| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olivier Pascual, Sarrah Ben Achour, Philippe Rostaing, Antoine Triller, Alain Bessi. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 4. 2012-03-28. PMID:22167804. |
we have used a combination of pharmacological approaches with electrophysiological analysis on acute hippocampal slices and atp assays in purified cell cultures to show that activation of microglia induces a rapid increase of spontaneous excitatory postsynaptic currents. |
2012-03-28 |
2023-08-12 |
Not clear |
| Flavia Antonucci, Alán Alpár, Johannes Kacza, Matteo Caleo, Claudia Verderio, Alice Giani, Henrik Martens, Farrukh A Chaudhry, Manuela Allegra, Jens Grosche, Dominik Michalski, Christian Erck, Anke Hoffmann, Tibor Harkany, Michela Matteoli, Wolfgang Härti. Cracking down on inhibition: selective removal of GABAergic interneurons from hippocampal networks. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323713. |
we also show the focal and indiscriminate loss of calbindin(+), calretinin(+), parvalbumin/system a transporter 1(+), somatostatin(+), vesicular glutamate transporter 3 (vglut3)/cholecystokinin/cb(1) cannabinoid receptor(+) and neuropeptide y(+) local-circuit interneurons upon sava microlesions to the ca1 subfield of the rodent hippocampus, with interneuron debris phagocytosed by infiltrating microglia. |
2012-03-27 |
2023-08-12 |
mouse |
| Xing-Mei Zhang, Xi-Jing Mao, Hong-Liang Zhang, Xiang-Yu Zheng, Therese Pham, Abdu Adem, Bengt Winblad, Eilhard Mix, Jie Zh. Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22079154. |
in the present study, we investigated the individual roles of apoe isoforms in the kainic acid (ka)-induced hippocampal neurodegeneration with focus on immune response and microglia functions. |
2012-03-25 |
2023-08-12 |
mouse |
| Xing-Mei Zhang, Xi-Jing Mao, Hong-Liang Zhang, Xiang-Yu Zheng, Therese Pham, Abdu Adem, Bengt Winblad, Eilhard Mix, Jie Zh. Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22079154. |
in conclusion, over-expression of apoe4 deteriorated ka-induced hippocampal neurodegeneration in c57bl/6 mice, which might result from a higher up-regulation of microglia activation compared to apoe2 and 3 transgenic mice and wt mice. |
2012-03-25 |
2023-08-12 |
mouse |
| Juyeon Park, Jimmy Zhang, Jianhua Qiu, Xiaoxia Zhu, Alexei Degterev, Eng H Lo, Michael J Whale. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 2. 2012-03-21. PMID:21934697. |
at 24 hours, p-s6rp was detected in neurons and was robustly induced in microglia and astrocytes in injured hippocampus. |
2012-03-21 |
2023-08-12 |
mouse |
| Peter Röhnert, Ulrich H Schröder, Iryna Ziabreva, Michael Täger, Klaus G Reymann, Frank Striggo. Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion. Journal of neuroscience research. vol 90. issue 1. 2012-03-13. PMID:21971686. |
cell- type-specific immunohistological staining of hippocampal slice cultures revealed that pyramidal neurons, in contrast to astrocytes and microglia, express free thiols only weakly. |
2012-03-13 |
2023-08-12 |
Not clear |
| Susan V Westmoreland, Lakshmanan Annamalai, Margaret R Lentz, Eva-Marie Ratai, Basel Assaf, Karen Boisvert, Thanhthao Huynh, Eric J Vallender, Gregory M Miller, Bertha K Madras, R Gilberto Gonzale. Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques. Journal of neurovirology. vol 17. issue 5. 2012-02-23. PMID:21789725. |
here we demonstrate that (1) gap-43 mrna and protein are induced with siv infection, (2) gap-43 protein is higher in the hippocampus outer molecular layer in siv-infected animals that received cart compared to those that did not, and (3) activated microglia and infiltrating siv-infected macrophages express abundant ephrin b3, an important axonal guidance molecule. |
2012-02-23 |
2023-08-12 |
Not clear |
| Bunmi Ojo, Payam Rezaie, Paul L Gabbott, Thelma R Cowely, Nikolay I Medvedev, Marina A Lynch, Michael G Stewar. A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21978973. |
these results demonstrate that fgl can indeed regulate neuroglial activation and reduce microglial cell density in the aged hippocampus, and support its potential use as a therapeutic agent in age-related brain disorders. |
2011-12-20 |
2023-08-12 |
rat |
| Annik Prat, Maik Behrendt, Edwige Marcinkiewicz, Sebastien Boridy, Ram M Sairam, Nabil G Seidah, Dusica Maysinge. A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. Journal of aging research. vol 2011. 2011-11-10. PMID:21969914. |
the most prominent changes in the cerebral cortex and hippocampus of these hypoestrogenic mice were marked hypertrophy of both cortical neurons and astrocytes and an increased number of activated microglia. |
2011-11-10 |
2023-08-12 |
mouse |
| Jung Hoon Choi, Moo-Ho Wo. Microglia in the normally aged hippocampus. Laboratory animal research. vol 27. issue 3. 2011-11-10. PMID:21998606. |
microglia in the normally aged hippocampus. |
2011-11-10 |
2023-08-12 |
Not clear |
| Jung Hoon Choi, Moo-Ho Wo. Microglia in the normally aged hippocampus. Laboratory animal research. vol 27. issue 3. 2011-11-10. PMID:21998606. |
therefore, in this review, we discuss morphological and functional changes of the hippocampus and microglia in the aging brain. |
2011-11-10 |
2023-08-12 |
Not clear |
| Hsing-Chieh Ke, Hei-Jen Huang, Keng-Chen Liang, Hsiu Mei Hsieh-L. Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise. Brain research. vol 1403. 2011-11-07. PMID:21689809. |
in addition, the exercise paradigm also reduced amyloid-β peptide (aβ) levels and microglia activation, but not enough to reduce the plaque loading in the hippocampus of the app/ps1 transgenic mice. |
2011-11-07 |
2023-08-12 |
mouse |
| Matthew K Schindler, J Daniel Bourland, M Elizabeth Forbes, Kun Hua, David R Riddl. Neurobiological responses to stereotactic focal irradiation of the adult rodent hippocampus. Journal of the neurological sciences. vol 306. issue 1-2. 2011-10-13. PMID:21481894. |
acute cell death and sustained changes in neurogenesis and in microglia occurred in the dentate gyrus of the targeted, but not the contralateral, hippocampus, providing experimental evidence that focal irradiation at doses received by peri-target regions during targeted radiation therapy produces robust normal tissue responses. |
2011-10-13 |
2023-08-12 |
rat |
| Marta Weinstock, Lisandro Luques, Tatyana Poltyrev, Corina Bejar, Shai Shoha. Ladostigil prevents age-related glial activation and spatial memory deficits in rats. Neurobiology of aging. vol 32. issue 6. 2011-09-13. PMID:19625104. |
when ladostigil (1mg/kg/day) was given for 6 months to 16-month-old rats it prevented the age-related increase in activated astrocytes and microglia in several hippocampal and white matter regions and increased prongf immunoreactivity in the hippocampus towards the levels in young rats. |
2011-09-13 |
2023-08-12 |
rat |
| Onder Albayram, Judith Alferink, Julika Pitsch, Anastasia Piyanova, Kim Neitzert, Karola Poppensieker, Daniela Mauer, Kerstin Michel, Anne Legler, Albert Becker, Krisztina Monory, Beat Lutz, Andreas Zimmer, Andras Bilkei-Gorz. Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 27. 2011-09-09. PMID:21690345. |
however, enhanced neuroinflammation characterized by an increased density of astrocytes and activated microglia as well as an enhanced expression of the inflammatory cytokine il-6 during aging was present in the hippocampus of cnr1(-/-) mice. |
2011-09-09 |
2023-08-12 |
mouse |
| Aya D Pusic, Yelena Y Grinberg, Heidi M Mitchell, Richard P Krai. Modeling neural immune signaling of episodic and chronic migraine using spreading depression in vitro. Journal of visualized experiments : JoVE. issue 52. 2011-09-09. PMID:21694695. |
in contrast, we examine immune signaling in mature hippocampal slice cultures since the cultures closely parallel their in vivo counterpart with mature trisynaptic function; show quiescent astrocytes, microglia, and cytokine levels; and sd is easily induced in an unanesthetized preparation. |
2011-09-09 |
2023-08-12 |
Not clear |
| Kelly R Conner, M Elizabeth Forbes, Won Hee Lee, Yong Woo Lee, David R Riddl. AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain. Radiation research. vol 176. issue 1. 2011-09-02. PMID:21545290. |
at the latter times, microglial density and proliferating and activated microglia were analyzed in the dentate gyrus of the hippocampus. |
2011-09-02 |
2023-08-12 |
rat |
| Kelly R Conner, M Elizabeth Forbes, Won Hee Lee, Yong Woo Lee, David R Riddl. AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain. Radiation research. vol 176. issue 1. 2011-09-02. PMID:21545290. |
l-158,809 treatment modestly increased mrna expression for ang ii receptors and tnf-α but had no effect on radiation-induced effects on hippocampal microglia or neurogenesis. |
2011-09-02 |
2023-08-12 |
rat |
| Ryan P Vetreno, Anna Klintsova, Lisa M Savag. Stage-dependent alterations of progenitor cell proliferation and neurogenesis in an animal model of Wernicke-Korsakoff syndrome. Brain research. vol 1391. 2011-08-30. PMID:21440532. |
dorsal hippocampal sections were immunostained for brdu (proliferating cell marker), neun (neurons), gfap (astrocytes), iba-1 (microglia), and o4 (oligodendrocytes). |
2011-08-30 |
2023-08-12 |
human |
| Justin A McClain, Stephanie A Morris, M Ayumi Deeny, S Alex Marshall, Dayna M Hayes, Zachary M Kiser, Kimberly Nixo. Adolescent binge alcohol exposure induces long-lasting partial activation of microglia. Brain, behavior, and immunity. vol 25 Suppl 1. 2011-08-08. PMID:21262339. |
ethanol induced significant morphological change in hippocampal microglia, consistent with activation. |
2011-08-08 |
2023-08-12 |
rat |