| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gurugirijha Rathnasamy, Wallace S Foulds, Eng-Ang Ling, Charanjit Kau. Retinal microglia - A key player in healthy and diseased retina. Progress in neurobiology. vol 173. 2020-02-17. PMID:29864456. |
the contribution of microglia in maintaining the purposeful and functional histo-architecture of the adult retina is indispensable. |
2020-02-17 |
2023-08-13 |
Not clear |
| Gurugirijha Rathnasamy, Wallace S Foulds, Eng-Ang Ling, Charanjit Kau. Retinal microglia - A key player in healthy and diseased retina. Progress in neurobiology. vol 173. 2020-02-17. PMID:29864456. |
in light of the above, the focus of this review is to highlight the role played by microglia in the healthy and diseased retina, based on findings of our own work and from that of others. |
2020-02-17 |
2023-08-13 |
Not clear |
| Paul G McMenamin, Daniel R Saban, Samantha J Dand. Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance. Progress in retinal and eye research. vol 70. 2020-02-07. PMID:30552975. |
this is in marked contrast to the neural parenchyma of the retina, which is populated almost solely by microglia. |
2020-02-07 |
2023-08-13 |
Not clear |
| Isha Akhtar-Schaefer, Raphael Reuten, Manuel Koch, Markus Pietsch, Thomas Langman. AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microglia. Advances in experimental medicine and biology. vol 1185. 2020-02-05. PMID:31884580. |
htra1 is known to inhibit transforming growth factor-β (tgf-β) signaling, a pathway regulating quiescence of microglia, the resident immune cells of the brain and retina. |
2020-02-05 |
2023-08-13 |
Not clear |
| C Henrique Alves, Jan Wijnhold. Microglial Cell Dysfunction in CRB1-Associated Retinopathies. Advances in experimental medicine and biology. vol 1185. 2020-02-05. PMID:31884605. |
microglia are the resident immune surveyor cells in the retina, and their roles have been heavily studied in several retinal diseases, including retinitis pigmentosa (rp), age-related macular degeneration, and diabetic retinopathy. |
2020-02-05 |
2023-08-13 |
Not clear |
| Chen Yu, Daniel R Saba. Identification of a Unique Subretinal Microglia Type in Retinal Degeneration Using Single Cell RNA-Seq. Advances in experimental medicine and biology. vol 1185. 2020-02-05. PMID:31884609. |
as the resident macrophages of central nervous system, microglia reside in the plexiform and nerve fiber layers of the retina. |
2020-02-05 |
2023-08-13 |
mouse |
| Jose A Fernández-Albarral, Ana I Ramírez, Rosa de Hoz, Nerea López-Villarín, Elena Salobrar-García, Inés López-Cuenca, Ester Licastro, Antonio M Inarejos-García, Paula Almodóvar, Maria D Pinazo-Durán, José M Ramírez, Juan J Salaza. Neuroprotective and Anti-Inflammatory Effects of a Hydrophilic Saffron Extract in a Model of Glaucoma. International journal of molecular sciences. vol 20. issue 17. 2020-01-22. PMID:31443568. |
activation of immune cells resident in the retina (microglia) may contribute to rgc death. |
2020-01-22 |
2023-08-13 |
mouse |
| Levi Todd, Isabella Palazzo, Lilianna Suarez, Xiaoyu Liu, Leo Volkov, Thanh V Hoang, Warren A Campbell, Seth Blackshaw, Ning Quan, Andy J Fische. Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina. Journal of neuroinflammation. vol 16. issue 1. 2020-01-13. PMID:31170999. |
reactive microglia and il1β/il-1r1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina. |
2020-01-13 |
2023-08-13 |
mouse |
| Scott W McPherson, Neal D Heuss, Ute Lehmann, Heidi Roehrich, Md Abedin, Dale S Gregerso. The retinal environment induces microglia-like properties in recruited myeloid cells. Journal of neuroinflammation. vol 16. issue 1. 2020-01-13. PMID:31325968. |
here, we ask whether new myeloid cells recruited to the retina are constrained to resemble endogenous microglia morphologically and functionally. |
2020-01-13 |
2023-08-13 |
Not clear |
| Federica Maria Conedera, Ana Maria Quintela Pousa, Nadia Mercader, Markus Tschopp, Volker Enzman. Retinal microglia signaling affects Müller cell behavior in the zebrafish following laser injury induction. Glia. vol 67. issue 6. 2019-12-30. PMID:30794326. |
microglia are the resident tissue macrophages of the central nervous system including the retina. |
2019-12-30 |
2023-08-13 |
zebrafish |
| Federica Maria Conedera, Ana Maria Quintela Pousa, Nadia Mercader, Markus Tschopp, Volker Enzman. Retinal microglia signaling affects Müller cell behavior in the zebrafish following laser injury induction. Glia. vol 67. issue 6. 2019-12-30. PMID:30794326. |
under pathophysiological conditions, microglia can signal to müller cells, the major glial component of the retina, affecting their morphological, molecular, and functional responses. |
2019-12-30 |
2023-08-13 |
zebrafish |
| Federica Maria Conedera, Ana Maria Quintela Pousa, Nadia Mercader, Markus Tschopp, Volker Enzman. Retinal microglia signaling affects Müller cell behavior in the zebrafish following laser injury induction. Glia. vol 67. issue 6. 2019-12-30. PMID:30794326. |
thus, microglia and müller cell signaling is pivotal to unlock the regenerative potential of müller cells in order to repair the damaged retina. |
2019-12-30 |
2023-08-13 |
zebrafish |
| Anna Polosa, Shasha Lv, Wassila Ait Igrine, Laura-Alexie Chevrolat, Hyba Bessaklia, Pierre Lachapell. Evidences Suggesting that Distinct Immunological and Cellular Responses to Light Damage Distinguishes Juvenile and Adult Rat Retinas. International journal of molecular sciences. vol 20. issue 11. 2019-11-25. PMID:31167447. |
ihc revealed a subtle migration of microglia (iba1 marker) from the inner to the outer retina after 3 days of exposure in jr contrasting with the stronger reaction seen after 1 day in ar. |
2019-11-25 |
2023-08-13 |
rat |
| Eleftherios I Paschalis, Fengyang Lei, Chengxin Zhou, Xiaohong Nancy Chen, Vassiliki Kapoulea, Pui-Chuen Hui, Reza Dana, James Chodosh, Demetrios G Vavvas, Claes H Dohlma. Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 2. 2019-10-28. PMID:30541880. |
reactive microglia and infiltrating peripheral monocytes have been implicated in many neurodegenerative diseases of the retina and cns. |
2019-10-28 |
2023-08-13 |
mouse |
| Yikui Zhang, Lian Zhao, Xu Wang, Wenxin Ma, Adam Lazere, Hao-Hua Qian, Jun Zhang, Mones Abu-Asab, Robert N Fariss, Jerome E Roger, Wai T Won. Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. Science advances. vol 4. issue 3. 2019-09-05. PMID:29750189. |
we examined microglial homeostasis in the adult mouse retina, a specialized neural compartment containing regular arrays of microglia in discrete synaptic laminae that can be directly visualized. |
2019-09-05 |
2023-08-13 |
mouse |
| Yikui Zhang, Lian Zhao, Xu Wang, Wenxin Ma, Adam Lazere, Hao-Hua Qian, Jun Zhang, Mones Abu-Asab, Robert N Fariss, Jerome E Roger, Wai T Won. Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. Science advances. vol 4. issue 3. 2019-09-05. PMID:29750189. |
using in vivo imaging and cell-fate mapping techniques, we discovered that repopulation originated from residual microglia proliferating in the central inner retina that subsequently spread by centrifugal migration to fully recapitulate pre-existing microglial distributions and morphologies. |
2019-09-05 |
2023-08-13 |
mouse |
| Emily G O'Koren, Chen Yu, Mikael Klingeborn, Alicia Y W Wong, Cameron L Prigge, Rose Mathew, Joan Kalnitsky, Rasha A Msallam, Aymeric Silvin, Jeremy N Kay, Catherine Bowes Rickman, Vadim Y Arshavsky, Florent Ginhoux, Miriam Merad, Daniel R Saba. Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration. Immunity. vol 50. issue 3. 2019-08-20. PMID:30850344. |
we combined lineage tracing, single-cell transcriptomics, and electrophysiology of the mouse retina and showed that adult retinal microglia shared a common developmental lineage and were long-lived but resided in two distinct niches. |
2019-08-20 |
2023-08-13 |
mouse |
| Jonathan B Lin, Rajendra S Apt. Visualizing the Heterogeneity of Retinal Microglia. Immunity. vol 50. issue 3. 2019-08-15. PMID:30893583. |
(2019) report that murine retinal microglia are long lived and are divided into two spatially and functionally distinct niches in the retina. |
2019-08-15 |
2023-08-13 |
Not clear |
| Lijuan Zhang, Xuan Cui, Ruben Jauregui, Karen Sophia Park, Sally Justus, Yi-Ting Tsai, Jimmy K Duong, Chun-Wei Hsu, Wen-Hsuan Wu, Christine L Xu, Chyuan-Sheng Lin, Stephen H Tsan. Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa. Molecular therapy : the journal of the American Society of Gene Therapy. vol 26. issue 8. 2019-07-29. PMID:30001913. |
microglia cells (mgcs) play a key role in scavenging pathogens and phagocytosing cellular debris in the central nervous system and retina. |
2019-07-29 |
2023-08-13 |
mouse |
| Daniel R Saba. New concepts in macrophage ontogeny in the adult neural retina. Cellular immunology. vol 330. 2019-06-24. PMID:29703455. |
yet, little attention has been payed to the retina as compared to elsewhere in the central nervous system with respect to microglia, the macrophages of the neural parenchyma. |
2019-06-24 |
2023-08-13 |
human |