| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erliang Kong, Yongchang Li, Peng Ma, Yixuan Zhang, Ruifeng Ding, Tong Hua, Mei Yang, Hongbin Yua. Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn. Journal of cellular and molecular medicine. 2023-05-03. PMID:37132040. |
lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating irf5 nuclear translocation in spinal dorsal horn. |
2023-05-03 |
2023-08-14 |
mouse |
| Yajing Xu, Dale Moulding, Wenanlan Jin, Simon Begg. Microglial phagocytosis mediates long-term restructuring of spinal GABAergic circuits following early life injury. Brain, behavior, and immunity. 2023-04-10. PMID:37037363. |
we hypothesised that neonatal injury (1) alters microglial phagocytosis of synapses in the dorsal horn leading to long-term structural changes in neurons, and/or (2) trains microglia, leading to a stronger microglial response after re-injury in adulthood. |
2023-04-10 |
2023-08-14 |
Not clear |
| Yajing Xu, Dale Moulding, Wenanlan Jin, Simon Begg. Microglial phagocytosis mediates long-term restructuring of spinal GABAergic circuits following early life injury. Brain, behavior, and immunity. 2023-04-10. PMID:37037363. |
dorsal horn microglia increased engulfment of synapses following injury, with a preference for those expressing the vesicular gaba transporter vgat and primary afferent a-fibre terminals in neonates. |
2023-04-10 |
2023-08-14 |
Not clear |
| Yifan Zhou, Yaowei Xu, Jingjie Yang, Zhixiang Yu, Wenting Wang, Meng Yuan, Yiming Wang, Qian Bai, Zhisong L. Spinal cannabinoid receptor 2 activation alleviates neuropathic pain by regulating microglia and suppressing P2X7 receptor. Frontiers in molecular neuroscience. vol 16. 2023-03-27. PMID:36969555. |
in this study, we report increased and more reactive microglia (with larger cell body, shorter processes, and fewer endpoints) observed in the spinal dorsal horn of spared nerve injury (sni) rats. |
2023-03-27 |
2023-08-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). |
2023-02-25 |
2023-08-14 |
rat |
| Xiaona Zhao, Xinxin Li, Huiling Guo, Panmei Liu, Minyu Ma, Yanping Wan. Resolvin D1 Attenuates Mechanical Allodynia after Burn Injury: Involvement of Spinal Glia, p38 MAPK, and BDNF/TrkB signaling. Molecular pain. 2023-02-11. PMID:36765459. |
pain behavior and the expression levels of spinal dorsal horn iba-1 (microglia marker), gfap (astrocyte marker), p-p38 mitogen-activated protein kinase (mapk), brain-derived neurotrophic factor (bdnf), and tropomyosin-related kinase b (trkb) were detected by behavioral and immunocytochemical assays. |
2023-02-11 |
2023-08-14 |
rat |
| Noosha Yousefpour, Samantha Locke, Haley Deamond, Chengyang Wang, Lucas Marques, Manon St-Louis, Johanne Ouellette, Arkady Khoutorsky, Yves De Koninck, Alfredo Ribeiro-da-Silv. Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain. Cell reports. vol 42. issue 1. 2023-01-19. PMID:36656715. |
together, these results define a specific role for microglia in the progression of neuropathic pain pathogenesis and implicate these immune cells in structural remodeling of dorsal horn circuitry. |
2023-01-19 |
2023-08-14 |
Not clear |
| Xu Gao, Long-Fei Gao, Xiang-Qing Kong, Ya-Nan Zhang, Shu Jia, Chun-Yang Men. Mesenchymal stem cell-derived extracellular vesicles carrying miR-99b-3p restrain microglial activation and neuropathic pain by stimulating autophagy. International immunopharmacology. vol 115. 2023-01-13. PMID:36638658. |
during in vivo studies, intrathecal injection of msc-evs significantly up-regulated the expression of mir-99b-3p, and alleviated mechanical allodynia caused by activated microglia in the spinal cord dorsal horn of cci rats. |
2023-01-13 |
2023-08-14 |
human |
| Jing Zhang, Jialin Si, Rongrong Liang, Yuxin Lu, Hongwei Shang, Xinwei Li, Shukai Sun, Li-An W. Ligand-gated ion channel P2X7 regulates hypoxia-induced factor-1α mediated pain induced by dental pulpitis in the medullary dorsal horn. Frontiers in molecular neuroscience. vol 15. 2022-11-17. PMID:36385758. |
accumulating evidence indicates that activated microglia in the medullary dorsal horn (mdh) contribute to dental pulpitis induced pain. |
2022-11-17 |
2023-08-14 |
rat |
| Rana Muhammad Shoaib, Muhammad Zaeem Ahsan, Usman Akhtar, Khalil Ali Ahmad, Usman Ali, Men-Yan Deng, Xin-Yan Li, Yong-Xiang Wan. Ginsenoside Rb1, a principal effective ingredient of Panax notoginseng, produces pain antihypersensitivity by spinal microglial dynorphin A expression. Neuroscience research. 2022-11-11. PMID:36368461. |
additionally, intrathecal ginsenoside rb1 specifically stimulated dynorphin a expression which was colocalized with microglia but not neurons or astrocytes in the spinal dorsal horn and primary cultured cells. |
2022-11-11 |
2023-08-14 |
Not clear |
| Nan Gu, Min-Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel, Jiyun Peng, Ukpong B Eyo, Christine L Hunt, Hailong Dong, Long-Jun W. Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity. Molecular brain. vol 15. issue 1. 2022-10-27. PMID:36289499. |
using an ablation strategy to specifically deplete resident microglia in the cns, we demonstrate that microglia participate in formalin-induced acute sustained pain behaviors by amplifying neuronal activity in the spinal dorsal horn. |
2022-10-27 |
2023-08-14 |
mouse |
| Masatake Fujimur. Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats. Toxicology letters. 2022-10-16. PMID:36244566. |
our recent study using minamata disease model rats demonstrated that mehg-mediated neurodegeneration in the sensory nervous system may induce inflammatory microglia production in the dorsal horn of the spinal cord and subsequent somatosensory cortical rewiring, leading to neuropathic pain. |
2022-10-16 |
2023-08-14 |
rat |
| Masatake Fujimur. Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats. Toxicology letters. 2022-10-16. PMID:36244566. |
in this model, fasudil significantly suppressed nerve injury-induced inflammatory microglia production in the dorsal horn of the spinal cord and prevented subsequent somatosensory cortical rewiring. |
2022-10-16 |
2023-08-14 |
rat |
| Xuan Lu, Lunhao Chen, Chao Jiang, Kelei Cao, Zhihua Gao, Yue Wan. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain. 2022-09-28. PMID:36170151. |
we found that nerve root compression using degenerated np tissues can initiate remarkable and persistent sciatica, with increased and prolonged macrophage infiltration in dorsal root ganglia (drg) and significant activation of microglia in the spinal dorsal horn. |
2022-09-28 |
2023-08-14 |
mouse |
| Jiang Bian, Bangjian Zhang, Ying Zhang, Yunyun Tian, LiYin, WanyunZo. FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-γ/NF-κB Signaling. Neuroscience. 2022-08-07. PMID:35934252. |
immunofluorescence staining and western blot detection revealed that fgf 10 expression was upregulated in the ipsilateral spinal dorsal horn of spared nerve injury (sni) rat models and was mainly detected in neurons and microglia. |
2022-08-07 |
2023-08-14 |
rat |
| Jian Zhang, Xuan Zhang, Liren Li, Liying Bai, Yan Gao, Yin Yang, Li Wang, Yiming Qiao, Xueli Wang, Ji-Tian X. Activation of Double-Stranded RNA-Activated Protein Kinase in the Dorsal Root Ganglia and Spinal Dorsal Horn Regulates Neuropathic Pain Following Peripheral Nerve Injury in Rats. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-06-02. PMID:35655111. |
in the dorsal horn, p-pkr was located in neuronal cells, astrocytes, and microglia. |
2022-06-02 |
2023-08-14 |
rat |
| Dylan Maixner, David Christy, Lingwei Kong, Viacheslav Viatchenko-Karpinski, Ashley Horner, Shelley Hooks, Han-Rong Wen. Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord. Molecular pain. 2022-06-01. PMID:35647699. |
lancl2 is expressed only in microglia in the spinal dorsal horn. |
2022-06-01 |
2023-08-13 |
rat |
| Dylan Maixner, David Christy, Lingwei Kong, Viacheslav Viatchenko-Karpinski, Ashley Horner, Shelley Hooks, Han-Rong Wen. Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord. Molecular pain. 2022-06-01. PMID:35647699. |
pre-emptive treatment with aba attenuates activation of microglia and astrocytes, erk activity, and tnf□ protein abundance in the dorsal horn in rats with psnl. |
2022-06-01 |
2023-08-13 |
rat |
| Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu, Song Ca. Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn. Journal of neuroinflammation. vol 19. issue 1. 2022-05-27. PMID:35624514. |
activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn. |
2022-05-27 |
2023-08-13 |
mouse |
| Shannon Tansley, Ning Gu, Alba Ureña Guzmán, Weihua Cai, Calvin Wong, Kevin Lister, Einer Muñoz-Pino, Noosha Yousefpour, R Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G Gkogkas, James W Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S Mogil, Arkady Khoutorsk. Microglia-mediated degradation of perineuronal nets promotes pain. Science (New York, N.Y.). 2022-05-26. PMID:35617374. |
activation of microglia in the spinal cord dorsal horn following peripheral nerve injury contributes to the development of pain hypersensitivity. |
2022-05-26 |
2023-08-13 |
Not clear |