| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Changes in proinflammatory cytokines, neuropeptides, and microglia in an animal model of monosodium iodoacetate-induced hip osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 36. issue 11. 2019-05-09. PMID:29888808. |
mia rats also presented significantly more fg-labeled gap-43-ir drg neurons than the sham group on post-induction days 28, 42, and 56 (p < 0.05), and a significantly higher number of iba-1-ir microglia in the ipsilateral dorsal horn than the other groups, on post-induction days 28, 42, and 56. |
2019-05-09 |
2023-08-13 |
rat |
| Andrea J Mothe, Nardos G Tassew, Alirezha P Shabanzadeh, Romeo Penheiro, Robin J Vigouroux, Lili Huang, Christine Grinnell, Yi-Fang Cui, Emma Fung, Philippe P Monnier, Bernhard K Mueller, Charles H Tato. RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury. Scientific reports. vol 7. issue 1. 2019-05-01. PMID:28874746. |
rgma antibody also attenuated neuropathic pain responses, which was associated with fewer activated microglia and reduced cgrp expression in the dorsal horn caudal to the lesion. |
2019-05-01 |
2023-08-13 |
human |
| Kelsi N Dodds, Elizabeth A H Beckett, Susan F Evans, Mark R Hutchinso. Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain. Reproductive sciences (Thousand Oaks, Calif.). vol 26. issue 3. 2019-04-17. PMID:29730970. |
spinal cords (t13-s1) from female c57bl/6 mice with endometriosis-like lesions (endo) were imaged via fluorescent immunohistochemistry for the expression of glial fibrillary acidic protein (gfap; astrocytes) and cd11b (microglia) in the dorsal horn (n = 5). |
2019-04-17 |
2023-08-13 |
mouse |
| Louise S C Nicol, Peter Thornton, Jon P Hatcher, Colin P Glover, Carl I Webster, Matthew Burrell, Kessia Hammett, Clare A Jones, Matthew A Sleeman, Andrew Billinton, Iain Chessel. Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain. Pain. vol 159. issue 3. 2019-04-01. PMID:29351125. |
despite observing gm-csf receptor expression in microglia and astrocytes, the gliosis response in the dorsal horn was not altered in nerve injured knockout mice compared with wild-type littermate controls as evaluated by ionized calcium binding adapter molecule 1 (iba1) and glial fibrillary acidic protein, respectively. |
2019-04-01 |
2023-08-13 |
mouse |
| Yuying Tang, Lian Liu, Dan Xu, Wensheng Zhang, Yi Zhang, Jieshu Zhou, Wei Huan. Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29080683. |
accumulation of microglia occurs in the dorsal horn in the rodent model of chronic post ischemic pain (cpip), while the mechanism how microglia affects the development of persistent pain largely remains unknown. |
2019-03-12 |
2023-08-13 |
rat |
| Yuying Tang, Lian Liu, Dan Xu, Wensheng Zhang, Yi Zhang, Jieshu Zhou, Wei Huan. Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29080683. |
the accumulated microglia released bdnf, increased neuronal excitability in dorsal horn, and produced pain behaviors in the modeled rodents. |
2019-03-12 |
2023-08-13 |
rat |
| Kelly Bruno, Sarah A Woller, Yury I Miller, Tony L Yaksh, Mark Wallace, Graham Beaton, Krishnan Chakravarth. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. vol 159. issue 10. 2019-02-19. PMID:29889119. |
the receptor is located not only on inflammatory cells (meningeal and peripheral macrophages) but on neuraxial glia (microglia and astrocytes), schwann cells, fibroblasts, dorsal root ganglia, and dorsal horn neurons. |
2019-02-19 |
2023-08-13 |
Not clear |
| Stephanie Mouchbahani-Constance, L Stephen Lesperance, Hugues Petitjean, Albena Davidova, Amanda Macpherson, Steven A Prescott, Reza Sharif-Naein. Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors. Pain. vol 159. issue 11. 2019-02-19. PMID:29965829. |
the algogenic substance(s) are heat-labile peptides that cause neurogenic inflammation at the site of injection and induction of fos and microglia activation in the superficial layers of the dorsal horn. |
2019-02-19 |
2023-08-13 |
Not clear |
| Xiaojuan Sun, Hongxing Zhan. miR-451 elevation relieves inflammatory pain by suppressing microglial activation-evoked inflammatory response via targeting TLR4. Cell and tissue research. vol 374. issue 3. 2019-01-14. PMID:30069596. |
in this study, the expression of mir-451 was decreased in spinal dorsal horn and spinal microglia of complete freund's adjuvant (cfa)-induced inflammatory pain mice model. |
2019-01-14 |
2023-08-13 |
mouse |
| Chao Li, Wei Mao, Yun-Ke Huang, Zhi-Qi Zhao, Ning Ly. [Roles of CX3CR1 in mediation of post-incision induced mechanical pain hypersensitivity: Effects of acupuncture-combined anesthesia]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 3. 2019-01-04. PMID:29926064. |
cx3cr1 was mainly expressed in microglia in the spinal cord dorsal horn, and its protein level was significantly increased at 3 d after incision compared with that of naïve c57bl/6j mice. |
2019-01-04 |
2023-08-13 |
mouse |
| Yi-Mei Ma, Chuan-da Li, Ya-Bing Zhu, Xia Xu, Jun Li, Hong Ca. [The mechanism of RvD1 alleviates type 2 diabetic neuropathic pain by influencing microglia polarization in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 33. issue 3. 2018-11-06. PMID:29931947. |
to study the relationship between microglia polarization in the spinal dorsal horn and type 2 diabetic neuropathic pain (dnp). |
2018-11-06 |
2023-08-13 |
rat |
| Tao Yang, Sujuan Du, Xianguo Liu, Xijiu Ye, Xuhong We. Withdrawal from spinal application of remifentanil induces long-term potentiation of c-fiber-evoked field potentials by activation of Src family kinases in spinal microglia. Neurochemical research. vol 43. issue 8. 2018-10-26. PMID:29959648. |
remifentanil withdrawal could activate src family kinases (sfks) in microglia, and upregulate the expression of tumor necrosis factor alpha (tnfα) in spinal dorsal horn. |
2018-10-26 |
2023-08-13 |
rat |
| Keita Kohno, Junko Kitano, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsud. Temporal Kinetics of Microgliosis in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rodents. Biological & pharmaceutical bulletin. vol 41. issue 7. 2018-10-24. PMID:29962405. |
previous studies have implicated activated microglia in the spinal dorsal horn (sdh) as key cellular intermediaries in neuropathic pain. |
2018-10-24 |
2023-08-13 |
Not clear |
| Satoru Koyanagi, Naoki Kusunose, Marie Taniguchi, Takahiro Akamine, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Kohro, Naoya Matsunaga, Makoto Tsuda, Michael W Salter, Kazuhide Inoue, Shigehiro Ohd. Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia. Nature communications. vol 7. 2018-09-05. PMID:27739425. |
diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of atp in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. |
2018-09-05 |
2023-08-13 |
mouse |
| Takahiro Masuda, Yui Ozono, Satsuki Mikuriya, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Ken Iwatsuki, Hisayuki Uneyama, Reiko Ichikawa, Michael W Salter, Makoto Tsuda, Kazuhide Inou. Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain. Nature communications. vol 7. 2018-09-04. PMID:27515581. |
these phenotypes were recapitulated in mice with specific deletion of vnut in spinal dorsal horn (sdh) neurons, but not in mice lacking vnut in primary sensory neurons, microglia or astrocytes. |
2018-09-04 |
2023-08-13 |
mouse |
| Laura Micheli, Elena Lucarini, Francesca Corti, Roberto Ciccocioppo, Girolamo Calò, Anna Rizzi, Carla Ghelardini, Lorenzo Di Cesare Mannell. Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad? European journal of pharmacology. vol 823. 2018-08-29. PMID:29378191. |
immunohistochemical analysis of the dorsal horn of the spinal cord of morphine tolerant nop(+/+) rats showed an increased number of iba1- and gfap-positive cells (microglia and astrocytes, respectively). |
2018-08-29 |
2023-08-13 |
rat |
| Jee Youn Lee, Hae Young Choi, Bong-Gun Ju, Tae Young Yun. Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 7. 2018-08-06. PMID:29653184. |
both microglia and astrocyte activation in the lamina i and ii of l4-5 dorsal horn was also inhibited by 17β-estradiol. |
2018-08-06 |
2023-08-13 |
rat |
| Xiao-Wen Meng, Jian-Ling Gao, Jian-Ling Zuo, Li-Na Wang, Si-Lan Liu, Xiao-Hong Jin, Ming Yao, Michael Namak. Toll-like receptor-4/p38 MAPK signaling in the dorsal horn contributes to P2X4 receptor activation and BDNF over-secretion in cancer induced bone pain. Neuroscience research. vol 125. 2018-08-03. PMID:28668500. |
our previous research suggested that the p2x4 receptor (p2x4r) expression in microglia was involved in the activation of toll-like receptor-4 (tlr4) in the dorsal horn in the rat model of cancer induced bone pain (cibp). |
2018-08-03 |
2023-08-13 |
rat |
| Yangliang Huang, Yongyong Li, Xiongxiong Zhong, Yuming Hu, Pan Liu, Yuanshu Zhao, Zhen Deng, Xianguo Liu, Shaoyu Liu, Yi Zhon. Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation. Molecular pain. vol 13. 2018-07-23. PMID:28952414. |
furthermore, we found that the expression of ionized calcium-binding adapter molecule 1 (marker of microglia), tumor necrosis factor-α, interleukin 1 -β in spinal dorsal horn was increased in rats with nucleus pulposus. |
2018-07-23 |
2023-08-13 |
rat |
| Jian Qi, Chen Chen, Qing-Xi Meng, Yan Wu, Haitao Wu, Ting-Bao Zha. Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia. Scientific reports. vol 6. 2018-06-21. PMID:27995982. |
crosstalk between activated microglia and neurons in the spinal dorsal horn contributes to stress-induced hyperalgesia. |
2018-06-21 |
2023-08-13 |
Not clear |