| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lili Zhang, Jie Liu, Chun Cheng, Ying Yuan, Biyun Yu, Aiguo Shen, Meijuan Ya. The neuroprotective effect of pyrroloquinoline quinone on traumatic brain injury. Journal of neurotrauma. vol 29. issue 5. 2012-07-23. PMID:22040225. |
lectin-fluorescent staining with rca-i also revealed that pqq contributed to expression upregulation of the galactosidase β-1 (gal β-1), 4-galactosyltransferase n-acylsphingosine (4-glcnac) group in microglia and neurons of the cortex and hippocampal ca2 region. |
2012-07-23 |
2023-08-12 |
Not clear |
| Alexander A Sosunov, Xiaoping Wu, Robert A McGovern, David G Coughlin, Charles B Mikell, Robert R Goodman, Guy M McKhan. The mTOR pathway is activated in glial cells in mesial temporal sclerosis. Epilepsia. vol 53 Suppl 1. 2012-07-16. PMID:22612812. |
in contrast, in sclerotic hippocampus, prominent p-s6 immunostaining was observed mainly in astrocytes and microglia located in the areas of neuronal loss and astrogliosis, whereas neurons in preserved areas of ca1 expressed significantly lower levels of p-s6 immunopositivity than neurons in nonsclerotic or control ca1 subfields. |
2012-07-16 |
2023-08-12 |
human |
| Holly F Green, Eimear Treacy, Aoife K Keohane, Aideen M Sullivan, Gerard W O'Keeffe, Yvonne M Nola. A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Molecular and cellular neurosciences. vol 49. issue 3. 2012-07-13. PMID:22270046. |
prolonged release of interleukin-1β (il-1β) from activated microglia has a deleterious effect on hippocampal neurons and is implicated in the impaired neurogenesis and cognitive dysfunction associated with aging, alzheimer's disease and depression. |
2012-07-13 |
2023-08-12 |
rat |
| Jana Vukovic, Michael J Colditz, Daniel G Blackmore, Marc J Ruitenberg, Perry F Bartlet. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 19. 2012-07-06. PMID:22573666. |
microglia modulate hippocampal neural precursor activity in response to exercise and aging. |
2012-07-06 |
2023-08-12 |
mouse |
| Jana Vukovic, Michael J Colditz, Daniel G Blackmore, Marc J Ruitenberg, Perry F Bartlet. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 19. 2012-07-06. PMID:22573666. |
here, we used transgenic csf1r-gfp mice to investigate whether hippocampal microglia directly influence the activation of neural precursor cells. |
2012-07-06 |
2023-08-12 |
mouse |
| Jana Vukovic, Michael J Colditz, Daniel G Blackmore, Marc J Ruitenberg, Perry F Bartlet. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 19. 2012-07-06. PMID:22573666. |
our results revealed that an exercise-induced increase in neural precursor cell activity was mediated via endogenous microglia and abolished when these cells were selectively removed from hippocampal cultures. |
2012-07-06 |
2023-08-12 |
mouse |
| Jana Vukovic, Michael J Colditz, Daniel G Blackmore, Marc J Ruitenberg, Perry F Bartlet. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 19. 2012-07-06. PMID:22573666. |
these findings provide the first direct evidence that endogenous microglia can exert a dual and opposing influence on neural precursor cell activity within the hippocampus, and that signaling through the cx(3)cl1-cx(3)cr1 axis critically contributes toward this process. |
2012-07-06 |
2023-08-12 |
mouse |
| Jonathan Vinet, Hilmar R J van Weering, Annette Heinrich, Roland E Kälin, Anja Wegner, Nieske Brouwer, Frank L Heppner, Nico van Rooijen, Hendrikus W G M Boddeke, Knut Bibe. Neuroprotective function for ramified microglia in hippocampal excitotoxicity. Journal of neuroinflammation. vol 9. 2012-06-06. PMID:22293457. |
neuroprotective function for ramified microglia in hippocampal excitotoxicity. |
2012-06-06 |
2023-08-12 |
Not clear |
| Peggy Schneider, Wolfgang Weber-Fahr, Nina Schweinfurth, Ying-Jui Ho, Alexander Sartorius, Rainer Spanagel, Cornelius R Pawla. Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge. Brain, behavior, and immunity. vol 26. issue 2. 2012-05-17. PMID:21983278. |
a significant correlation of anxiety-like measures and myo-inositol, a marker for microglia activity, was found in the hippocampus. |
2012-05-17 |
2023-08-12 |
rat |
| Peggy Schneider, Wolfgang Weber-Fahr, Nina Schweinfurth, Ying-Jui Ho, Alexander Sartorius, Rainer Spanagel, Cornelius R Pawla. Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge. Brain, behavior, and immunity. vol 26. issue 2. 2012-05-17. PMID:21983278. |
the facs analysis showed a significant increase in cd25(+) microglia in the hippocampus compared to controls. |
2012-05-17 |
2023-08-12 |
rat |
| Matthew G Frank, Brittany M Thompson, Linda R Watkins, Steven F Maie. Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain, behavior, and immunity. vol 26. issue 2. 2012-05-17. PMID:22041296. |
here, stress-induced gc signaling was manipulated in vivo and hippocampal microglia challenged with the pro-inflammatory stimulus lps ex vivo. |
2012-05-17 |
2023-08-12 |
rat |
| Matthew G Frank, Brittany M Thompson, Linda R Watkins, Steven F Maie. Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain, behavior, and immunity. vol 26. issue 2. 2012-05-17. PMID:22041296. |
animals were then exposed to an acute stressor (inescapable tailshock; is) and 24 h later hippocampal microglia were isolated and challenged with lps to probe for stress-induced sensitization of pro-inflammatory responses. |
2012-05-17 |
2023-08-12 |
rat |
| Tünde Tokés, Gábor Eros, Attila Bebes, Petra Hartmann, Szilvia Várszegi, Gabriella Varga, József Kaszaki, Károly Gulya, Miklós Ghyczy, Mihály Boro. Protective effects of a phosphatidylcholine-enriched diet in lipopolysaccharide-induced experimental neuroinflammation in the rat. Shock (Augusta, Ga.). vol 36. issue 5. 2012-05-16. PMID:21937953. |
immunohistochemistry was performed to visualize the bromodeoxyuridine and doublecortin-positive neuroprogenitor cells and iba1-positive microglia in the hippocampus, whereas the degree of mucosal damage was evaluated on ileal and colon biopsy samples after hematoxylin-eosin staining. |
2012-05-16 |
2023-08-12 |
rat |
| Tünde Tokés, Gábor Eros, Attila Bebes, Petra Hartmann, Szilvia Várszegi, Gabriella Varga, József Kaszaki, Károly Gulya, Miklós Ghyczy, Mihály Boro. Protective effects of a phosphatidylcholine-enriched diet in lipopolysaccharide-induced experimental neuroinflammation in the rat. Shock (Augusta, Ga.). vol 36. issue 5. 2012-05-16. PMID:21937953. |
the inflammatory challenge transiently increased the hippocampal nox level and led to microglia accumulation and decreased neurogenesis. |
2012-05-16 |
2023-08-12 |
rat |
| Bin Li, Dong-Sung Lee, Gil-Saeng Jeong, Youn-Chul Ki. Involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22119385. |
involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells. |
2012-05-03 |
2023-08-12 |
mouse |
| Bin Li, Dong-Sung Lee, Gil-Saeng Jeong, Youn-Chul Ki. Involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22119385. |
the present study proposed to examine the role of dmf as an anti-oxidative and anti-inflammatory heme oxygenase-1 (ho-1) inducer in mouse hippocampal ht22 cells and bv2 microglia cells. |
2012-05-03 |
2023-08-12 |
mouse |
| Lan Wei, Arthur Simen, Shrikant Mane, Arie Kaffma. Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21993208. |
lbp levels peak in the normally developing hippocampus at a period of intense synaptic pruning, during which lbp is colocalized with the synaptic marker psd95 and is found in close proximity to processes of microglia cells. |
2012-04-17 |
2023-08-12 |
mouse |
| Jianxiong Jiang, Thota Ganesh, Yuhong Du, Yi Quan, Geidy Serrano, Min Qui, Iris Speigel, Asheebo Rojas, Nadia Lelutiu, Raymond Dingledin. Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 8. 2012-04-12. PMID:22323596. |
a brain-permeant compound completely suppressed the up-regulation of cox-2 mrna in rat cultured microglia by ep2 activation and significantly reduced neuronal injury in hippocampus when administered in mice beginning 1 h after termination of pilocarpine-induced status epilepticus. |
2012-04-12 |
2023-08-12 |
mouse |
| Karim Belarbi, Carla Arellano, Ryan Ferguson, Timothy Jopson, Susanna Ros. Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks. Brain, behavior, and immunity. vol 26. issue 1. 2012-03-30. PMID:21787860. |
there was a positive correlation between the density of activated microglia and alterations in the fraction of existing granule neurons expressing arc, suggesting that neuroinflammation induced a long-term disruption of hippocampal network activity. |
2012-03-30 |
2023-08-12 |
rat |
| Olivier Pascual, Sarrah Ben Achour, Philippe Rostaing, Antoine Triller, Alain Bessi. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 4. 2012-03-28. PMID:22167804. |
in the adult hippocampus, microglia are the other major glial cell type. |
2012-03-28 |
2023-08-12 |
Not clear |