| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Tsuda, Hikaru Ueno, Ayako Kataoka, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia. vol 56. issue 4. 2008-05-30. PMID:18186080. |
activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. |
2008-05-30 |
2023-08-12 |
rat |
| Makoto Tsuda, Hikaru Ueno, Ayako Kataoka, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia. vol 56. issue 4. 2008-05-30. PMID:18186080. |
in the present study, using streptozotocin (stz)-induced diabetic rats that displayed tactile allodynia, we found several morphological changes of activated microglia in the dorsal horn. |
2008-05-30 |
2023-08-12 |
rat |
| Makoto Tsuda, Hikaru Ueno, Ayako Kataoka, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia. vol 56. issue 4. 2008-05-30. PMID:18186080. |
furthermore, in the dorsal horn of stz diabetic rats, extracellular signal-regulated protein kinase (erk) and an upstream kinase, src-family kinase (sfk), both of which are implicated in microglial functions, were activated exclusively in microglia. |
2008-05-30 |
2023-08-12 |
rat |
| Makoto Tsuda, Hikaru Ueno, Ayako Kataoka, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia. vol 56. issue 4. 2008-05-30. PMID:18186080. |
together, these results suggest that activated dorsal horn microglia may be a crucial component of diabetes-induced tactile allodynia, mediated, in part, by the erk signaling pathway. |
2008-05-30 |
2023-08-12 |
rat |
| Makoto Tsuda, Hikaru Ueno, Ayako Kataoka, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia. vol 56. issue 4. 2008-05-30. PMID:18186080. |
thus, inhibiting microglia activation in the dorsal horn may represent a therapeutic strategy for treating diabetic tactile allodynia. |
2008-05-30 |
2023-08-12 |
rat |
| Yi-Wen Gu, Dian-San Su, Jie Tian, Xiang-Rui Wan. Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats. Neuroscience letters. vol 431. issue 2. 2008-05-02. PMID:18191894. |
previous evidences suggest that the activation of the p38 mapk signaling pathway in hyperactive microglia in the dorsal horn of spinal cord involves in nerve injury-induced neuropathic pain. |
2008-05-02 |
2023-08-12 |
rat |
| Stefania Echeverry, Xiang Qun Shi, Ji Zhan. Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain. vol 135. issue 1-2. 2008-03-25. PMID:17560721. |
there was a close temporal correlation between microglial proliferation in the spinal cord dorsal horn and the abnormal pain responses, suggesting a contribution of the new microglia to the genesis of the neuropathic pain symptoms. |
2008-03-25 |
2023-08-12 |
rat |
| Ting Lin, Kai Li, Fei-Yu Zhang, Zhen-Kang Zhang, Alan R Light, Kai-Yuan F. Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models. Journal of neuroimmunology. vol 192. issue 1-2. 2008-03-14. PMID:17919739. |
both qualitative and quantitative analyses showed signs of microglia activation on the ipsilateral side of the lumbar dorsal horn on day 3, day 7 and day 14 after formalin injection. |
2008-03-14 |
2023-08-12 |
Not clear |
| A Florence Keller, Simon Beggs, Michael W Salter, Yves De Koninc. Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Molecular pain. vol 3. 2008-01-02. PMID:17900333. |
disinhibition of neurons in the superficial spinal dorsal horn, via microglia - neuron signaling leading to disruption of chloride homeostasis, is a potential cellular substrate for neuropathic pain. |
2008-01-02 |
2023-08-12 |
Not clear |
| Makoto Tsuda, Kazuhide Inou. [Neuropathic pain and ATP receptors in spinal microglia]. Brain and nerve = Shinkei kenkyu no shinpo. vol 59. issue 9. 2007-10-19. PMID:17886477. |
within the spinal dorsal horn, peripheral nerve injury leads to a progressive series of changes in microglia including morphological hypertrophy of the cell body and proliferation that are considered indicative of activation. |
2007-10-19 |
2023-08-12 |
Not clear |
| Peng Zhao, Stephen G Waxman, Bryan C Hain. Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 33. 2007-09-14. PMID:17699671. |
we have previously shown that activated microglia, through an erk (extracellular signal-regulated kinase)-regulated pge(2) (prostaglandin e(2)) signaling mechanism, maintain neuronal hyperexcitability in the lumbar dorsal horn. |
2007-09-14 |
2023-08-12 |
Not clear |
| Simon Beggs, Michael W Salte. Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Brain, behavior, and immunity. vol 21. issue 5. 2007-08-31. PMID:17267172. |
design-based stereological techniques were combined with iba-1 immunohistochemistry to estimate the total number of microglia in the spinal dorsal horn in naïve and peripheral nerve-injured adult rats. |
2007-08-31 |
2023-08-12 |
rat |
| Simon Beggs, Michael W Salte. Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Brain, behavior, and immunity. vol 21. issue 5. 2007-08-31. PMID:17267172. |
following sni there was a marked increase in the number of spinal microglia: the total number of microglia (mean+/-sd) in the dorsal horn sciatic territory of the naïve rat was estimated to be 28,591+/-2715. |
2007-08-31 |
2023-08-12 |
rat |
| Anna K Clark, Ping K Yip, John Grist, Clive Gentry, Amelia A Staniland, Fabien Marchand, Maliheh Dehvari, Glen Wotherspoon, Janet Winter, Jakir Ullah, Stuart Bevan, Marzia Malcangi. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 25. 2007-08-15. PMID:17551020. |
after injury, cats was exclusively expressed by activated microglia in the ipsilateral dorsal horn, where expression peaked at day 7, remaining high on day 14. |
2007-08-15 |
2023-08-12 |
mouse |
| Andrew Moss, Simon Beggs, David Vega-Avelaira, Michael Costigan, Gareth J Hathway, Michael W Salter, Maria Fitzgeral. Spinal microglia and neuropathic pain in young rats. Pain. vol 128. issue 3. 2007-04-03. PMID:17110040. |
dorsal horn iba-1+ve microglia could be activated, however, by intraspinal injections of lipopolysaccharide (lps) or n-methyl-d-aspartate (nmda) at p10, although the increase in the levels of mrna for all microglial markers was less than in the adult rat. |
2007-04-03 |
2023-08-12 |
rat |
| Peng Zhao, Stephen G Waxman, Bryan C Hain. Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329433. |
four weeks after injury when lumbar dorsal horn multireceptive neurons became hyperresponsive and when behavioral nociceptive thresholds to mechanical and thermal stimuli were decreased, we tested the hypothesis that prostaglandin e2 (pge2) contributes to signaling between microglia and neurons. |
2007-03-19 |
2023-08-12 |
mouse |
| Peng Zhao, Stephen G Waxman, Bryan C Hain. Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329433. |
selective targeting of dorsal horn microglia with the mac-1-sap immunotoxin, a chemical conjugate of mouse monoclonal antibody to cd11b and the ribosome-inactivating protein saporin, resulted in reduced microglia staining, reduction in pge2 levels, and reversed pain-related behaviors [corrected]. |
2007-03-19 |
2023-08-12 |
mouse |
| Anna K Clark, Clive Gentry, Elizabeth J Bradbury, Stephen B McMahon, Marzia Malcangi. Role of spinal microglia in rat models of peripheral nerve injury and inflammation. European journal of pain (London, England). vol 11. issue 2. 2007-02-28. PMID:16545974. |
we observed significant ipsilateral dorsal horn microglia activation 2 weeks after injury and bilateral activation 50 days following nerve injury as well as 24 h following intraplantar zymosan but not intraplantar complete freund's adjuvant (cfa). |
2007-02-28 |
2023-08-12 |
rat |
| Weiya Ma, Remi Quirio. The ERK/MAPK pathway, as a target for the treatment of neuropathic pain. Expert opinion on therapeutic targets. vol 9. issue 4. 2007-01-25. PMID:16083338. |
following nerve injury, phosphorylation of extracellular signal-regulated protein kinase (erk), an important member of this family, is sequentially increased in neurons, microglia and astrocytes of the dorsal horn and gracile nucleus, and in injured large drg neurons. |
2007-01-25 |
2023-08-12 |
Not clear |
| Anna K Clark, Fulvio D'Aquisto, Clive Gentry, Fabien Marchand, Stephen B McMahon, Marzia Malcangi. Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16942597. |
extensive microglial cell activation in the dorsal horn, as determined by immunoreactivity for phosphorylated p38 mapk, was found to correlate with the occurrence of il-1beta secretion. |
2006-12-20 |
2023-08-12 |
rat |