| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norimitsu Morioka, Fang Fang Zhang, Yoki Nakamura, Tomoya Kitamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice. Brain, behavior, and immunity. vol 49. 2016-06-07. PMID:26116449. |
in mice, cx43 is mainly expressed in astrocytes, not neurons or microglia, in the spinal dorsal horn. |
2016-06-07 |
2023-08-13 |
mouse |
| Víctor M López-Álvarez, Laura Modol, Xavier Navarro, Stefano Cobianch. Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury. Pain. vol 156. issue 9. 2016-05-17. PMID:26090759. |
itr normalized nkcc1 and boosted kcc2 expression, together with a significant reduction of microgliosis in l3-l5 dorsal horn, and a reduction of bdnf expression in microglia at 1 to 2 weeks postinjury. |
2016-05-17 |
2023-08-13 |
rat |
| William Galbavy, Martin Kaczocha, Michelino Puopolo, Lixin Liu, Mario J Rebecch. Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. PloS one. vol 10. issue 8. 2016-05-10. PMID:26241743. |
immunofluorescence images of dorsal horn microglia from middle-aged naïve or sham rats were typically hypertrophic with mostly thickened, de-ramified processes, similar to microglia following cci. |
2016-05-10 |
2023-08-13 |
rat |
| Nian Liu, Kai-Kai Zang, Yu-Qiu Zhan. [Activation of microglia and astrocytes in different spinal segments after peripheral nerve injury in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 67. issue 6. 2016-05-03. PMID:26701632. |
however, little is known about the expression patterns of activated microglia and astrocytes in the spinal dorsal horn. |
2016-05-03 |
2023-08-13 |
mouse |
| Yuya Yamamoto, Ryuji Terayama, Noriko Kishimoto, Kotaro Maruhama, Masahide Mizutani, Seiji Iida, Tomosada Sugimot. Activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain. Neurochemical research. vol 40. issue 5. 2016-04-01. PMID:25784443. |
activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain. |
2016-04-01 |
2023-08-13 |
Not clear |
| Yuya Yamamoto, Ryuji Terayama, Noriko Kishimoto, Kotaro Maruhama, Masahide Mizutani, Seiji Iida, Tomosada Sugimot. Activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain. Neurochemical research. vol 40. issue 5. 2016-04-01. PMID:25784443. |
the activation of microglia in the spinal dorsal horn following peripheral nerve injury has been reported previously, and this change has been proposed to contribute to the development of a neuropathic pain state. |
2016-04-01 |
2023-08-13 |
Not clear |
| Qian Song, Ming-Gang Liu, Min Zhu. Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Molecular pain. vol 11. 2016-03-08. PMID:25933605. |
it has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. |
2016-03-08 |
2023-08-13 |
mouse |
| Yan Shen, Zhi-Jun Zhang, Ming-Di Zhu, Bao-Chun Jiang, Tian Yang, Yong-Jing Ga. Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice. Neurobiology of disease. vol 79. 2016-03-02. PMID:25956228. |
immunostaining showed that ho-1 was mainly expressed in neurons of spinal cord dorsal horn in naïve animals, but induced in astrocytes and microglia after vincristine injection. |
2016-03-02 |
2023-08-13 |
mouse |
| Wu-Fu Chen, Shi-Ying Huang, Chang-Yi Liao, Chun-Sung Sung, Jyh-Yih Chen, Zhi-Hong We. The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent. Biomaterials. vol 53. 2016-01-19. PMID:25890701. |
furthermore, cci-mediated activation of microglia and astrocytes in the dorsal horn of the lumbar spinal cord were decreased by pcd-1. |
2016-01-19 |
2023-08-13 |
rat |
| Lorenzo Di Cesare Mannelli, Francesca Corti, Laura Micheli, Matteo Zanardelli, Carla Ghelardin. Delay of morphine tolerance by palmitoylethanolamide. BioMed research international. vol 2015. 2015-12-28. PMID:25874232. |
pea prevented both microglia and astrocyte cell number increase induced by morphine in the dorsal horn; on the contrary, the morphine-dependent increase of spinal tnf-α levels was not modified by pea. |
2015-12-28 |
2023-08-13 |
rat |
| Qian-Jun Li, Zhen Wang, Yong-Xing Yao, Shen-Hui Jin, Mei-Zi Qian, Na-Na Li, Ya-Nan Wang, Ya-Wen Zhang, Bin-Yu Chen, Dan-Yun Jia, Ying Shen, Jun-Lu Wan. Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw. Neurochemical research. vol 40. issue 3. 2015-12-04. PMID:25547463. |
furthermore, the number of activated microglia in spinal dorsal horn increased in line with pain hypersensitivity. |
2015-12-04 |
2023-08-13 |
mouse |
| Lorenzo Di Cesare Mannelli, Lorenzo Cinci, Laura Micheli, Matteo Zanardelli, Alessandra Pacini, J Michael McIntosh, Carla Ghelardin. α-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement. Pain. vol 155. issue 10. 2015-11-24. PMID:25008370. |
in the dorsal horn of the spinal cord, rgia prevented cci-induced activation of microglia and astrocytes. |
2015-11-24 |
2023-08-13 |
rat |
| Iriana Galan-Arriero, Gerardo Avila-Martin, Agueda Ferrer-Donato, Julio Gomez-Soriano, Elisabeth Bravo-Esteban, Julian Taylo. Oral administration of the p38α MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury. Pain. vol 155. issue 10. 2015-11-24. PMID:25180015. |
the effect of ur13870, a p38α mapk inhibitor, on microglia expression in the anterior cingulate cortex (acc) and spinal dorsal horn was addressed after t9 contusion spinal cord injury (sci) in the rat, in addition to behavioral testing of pain-related aversion and anxiety. |
2015-11-24 |
2023-08-13 |
rat |
| Cayo Almeida, Aline DeMaman, Ricardo Kusuda, Flaviane Cadetti, Maria Ida Ravanelli, André L Queiroz, Thais A Sousa, Sonia Zanon, Leonardo R Silveira, Guilherme Luca. Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain. Pain. vol 156. issue 3. 2015-11-02. PMID:25687543. |
finally, prolonged swim exercise reversed astrocyte and microglia hyperactivity in the dorsal horn after nerve lesion, which remained normalized after training cessation. |
2015-11-02 |
2023-08-13 |
mouse |
| Hideaki Matsuo, Kenzo Uchida, Hideaki Nakajima, Alexander Rodriguez Guerrero, Shuji Watanabe, Naoto Takeura, Daisuke Sugita, Seiichiro Shimada, Terumasa Nakatsuka, Hisatoshi Bab. Early transcutaneous electrical nerve stimulation reduces hyperalgesia and decreases activation of spinal glial cells in mice with neuropathic pain. Pain. vol 155. issue 9. 2015-10-26. PMID:25010326. |
early tens decreased p-p38 within microglia (p<0.05), the expression levels of protein kinase c (pkc-γ), and phosphorylated anti-phospho-cyclic amp response element-binding protein (p-creb) in the superficial spinal dorsal horn neurons (p<0.05), mitogen-activated protein (map) kinases, and proinflammatory cytokines, and increased the expression levels of opioid receptors (p<0.05). |
2015-10-26 |
2023-08-13 |
mouse |
| Xiao-Hui Zhao, Ting Zhang, Yun-Qing L. The up-regulation of spinal Toll-like receptor 4 in rats with inflammatory pain induced by complete Freund's adjuvant. Brain research bulletin. vol 111. 2015-10-22. PMID:25592618. |
the results show that cfa induces significant pain hypersensitivity and paw edema as well as spinal dorsal horn (sdh) microglia activation with the increased expressions of ox-42 and tlr4 during the inflammatory pain, respectively. |
2015-10-22 |
2023-08-13 |
rat |
| Nan-Fu Chen, Shi-Ying Huang, Ching-Hsiang Lu, Chun-Lin Chen, Chien-Wei Feng, Chun-Hong Chen, Han-Chun Hung, Yen-You Lin, Ping-Jyun Sung, Chun-Sung Sung, San-Nan Yang, Hui-Min David Wang, Yu-Chia Chang, Jyh-Horng Sheu, Wu-Fu Chen, Zhi-Hong We. Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-β1 in neuropathic rats. Marine drugs. vol 12. issue 7. 2015-10-12. PMID:24979268. |
flexibilide significantly inhibited cci-induced activation of microglia and astrocytes, as well as the upregulated proinflammatory enzyme, inducible nitric oxide synthase, in the ipsilateral spinal dorsal horn. |
2015-10-12 |
2023-08-13 |
rat |
| F Guida, R Lattanzi, S Boccella, D Maftei, R Romano, V Marconi, G Balboni, S Salvadori, M A Scafuro, V de Novellis, L Negri, S Maione, L Luong. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacological research. vol 91. 2015-10-09. PMID:25434589. |
emerging evidence indicates that the enhanced activity of dorsal horn neurons requires communication with glia and microglia, cells that are physiologically involved in neuronal wellbeing. |
2015-10-09 |
2023-08-13 |
mouse |
| Xuehai Guan, Qiaochu Fu, Bingrui Xiong, Zhenpeng Song, Bin Shu, Huilian Bu, Bing Xu, Anne Manyande, Fei Cao, Yuke Tia. Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25919859. |
our results showed that pi3kγ and its downstream target pakt were up-regulated in a time-dependent manner and distributed predominately in the superficial layers of the spinal dorsal horn neurons, astrocytes and a minority of microglia, and were colocalized with non-peptidergic, calcitonin gene-related peptide-peptidergic, and a-type neurons in dorsal root ganglion ipsilateral to tumor cell inoculation in rats. |
2015-10-09 |
2023-08-13 |
rat |
| Tian-tian Zhou, Jing-ru Wu, Zi-yang Chen, Zhen-xiu Liu, Bei Mia. Effects of dexmedetomidine on P2X4Rs, p38-MAPK and BDNF in spinal microglia in rats with spared nerve injury. Brain research. vol 1568. 2015-08-21. PMID:24792496. |
thus, dex could attenuate the neuropathic pain in sni rats, of which the mechanism might be related to the down-expressed p2x4rs, p-p38 and bdnf in microglia of spinal dorsal horn. |
2015-08-21 |
2023-08-13 |
rat |