| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Rodriguez Parkitna, M Korostynski, D Kaminska-Chowaniec, I Obara, J Mika, B Przewlocka, R Przewlock. Comparison of gene expression profiles in neuropathic and inflammatory pain. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 57. issue 3. 2006-11-06. PMID:17033093. |
our data point at the importance of immune response- and microglia activation-related genes in the development of chronic neuropathic pain, and suggest that expression of cgrp gene in the dorsal horn of the spinal cord could be involved in persistence of its symptoms. |
2006-11-06 |
2023-08-12 |
rat |
| Hirokazu Katsura, Koichi Obata, Toshiyuki Mizushima, Jun Sakurai, Kimiko Kobayashi, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Masafumi Sakagami, Koichi Noguch. Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928856. |
nerve injury induced a striking increase in sfk phosphorylation in the ipsilateral dorsal horn, and sfks were activated in hyperactive microglia but not in neurons or astrocytes. |
2006-09-28 |
2023-08-12 |
Not clear |
| Ming Qin, Jing-Jie Wang, Rong Cao, Hui Zhang, Li Duan, Bei Gao, Ying-Fei Xiong, Liang-Wei Chen, Zhi-Ren Ra. The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat. Neuroscience research. vol 55. issue 4. 2006-09-08. PMID:16759728. |
it was demonstrated that fos/neun immunoreactive (-ir) neurons, glial fibrillary acidic protein (gfap)-ir astrocytes and ox42-ir microglia were distributed in dorsal horn of lumbar spinal cord, predominantly in the superficial layer. |
2006-09-08 |
2023-08-12 |
rat |
| Minoru Narita, Takuya Yoshida, Mayumi Nakajima, Michiko Narita, Mayumi Miyatake, Tomoe Takagi, Yoshinori Yajima, Tsutomu Suzuk. Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16606373. |
furthermore, 5-bromo-2'-deoxyuridine (brdu)-positive cells on the ipsilateral dorsal horn of the spinal cord were significantly increased at 7 days after nerve ligation and were highly co-localized with another microglia marker, ionized calcium-binding adaptor molecule 1 (iba1), but neither with gfap nor a specific neural nuclei marker, neun, in the spinal dorsal horn of nerve-ligated mice. |
2006-07-21 |
2023-08-12 |
mouse |
| Makoto Tsuda, Kazuhide Inou. [Role of molecules expressed in spiral microglia in neuropathic pain]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 26. issue 1. 2006-06-15. PMID:16637597. |
we expect that understanding the key roles of these molecules in spinal microglia may lead to new strategies for the management of neuropathic pain, strategies not previously anticipated by a neuron-centric view of pain plasticity in the dorsal horn. |
2006-06-15 |
2023-08-12 |
Not clear |
| Jill A Lindia, Erin McGowan, Nina Jochnowitz, Catherine Abbadi. Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. The journal of pain. vol 6. issue 7. 2005-09-08. PMID:15993821. |
however, after spinal nerve injury, cx3cr1-li was upregulated in microglia throughout the dorsal horn. |
2005-09-08 |
2023-08-12 |
rat |
| Liang-Hao Guo, Katrin Trautmann, Hermann J Schluesene. Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain. Journal of neuroimmunology. vol 163. issue 1-2. 2005-07-07. PMID:15885314. |
after formalin administration, an increase of p2x4r+ microglia were observed in the spinal cord dorsal horn on the side ipsilateral to the injection, reaching maximal levels by day 7, and then decreasing to normal levels by day 14. |
2005-07-07 |
2023-08-12 |
rat |
| Zhi-Ye Zhuang, Peter Gerner, Clifford J Woolf, Ru-Rong J. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain. vol 114. issue 1-2. 2005-05-16. PMID:15733640. |
on day 10, perk is expressed both in astrocytes and microglia, but by day 21 predominantly in astrocytes in the dorsal horn. |
2005-05-16 |
2023-08-12 |
Not clear |
| Zhi-Ye Zhuang, Peter Gerner, Clifford J Woolf, Ru-Rong J. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain. vol 114. issue 1-2. 2005-05-16. PMID:15733640. |
the sequential activation of erk in dorsal horn microglia and then in astrocytes might reflect distinct roles for these two subtypes of glia in the temporal evolution of neuropathic pain. |
2005-05-16 |
2023-08-12 |
Not clear |
| Thomas Beiter, Matthias R Artelt, Katrin Trautmann, Hermann J Schluesene. Experimental autoimmune neuritis induces differential microglia activation in the rat spinal cord. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710454. |
a significant increase in ed1(+) microglia predominantly located in the dorsal horn grey matter of lumbar and thoracic spinal cord levels was observed on day 12. |
2005-04-28 |
2023-08-12 |
rat |
| Makoto Tsuda, Kazuhide Inoue, Michael W Salte. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends in neurosciences. vol 28. issue 2. 2005-04-25. PMID:15667933. |
it is important to establish how these molecules are activated in spinal microglia following nerve injury and how they cause signaling to neurons in the dorsal horn pain transmission network. |
2005-04-25 |
2023-08-12 |
Not clear |
| Camilla I Svensson, Bethany Fitzsimmons, Sara Azizi, Henry C Powell, Xiao-Ying Hua, Tony L Yaks. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. Journal of neurochemistry. vol 92. issue 6. 2005-04-22. PMID:15748168. |
here we demonstrate that the isoforms are distinctly expressed in spinal dorsal horn: p38alpha in neurons and p38beta in microglia. |
2005-04-22 |
2023-08-12 |
rat |
| Ru-Rong Ji, Gary Strichart. Cell signaling and the genesis of neuropathic pain. Science's STKE : signal transduction knowledge environment. vol 2004. issue 252. 2004-11-16. PMID:15454629. |
in particular, peripheral nerve lesions result in activation of mapks (p38, extracellular signal-regulated kinase, and c-jun n-terminal kinase) in microglia or astrocytes in the spinal cord, or both, leading to the production of inflammatory mediators that sensitize dorsal horn neurons. |
2004-11-16 |
2023-08-12 |
Not clear |
| Kazuhide Inoue, Makoto Tsuda, Schuichi Koizum. Chronic pain and microglia: the role of ATP. Novartis Foundation symposium. vol 261. 2004-11-10. PMID:15469044. |
in the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38mapk (phospho-p38mapk) was increased. |
2004-11-10 |
2023-08-12 |
rat |
| Marucia Chacur, José Maria Gutiérrez, Erin D Milligan, Julie Wieseler-Frank, Luiz R G Britto, Steven F Maier, Linda R Watkins, Yara Cur. Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators. Pain. vol 111. issue 1-2. 2004-11-09. PMID:15327810. |
in support, immunohistochemical analysis revealed activation of dorsal horn astrocytes and microglia after intraplantar injection of either spla2. |
2004-11-09 |
2023-08-12 |
rat |
| Kazuhide Inoue, Makoto Tsuda, Schuichi Koizum. ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. Journal of pharmacological sciences. vol 94. issue 2. 2004-10-20. PMID:14978347. |
in the rats, activated microglia were detected in the injured side of the dorsal horn and the level of the dually-phosphorylated active form of p38mapk (phospho-p38mapk) in these microglia was increased. |
2004-10-20 |
2023-08-12 |
rat |
| Bryan C Hains, Carl Y Saab, Joshua P Klein, Matthew J Craner, Stephen G Waxma. Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 20. 2004-09-10. PMID:15152043. |
in situ hybridization, quantitative reverse transcription-pcr, and immunocytochemical analysis revealed upregulation of na(v)1.3 in dorsal horn nociceptive neurons but not in astrocytes or microglia, and unit recordings demonstrated hyperresponsiveness of dorsal horn sensory neurons. |
2004-09-10 |
2023-08-12 |
rat |
| Marucia Chacur, Erin D Milligan, Evan M Sloan, Julie Wieseler-Frank, Ruth M Barrientos, David Martin, Stephen Poole, Brono Lomonte, Jose Maria Gutiérrez, Steven F Maier, Yara Cury, Linda R Watkin. Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide. Pain. vol 108. issue 1-2. 2004-06-03. PMID:15109522. |
these demonstrated that both spla2s produce activation of dorsal horn astrocytes and microglia that is more prominent ipsilateral to the site of injection. |
2004-06-03 |
2023-08-12 |
rat |
| Makoto Tsuda, Akito Mizokoshi, Yukari Shigemoto-Mogami, Schuichi Koizumi, Kazuhide Inou. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. vol 45. issue 1. 2004-02-10. PMID:14648549. |
interestingly, the phospho-p38mapk immunofluorescence in the dorsal horn was found exclusively in microglia, but not in neurons or astrocytes. |
2004-02-10 |
2023-08-12 |
Not clear |
| Makoto Tsuda, Akito Mizokoshi, Yukari Shigemoto-Mogami, Schuichi Koizumi, Kazuhide Inou. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. vol 45. issue 1. 2004-02-10. PMID:14648549. |
taken together, our results demonstrate that nerve injury-induced pain hypersensitivity depends on activation of the p38mapk signaling pathway in hyperactive microglia in the dorsal horn following peripheral nerve injury. |
2004-02-10 |
2023-08-12 |
Not clear |