yoki Nakamura, Ayako Fukuta, Keita Miyashita, Fang Fang Zhang, Dengli Wang, Keyue Liu, Hidenori Wake, Kazue Hisaoka-Nakashima, Masahiro Nishibori, Norimitsu Moriok. Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: Involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn. Biochemical pharmacology. vol 186. 2021-06-30. PMID:33667472. |
perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: involvement of glutamate-nmda receptor dependent mechanism in spinal dorsal horn. |
2021-06-30 |
2023-08-13 |
mouse |
| Yoki Nakamura, Ayako Fukuta, Keita Miyashita, Fang Fang Zhang, Dengli Wang, Keyue Liu, Hidenori Wake, Kazue Hisaoka-Nakashima, Masahiro Nishibori, Norimitsu Moriok. Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: Involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn. Biochemical pharmacology. vol 186. 2021-06-30. PMID:33667472. |
the current study shows that perineural treatment of naïve mice with recombinant hmgb1, which mimics increased hmgb1 around the injured sciatic nerve of psnl mice, significantly induced activation of microglia, but not astrocytes, in the spinal dorsal horn. |
2021-06-30 |
2023-08-13 |
mouse |
| Xiao Yang, Lin Zhu, Bingcheng Zhao, Jingjuan Hu, Fan Deng, Shaohui Lei, Zhi-Wen Yao, Kexuan Li. Screening and Identification of Key Genes, Pathways, and Drugs Associated with Neuropathic Pain in Dorsal Horn: Evidence from Bioinformatic Analysis. Journal of pain research. vol 14. 2021-06-26. PMID:34168490. |
microglia in dorsal horn drives neuropathic pain as a kind of immune cell. |
2021-06-26 |
2023-08-13 |
Not clear |
| Hiroki Ota, Haruna Takebe, Kazue Mizumura, Toru Taguch. Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats. The journal of physiological sciences : JPS. vol 71. issue 1. 2021-06-24. PMID:34162322. |
the number of microglia and cell diameters significantly increased in the superficial dorsal horn of the lumbar spinal cord. |
2021-06-24 |
2023-08-13 |
rat |
| Lijuan Wang, Cui Yin, Xiangying Xu, Tianya Liu, Bin Wang, Mannan Abdul, Yan Zhou, Junli Cao, Chen L. Pellino1 Contributes to Morphine Tolerance by Microglia Activation via MAPK Signaling in the Spinal Cord of Mice. Cellular and molecular neurobiology. vol 40. issue 7. 2021-06-11. PMID:31989355. |
notably, peli1 was expressed in a great majority of microglia in the spinal dorsal horn, while downregulation of spinal peli1 attenuated the development of morphine tolerance and associated hyperalgesia. |
2021-06-11 |
2023-08-13 |
mouse |
| Nuria García-Magro, Yasmina B Martin, Pilar Negredo, Francisco Zafra, Carlos Avendañ. Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain. International journal of molecular sciences. vol 22. issue 9. 2021-06-03. PMID:33925417. |
microglia and inhibitory circuitry in the medullary dorsal horn: laminar and time-dependent changes in a trigeminal model of neuropathic pain. |
2021-06-03 |
2023-08-13 |
mouse |
| Vittoria Borgonetti, Nicoletta Galeott. Intranasal delivery of an antisense oligonucleotide to the RNA-binding protein HuR relieves nerve injury-induced neuropathic pain. Pain. vol 162. issue 5. 2021-05-19. PMID:33259457. |
immunofluorescence studies showed that hur was expressed in activated microglia, colocalized with p38 and, partially, with extracellular signal-regulated kinase (erk)1/2 within the spinal cord dorsal horn. |
2021-05-19 |
2023-08-13 |
mouse |
| Yuyin Zheng, Chengqian Jia, Xia Jiang, Jie Chen, Xiao-Long Chen, Xinwang Ying, Jiayu Wu, Mingchen Jiang, Guanhu Yang, Wenzhan Tu, Kecheng Zhou, Songhe Jian. Electroacupuncture effects on the P2X4R pathway in microglia regulating the excitability of neurons in the substantia gelatinosa region of rats with spinal nerve ligation. Molecular medicine reports. vol 23. issue 3. 2021-05-05. PMID:33398365. |
high p2x4 receptor (p2x4r) expression levels demonstrate a notable increase in hyperactive microglia in the ipsilateral spinal dorsal horn following pni. |
2021-05-05 |
2023-08-13 |
rat |
| Xiaohan Xu, Xin Tao, Ping Huang, Feng Lin, Qing Liu, Li Xu, Jijun Xu, Yuguang Huan. N-methyl-d-aspartate receptor subunit 2B on keratinocyte mediates peripheral and central sensitization in chronic post-ischemic pain in male rats. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32032782. |
central sensitization-related c-fos induction, as well as astrocytes and microglia activation in the spinal cord dorsal horn (sdh) were studied using immunofluorescence. |
2021-04-27 |
2023-08-13 |
human |
| Zhiqiang Liu, Stephen F Murphy, Larry Wong, Anthony J Schaeffer, Praveen Thumbika. Neuronal/astrocytic expression of chemokine (C-C motif) ligand 2 is associated with monocyte/macrophage recruitment in male chronic pelvic pain. Pain. vol 161. issue 11. 2021-03-25. PMID:32541388. |
myeloid-derived cd45 iba1+ cells were localized with iba1+ tmem199+ microglia in the dorsal horn of the spinal cord in eap, with intimate association of the 2 cell types suggesting cell-cell interactions. |
2021-03-25 |
2023-08-13 |
mouse |
| Gerda Reischer, Bernhard Heinke, Jürgen Sandkühle. Interferon-γ facilitates the synaptic transmission between primary afferent C-fibres and lamina I neurons in the rat spinal dorsal horn via microglia activation. Molecular pain. vol 16. 2021-02-23. PMID:32264753. |
interferon-γ facilitates the synaptic transmission between primary afferent c-fibres and lamina i neurons in the rat spinal dorsal horn via microglia activation. |
2021-02-23 |
2023-08-13 |
rat |
| Lulin Ma, Juan Li, Junli Zhou, Dexin Zhang, Zhi Xiao, Tian Yu, Ying Li, Song Ca. Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes. iScience. vol 24. issue 2. 2021-02-20. PMID:33604528. |
microglia and astrocytes in spinal dorsal horn (sdh), prefrontal cortex (pfc), anterior cingulate cortex (acc), and hippocampus were analyzed. |
2021-02-20 |
2023-08-13 |
rat |
| Chan Noh, Hyo Jung Shin, Seounghun Lee, Song I Kim, Yoon-Hee Kim, Won Hyung Lee, Dong Woon Kim, Sun Yeul Lee, Young Kwon K. CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation. International journal of molecular sciences. vol 21. issue 10. 2021-02-11. PMID:32423102. |
cx3cr1 sirna-treated rats exhibited significant reductions in the activation of microglia in the spinal dorsal horn and a downregulation of proinflammatory mediators, as well as a significant attenuation of mechanical allodynia. |
2021-02-11 |
2023-08-13 |
rat |
| Qiu-Li He, Hou-Sheng Deng, Long-Sheng Xu, Jian-Jun Zhu, Hua-Dong Ni, Ting-Ting Wang, Yun-Gong Wang, Hui Shen, Huan Pan, Ming Ya. SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors. Neuroscience letters. vol 714. 2021-01-04. PMID:31682872. |
this study investigated the role of sap102 in the formation of hyperalgesia in rats with cibp sap102 is present in spinal dorsal horn neurons, but not in astrocytes or microglia. |
2021-01-04 |
2023-08-13 |
rat |