| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordan E Rumford, Ailis Grieshaber, Samantha Lewiston, Jordan L Reed, Samuel S Long, Diana M Mitchel. Forced MyD88 signaling in microglia impacts the production and survival of regenerated retinal neurons. Frontiers in cell and developmental biology. vol 12. 2024-12-05. PMID:39633708. |
despite such findings, direct connection of microglia-specific inflammatory factors as drivers of regenerative responses in the retina are still not defined, and intracellular pathways activated to stimulate such signals from microglia are currently unknown. |
2024-12-05 |
2024-12-07 |
Not clear |
| Hasan U Banna, Mary Slayo, James A Armitage, Blanca Del Rosal, Loretta Vocale, Sarah J Spence. Imaging the eye as a window to brain health: frontier approaches and future directions. Journal of neuroinflammation. vol 21. issue 1. 2024-11-30. PMID:39614308. |
in this review, we discuss the gross anatomy of the eye, focusing on the sensory and non-sensory cells of the retina, especially microglia, that lend themselves to diagnosing brain disease by imaging the retina. |
2024-11-30 |
2024-12-02 |
Not clear |
| Chen Lu, Xiying Mao, Songtao Yua. Decoding physiological and pathological roles of innate immune cells in eye diseases: the perspectives from single-cell RNA sequencing. Frontiers in immunology. vol 15. 2024-11-15. PMID:39544948. |
notably, resident microglia and infiltrating neutrophils exhibit swift responses during the initial phase of injury, while peripheral monocyte-derived macrophages exhibit transcriptomic profiles akin to those of activated microglia, suggesting their potential for long-term residence within the retina. |
2024-11-15 |
2024-11-17 |
Not clear |
| Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei L. Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. eLife. vol 12. 2024-11-08. PMID:39514271. |
human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. |
2024-11-08 |
2024-11-16 |
mouse |
| Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei L. Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. eLife. vol 12. 2024-11-08. PMID:39514271. |
microglia exhibit both maladaptive and adaptive roles in the pathogenesis of neurodegenerative diseases and have emerged as a cellular target for central nervous system (cns) disorders, including those affecting the retina. |
2024-11-08 |
2024-11-16 |
mouse |
| Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei L. Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. eLife. vol 12. 2024-11-08. PMID:39514271. |
furthermore, these cells were found juxtaposed alongside residual endogenous murine microglia for up to 8 months in the retina, indicating their ability to establish a stable homeostatic state in vivo. |
2024-11-08 |
2024-11-16 |
mouse |
| Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei L. Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. eLife. vol 12. 2024-11-08. PMID:39514271. |
our findings indicate the feasibility of microglial transplantation and integration in the retina and suggest that modulating microglia through replacement may be a therapeutic strategy for treating neurodegenerative retinal diseases. |
2024-11-08 |
2024-11-16 |
mouse |
| Lushu Chen, HuiYing Zhang, Ying Zhang, Xiumiao Li, MeiHuan Wang, Yaming Shen, Yuan Cao, Yong Xu, Jin Ya. Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis. Journal of neuroinflammation. vol 21. issue 1. 2024-10-29. PMID:39468551. |
notably, retinal microglia, the intrinsic immune cells of the retina, play a crucial role in the pathogenesis of retinopathy. |
2024-10-29 |
2024-10-31 |
Not clear |
| Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samue. Retinal ganglion cell circuits and glial interactions in humans and mice. Trends in neurosciences. 2024-10-25. PMID:39455342. |
rgcs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. |
2024-10-25 |
2024-10-29 |
mouse |
| Yuedan Wang, Ying Li, Jiaqing Feng, Chuansen Wang, Yuwei Wan, Bingyang Lv, Yinming Li, Hao Xie, Ting Chen, Faxi Wang, Ziyue Li, Anhuai Yang, Xuan Xia. Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion. eLife. vol 13. 2024-10-09. PMID:39382568. |
a pronounced increase in microglia within the retina and peripheral leukocytes accessing the retina was observed during reperfusion periods. |
2024-10-09 |
2024-10-11 |
mouse |
| Olivia Taylor, Nicholas DeGroff, Heithem El-Hodiri, Chengyu Gao, Andy J Fische. Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells. bioRxiv : the preprint server for biology. 2024-10-01. PMID:39149287. |
further, ablation of microglia from the retina, wherein the formation of mgpcs in damaged retinas is impaired, has a significant impact upon expression patterns of s1p-related genes in mg. inhibition of s1pr1 and sphk1 partially rescued the formation of mgpcs in damaged retinas missing microglia. |
2024-10-01 |
2024-10-03 |
Not clear |
| Olivia Taylor, Nicholas DeGroff, Heithem El-Hodiri, Chengyu Gao, Andy J Fische. Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells. bioRxiv : the preprint server for biology. 2024-10-01. PMID:39149287. |
finally, we show that tgfβ/smad3 signaling in the resting retina maintains s1pr1 expression in mg. we conclude that the s1p signaling is dynamically regulated in mg and mgpcs and activation of s1p signaling depends, in part, on signals produced by reactive microglia. |
2024-10-01 |
2024-10-03 |
Not clear |
| Ruihan Xiao, Xi Huang, Sheng Gao, Jianan Duan, Yun Zhang, Meixia Zhan. Microglia in retinal diseases: From pathogenesis towards therapeutic strategies. Biochemical pharmacology. 2024-09-22. PMID:39307318. |
microglia, a widely dispersed cohort of immune cells in the retina, are intricately involved in a diverse range of pivotal biological processes, including inflammation, vascular development, complement activation, antigen presentation, and phagocytosis. |
2024-09-22 |
2024-09-26 |
Not clear |
| Ruihan Xiao, Xi Huang, Sheng Gao, Jianan Duan, Yun Zhang, Meixia Zhan. Microglia in retinal diseases: From pathogenesis towards therapeutic strategies. Biochemical pharmacology. 2024-09-22. PMID:39307318. |
recent studies on the ontogeny and broad functions of microglia in the retina have elucidated their characteristics during retinal development, homeostasis, and disease. |
2024-09-22 |
2024-09-26 |
Not clear |
| Yuebing Wang, Sayaka Harada, Yoshio Goshima, Toshio Ohshim. Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury. Neuromolecular medicine. vol 26. issue 1. 2024-09-13. PMID:39266914. |
inhibition of crmp2 phosphorylation suppresses microglia activation in the retina and optic nerve and promotes optic nerve regeneration after optic nerve injury. |
2024-09-13 |
2024-09-15 |
mouse |
| Eiman Mee. Role of Noncoding RNAs in Modulating Microglial Phenotype. Global medical genetics. vol 11. issue 4. 2024-09-11. PMID:39258255. |
microglia are immunocompetent cells that are present in the retina and central nervous system, and are involved in the development maintenance and immune functions in these systems. |
2024-09-11 |
2024-09-13 |
Not clear |
| Eiman Mee. Role of Noncoding RNAs in Modulating Microglial Phenotype. Global medical genetics. vol 11. issue 4. 2024-09-11. PMID:39258255. |
microglia are also present in close association with resident cells in the retina where they engage in synapse formation, support normal functions, as well as immune defense. |
2024-09-11 |
2024-09-13 |
Not clear |
| German Cuevas-Rios, Tawfik Abou Assale, Jannis Wissfeld, Annemarie Bungartz, Julia Hofmann, Thomas Langmann, Harald Neuman. Decreased sialylation elicits complement-related microglia response and bipolar cell loss in the mouse retina. Glia. 2024-09-04. PMID:39228105. |
decreased sialylation elicits complement-related microglia response and bipolar cell loss in the mouse retina. |
2024-09-04 |
2024-09-06 |
mouse |
| Ping Song, Dhwani Parsana, Rupesh Singh, Lana M Pollock, Bela Anand-Apte, Brian D Perkin. Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage. Scientific reports. vol 14. issue 1. 2024-08-29. PMID:39209978. |
microglia are resident immune cells in the central nervous system, including the retina that surveil the environment for damage and infection. |
2024-08-29 |
2024-09-04 |
zebrafish |
| Katerina Palacka, Barbora Hermankova, Tereza Cervena, Pavel Rossner, Alena Zajicova, Eva Uherkova, Vladimir Holan, Eliska Javorkov. The Immunomodulatory Effect of Silver Nanoparticles in a Retinal Inflammatory Environment. Inflammation. 2024-08-27. PMID:39190103. |
these data indicate that agnps regulate reactivity of activated microglia in the diseased retina and thus could provide a beneficial effect for the treatment of several retinal diseases. |
2024-08-27 |
2024-08-30 |
mouse |