| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideo Kohno, Hideto Koso, Kiichiro Okano, Thomas R Sundermeier, Saburo Saito, Sumiko Watanabe, Hiroshi Tsuneoka, Tsutomu Saka. Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration. Journal of neuroinflammation. vol 12. 2016-06-21. PMID:26458944. |
though accumulating evidence suggests that microglia, resident macrophages in the retina, and bone marrow-derived macrophages can cause retinal inflammation which accelerates photoreceptor cell death, the details of how these cells are activated during retinal degeneration (rd) remain uncertain. |
2016-06-21 |
2023-08-13 |
mouse |
| Bikun Xian, Bing Huan. The immune response of stem cells in subretinal transplantation. Stem cell research & therapy. vol 6. 2016-06-17. PMID:26364954. |
despite low rates of graft rejection in animal models, survival rates for escs, mscs, and ipscs in retina are generally poor, possibly due to resident microglia activated by cell transplantation. |
2016-06-17 |
2023-08-13 |
Not clear |
| Pablo de Gracia, Beatriz I Gallego, Blanca Rojas, Ana I Ramírez, Rosa de Hoz, Juan J Salazar, Alberto Triviño, José M Ramíre. Automatic Counting of Microglial Cells in Healthy and Glaucomatous Mouse Retinas. PloS one. vol 10. issue 11. 2016-06-17. PMID:26580208. |
a new algorithm was developed in matlab for microglial quantification; it enabled the quantification of microglial cells in the inner and outer plexiform layers and evaluates the area of the retina occupied by iba-1+ microglia in the nerve fiber-ganglion cell layer. |
2016-06-17 |
2023-08-13 |
mouse |
| Sandra M Cardona, Andrew S Mendiola, Ya-Chin Yang, Sarina L Adkins, Vanessa Torres, Astrid E Cardon. Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina. ASN neuro. vol 7. issue 5. 2016-06-07. PMID:26514658. |
notably, double immunofluorescence staining shows that astrocytes act as a source of il-1β in the ins2(akita) retina, and cx3cr1-deficient microglia potentiate the inflammatory response via il-1β release. |
2016-06-07 |
2023-08-13 |
mouse |
| Wenxin Ma, Wai T Won. Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease. Advances in experimental medicine and biology. vol 854. 2016-04-18. PMID:26427396. |
microglia are long-lived, resident immune cells of the retina, and mediate local neuroinflammatory reactions. |
2016-04-18 |
2023-08-13 |
Not clear |
| Marie E Burns, Emily S Levine, Eric B Miller, Azhar Zam, Pengfei Zhang, Robert J Zawadzki, Edward N Pug. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo. Advances in experimental medicine and biology. vol 854. 2016-04-18. PMID:26427421. |
these early changes in photoreceptor structure coincided with activation of retinal microglia, which migrated vertically from the inner to the outer retina to phagocytose photoreceptor cell bodies (levine et al., vis res 102:71-79, 2014). |
2016-04-18 |
2023-08-13 |
mouse |
| Li Wang, Ka Chen, Kai Liu, Yong Zhou, Ting Zhang, Bin Wang, Mantian M. DHA inhibited AGEs-induced retinal microglia activation via suppression of the PPARγ/NFκB pathway and reduction of signal transducers in the AGEs/RAGE axis recruitment into lipid rafts. Neurochemical research. vol 40. issue 4. 2016-04-05. PMID:25596942. |
retinal microglia are a specialized population of macrophages in retina. |
2016-04-05 |
2023-08-13 |
Not clear |
| Ti-Fei Yuan, Yu-Xiang Liang, Bo Peng, Bin Lin, Kwok-Fai S. Local proliferation is the main source of rod microglia after optic nerve transection. Scientific reports. vol 5. 2016-03-24. PMID:26035780. |
in optical nerve transection (ont) model in the retina, the retrograde degeneration of retinal ganglion cells (rgcs) induces microglial activations to a unique morphology termed "rod" microglia. |
2016-03-24 |
2023-08-13 |
Not clear |
| Ti-Fei Yuan, Yu-Xiang Liang, Bo Peng, Bin Lin, Kwok-Fai S. Local proliferation is the main source of rod microglia after optic nerve transection. Scientific reports. vol 5. 2016-03-24. PMID:26035780. |
a few studies described the "rod" microglia in the cortex and retina; however, the function and origin of "rod" microglia are largely unknown. |
2016-03-24 |
2023-08-13 |
Not clear |
| Rebecca Scholz, Markus Sobotka, Albert Caramoy, Thomas Stempfl, Christoph Moehle, Thomas Langman. Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. Journal of neuroinflammation. vol 12. 2016-03-22. PMID:26576678. |
minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. |
2016-03-22 |
2023-08-13 |
mouse |
| Alejandra Bosco, Cesar O Romero, Kevin T Breen, Alexis A Chagovetz, Michael R Steele, Balamurali K Ambati, Monica L Vette. Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma. Disease models & mechanisms. vol 8. issue 5. 2016-02-29. PMID:25755083. |
because the retina allows live tracking of fluorescent microglia in their intact niche, here we investigated their early changes in relation to later optic nerve neurodegeneration. |
2016-02-29 |
2023-08-13 |
mouse |
| Alejandra Bosco, Cesar O Romero, Kevin T Breen, Alexis A Chagovetz, Michael R Steele, Balamurali K Ambati, Monica L Vette. Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma. Disease models & mechanisms. vol 8. issue 5. 2016-02-29. PMID:25755083. |
we also observed heterogeneous and dynamic patterns of early microglia activation in the retina. |
2016-02-29 |
2023-08-13 |
mouse |
| Daniel J Wahl, Yifan Jian, Stefano Bonora, Robert J Zawadzki, Marinko V Saruni. Wavefront sensorless adaptive optics fluorescence biomicroscope for in vivo retinal imaging in mice. Biomedical optics express. vol 7. issue 1. 2016-01-28. PMID:26819812. |
in this report, we demonstrated a hill-climbing algorithm for wsao with a variable focus lens and deformable mirror for non-invasive in vivo imaging of egfp (enhanced green fluorescent protein) labelled ganglion cells and microglia cells in the mouse retina. |
2016-01-28 |
2023-08-13 |
mouse |
| Ana Santos-Carvalho, António Francisco Ambrósio, Cláudia Cavada. Neuropeptide Y system in the retina: From localization to function. Progress in retinal and eye research. vol 47. 2016-01-26. PMID:25797468. |
in the present review, we highlight the putative roles of npy receptor activation in the retina, discussing, in particular, their involvement in retinal development, neurotransmitter release modulation, neuroprotection, microglia and muller cells function, retinal pigmented epithelium changes, retinal endothelial physiology and proliferation of retinal progenitor cells. |
2016-01-26 |
2023-08-13 |
Not clear |
| Yunhe Xu, Balini Balasubramaniam, David A Copland, Jian Liu, M John Armitage, Andrew D Dic. Activated adult microglia influence retinal progenitor cell proliferation and differentiation toward recoverin-expressing neuron-like cells in a co-culture model. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 253. issue 7. 2016-01-13. PMID:25680876. |
microglia contribute to immune homeostasis of the retina, and thus act as a potential regulator determining successful repair or retinal stem cell transplantation. |
2016-01-13 |
2023-08-13 |
human |
| Alejandra Bosco, Cesar O Romero, Balamurali K Ambati, Monica L Vette. In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma. Journal of visualized experiments : JoVE. issue 99. 2015-12-15. PMID:25992962. |
the retina, a cns organ amenable to non-invasive live imaging, offers a powerful system to visualize and characterize the dynamics of microglia activation during chronic disorders. |
2015-12-15 |
2023-08-13 |
mouse |
| Alejandra Bosco, Cesar O Romero, Balamurali K Ambati, Monica L Vette. In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma. Journal of visualized experiments : JoVE. issue 99. 2015-12-15. PMID:25992962. |
this approach should be useful to investigate the contributions of microglia to neuronal and axonal decline in chronic cns disorders that affect the retina and optic nerve. |
2015-12-15 |
2023-08-13 |
mouse |
| Lulu Yan, Sangmi Lee, Douglas R Lazzaro, Jacob Aranda, Maria B Grant, Brahim Chaqou. Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia. The Journal of biological chemistry. vol 290. issue 38. 2015-12-15. PMID:26242736. |
single and compound knock-outs of microrna (mirna)-155 and its angiogenic gene target ccn1 in mice alter vascular and neovascular growth in the retina via resident microglia. |
2015-12-15 |
2023-08-13 |
mouse |
| Maanasa Indaram, Wenxin Ma, Lian Zhao, Robert N Fariss, Ignacio R Rodriguez, Wai T Won. 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. Scientific reports. vol 5. 2015-12-04. PMID:25775051. |
to explore the potential relationship between 7kch and microglial activation, we localized 7kch and microglia to the outer retina of aged mice and investigated 7kch effects on retinal microglia in both in vitro and in vivo systems. |
2015-12-04 |
2023-08-13 |
mouse |
| Maanasa Indaram, Wenxin Ma, Lian Zhao, Robert N Fariss, Ignacio R Rodriguez, Wai T Won. 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. Scientific reports. vol 5. 2015-12-04. PMID:25775051. |
the interaction of retinal microglia with 7kch in the aged retina may thus underlie how outer retinal lipid accumulation in intermediate amd results in neuroinflammation that ultimately drives progression towards advanced amd. |
2015-12-04 |
2023-08-13 |
mouse |