| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurence Daulhac, Violette Maffre, Christophe Mallet, Monique Etienne, Anne-Marie Privat, Aline Kowalski-Chauvel, Catherine Seva, Joseph Fialip, Alain Eschalie. Phosphorylation of spinal N-methyl-d-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful neuropathy. European journal of pain (London, England). vol 15. issue 2. 2011-05-06. PMID:20594879. |
phosphorylation of spinal n-methyl-d-aspartate receptor nr1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful neuropathy. |
2011-05-06 |
2023-08-12 |
rat |
| Li-Jun Zhou, Tao Yang, Xiao Wei, Yong Liu, Wen-Jun Xin, Yuan Chen, Rui-Ping Pang, Ying Zang, Yong-Yong Li, Xian-Guo Li. Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain, behavior, and immunity. vol 25. issue 2. 2011-05-04. PMID:20933591. |
following sni bdnf and trkb receptor were up-regulated mainly in dorsal horn neurons and in activated microglia, and p-sfks and p-p38 mapk were increased exclusively in microglia. |
2011-05-04 |
2023-08-12 |
rat |
| Li-Jun Zhou, Tao Yang, Xiao Wei, Yong Liu, Wen-Jun Xin, Yuan Chen, Rui-Ping Pang, Ying Zang, Yong-Yong Li, Xian-Guo Li. Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain, behavior, and immunity. vol 25. issue 2. 2011-05-04. PMID:20933591. |
thus, the increased bdnf/trkb signaling in spinal dorsal horn may contribute to neuropathic pain by activation of microglia following peripheral nerve injury and inhibition of sfks or p38 mapk may selectively inhibit microglia in spinal dorsal horn. |
2011-05-04 |
2023-08-12 |
rat |
| Shunji Kunori, Shinji Matsumura, Emiko Okuda-Ashitaka, Tayo Katano, Laurent P Audoly, Yoshihiro Urade, Seiji It. A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord. Glia. vol 59. issue 2. 2011-04-14. PMID:21125641. |
mice deficient in microsomal prostaglandin e synthase-1 impaired the activation of microglia and the nmda-nitric oxide (no) cascade in spinal neurons in the dorsal horn and did not exhibit mechanical allodynia after peripheral nerve injury. |
2011-04-14 |
2023-08-12 |
mouse |
| Takayuki Nakagawa, Shuji Kanek. Spinal astrocytes as therapeutic targets for pathological pain. Journal of pharmacological sciences. vol 114. issue 4. 2011-03-22. PMID:21081837. |
although astrocyte-to-neuron signals implicated in pathological pain is poorly understood, activated astrocytes, as well as microglia, produce proinflammatory cytokines and chemokines, which lead to adaptation of the dorsal horn neurons. |
2011-03-22 |
2023-08-12 |
Not clear |
| Christina A Christianson, Maripat Corr, Gary S Firestein, Anahita Mobargha, Tony L Yaksh, Camilla I Svensso. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. vol 151. issue 2. 2011-02-14. PMID:20739123. |
the superficial dorsal horn of arthritic mice displayed increased staining of microglia at early and late time points, but astrocyte staining increased only during the inflammatory phase. |
2011-02-14 |
2023-08-12 |
mouse |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
nerve injury-activated microglia engulf myelinated axons in a p2y12 signaling-dependent manner in the dorsal horn. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
however, several studies have implied a role for reactive microglia located in the dorsal horn in neuropathic pain. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
to clarify the roles of activated microglia in neuropathic pain, we investigated the interactions among microglia and other neural components in the dorsal horn using electron microscopy. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
microglia were more abundantly localized in layers ii-iii of the dorsal horn than in other areas, and some of them adhered to and engulfed both injured and uninjured myelinated axons. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
this microglial engulfment was rarely observed in the normal dorsal horn, and the number of microglia attached to myelinated axons was markedly increased on postoperative day 7 on the operated side. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
these results indicate that engulfment of myelinated axons by activated microglia via p2y12 signaling in the dorsal horn may be a critical event in the pathogenesis of neuropathic pain. |
2011-01-26 |
2023-08-12 |
Not clear |
| Yinyin Xia, Haiou Liu, Aiguo Shen, Yonghua Liu, Linlin Sun, Tao Tao, Qing Ke, Chun Chen. A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury. Neuromolecular medicine. vol 12. issue 3. 2011-01-13. PMID:19937403. |
double immunofluorescence staining showed ssecks immunoreactivity was mostly co-localized with neurons, partly with activated astrocytes and rarely with microglia in the superficial laminar of spinal dorsal horn. |
2011-01-13 |
2023-08-12 |
rat |
| S Matsumura, K Takagi, E Okuda-Ashitaka, J Lu, H Naritsuka, M Yamaguchi, S It. Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20673789. |
on the other hand, the activation and increase in number of microglia and astrocytes are restricted to the superficial layer of the dorsal horn, the central terminal of injured primary afferent fibers. |
2011-01-11 |
2023-08-12 |
mouse |
| Simon Beggs, Michael W Salte. Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0. Current opinion in neurobiology. vol 20. issue 4. 2011-01-06. PMID:20817512. |
the core signalling pathway is through p2x4 purinergic receptors on the microglia which, via the release of brain-derived neurotrophic factor, cause disinhibition of nociceptive dorsal horn neurons by raising intracellular chloride levels. |
2011-01-06 |
2023-08-12 |
Not clear |
| Lingli Liang, Zhiyong Wang, Ning Lü, Jiale Yang, Yuqiu Zhang, Zhiqi Zha. Involvement of nerve injury and activation of peripheral glial cells in tetanic sciatic stimulation-induced persistent pain in rats. Journal of neuroscience research. vol 88. issue 13. 2010-12-06. PMID:20544834. |
furthermore, reactive microglia and astrocytes were found in the spinal dorsal horn after tss. |
2010-12-06 |
2023-08-12 |
rat |
| Yi Zhong, Li-Jun Zhou, Wen-Jie Ren, Wen-Jun Xin, Yong-Yong Li, Tong Zhang, Xian-Guo Li. The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha. Brain, behavior, and immunity. vol 24. issue 6. 2010-10-08. PMID:20116424. |
the direction of synaptic plasticity mediated by c-fibers in spinal dorsal horn is decided by src-family kinases in microglia: the role of tumor necrosis factor-alpha. |
2010-10-08 |
2023-08-12 |
mouse |
| Yi Zhong, Li-Jun Zhou, Wen-Jie Ren, Wen-Jun Xin, Yong-Yong Li, Tong Zhang, Xian-Guo Li. The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha. Brain, behavior, and immunity. vol 24. issue 6. 2010-10-08. PMID:20116424. |
the results suggested that in spinal dorsal horn activation of sfks in microglia might control the direction of plastic changes at c-fiber synapses and tnf-alpha might be involved in the process. |
2010-10-08 |
2023-08-12 |
mouse |
| Donghoon Kim, Byunghyun You, Eun-Kyeong Jo, Sang-Kyou Han, Melvin I Simon, Sung Joong Le. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 33. 2010-09-27. PMID:20679217. |
nox2 expression was induced in dorsal horn microglia immediately after l5 spinal nerve transection (snt). |
2010-09-27 |
2023-08-12 |
mouse |
| James E Biggs, Van B Lu, Martin J Stebbing, Sridhar Balasubramanyan, Peter A Smit. Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization? Molecular pain. vol 6. 2010-09-23. PMID:20653959. |
is bdnf sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization? |
2010-09-23 |
2023-08-12 |
Not clear |