| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Matsui, T Ohgomori, T Natori, K Miyamoto, S Kusunoki, K Sakamoto, N Ishiguro, S Imagama, K Kadomats. Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis. Cell death & disease. vol 4. 2014-06-12. PMID:24309933. |
ks was positive in 50% microglia in the ventral horn and 20% in the dorsal horn. |
2014-06-12 |
2023-08-12 |
rat |
| Na Li, Grewo Lim, Lucy Chen, Michael F McCabe, Hyangin Kim, Shuzhuo Zhang, Jianren Ma. Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. Brain research. vol 1535. 2014-05-08. PMID:23998984. |
we found that (1) yap was mainly expressed on cgrp- and ib4-immunoreactive primary afferent nerve terminals without noticeable expression on glial cells, whereas taz was mainly expressed on spinal cord second order neurons as well as microglia; (2) upregulation of yap and taz expression followed two distinct temporal patterns after cci, such that the highest expression of yap and taz was on day 14 and day 1 after cci, respectively; (3) there were also unique topographic patterns of yap and taz distribution in the spinal cord dorsal horn consistent with their distinctive association with primary afferents and second order neurons; (4) changes in the yap expression were selectively induced by cci but not cfa-induced hindpaw inflammation; and (5) the number of nuclear profiles of taz expression was significantly increased after cci, indicating translocation of taz from the cytoplasma to nucleus. |
2014-05-08 |
2023-08-12 |
rat |
| Yu-Ying Li, Xu-Hong Wei, Zhen-He Lu, Jin-Sheng Chen, Qiao-Dong Huang, Qing-Juan Gon. Src/p38 MAPK pathway in spinal microglia is involved in mechanical allodynia induced by peri-sciatic administration of recombinant rat TNF-α. Brain research bulletin. vol 96. 2014-03-19. PMID:23680572. |
these results suggest that activation of the sfks/p38 mapk pathway in microglia and subsequent tnf-α expression in the spinal dorsal horn may contribute to the mechanical hyperalgesic state induced by peri-sciatic administered rrtnf. |
2014-03-19 |
2023-08-12 |
rat |
| Ryutaro Iwasaki, Yusuke Matsuura, Seiji Ohtori, Takane Suzuki, Kazuki Kuniyoshi, Kazuhisa Takahash. Activation of astrocytes and microglia in the C3-T4 dorsal horn by lower trunk avulsion in a rat model of neuropathic pain. The Journal of hand surgery. vol 38. issue 5. 2014-02-11. PMID:23528426. |
activation of astrocytes and microglia in the c3-t4 dorsal horn by lower trunk avulsion in a rat model of neuropathic pain. |
2014-02-11 |
2023-08-12 |
rat |
| Makoto Tsuda, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Microglial regulation of neuropathic pain. Journal of pharmacological sciences. vol 121. issue 2. 2014-02-04. PMID:23337437. |
after peripheral nerve injury, microglia transform to reactive states through the expression of various genes such as cell-surface receptors (including purinergic receptors) and proinflammatory cytokines that enhance synaptic transmission in dorsal horn neurons. |
2014-02-04 |
2023-08-12 |
Not clear |
| J Morgenweck, R B Griggs, R R Donahue, J E Zadina, B K Taylo. PPARγ activation blocks development and reduces established neuropathic pain in rats. Neuropharmacology. vol 70. 2013-11-26. PMID:23415633. |
intraperitoneal pioglitazone significantly reduced the nerve injury-induced up-regulation of cd11b, gfap, and p-p38 in the dorsal horn, indicating a mechanism of action involving spinal microglia and/or astrocyte activation. |
2013-11-26 |
2023-08-12 |
rat |
| Hee Kyung Cho, Yun Woo Cho, Eun Hyuk Kim, Menno E Sluijter, Se Jin Hwang, Sang Ho Ah. Changes in pain behavior and glial activation in the spinal dorsal horn after pulsed radiofrequency current administration to the dorsal root ganglion in a rat model of lumbar disc herniation: laboratory investigation. Journal of neurosurgery. Spine. vol 19. issue 2. 2013-10-17. PMID:23746090. |
using immunohistochemistry methods in the dorsal horn of a rat model of lumbar disc herniation, the authors investigated the effects of pulsed radiofrequency (prf) current administration to the dorsal root ganglion (drg) on pain-related behavior and activation of microglia, astrocytes, and mitogen-activated protein kinase. |
2013-10-17 |
2023-08-12 |
rat |
| Chun-Sung Sung, Chen-Hwan Cherng, Zhi-Hong Wen, Wen-Kuei Chang, Shi-Ying Huang, Shinn-Long Lin, Kwok-Hon Chan, Chih-Shung Won. Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL-1β-induced thermal hyperalgesic rats. Glia. vol 60. issue 12. 2013-08-05. PMID:22972308. |
the results demonstrated that intrathecal il-1β activated microglia and astrocytes, but not neurons, in the dorsal horn of the lumbar spinal cord, as evidenced by morphological changes and increased immunoreactivity, phosphorylated p38 (p-p38) mapk, and inos expression; the activation of microglia and astrocytes peaked at 30 min and lasted for 6 h. the immunoreactivities of microglia and astrocytes were significantly increased at 30 min (6.6- and 2.7-fold, respectively) and 6 h (3.3- and 4.0-fold, respectively) following il-1β injection, as compared with saline controls at 30 min (all p < 0.01). |
2013-08-05 |
2023-08-12 |
rat |
| Alessandra Cifra, Graciela L Mazzone, Francesca Nani, Andrea Nistri, Miranda Mladini. Postnatal developmental profile of neurons and glia in motor nuclei of the brainstem and spinal cord, and its comparison with organotypic slice cultures. Developmental neurobiology. vol 72. issue 8. 2013-05-15. PMID:22021114. |
in the spinal gray matter, the highest neuronal density was in the dorsal horn (>80%) and the lowest in the ventral horn (≤57%) with inverse astroglia numbers and few microglia. |
2013-05-15 |
2023-08-12 |
rat |
| Guihua Chen, Kumiko Tanabe, Fumi Yanagidate, Yasuhiko Kawasaki, Lianxi Zhang, Shuji Dohi, Hiroki Iid. Intrathecal endothelin-1 has antinociceptive effects in rat model of postoperative pain. European journal of pharmacology. vol 697. issue 1-3. 2013-05-02. PMID:23041152. |
endothelin-1 decreased the incision-induced increase in the numbers of phosphorylated erk-positive neurons in drg and activated microglia in the dorsal horn, without affecting the numbers of phosphorylated erk-positive neurons in the dorsal horn. |
2013-05-02 |
2023-08-12 |
rat |
| Satoshi Imai, Daigo Ikegami, Akira Yamashita, Toshikazu Shimizu, Michiko Narita, Keiichi Niikura, Masaharu Furuya, Yasuhisa Kobayashi, Kazuhiko Miyashita, Daiki Okutsu, Akira Kato, Atsushi Nakamura, Akiko Araki, Kazuo Omi, Masaya Nakamura, Hirotaka James Okano, Hideyuki Okano, Takayuki Ando, Hideyuki Takeshima, Toshikazu Ushijima, Naoko Kuzumaki, Tsutomu Suzuki, Minoru Narit. Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain : a journal of neurology. vol 136. issue Pt 3. 2013-04-23. PMID:23364351. |
a robust increase in mcp-3 protein, which lasted for up to 2 weeks after surgery, in the dorsal horn of the spinal cord of mice with partial sciatic nerve ligation was seen mostly in astrocytes, but not microglia or neurons. |
2013-04-23 |
2023-08-12 |
mouse |
| Xu-Hong Wei, Xiao-Dong Na, Guang-Jie Liao, Qiu-Ying Chen, Yu Cui, Feng-Ying Chen, Yong-Yong Li, Ying Zang, Xian-Guo Li. The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection. Experimental neurology. vol 241. 2013-04-08. PMID:23261764. |
double immunofluorescence stainings revealed that in drgs the increased immunoreactivity (ir) of il-6 was almost restricted in neuronal cells, while in the spinal dorsal horn il-6-ir up-regulated in both glial cells (astrocyte and microglia) and neurons. |
2013-04-08 |
2023-08-12 |
Not clear |
| Xu-Hong Wei, Xiao Wei, Feng-Ying Chen, Ying Zang, Wen-Jun Xin, Rui-Ping Pang, Yuan Chen, Jun Wang, Yong-Yong Li, Kai-Feng Shen, Li-Jun Zhou, Xian-Guo Li. The upregulation of translocator protein (18 kDa) promotes recovery from neuropathic pain in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 4. 2013-03-20. PMID:23345228. |
here, we report that tspo was upregulated in astrocytes and microglia in the ipsilateral spinal dorsal horn of rats following l5 spinal nerve ligation (l5 snl), lasting until the vanishing of the behavioral signs of neuropathic pain (∼50 d). |
2013-03-20 |
2023-08-12 |
rat |
| Meng-Ling Chen, Hong Cao, Yu-Xia Chu, Long-Zhen Cheng, Ling-Li Liang, Yu-Qiu Zhang, Zhi-Qi Zha. Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cord. The journal of pain. vol 13. issue 10. 2013-03-14. PMID:22968128. |
chronic morphine treatment induced an increase in the expression of interleukin (il)-18 by microglia, il-18 receptor (il-18r) by astrocytes, and protein kinase cγ (pkcγ) by neurons in the spinal dorsal horn, respectively, which was blocked by a p2x7r antagonist or targeting sirna. |
2013-03-14 |
2023-08-12 |
rat |
| Qi-Liang Mao-Ying, Xiao-Wei Wang, Chang-Jiang Yang, Xiu Li, Wen-Li Mi, Gen-Cheng Wu, Yan-Qing Wan. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats. Molecular brain. vol 5. 2013-03-11. PMID:22607655. |
nine days after walker 256 inoculation, a robust activation of both astrocytes and microglia in bilateral spinal dorsal horn was observed together with significant bilateral mechanical allodynia. |
2013-03-11 |
2023-08-12 |
rat |
| Hye J Jeon, Seung R Han, Min K Park, Kui Y Yang, Yong C Bae, Dong K Ah. A novel trigeminal neuropathic pain model: compression of the trigeminal nerve root produces prolonged nociception in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 2. 2013-01-21. PMID:22449477. |
in the medullary dorsal horn, phospho-p38 (p-p38) mitogen-activated protein kinase (mapk) was found to be exclusively expressed in the microglia on pod 14. |
2013-01-21 |
2023-08-12 |
rat |
| Toshiya Kuroi, Toshihiko Shimizu, Mamoru Shibata, Haruki Toriumi, Megumi Funakubo, Tatsuo Iwashita, Hitoshi Sato, Kenzo Koizumi, Norihiro Suzuk. Alterations in microglia and astrocytes in the trigeminal nucleus caudalis by repetitive TRPV1 stimulation on the trigeminal nociceptors. Neuroreport. vol 23. issue 9. 2012-10-17. PMID:22562048. |
trpv1 stimulation has been shown to lead to the activation of microglia and astrocytes in the dorsal horn of the spinal cord. |
2012-10-17 |
2023-08-12 |
Not clear |
| S Iwai, T Maeda, N Kiguchi, Y Kobayashi, Y Fukazawa, M Ozaki, S Kishiok. Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury. Drug discoveries & therapeutics. vol 2. issue 6. 2012-10-02. PMID:22504745. |
to test the possibility of a peroxisome proliferator activated receptor (ppar) γ agonist to treat neuropathic pain, we examined the effects of pioglitazone, a pparγ agonist, on tactile allodynia and expression of activated microglia in the dorsal horn of spinal cord using neuropathic pain model. |
2012-10-02 |
2023-08-12 |
mouse |
| S Iwai, T Maeda, N Kiguchi, Y Kobayashi, Y Fukazawa, M Ozaki, S Kishiok. Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury. Drug discoveries & therapeutics. vol 2. issue 6. 2012-10-02. PMID:22504745. |
moreover, on day 6, the number of activated microglia was significantly increased in the ipsilateral dorsal horn of mice. |
2012-10-02 |
2023-08-12 |
mouse |
| S Iwai, T Maeda, N Kiguchi, Y Kobayashi, Y Fukazawa, M Ozaki, S Kishiok. Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury. Drug discoveries & therapeutics. vol 2. issue 6. 2012-10-02. PMID:22504745. |
these results suggest that pparγ activation inhibits the development of tactile allodynia and the expression of activated microglia in the dorsal horn of spinal cord in mice with pslinduced peripheral nerve injury. |
2012-10-02 |
2023-08-12 |
mouse |