| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yajing Xu, Stephanie C Koch, Alexander Chamessian, Qianru He, Mayya Sundukova, Paul Heppenstall, RuRong Ji, Maria Fitzgerald, Simon Begg. Microglial refinement of A-fibre projections in the postnatal spinal cord dorsal horn is required for normal maturation of dynamic touch. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-11-21. PMID:37989592. |
thus, functional microglia are necessary for the normal postnatal development of dorsal horn sensory circuits. |
2023-11-21 |
2023-11-29 |
mouse |
| Dongxia Duan, Lian Wang, Yueyang Feng, Daiyu Hu, Donghong Cu. Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission. Canadian journal of physiology and pharmacology. 2023-11-17. PMID:37976472. |
picroside Ⅱ (pⅡ) attenuated neuropathic pain by inhibiting the neuroinflammation of the spinal dorsal horn, however, how it engaged in the cross-talk between microglia and neurons remained ambiguous. |
2023-11-17 |
2023-11-20 |
rat |
| Fumihiro Saika, Yohji Fukazawa, Shiroh Kishioka, Norikazu Kiguch. Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis. Journal of pharmacological sciences. vol 153. issue 4. 2023-11-16. PMID:37973215. |
ablation of itch-related sensory neurons using resiniferatoxin decreased itch-related scratching behavior and the number of hypertrophic microglia in the spinal dorsal horn. |
2023-11-16 |
2023-11-20 |
mouse |
| Siyuan Wang, Chao Jiang, Kelei Cao, Run Li, Zhihua Gao, Yue Wan. HK2 in microglia and macrophages contribute to the development of neuropathic pain. Glia. 2023-11-01. PMID:37909251. |
however, selective ablation of hk2 in microglia reduced microgliosis in the spinal dorsal horn (sdh) with little analgesic effects. |
2023-11-01 |
2023-11-08 |
Not clear |
| Zhe-Hao Xu, Jing-Cheng Zhang, Ke Chen, Xuan Liu, Xian-Zhi Li, Ming Yuan, Yue Wang, Jing-Yu Tia. Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse. European journal of pharmacology. 2023-10-22. PMID:37866747. |
intrathecal pd-l1 (1 μg, 4 times a week for 1 week) suppressed the activation of the microglia in the spinal dorsal horn to relieve the chronic itch that was elicited by imiquimod-induced psoriasis and dnfb-induced allergic contact dermatitis. |
2023-10-22 |
2023-11-08 |
mouse |
| Zhe-Hao Xu, Jing-Cheng Zhang, Ke Chen, Xuan Liu, Xian-Zhi Li, Ming Yuan, Yue Wang, Jing-Yu Tia. Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse. European journal of pharmacology. 2023-10-22. PMID:37866747. |
although the activation of the microglia in the spinal dorsal horn was not detected in the aew-treated mice, intrathecal pd-l1 still reduced the number of scratches that were elicited by aew. |
2023-10-22 |
2023-11-08 |
mouse |
| Jee Youn Lee, Chan Sol Park, Kyung Jin Seo, In Yi Kim, Sungmin Han, Inchan Youn, Tae Young Yun. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Experimental neurology. 2023-10-20. PMID:37863306. |
in particular, ag490 treatment inhibited both microglial and astrocyte activation in the lumbar (l) 4-5 dorsal horn and significantly decreased levels of p-p38mapk, p-erk and p-jnk, which are known to be activated in microglia (p-p38mapk and p-erk) and astrocyte (p-jnk). |
2023-10-20 |
2023-11-08 |
rat |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
however, aging causes microglia in the ventral but not dorsal horn to lose their spatial organization. |
2023-09-22 |
2023-10-07 |
mouse |
| Longqing Zhang, Xi Tan, Fanhe Song, Danyang Li, Jiayi Wu, Shaojie Gao, Jia Sun, Daiqiang Liu, Yaqun Zhou, Wei Me. Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model. Neural regeneration research. vol 19. issue 3. 2023-09-18. PMID:37721302. |
in this study, we established a sprague-dawley rat model of spared nerve injury-induced neuropathic pain and found that gpr39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated rats. |
2023-09-18 |
2023-10-07 |
rat |
| Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T Supura. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia. European journal of medicinal chemistry. vol 260. 2023-09-07. PMID:37678143. |
by means of repeated treatment of 3 daily administrations for 17 days, fentanyl (0.1 mg/kg, subcutaneously) led to tolerance development, pain threshold alterations and withdrawal symptoms in cd-1 mice, as well as astrocyte and microglia activation in the dorsal horn of the lumbar spinal cord. |
2023-09-07 |
2023-10-07 |
mouse |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
moreover, sni-induced microglia activation and upregulation of p2x7r in spinal dorsal horn could be markedly inhibited by prf + drg. |
2023-08-14 |
2023-08-16 |
Not clear |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
the results suggest that the analgesic effect of prf + drg increased with time whereas the other two not and microglia and p2x7r in the ipsilateral spinal dorsal horn may be involved in the process. |
2023-08-14 |
2023-08-16 |
Not clear |
| Yaswanth Kuthati, Vaikar Navakanth Rao, Wei-Hsiu Huang, Prabhakar Busa, Chih-Shung Won. Teneligliptin Co-Infusion Alleviates Morphine Tolerance by Inhibition of Spinal Microglial Cell Activation in Streptozotocin-Induced Diabetic Rats. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508016. |
microglial cell activation and mononucleate cell infiltration in the spinal cord dorsal horn were assessed by immunofluorescence assay (ifa) and western blotting (wb). |
2023-07-29 |
2023-08-14 |
rat |
| Yaswanth Kuthati, Vaikar Navakanth Rao, Wei-Hsiu Huang, Prabhakar Busa, Chih-Shung Won. Teneligliptin Co-Infusion Alleviates Morphine Tolerance by Inhibition of Spinal Microglial Cell Activation in Streptozotocin-Induced Diabetic Rats. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508016. |
the results showed that co-infusion of ten with mor significantly attenuated mat in dnp rats through the restoration of neuroprotective proteins nrf2 and ho-1 and suppression of microglial cell activation in the dorsal horn. |
2023-07-29 |
2023-08-14 |
rat |
| Jia-Xuan Yang, Jiang Zhu, Kun Ni, Hai-Kou Yang, Hai-Long Zhang, Zheng-Liang M. Electroacupuncture relieves chronic pain by promoting microglia M2 polarization in lumbar disc herniation rats. Neuroreport. vol 34. issue 12. 2023-07-20. PMID:37470743. |
we show that pwt and pwl decreased in the ldh group while iba-1, inos, and tnf-α expression increased significantly in lumbar spinal dorsal horn (sdh) after ldh surgery, and revealing that microglia were activated and polarized towards proinflammatory m1 phenotype. |
2023-07-20 |
2023-08-14 |
rat |
| Xuan Zhao, Tingting Zhang, Yun Wang, Zihan Hu, Xinren Yu, Pei Chen, Keyu Jin, Jing Zhou, Guoxiang Wang, Jiangning Yu, Tong Wu, Yulong Wang, Fuqing Li. BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury. Molecular pain. 2023-06-15. PMID:37321969. |
the over activation of microglia in the spinal dorsal horn after sni was at least one of the triggers in sni-induced mkcc2 reduction and dynamic allodynia, as these effects were blocked by the inhibition of microglial activation. |
2023-06-15 |
2023-08-14 |
mouse |
| Xin Jia, Ziyang Li, Xiafeng Shen, Yu Zhang, Li Zhang, Ling Zhan. High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic post-ischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282487. |
finally, shrna-mediated silencing of chemerin receptor 23 in the spinal cord reversed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammatory polarization of microglia in the dorsal horn of the spinal cord. |
2023-06-07 |
2023-08-14 |
mouse |
| Xue Wang, Cong Lin, Sha Jin, Yibo Wang, Yinghua Peng, Xiaohui Wan. Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5. Brain, behavior, and immunity. 2023-05-17. PMID:37196785. |
furthermore, systemic administration of cbd inhibited chronic constriction injury (cci)-induced microglia activation and fkbp5 overexpression in lumbar spinal cord dorsal horn. |
2023-05-17 |
2023-08-14 |
Not clear |
| Erliang Kong, Yongchang Li, Peng Ma, Yixuan Zhang, Ruifeng Ding, Tong Hua, Mei Yang, Hongbin Yua. Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn. Journal of cellular and molecular medicine. 2023-05-03. PMID:37132040. |
lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating irf5 nuclear translocation in spinal dorsal horn. |
2023-05-03 |
2023-08-14 |
mouse |
| Erliang Kong, Yongchang Li, Peng Ma, Yixuan Zhang, Ruifeng Ding, Tong Hua, Mei Yang, Hongbin Yua. Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn. Journal of cellular and molecular medicine. 2023-05-03. PMID:37132040. |
cci led to the upregulation of lyn expression and glycolysis enhancement in microglia of spinal dorsal horn. |
2023-05-03 |
2023-08-14 |
mouse |