| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shannon Tansley, Ning Gu, Alba Ureña Guzmán, Weihua Cai, Calvin Wong, Kevin Lister, Einer Muñoz-Pino, Noosha Yousefpour, R Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G Gkogkas, James W Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S Mogil, Arkady Khoutorsk. Microglia-mediated degradation of perineuronal nets promotes pain. Science (New York, N.Y.). 2022-05-26. PMID:35617374. |
we discovered that following peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (pnns), in lamina i of the spinal cord dorsal horn. |
2022-05-26 |
2023-08-13 |
Not clear |
| Qin Qingguang, Chen Zujiang, Fan Weimin, L I Junhua, Liao Liqing, L I Yika. Hyperpolarization-activated cyclic nucleotide-gated 2 contributes to electroacupuncture analgesia on lumbar disc herniation-induced radicular pain through activation of microglia in spinal dorsal horn. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 42. issue 3. 2022-05-24. PMID:35610006. |
hyperpolarization-activated cyclic nucleotide-gated 2 contributes to electroacupuncture analgesia on lumbar disc herniation-induced radicular pain through activation of microglia in spinal dorsal horn. |
2022-05-24 |
2023-08-13 |
Not clear |
| YuShan Tu, Milind M Muley, Simon Beggs, Michael W Salte. Microglia-independent peripheral neuropathic pain in male and female mice. Pain. 2022-04-06. PMID:35384869. |
the dominant view in the field of pain is that peripheral neuropathic pain is driven by microglia in the somatosensory processing region of the spinal dorsal horn. |
2022-04-06 |
2023-08-13 |
mouse |
| Donghwi Park, Min Cheol Chan. The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review. Journal of Yeungnam medical science. 2022-04-06. PMID:35385898. |
in addition, deactivation of microglia at the level of the spinal dorsal horn, reduction of proinflammatory cytokines, increased endogenous opioid precursor messenger ribonucleic acid, enhancement of noradrenergic and serotonergic descending pain inhibitory pathways, suppression of excitation of c-afferent fibers, and microscopic damage of nociceptive c- and a-delta fibers have been found to contribute to pain reduction after prf application. |
2022-04-06 |
2023-08-13 |
Not clear |
| Danny Mortensen, Maria Soendergaard Thoefner, Joergen Steen Agerholm, Lasse Slumstrup, Troels Staehelin Jensen, Ole Jannik Bjerrum, Mette Berendt, Jens Randel Nyengaar. Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching. Pain. 2022-03-30. PMID:35353770. |
significant changes in cell number density were not found for astrocytes or microglia, suggesting that the dogs represented cases of end-stage syringomyelia and thus could not reveal astrogliosis and microgliosis, which may be involved in the early phases of syrinx development and phantom scratch.the present relationship between clinical findings and dorsal horn and pain pathway pathology in ckcs suggests that these dogs may be of interest as a supplement to experimental model pain research. |
2022-03-30 |
2023-08-13 |
Not clear |
| Rita Silva, Marzia Malcangi. Fractalkine/CX Frontiers in pain research (Lausanne, Switzerland). vol 2. 2022-03-17. PMID:35295489. |
specifically, following peripheral nerve injury, microglia, which are cns resident immune cells, respond to the activity of the first pain synapse in the dorsal horn of spinal cord and also to neuronal activity in higher centres in the brain. |
2022-03-17 |
2023-08-13 |
Not clear |
| Baorui Xing, Nana Feng, Juan Zhang, Yunmei Li, Xiuxiu Hou, Hao Wu, Wendong Liu, Guangpu Ha. Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats. Journal of neurophysiology. 2022-01-05. PMID:34986062. |
the microglia and astrocytes activation and proliferation markers in the spinal dorsal horn were detected with real-time pcr and immunofluorescence staining. |
2022-01-05 |
2023-08-13 |
rat |
| Baorui Xing, Nana Feng, Juan Zhang, Yunmei Li, Xiuxiu Hou, Hao Wu, Wendong Liu, Guangpu Ha. Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats. Journal of neurophysiology. 2022-01-05. PMID:34986062. |
pcn alleviated hip fracture-induced hind paw nociceptive (allodynia and unweighting) and vascular changes (warmth and thickness) in aged rats with diminished microglia and astrocytes activation and proliferation in the spinal dorsal horn. |
2022-01-05 |
2023-08-13 |
rat |
| Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian X. KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34464689. |
double immunofluorescence staining revealed that the kdm6b expressed in myelinated a- and unmyelinated c-fibers in the drg; and located in neuronal cells, astrocytes, and microglia in the dorsal horn. |
2021-12-09 |
2023-08-13 |
rat |
| Pascale Vergne-Salle, Philippe Berti. Chronic pain and neuroinflammation. Joint bone spine. vol 88. issue 6. 2021-11-22. PMID:34022418. |
these afferent fibers release neurotransmitters in the dorsal root ganglion and dorsal horn of the spinal cord, capable of activating microglia, which are the local immune cells. |
2021-11-22 |
2023-08-13 |
Not clear |
| Sungkun Chun, Jun-Ho Lee, Seo-Yeon Yoon, Young-Bae Kwo. The Peripheral Role of CCL2 in the Anti-Nociceptive Effect of Sigma-1 Receptor Antagonist BD1047 on Inflammatory Hyperalgesia in Rats. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769165. |
single treatment of bd1047 before intraplantar injection of zymosan in rats significantly reduced thermal hyperalgesia and mechanical hyperalgesia, as well as ccl2 expression in drg neurons and microglia activation in the spinal dorsal horn. |
2021-11-18 |
2023-08-13 |
rat |
| Jian Wang, Xiao-Chen Wu, Ming-Ming Zhang, Jia-Hao Ren, Yi Sun, Jing-Zhen Liu, Xi-Qiang Wu, Si-Yi He, Yun-Qing Li, Jin-Bao Zhan. Spinal cord stimulation reduces cardiac pain through microglial deactivation in rats with chronic myocardial ischemia. Molecular medicine reports. vol 24. issue 6. 2021-11-11. PMID:34608504. |
moreover, scs inhibited cmi‑induced spinal expression of phosphorylated‑p38 mapk, which was specifically colocalized with the spinal dorsal horn microglia rather than astrocytes and neurons. |
2021-11-11 |
2023-08-13 |
rat |
| Jia Sun, Ya-Qun Zhou, Bing-Yang Xu, Jia-Yan Li, Long-Qing Zhang, Dan-Yang Li, Shuang Zhang, Jia-Yi Wu, Shao-Jie Gao, Da-Wei Ye, Wei Me. STING/NF-κB/IL-6-Mediated Inflammation in Microglia Contributes to Spared Nerve Injury (SNI)-Induced Pain Initiation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-11-02. PMID:34727296. |
early but not the late intrathecal injection of c-176 attenuated sni-induced pain hypersensitivity, microglia activation, proinflammatory factors, and phosphorylated jak2/stat3 in the spinal cord dorsal horn, and the analgesic effect of c-176 was greatly abolished by recombinant il-6 following sni. we provided evidence clarifying dsdna mediated activation of microglia sting signaling pathway, after which promoting expression of proinflammatory cytokines that are required for hyperalgesia initiation in the spinal cord dorsal horn of sni model. |
2021-11-02 |
2023-08-13 |
Not clear |
| Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka, Norikazu Kiguch. Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice. Cells. vol 10. issue 4. 2021-10-20. PMID:33921365. |
it is important to investigate the sex-dependent roles of microglia in pain hypersensitivity as reactive microglia within the spinal dorsal horn (dh) have been reported to be pivotal in neuropathic pain induction in male rodents upon nerve injury. |
2021-10-20 |
2023-08-13 |
mouse |
| Yuyin Zheng, Ye Zhou, Qiaoyun Wu, Jingjing Yue, Xinwang Ying, Sisi Li, Xinfa Lou, Guanhu Yang, Wenzhan Tu, Kecheng Zhou, Songhe Jian. Effect of electroacupuncture on the expression of P2 × 4, GABAA γ 2 and long-term potentiation in spinal cord of rats with neuropathic pain. Brain research bulletin. vol 162. 2021-09-29. PMID:32428626. |
to observe the impacts of electroacupuncture (ea) stimulation at "zusanli and kunlun points" on spinal dorsal horn microglia activation in l5 spinal nerve ligation (snl) rats and bndf, p2 × 4 and gabaaγ2, and the changes in spinal dorsal horn synaptic plasticity in model rats. |
2021-09-29 |
2023-08-13 |
rat |
| Karli Montague-Cardoso, Marzia Malcangi. Changes in blood-spinal cord barrier permeability and neuroimmune interactions in the underlying mechanisms of chronic pain. Pain reports. vol 6. issue 1. 2021-09-29. PMID:33981925. |
in the spinal cord, not only do dorsal horn neurons partake in mechanistically important bidirectional communication with resident immune cells such as microglia, but in some cases, they can also partake in bidirectional crosstalk with immune cells, such as monocytes/macrophages, which have infiltrated into the spinal cord from the circulation. |
2021-09-29 |
2023-08-13 |
Not clear |
| Xiaobing Yu, Allan Basbaum, Zhonghui Gua. Contribution of colony-stimulating factor 1 to neuropathic pain. Pain reports. vol 6. issue 1. 2021-09-29. PMID:33981926. |
molecular and cellular interactions among spinal dorsal horn neurons and microglia, the resident macrophages of the central nervous system, contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury. |
2021-09-29 |
2023-08-13 |
Not clear |
| John R Bethea, Roman Fische. Role of Peripheral Immune Cells for Development and Recovery of Chronic Pain. Frontiers in immunology. vol 12. 2021-09-22. PMID:33692810. |
in particular, in neuropathic mice and humans, microglia are activated in the dorsal horn and peripheral immune cells infiltrate the nervous system to promote chronic neuroinflammation and contribute to the initiation and progression of cnp. |
2021-09-22 |
2023-08-13 |
mouse |
| Song I Kim, Juhee Shin, Quangdon Tran, Hyewon Park, Hyeok Hee Kwon, Nara Shin, Jeong-Ah Hwang, Hyo Jung Shin, Jiyong Lee, Won Hyung Lee, Sun Yeul Lee, Dong Woon Ki. Application of PLGA nanoparticles to enhance the action of duloxetine on microglia in neuropathic pain. Biomaterials science. vol 9. issue 18. 2021-09-16. PMID:34378557. |
dlx nps were localized to the spinal microglia and suppressed microglial activation, phosphorylation of p38/nf-κb-mediated pathways and the production of inflammatory cytokines in the spinal dorsal horn of snl rats. |
2021-09-16 |
2023-08-13 |
rat |
| Lital Livni, Brooke A Keating, Nathan T Fiore, Justin G Lees, David Goldstein, Gila Moalem-Taylo. Effects of combined chemotherapy and anti-programmed cell death protein 1 treatment on peripheral neuropathy and neuroinflammation in mice. Pain. 2021-08-18. PMID:34224494. |
mice treated with paclitaxel or cotherapy had increased macrophage presence in the drg, and all treated groups presented an altered expression of microglia markers in the dorsal horn of the spinal cord. |
2021-08-18 |
2023-08-13 |
mouse |