| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabella Palazzo, Lisa Kelly, Lindsay Koenig, Andy J Fische. Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina. Experimental neurology. 2022-09-29. PMID:36174748. |
patterns of nfkb activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina. |
2022-09-29 |
2023-08-14 |
mouse |
| Bingsheng Lou, Lei Zeng, Xinbo Gao, Xiaobing Qian, Jing Jing Li, Xinyu Gu, Zheng Liu, Keli Liu, Xun Chen, Xiaofeng Lin, Feng Zhan. A single-cell transcriptomic atlas of the human ciliary body. Cellular and molecular life sciences : CMLS. vol 79. issue 10. 2022-09-26. PMID:36163311. |
importantly, we discovered the transitional states that probably contribute to the transition of ciliary macrophage into retina microglia and verified no lymphatics in the ciliary body. |
2022-09-26 |
2023-08-14 |
human |
| Kangjia Lv, Hui Ying, Guangyi Hu, Jing Hu, Qizhi Jian, Fang Zhan. Integrated multi-omics reveals the activated retinal microglia with intracellular metabolic reprogramming contributes to inflammation in STZ-induced early diabetic retinopathy. Frontiers in immunology. vol 13. 2022-09-19. PMID:36119084. |
these findings suggest that activated microglia with intracellular metabolic reprogramming in retina may contribute to pro-inflammation in the early dr. |
2022-09-19 |
2023-08-14 |
mouse |
| Haoshen Shi, Zhuoran Yin, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Miyah R Davis, Jered W Wilson, Milica A Margeta, Kristen M Pitts, Shawn Herron, Seiko Ikezu, Tsuneya Ikezu, Stuart L Graham, Vivek K Gupta, Keith L Black, Mehdi Mirzaei, Oleg Butovsky, Maya Koronyo-Hamaou. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3 Acta neuropathologica communications. vol 10. issue 1. 2022-09-08. PMID:36076283. |
despite growing interest in studying manifestations of alzheimer's disease (ad) in the retina, a cns organ accessible to noninvasive high-resolution imaging, to date mgnd microglia have not been studied in the ad retina. |
2022-09-08 |
2023-08-14 |
Not clear |
| Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E Egwuag. Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897732. |
interleukin-27 is constitutively secreted by microglia in the retina or brain, and upregulation of il-27 during neuroinflammation suppresses encephalomyelitis and autoimmune uveitis. |
2022-07-28 |
2023-08-14 |
mouse |
| Yan Tao, Yusuke Murakami, Demetrios G Vavvas, Koh-Hei Sonod. Necroptosis and Neuroinflammation in Retinal Degeneration. Frontiers in neuroscience. vol 16. 2022-07-18. PMID:35844208. |
receptor-interacting protein kinase (ripk) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse neurodegenerative diseases in the central nervous system and the retina. |
2022-07-18 |
2023-08-14 |
Not clear |
| Jacob K Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J McCright, Mingyao Li, Randy J Zauhar, Sandra R Montezuma, Rebecca J Kapphahn, Venkata R M Chavali, David A Hill, Deborah A Ferrington, Dwight Stambolian, Robert F Mullins, David Merrick, Joshua L Dunaie. Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction. Cell reports. vol 39. issue 11. 2022-06-15. PMID:35705048. |
rna sequencing (rna-seq) analysis of choroid and retina from human donors revealed that hallmarks of this pathway are present in amd microglia and macrophages. |
2022-06-15 |
2023-08-14 |
human |
| Marco Puthenparampil, Tommaso Torresin, Silvia Franciotta, Annachiara Marin, Federica De Napoli, Valentina Annamaria Mauceri, Silvia Miante, Elisabetta Pilotto, Edoardo Midena, Paolo Gall. Hyper-Reflecting Foci in Multiple Sclerosis Retina Associate With Macrophage/Microglia-Derived Cytokines in Cerebrospinal Fluid. Frontiers in immunology. vol 13. 2022-06-06. PMID:35664007. |
since microglia are widespread activated in multiple sclerosis (ms) brain, its evaluation in retina may help to understand and monitor ms-related pathology. |
2022-06-06 |
2023-08-14 |
Not clear |
| Assraa Hassan Jassim, Nana Yaa Nsiah, Denise M Inma. Ocular Hypertension Results in Hypoxia within Glia and Neurons throughout the Visual Projection. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624752. |
hypoxia was detected primarily in müller glia in the retina, and microglia and astrocytes in the on and optic nerve head (onh). |
2022-05-28 |
2023-08-13 |
mouse |
| Marta Pengo, Silvia Miante, Silvia Franciotta, Marta Ponzano, Tommaso Torresin, Francesca Bovis, Francesca Rinaldi, Paola Perini, Martina Saiani, Monica Margoni, Alessandra Bertoldo, Maria Pia Sormani, Elisabetta Pilotto, Edoardo Midena, Paolo Gallo, Marco Puthenparampi. Retinal Hyperreflecting Foci Associate With Cortical Pathology in Multiple Sclerosis. Neurology(R) neuroimmunology & neuroinflammation. vol 9. issue 4. 2022-05-23. PMID:35606113. |
microglia, the resident immune cell of the brain and retina, is widespread activated in the white and gray matter (gm) in multiple sclerosis (ms). |
2022-05-23 |
2023-08-13 |
Not clear |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
microglia prevent the loss of visual function in the aging retina by maintaining the health of retinal pigment epithelial cells. |
2022-05-13 |
2023-08-13 |
mouse |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
interestingly, aging also coincides with the migration of microglia from the inner to the outer retina where they reside in the subretinal space between photoreceptor outer segments and the apical surface of rpe. |
2022-05-13 |
2023-08-13 |
mouse |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
healthy young microglia act as the immune sentinels of the retina, and thus are protective and maintain retinal homeostasis. |
2022-05-13 |
2023-08-13 |
mouse |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
we conclude that microglia in aging mice migrate to the subretinal space of the outer retina to support and maintain rpe cell functions that preserves vision. |
2022-05-13 |
2023-08-13 |
mouse |
| Anne Klotzsche-von Ameln, David Sprot. Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies? Pflugers Archiv : European journal of physiology. 2022-05-07. PMID:35524802. |
during the manifestation of ir, the retina, normally an immune privileged tissue, encounters enhanced levels of cellular stress and inflammation that attract mononuclear phagocytes (mps) from the blood stream and activate resident mps (microglia). |
2022-05-07 |
2023-08-13 |
Not clear |
| Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vette. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. eLife. vol 11. 2022-04-28. PMID:35481836. |
using early postnatal mouse retina, a cns region undergoing significant developmental remodeling, we performed scrnaseq on microglia from mice that are wild-type, lack neuronal apoptosis (bax ko), or are treated with csf1r inhibitor (plx3397). |
2022-04-28 |
2023-08-13 |
mouse |
| Dennis-Dominik Rosmus, Clemens Lange, Franziska Ludwig, Bahareh Ajami, Peter Wieghofe. The Role of Osteopontin in Microglia Biology: Current Concepts and Future Perspectives. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453590. |
whereas the cns borders harbor extraparenchymal cns-associated macrophages whose main duty is to build up a defense against invading pathogens and other damaging factors from the periphery, the resident immune cells of the cns parenchyma and the retina, microglia, are highly dynamic cells with a plethora of functions during homeostasis and disease. |
2022-04-23 |
2023-08-13 |
Not clear |
| Whitney A Thiel, Zachary I Blume, Diana M Mitchel. Compensatory engulfment and Müller glia reactivity in the absence of microglia. Glia. 2022-04-22. PMID:35451181. |
microglia are known for important phagocytic functions in the vertebrate retina. |
2022-04-22 |
2023-08-13 |
zebrafish |
| Whitney A Thiel, Zachary I Blume, Diana M Mitchel. Compensatory engulfment and Müller glia reactivity in the absence of microglia. Glia. 2022-04-22. PMID:35451181. |
here, we investigate müller glial engulfment of dying cells in the developing zebrafish retina in the presence and absence of microglia, using a genetic mutant in which microglia do not develop. |
2022-04-22 |
2023-08-13 |
zebrafish |
| Mei-Ling Gao, Xiao Zhang, Fang Han, Jia Xu, Si-Jian Yu, Kangxin Jin, Zi-Bing Ji. Functional microglia derived from human pluripotent stem cells empower retinal organ. Science China. Life sciences. 2022-04-22. PMID:35451725. |
microglia are known to play essential roles in the development, progression and treatment of diverse neurodegenerative diseases in the central nervous system, including the retina, brain and spinal cord. |
2022-04-22 |
2023-08-13 |
human |