| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew M LaVail, Shimpei Nishikawa, Roy H Steinberg, Muna I Naash, Jacque L Duncan, Nikolaus Trautmann, Michael T Matthes, Douglas Yasumura, Cathy Lau-Villacorta, Jeannie Chen, Ward M Peterson, Haidong Yang, John G Flanner. Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Experimental eye research. vol 167. 2018-10-05. PMID:29122605. |
here we present a comprehensive study of the 8 tg lines, including the time course of pr degeneration from the onset to one year of age, retinal structure by light and electron microscopy (em), hemispheric asymmetry and gradients of rod and cone degeneration, rhodopsin content, gene dosage effect, rapid activation and invasion of the outer retina by presumptive microglia, rod outer segment disc shedding and phagocytosis by the retinal pigmented epithelium (rpe), and retinal function by the electroretinogram (erg). |
2018-10-05 |
2023-08-13 |
rat |
| Yoko Okunuki, Ryo Mukai, Elizabeth A Pearsall, Garrett Klokman, Deeba Husain, Dong-Ho Park, Ekaterina Korobkina, Howard L Weiner, Oleg Butovsky, Bruce R Ksander, Joan W Miller, Kip M Conno. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 27. 2018-09-04. PMID:29915052. |
microglia are the resident immune cells of the central nervous system, including the retina, and function in the homeostatic maintenance of the neuro-retinal microenvironment. |
2018-09-04 |
2023-08-13 |
Not clear |
| Yoko Okunuki, Ryo Mukai, Elizabeth A Pearsall, Garrett Klokman, Deeba Husain, Dong-Ho Park, Ekaterina Korobkina, Howard L Weiner, Oleg Butovsky, Bruce R Ksander, Joan W Miller, Kip M Conno. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 27. 2018-09-04. PMID:29915052. |
depletion of retinal microglia results in increased disease severity and inhibition of macrophage infiltration, suggesting that microglia are involved in regulating neuroinflammation in the retina. |
2018-09-04 |
2023-08-13 |
Not clear |
| Su-Hua Zhu, Bing-Qian Liu, Mao-Juan Hao, Yi-Xin Fan, Cheng Qian, Peng Teng, Xiao-Wei Zhou, Liang Hu, Wen-Tao Liu, Zhi-Lan Yuan, Qing-Ping L. Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy. Inflammation. vol 40. issue 5. 2018-08-15. PMID:28639050. |
evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in dr. microglial matrix metalloproteinase 9 (mmp-9) has an important role in the destruction of the integrity of the blood-retinal barrier (brb) associated with the development of dr. mmp-9 was also considered important for regulating inflammatory responses. |
2018-08-15 |
2023-08-13 |
mouse |
| Christine Altmann, Mirko H H Schmid. The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration. International journal of molecular sciences. vol 19. issue 1. 2018-08-01. PMID:29301251. |
microglia, the resident monocytes of the retina, are activated due to a complex interplay between the different cell types of the retina and diverse pathological pathways. |
2018-08-01 |
2023-08-13 |
Not clear |
| Zijing Huang, Tian Zhou, Xiaowei Sun, Yingfeng Zheng, Bing Cheng, Mei Li, Xialin Liu, Chang H. Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28885615. |
microglia, the resident innate immune cells in retina, are implicated as principal components of the immunological insult to retinal neural cells. |
2018-07-16 |
2023-08-13 |
mouse |
| Raquel Boia, Filipe Elvas, Maria H Madeira, Inês D Aires, Ana C Rodrigues-Neves, Pedro Tralhão, Eszter C Szabó, Younis Baqi, Christa E Müller, Ângelo R Tomé, Rodrigo A Cunha, António F Ambrósio, Ana R Santiag. Treatment with A Cell death & disease. vol 8. issue 10. 2018-06-08. PMID:28981089. |
evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia reactivity may afford neuroprotection to the retina against the damage induced by ischemia-reperfusion (i-r). |
2018-06-08 |
2023-08-13 |
Not clear |
| Agustina Noailles, Victoria Maneu, Laura Campello, Violeta Gómez-Vicente, Pedro Lax, Nicolás Cuenc. Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration. Scientific reports. vol 6. 2018-06-04. PMID:27624537. |
microglia act as the resident immune cells of the central nervous system, including the retina. |
2018-06-04 |
2023-08-13 |
rat |
| Caroline E Walsh, Peter F Hitchcoc. Progranulin regulates neurogenesis in the developing vertebrate retina. Developmental neurobiology. vol 77. issue 9. 2018-04-30. PMID:28380680. |
at 24 hpf pgrn-a is expressed throughout the forebrain, but by 48 hpf pgrn-a is exclusively expressed by microglia and/or microglial precursors within the brain and retina. |
2018-04-30 |
2023-08-13 |
zebrafish |
| Xiao He, Dayu Sun, Siyu Chen, Haiwei X. Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404878. |
recently, immune cells, including microglia, müller cells and astrocytes, in degenerative retina are demonstrated to play key roles in the development of rd and can be used as potential therapeutic targets. |
2018-03-05 |
2023-08-13 |
mouse |
| Jorge L Cueva Vargas, Nicolas Belforte, Adriana Di Pol. The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling. Neurobiology of disease. vol 93. 2018-02-27. PMID:27163643. |
here, we demonstrate that intraocular administration of ibudilast dampened macroglia and microglia reactivity in the retina and optic nerve hence decreasing production of proinflammatory cytokines in a rat model of ocular hypertension. |
2018-02-27 |
2023-08-13 |
rat |
| Jung Woo Han, Juhye Choi, Young Shin Kim, Jina Kim, Ralf Brinkmann, Jungmook Lyu, Tae Kwann Par. Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 256. issue 2. 2018-02-14. PMID:29322247. |
this study investigated microglia and inflammatory cell responses after selective retina therapy (srt) with microsecond-pulsed laser in comparison to continuous-wave laser photocoagulation (cwpc). |
2018-02-14 |
2023-08-13 |
mouse |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
microglia, the principal resident immune cell in the retina, play constitutive roles in immune surveillance and synapse maintenance, and are also associated with retinal disease, including those occurring in the macula. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
perspectives on retinal microglia function have derived largely from rodent models and how these relate to the macula-bearing primate retina is unclear. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
we found that microglia density peaked in the parafoveal retina and decreased in the peripheral retina. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
comparing retinal microglia between young and middle-aged animals, microglial density increased in the macular, but not in the peripheral retina with age, while microglial morphology across all locations remained relatively unchanged. |
2018-01-30 |
2023-08-13 |
monkey |
| Yanhe Wang, Zhiyuan Yin, Lixiong Gao, Dayu Sun, Xisu Hu, Langyue Xue, Jiaman Dai, YuXiao Zeng, Siyu Chen, Boju Pan, Min Chen, Jing Xie, Haiwei X. Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 44. issue 2. 2018-01-18. PMID:29145208. |
curcumin delays retinal degeneration by regulating microglia activation in the retina of rd1 mice. |
2018-01-18 |
2023-08-13 |
mouse |
| Samantha J Dando, Cecilia Naranjo Golborne, Holly R Chinnery, Marc J Ruitenberg, Paul G McMenami. A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. Glia. vol 64. issue 8. 2018-01-04. PMID:27189804. |
a case of mistaken identity: cd11c-eyfp(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. |
2018-01-04 |
2023-08-13 |
mouse |
| Hideto Koso, Asano Tsuhako, Chen-Yi Lai, Yukihiro Baba, Makoto Otsu, Kazuko Ueno, Masao Nagasaki, Yutaka Suzuki, Sumiko Watanab. Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina. Glia. vol 64. issue 11. 2018-01-04. PMID:27459098. |
bone marrow transplantation revealed the invasion of monocyte-derived macrophages into the retina, with microglia and the infiltrating macrophages showing distinct distribution patterns in the retina. |
2018-01-04 |
2023-08-13 |
mouse |
| Ana I Arroba, Ángela M Valverd. Modulation of microglia in the retina: new insights into diabetic retinopathy. Acta diabetologica. vol 54. issue 6. 2017-12-26. PMID:28349217. |
modulation of microglia in the retina: new insights into diabetic retinopathy. |
2017-12-26 |
2023-08-13 |
Not clear |