| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philipp Dörschmann, Florentine Hunger, Hannah Schroth, Sibei Chen, Georg Kopplin, Johann Roider, Alexa Klettne. Effects of Fucoidans on Activated Retinal Microglia. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38892206. |
in this study, we tested the effects of different fucoidans (and of fucoidan-treated rpe cells) on retinal microglia to investigate whether its anti-inflammatory effect can be extrapolated to the innate immune cells of the retina. |
2024-06-19 |
2024-06-21 |
Not clear |
| Veronica Carnicelli, Noemi De Dominicis, Lucia Scipioni, Marina Fava, Federico Fanti, Benedetta Cinque, Alessandro Leuti, Clotilde Beatrice Angelucci, Anna Rita Lizzi, Roberto Giacominelli-Stuffler, Vincenzo Flati, Manuel Sergi, Dario Compagnone, Anna Maria Sardanelli, Annamaria Tisi, Sergio Oddi, Mauro Maccarron. Protective effects of fatty acid amide hydrolase inhibition in UVB-activated microglia. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2024-06-10. PMID:38857757. |
in this study, we interrogated for the first time the impact of the signaling of these bioactive lipids on microglial cell responses to a sub-lethal acute uvb radiation, a physical stressor responsible of microglia reactivity in either the retina or the brain. |
2024-06-10 |
2024-06-14 |
mouse |
| Xiyu Wu, Haoxian Zhu, Junbin Liu, Shuyi Ouyang, Zheng Lyu, Yeanqi Jin, Xinyu Chen, Qianli Men. Jagged1-Notch1 Signaling Pathway Induces M1 Microglia to Disrupt the Barrier Function of Retinal Microvascular Endothelial Cells. Current eye research. 2024-05-24. PMID:38783634. |
the primary objective of this research was to investigate the impact and mechanism of m1 phenotype microglia on the barrier function of retina microvascular endothelial cells. |
2024-05-24 |
2024-05-27 |
Not clear |
| Alexander P Young, Anna-Maria Szczesniak, Karolynn Hsu, Melanie E M Kelly, Eileen M Denovan-Wrigh. Enantiomeric Agonists of the Type 2 Cannabinoid Receptor Reduce Retinal Damage during Proliferative Vitreoretinopathy and Inhibit Hyperactive Microglia ACS pharmacology & translational science. vol 7. issue 5. 2024-05-17. PMID:38751621. |
enantiomeric agonists of the type 2 cannabinoid receptor reduce retinal damage during proliferative vitreoretinopathy and inhibit hyperactive microglia microglia are resident immune cells of the central nervous system (cns) and propagate inflammation following damage to the cns, including the retina. |
2024-05-17 |
2024-05-27 |
Not clear |
| Daijin Li, Jie Chang, Yujue Wang, Xiaoye Du, Jing Xu, Jingang Cui, Teng Zhang, Yu Che. Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation. Acta neuropathologica communications. vol 12. issue 1. 2024-05-17. PMID:38755736. |
activated microglia play an important role in driving photoreceptor degeneration-associated neuroinflammation in the retina. |
2024-05-17 |
2024-05-27 |
Not clear |
| Yinting Song, Yuefeng Liao, Tong Liu, Yanxian Chen, Fei Wang, Zixia Zhou, Weili Zhang, Jinying L. Microglial repopulation restricts ocular inflammation and choroidal neovascularization in mice. Frontiers in immunology. vol 15. 2024-05-07. PMID:38711521. |
age-related macular degeneration (amd) is a prevalent, chronic and progressive retinal degenerative disease characterized by an inflammatory response mediated by activated microglia accumulating in the retina. |
2024-05-07 |
2024-05-27 |
mouse |
| Luwei Cai, Mengxue Xia, Fang Zhan. Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671871. |
microglia, resident immune cells in the retina, are recognized as crucial drivers in the dr process. |
2024-04-27 |
2024-04-29 |
Not clear |
| Jun Tong, Genhong Yao, Yueqin Chen, Hairong Xie, Xinyu Zheng, Lingyun Sun, Zhenping Huang, Zhenggao Xi. Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy. Inflammation. 2024-04-16. PMID:38625640. |
activated microglia express many pro-inflammatory cytokines that exacerbate retina inflammation and disruption. |
2024-04-16 |
2024-04-18 |
rat |
| Haoran Li, Biao Li, Yanlin Zhen. Role of microglia/macrophage polarisation in intraocular diseases (Review). International journal of molecular medicine. vol 53. issue 5. 2024-03-29. PMID:38551157. |
the neural retina is also populated by specialised resident macrophages called microglia. |
2024-03-29 |
2024-03-31 |
Not clear |
| Jiaxing Huang, Xiaotang Wang, Na Li, Wei Fan, Xingran Li, Qian Zhou, Jiangyi Liu, Wanqian Li, Zhi Zhang, Xiaoyan Liu, Shuhao Zeng, Hui Yang, Meng Tian, Peizeng Yang, Shengping Ho. YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-03-17. PMID:38493498. |
activated microglia in the retina are essential for the development of autoimmune uveitis. |
2024-03-17 |
2024-03-20 |
Not clear |
| Mandy Hector, Thomas Langmann, Anne Wol. Translocator protein (18 kDa) (Tspo) in the retina and implications for ocular diseases. Progress in retinal and eye research. 2024-03-02. PMID:38430990. |
this review summarizes state-of-the-art knowledge of tspo expression and its proposed functions in different cells of the retina including microglia, retinal pigment epithelium and müller cells. |
2024-03-02 |
2024-03-06 |
Not clear |
| Fazeleh Etebar, Damien G Harkin, Anthony R White, Samantha J Dand. Non-invasive Frontiers in cellular neuroscience. vol 18. 2024-02-13. PMID:38348116. |
microglia in the retina, as an extension of the cns, have also been shown to be affected in many neurological diseases. |
2024-02-13 |
2024-02-15 |
Not clear |
| Xingxing Wang, Changlin Xu, Cunxin Bian, Pengfei Ge, Jie Lei, Jingfan Wang, Tianhao Xiao, Yuanyuan Fan, Qinyuan Gu, Hong-Ying Li, Jingyi Xu, Zizhong Hu, Ping Xi. M2 microglia-derived exosomes promote vascular remodeling in diabetic retinopathy. Journal of nanobiotechnology. vol 22. issue 1. 2024-02-09. PMID:38336783. |
further in vivo and in vitro experiments showed that exosomes derived from m2 polarized microglia (m2-exo) could reduce pericyte apoptosis and promote endothelial cell proliferation, thereby promoting vascular remodeling and reducing vascular leakage from the diabetic retina. |
2024-02-09 |
2024-02-12 |
mouse |
| Derek Rodriguez, Kaira A Church, Alicia N Pietramale, Sandra M Cardona, Difernando Vanegas, Colin Rorex, Micah C Leary, Isabel A Muzzio, Kevin R Nash, Astrid E Cardon. Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina. Journal of neuroinflammation. vol 21. issue 1. 2024-02-04. PMID:38311721. |
diabetic retinopathy (dr) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promoting neuronal and vascular damage. |
2024-02-04 |
2024-02-07 |
mouse |
| Nils Laudenberg, Urbanus Muthai Kinuthia, Thomas Langman. Microglia depletion/repopulation does not affect light-induced retinal degeneration in mice. Frontiers in immunology. vol 14. 2024-01-30. PMID:38288111. |
despite their role in driving detrimental inflammation, microglia also play supporting roles in the retina as they are a crucial cellular component of the regulatory innate immune system. |
2024-01-30 |
2024-02-01 |
mouse |
| Nils Laudenberg, Urbanus Muthai Kinuthia, Thomas Langman. Microglia depletion/repopulation does not affect light-induced retinal degeneration in mice. Frontiers in immunology. vol 14. 2024-01-30. PMID:38288111. |
interestingly, we found prominent cell debris accumulation in the outer retina under conditions of microglia depletion, presumably due to the lack of efficient phagocytosis that could not be compensated by the retinal pigment epithelium. |
2024-01-30 |
2024-02-01 |
mouse |
| Jia Xu, Si-Jian Yu, Shuning Sun, Yan-Ping Li, Xiao Zhang, Kangxin Jin, Zi-Bing Ji. Enhanced innate responses in microglia derived from retinoblastoma patient-specific iPSCs. Glia. 2024-01-23. PMID:38258347. |
in this study, microglia were successfully differentiated from rb patient- derived human induced pluripotent stem cells (hipscs) and human embryonic stem cells (hescs), and then we investigated the function of rb1 in microglia by live imaging phagocytosis assay, immunofluorescence, rna-seq, qrt-pcr, elisa and retina organoids/microglia co-culturing. |
2024-01-23 |
2024-01-25 |
human |
| Elena Beltramo, Aurora Mazzeo, Massimo Port. Release of Pro-Inflammatory/Angiogenic Factors by Retinal Microvascular Cells Is Mediated by Extracellular Vesicles Derived from M1-Activated Microglia. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203187. |
microglia is responsible for the immune response to inflammation inside the retina, which could be mediated by paracrine signals carried by extracellular vesicles (evs). |
2024-01-11 |
2024-01-13 |
human |
| Xingyu Zhu, Jiaxu Hong, Xujiao Zho. Biological Immune Mechanism of Retina. Frontiers in bioscience (Landmark edition). vol 28. issue 12. 2024-01-05. PMID:38179761. |
with the aim of better understanding the biology of immunological processes within the retina, this article reviews the brb and discusses the factors, systemic immune responses, microglia, rpe, and their associated enzymes that enable the brb. |
2024-01-05 |
2024-01-07 |
Not clear |
| Michael Morales, Anna P Findley, Diana M Mitchel. Intercellular contact and cargo transfer between Müller glia and to microglia precede apoptotic cell clearance in the developing retina. Development (Cambridge, England). vol 151. issue 1. 2024-01-04. PMID:38174987. |
intercellular contact and cargo transfer between müller glia and to microglia precede apoptotic cell clearance in the developing retina. |
2024-01-04 |
2024-01-06 |
zebrafish |