| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y Shu, Shintaro Shirahama, Bruce R Ksander, Magali Saint-Genie. Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health. Immunity & ageing : I & A. vol 20. issue 1. 2023-10-14. PMID:37838654. |
one important characteristic of retinal aging is the migration of microglia from the inner to outer retina where they reside in the subretinal space (srs) in contact with the retinal pigment epithelial (rpe) cells. |
2023-10-14 |
2023-11-08 |
mouse |
| Haixiang Wu, Fangcheng Xu, Yunfang Luo, Yibao Zhang, Min Tan. 3D bioprinted endothelial cell-microglia coculture for diabetic retinopathy modeling. Biofabrication. 2023-09-19. PMID:37725996. |
this study used digital light processing bioprinting to construct a 3d coculture model of endothelial cells (ecs) and microglia under varying glucose conditions, with a hydrogel stiffness of 4.6-7.1 kpa to mimic the extracellular matrix property of retina plexiform. |
2023-09-19 |
2023-10-07 |
Not clear |
| Ke Yao, Qianxue Mou, Xiaotong Lou, Meng Ye, Bowen Zhao, Yuanyuan Hu, Jing Luo, Hong Zhang, Xing Li, Yin Zha. Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition. Journal of neuroinflammation. vol 20. issue 1. 2023-09-05. PMID:37670386. |
microglia is the resistant immune cell in brain and retina and has been demonstrated to be highly related with neuron and synapse injury. |
2023-09-05 |
2023-10-07 |
Not clear |
| Wenna Gao, Xuemin Jin, Pengyi Zhou, Haiyan Zhu, Kunpeng Xie, Bo Jin, Liping D. Relationship between uveitis and the differential reactivity of retinal microglia. Ophthalmic research. 2023-09-04. PMID:37666222. |
as innate immune cells in the retina, microglia occupy a salient position in retinal homeostasis. |
2023-09-04 |
2023-09-07 |
Not clear |
| Kota Sato, Michiko Ohno-Oishi, Masaaki Yoshida, Taimu Sato, Takaharu Aizawa, Yuto Sasaki, Shigeto Maekawa, Makoto Ishikawa, Kazuko Omodaka, Chihiro Kawano, Ryuji Ohue-Kitano, Ikuo Kimura, Toru Nakazaw. The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury. Glia. 2023-07-20. PMID:37470163. |
resident microglia are important to maintain homeostasis in the central nervous system, which includes the retina. |
2023-07-20 |
2023-08-14 |
Not clear |
| Yehonatan Weinberger, Ivan Budnik, Yael Nisgav, Dahlia Palevski, Gil Ben-David, José A Fernández, Shany Nivinsky Margalit, Sarina Levy-Mendelovich, Gili Kenet, Dov Weinberger, John H Griffin, Tami Livna. 3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445820. |
our results demonstrated that 3k3a-apc treatment significantly reduced the accumulation and activation of myeloid cells and microglia in the cnv area and decreased the nlrp3 and il-1β levels at the cnv site and the surrounding retina. |
2023-07-14 |
2023-08-14 |
Not clear |
| Cassie L Rayner, Steven E Bottle, Alexander P Martyn, Nigel L Barnet. Preserving Retinal Structure and Function with the Novel Nitroxide Antioxidant, DCTEIO. Neurochemical research. 2023-07-14. PMID:37450210. |
the number of 'activated' microglia, particularly in the outer retina, in response to cellular stress was also significantly reduced by dcteio, potentially suggesting reduced inflammasome activation and cell death. |
2023-07-14 |
2023-08-14 |
Not clear |
| Asha Kumari, Shyamanga Borooa. The Role of Microglia in Inherited Retinal Diseases. Advances in experimental medicine and biology. vol 1415. 2023-07-13. PMID:37440034. |
microglia are the primary immune cells in the retina and actively contribute to disease pathogenesis when activated locally by phagocytosing photoreceptors, inducing inflammation and signaling infiltration of circulating monocytes. |
2023-07-13 |
2023-08-14 |
mouse |
| Yishen Wang, Yiwen Hong, Shudi Mao, Jianying Pan, Yamei Cui, Jing Lu, Tao Wen, Xiao Wang, Yan Lu. Downregulation of miR-124-3p suppresses the development of the deep retinal blood vessels by enhancing the Stat1/Ripk1 pathway in mouse retinal microglia. Experimental eye research. 2023-06-25. PMID:37356537. |
immunofluorescent staining of both retinal frozen sections and whole retina were used to observe retinal vascular development in the p6, p9 and p12 mice, as well as the changes in retinal ganglion cells, astrocytes, müller cells and microglia. |
2023-06-25 |
2023-08-14 |
mouse |
| Yishen Wang, Yiwen Hong, Shudi Mao, Jianying Pan, Yamei Cui, Jing Lu, Tao Wen, Xiao Wang, Yan Lu. Downregulation of miR-124-3p suppresses the development of the deep retinal blood vessels by enhancing the Stat1/Ripk1 pathway in mouse retinal microglia. Experimental eye research. 2023-06-25. PMID:37356537. |
the microglia penetrated deep into the retina and the activation of ripk1(+) microglia significantly increased, which was accompanied by an increased level of apoptosis to inhibit the deep vascular sprout. |
2023-06-25 |
2023-08-14 |
mouse |
| Heithem M El-Hodiri, James Bentley, Alana Reske, Isabella Palazzo, Warren A Campbell, Nicklaus R Halloy, Andy J Fische. Formation of Müller glia-derived progenitor cells in retinas depleted of microglia. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333380. |
we generated scrna-seq libraries to identify transcriptional changes in müller glia (mg) that result from the depletion of microglia from the chick retina. |
2023-06-19 |
2023-08-14 |
mouse |
| Ayumi Usui-Ouchi, Sarah Giles, Sarah Harkins-Perry, Elizabeth A Mills, Roberto Bonelli, Guoqin Wei, Yasuo Ouchi, Nobuyuki Ebihara, Shintaro Nakao, Martin Friedlander, Kevin T Ead. Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche. Glia. 2023-06-19. PMID:37335016. |
in the retina, microglia are resident immune cells that are essential for development and function. |
2023-06-19 |
2023-08-14 |
human |
| Ayumi Usui-Ouchi, Sarah Giles, Sarah Harkins-Perry, Elizabeth A Mills, Roberto Bonelli, Guoqin Wei, Yasuo Ouchi, Nobuyuki Ebihara, Shintaro Nakao, Martin Friedlander, Kevin T Ead. Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche. Glia. 2023-06-19. PMID:37335016. |
increasing cellular diversity in ros by including resident microglia would more accurately represent the native retina and better model diseases in which microglia play a key role. |
2023-06-19 |
2023-08-14 |
human |
| Jie Chang, Yujue Wang, Jing Xu, Xiaoye Du, Jingang Cui, Teng Zhang, Yu Che. Ginsenoside Re Mitigates Photooxidative Stress-Mediated Photoreceptor Degeneration and Retinal Inflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-16. PMID:37326907. |
meanwhile, photoreceptor degeneration interacts closely with neurotoxic inflammatory responses primarily mediated by aberrantly activated microglia in the retina. |
2023-06-16 |
2023-08-14 |
Not clear |
| Jie Chang, Yujue Wang, Jing Xu, Xiaoye Du, Jingang Cui, Teng Zhang, Yu Che. Ginsenoside Re Mitigates Photooxidative Stress-Mediated Photoreceptor Degeneration and Retinal Inflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-16. PMID:37326907. |
furthermore, re treatment preserves the morphological and functional integrity of the retina, counteracts photooxidative stress-induced perturbation of the retinal gene expression profiles and mitigates photoreceptor degeneration-associated neuroinflammatory responses and microglia activation in the retina. |
2023-06-16 |
2023-08-14 |
Not clear |
| Sandeep Kumar, Abram Akopian, Stewart A Bloomfiel. Neuroprotection of Retinal Ganglion Cells Suppresses Microglia Activation in a Mouse Model of Glaucoma. Investigative ophthalmology & visual science. vol 64. issue 7. 2023-06-15. PMID:37318444. |
we therefore investigated the temporal and spatial appearance of activated microglia in retina and their correspondence to rgc degeneration in glaucoma. |
2023-06-15 |
2023-08-14 |
mouse |
| Huan Yu, Huimin Zhong, Jun Sun, Na Li, Junjue Chen, Bingqiao Shen, Ping Huang, Xi Shen, Shouyue Huang, Yisheng Zhon. Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma. iScience. vol 26. issue 6. 2023-05-30. PMID:37250793. |
interactions between microglia and macroglia play important roles in the neurodegeneration of the central nervous system and so is the situation between microglia and müller cells in retina neurodegenerations like glaucoma. |
2023-05-30 |
2023-08-14 |
rat |
| Peiyao Mao, Yinchen Shen, Xiying Mao, Kun Liu, Jiawei Zhon. The single-cell landscape of alternative transcription start sites of diabetic retina. Experimental eye research. 2023-05-26. PMID:37236522. |
furthermore, by comparing tss expression between healthy and diabetic retina, we identified elevated apoptosis signal in müller glia and microglia, which can be served as a putative early sign of diabetic retinopathy. |
2023-05-26 |
2023-08-14 |
Not clear |
| Kevin Emmerich, David T White, Siva P Kambhampati, Grace L Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T Saxena, Steven L Walker, Eric Betzig, Rangaramanujam M Kannan, Jeff S Mum. Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina. Communications biology. vol 6. issue 1. 2023-05-18. PMID:37202450. |
nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina. |
2023-05-18 |
2023-08-14 |
mouse |
| Kevin Emmerich, David T White, Siva P Kambhampati, Grace L Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T Saxena, Steven L Walker, Eric Betzig, Rangaramanujam M Kannan, Jeff S Mum. Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina. Communications biology. vol 6. issue 1. 2023-05-18. PMID:37202450. |
similarly, microglia ablation enhances regenerative outcomes in the mouse retina. |
2023-05-18 |
2023-08-14 |
mouse |