| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junya Masuda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia. Molecular pain. vol 5. 2009-10-22. PMID:19426564. |
moreover, in rats with an injury to the fifth lumbar spinal nerve (an animal model of neuropathic pain), the immunofluorescence for p-pdgfr beta was markedly enhanced exclusively in microglia in the ipsilateral dorsal horn. |
2009-10-22 |
2023-08-12 |
rat |
| Jessica K Alexander, A Courtney DeVries, Kristina A Kigerl, Jason M Dahlman, Phillip G Popovic. Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation. Brain, behavior, and immunity. vol 23. issue 6. 2009-09-23. PMID:19361551. |
activation of dorsal horn microglia was accelerated by stress; however, this effect was transient and was not associated with the onset or maintenance of a pro-inflammatory phenotype. |
2009-09-23 |
2023-08-12 |
mouse |
| Y S Gwak, C E Hulsebosc. Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19332108. |
in immunohistochemical studies, astrocytes and microglia in rats with spinal hemisection showed significantly increased gfap and ox-42 expression in both superficial and deep dorsal horns in the lumbar spinal dorsal horn compared to sham controls (* p<0.05) that was prevented in a dose-related manner by ppf. |
2009-08-24 |
2023-08-12 |
rat |
| Ronald Deumens, Robby J P Jaken, Liesbeth Knaepen, Inge van der Meulen, Elbert A J Jooste. Inverse relation between intensity of GFAP expression in the substantia gelatinosa and degree of chronic mechanical allodynia. Neuroscience letters. vol 452. issue 2. 2009-06-29. PMID:19383423. |
here, the persistent responses of astroglia and microglia to peripheral nerve injury within central pain networks in the upper dorsal horn laminae were studied. |
2009-06-29 |
2023-08-12 |
Not clear |
| Anna K Clark, Ping K Yip, Marzia Malcangi. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474321. |
indeed, the acute activation of dorsal horn microglia by lipopolysaccharide results in increased cats activity in the superfusates, followed by increased sfkn contents. |
2009-06-23 |
2023-08-12 |
rat |
| Anna K Clark, Ping K Yip, Marzia Malcangi. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474321. |
finally, because we found that both fkn immunoreactivity and mrna are confined to dorsal horn neurons, we suggest that under neuropathic conditions, noxious stimulation of primary afferent fibers induces release of cats from microglia, which liberates fkn from dorsal horn neurons, thereby contributing to the amplification and maintenance of chronic pain. |
2009-06-23 |
2023-08-12 |
rat |
| Makoto Tsuda, Takahiro Masuda, Junko Kitano, Hiroshi Shimoyama, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 19. 2009-06-22. PMID:19380717. |
conversely, ablating ifn-gammar severely impairs nerve injury-evoked microglia activation and tactile allodynia without affecting microglia in the contralateral dorsal horn or basal pain sensitivity. |
2009-06-22 |
2023-08-12 |
Not clear |
| Qing-Juan Gong, Yu-Ying Li, Wen-Jun Xin, Ying Zang, Wen-Jie Ren, Xu-Hong Wei, Yong-Yong Li, Tong Zhang, Xian-Guo Li. ATP induces long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn: the roles of P2X4 receptors and p38 MAPK in microglia. Glia. vol 57. issue 6. 2009-05-13. PMID:18837052. |
atp induces long-term potentiation of c-fiber-evoked field potentials in spinal dorsal horn: the roles of p2x4 receptors and p38 mapk in microglia. |
2009-05-13 |
2023-08-12 |
Not clear |
| Norikazu Kiguchi, Takehiko Maeda, Yuka Kobayashi, Shiroh Kishiok. Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice. Neuroscience letters. vol 445. issue 2. 2009-04-14. PMID:18790011. |
as measured by immunohistochemistry, microglia and astrocytes were activated in the spinal dorsal horn on day 7 of vcr administration. |
2009-04-14 |
2023-08-12 |
mouse |
| Tuan Trang, Simon Beggs, Xiang Wan, Michael W Salte. P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295157. |
microglia in the dorsal horn of the spinal cord are increasingly recognized as being crucial in the pathogenesis of pain hypersensitivity after injury to a peripheral nerve. |
2009-04-13 |
2023-08-12 |
Not clear |
| Aiguo Shen, Dan Zhou, Qin Shen, Hai-ou Liu, Linlin Sun, Yonghua Liu, Jianping Chen, Junling Yang, Yuhong Ji, Chun Chen. The expression of tumor necrosis factor-alpha (TNF-alpha) by the intrathecal injection of lipopolysaccharide in the rat spinal cord. Neurochemical research. vol 34. issue 2. 2009-03-30. PMID:18618248. |
the enzyme-linked immunosorbent (elisa) assay showed that the protein level of tnf-alpha reached peak at 8 h. double immunofluorescence revealed that lps-induced expression of tnf-alpha exclusively located in a subpopulation of microglia, which increased at 8 h in the rat spinal dorsal horn (the injected side). |
2009-03-30 |
2023-08-12 |
rat |
| Young Seob Gwak, Eric D Crown, Geda C Unabia, Claire E Hulsebosc. Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat. Pain. vol 138. issue 2. 2009-01-26. PMID:18353556. |
in addition, astrocytes and microglia showed soma hypertrophy as determined by increased soma area and increased gfap and cd11b on both sides of the lumbar dorsal horn compared to sham controls, respectively (p<0.05). |
2009-01-26 |
2023-08-12 |
rat |
| Kan Miyoshi, Koichi Obata, Takashi Kondo, Haruki Okamura, Koichi Noguch. Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 48. 2009-01-26. PMID:19036970. |
nerve injury induced a striking increase in il-18 and il-18r expression in the dorsal horn, and il-18 and il-18r were upregulated in hyperactive microglia and astrocytes, respectively. |
2009-01-26 |
2023-08-12 |
Not clear |
| Lauriane Ulmann, Jon P Hatcher, Jane P Hughes, Séverine Chaumont, Paula J Green, François Conquet, Gary N Buell, Alison J Reeve, Iain P Chessell, Francois Rassendre. Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 44. 2008-11-18. PMID:18971468. |
using in vitro and in vivo models, we provide direct evidence that p2x(4)r stimulation leads to the release of bdnf from activated microglia and, most likely phosphorylation of the nr1 subunit of nmda receptors in dorsal horn neurons of the spinal cord. |
2008-11-18 |
2023-08-12 |
mouse |
| R Terayama, S Omura, N Fujisawa, T Yamaai, H Ichikawa, T Sugimot. Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury. Neuroscience. vol 153. issue 4. 2008-10-08. PMID:18440713. |
these results demonstrate that snl activates p38 mapk pathway in microglia in the gracile nucleus as well as in the spinal cord dorsal horn. |
2008-10-08 |
2023-08-12 |
rat |
| Eric D Crown, Young Seob Gwak, Zaiming Ye, Kathia M Johnson, Claire E Hulsebosc. Activation of p38 MAP kinase is involved in central neuropathic pain following spinal cord injury. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18590729. |
immunocytochemical analyses indicate that the increases in p38 mapk activation occurred in astrocytes, microglia, and dorsal horn neurons in the spinal cord rostral to the site of injury. |
2008-10-08 |
2023-08-12 |
rat |
| Alban Latrémolière, Annie Mauborgne, Justine Masson, Sylvie Bourgoin, Valérie Kayser, Michel Hamon, Michel Poh. Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 34. 2008-09-16. PMID:18716207. |
we show that il-6 can upregulate ox-42 and atf3 expression in cultured microglia and neurons from spinal cord, respectively, as well as in the dorsal horn after acute intrathecal administration of the cytokine. |
2008-09-16 |
2023-08-12 |
rat |
| D H Kim, B Fitzsimmons, M P Hefferan, C I Svensson, E Wancewicz, B P Monia, G Hung, M Butler, M Marsala, X-Y Hua, T L Yaks. Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia. Neuroscience. vol 154. issue 3. 2008-08-29. PMID:18511207. |
here we demonstrate that cpla(2)iva is constitutively expressed in rat spinal cord, predominantly in dorsal horn neurons and oligodendrocytes but not in astrocytes or microglia. |
2008-08-29 |
2023-08-12 |
rat |
| Hirokazu Katsura, Koichi Obata, Kan Miyoshi, Takashi Kondo, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Masafumi Sakagami, Koichi Noguch. Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury. Glia. vol 56. issue 7. 2008-08-01. PMID:18293403. |
nerve injury induced a striking increase in the expression of tak1 in the ipsilateral dorsal horn, and tak1 was increased in hyperactive astrocytes, but not in neurons or microglia. |
2008-08-01 |
2023-08-12 |
Not clear |
| Fuxing Zhang, Kujumon I Vadakkan, Susan S Kim, Long-Jun Wu, Yuze Shang, Min Zhu. Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Molecular pain. vol 4. 2008-07-08. PMID:18423014. |
we found that microglia showed a uniform distribution throughout the cns, and peripheral nerve injury selectively activated microglia in the spinal cord dorsal horn and related ventral horn. |
2008-07-08 |
2023-08-12 |
mouse |