| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minghuan Wang, Jeffrey J Iliff, Yonghong Liao, Michael J Chen, Matthew S Shinseki, Arun Venkataraman, Jessica Cheung, Wei Wang, Maiken Nedergaar. Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 50. 2013-02-27. PMID:23238711. |
microinfarcts were spread throughout the deep cortex, subcortical tissue, and hippocampus and were comprised of a core positive for cd68 (a marker for reactive microglia and macrophages), surrounded by large regions of glial fibrillary acidic protein-positive reactive astrogliosis. |
2013-02-27 |
2023-08-12 |
mouse |
| John D Johnson, Zachary R Zimomra, Luke T Stewar. Beta-adrenergic receptor activation primes microglia cytokine production. Journal of neuroimmunology. vol 254. issue 1-2. 2013-02-25. PMID:22944319. |
to determine if β-ar stimulation is sufficient to prime microglia, rats were intra-cerebroventricularly administered isoproterenol (β-ar agonist) or vehicle and 24 h later hippocampal microglia were placed in culture with media or lps. |
2013-02-25 |
2023-08-12 |
mouse |
| Ming-Chao Liu, Xin-Qin Liu, Wen Wang, Xue-Feng Shen, Hong-Lei Che, Yan-Yan Guo, Ming-Gao Zhao, Jing-Yuan Chen, Wen-Jing Lu. Involvement of microglia activation in the lead induced long-term potentiation impairment. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952811. |
activation of hippocampal microglia also impairs spatial learning and memory. |
2013-02-19 |
2023-08-12 |
Not clear |
| Ming-Chao Liu, Xin-Qin Liu, Wen Wang, Xue-Feng Shen, Hong-Lei Che, Yan-Yan Guo, Ming-Gao Zhao, Jing-Yuan Chen, Wen-Jing Lu. Involvement of microglia activation in the lead induced long-term potentiation impairment. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952811. |
thus, we raised the hypothesis that activation of microglia is involved in the pb exposure induced hippocampal ltp impairment and neuronal injury. |
2013-02-19 |
2023-08-12 |
Not clear |
| Ming-Chao Liu, Xin-Qin Liu, Wen Wang, Xue-Feng Shen, Hong-Lei Che, Yan-Yan Guo, Ming-Gao Zhao, Jing-Yuan Chen, Wen-Jing Lu. Involvement of microglia activation in the lead induced long-term potentiation impairment. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952811. |
to test this hypothesis and clarify its underlying mechanisms, we investigated the pb-exposure on the microglia activation, cytokine release, hippocampal ltp level as well as neuronal injury in in vivo or in vitro model. |
2013-02-19 |
2023-08-12 |
Not clear |
| Ming-Chao Liu, Xin-Qin Liu, Wen Wang, Xue-Feng Shen, Hong-Lei Che, Yan-Yan Guo, Ming-Gao Zhao, Jing-Yuan Chen, Wen-Jing Lu. Involvement of microglia activation in the lead induced long-term potentiation impairment. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952811. |
long-term low dose pb exposure (100 ppm for 8 weeks) caused significant reduction of ltp in acute slice preparations, meanwhile, such treatment also significantly increased hippocampal microglia activation as well as neuronal injury. |
2013-02-19 |
2023-08-12 |
Not clear |
| Ming-Chao Liu, Xin-Qin Liu, Wen Wang, Xue-Feng Shen, Hong-Lei Che, Yan-Yan Guo, Ming-Gao Zhao, Jing-Yuan Chen, Wen-Jing Lu. Involvement of microglia activation in the lead induced long-term potentiation impairment. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952811. |
in vitro pb-exposure also induced significantly increase of microglia activation, up-regulate the release of cytokines including tumor necrosis factor-alpha (tnf-α), interleukin-1β (il-1β) and inducible nitric oxide synthase (inos) in microglia culture alone as well as neuronal injury in the co-culture with hippocampal neurons. |
2013-02-19 |
2023-08-12 |
Not clear |
| Ming-Chao Liu, Xin-Qin Liu, Wen Wang, Xue-Feng Shen, Hong-Lei Che, Yan-Yan Guo, Ming-Gao Zhao, Jing-Yuan Chen, Wen-Jing Lu. Involvement of microglia activation in the lead induced long-term potentiation impairment. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952811. |
our results showed that pb can cause microglia activation, which can up-regulate the level of il-1β, tnf-α and inos, these proinflammatory factors may cause hippocampal neuronal injury as well as ltp deficits. |
2013-02-19 |
2023-08-12 |
Not clear |
| D E Korzhevskiĭ, M V Lentsman, O V Kirik, V A Otelli. [Morphological types of activated microglia in the hippocampus observed following transient total brain ischemia]. Morfologiia (Saint Petersburg, Russia). vol 142. issue 5. 2013-02-13. PMID:23330434. |
[morphological types of activated microglia in the hippocampus observed following transient total brain ischemia]. |
2013-02-13 |
2023-08-12 |
rat |
| D E Korzhevskiĭ, M V Lentsman, O V Kirik, V A Otelli. [Morphological types of activated microglia in the hippocampus observed following transient total brain ischemia]. Morfologiia (Saint Petersburg, Russia). vol 142. issue 5. 2013-02-13. PMID:23330434. |
the aim of the study was to evaluate, by using immunohistochemistry (demonstration of iba-1 protein), the morphological features of the rat hippocampal microglia and to describe its cellular types during the response to a single total brain ischemia of 12 min duration. |
2013-02-13 |
2023-08-12 |
rat |
| Si Yun Ng, Bridgette D Semple, M Cristina Morganti-Kossmann, Nicole By. Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice. Journal of neurotrauma. vol 29. issue 7. 2013-02-05. PMID:22260446. |
contrary to our hypothesis, despite the attenuation of activated microglia, minocycline did not support neurogenesis in the hippocampus, lateral ventricles, or pericontusional cortex, with none of the neurogenic stages being affected by treatment. |
2013-02-05 |
2023-08-12 |
mouse |
| Lisa C Loram, Paige W Sholar, Frederick R Taylor, Julie L Wiesler, Jessica A Babb, Keith A Strand, Debra Berkelhammer, Heidi E W Day, Steven F Maier, Linda R Watkin. Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats. Psychoneuroendocrinology. vol 37. issue 10. 2013-02-01. PMID:22497984. |
hippocampal microglia were isolated from adult male and female rats and stimulated ex vivo with lps. |
2013-02-01 |
2023-08-12 |
rat |
| Lisa C Loram, Paige W Sholar, Frederick R Taylor, Julie L Wiesler, Jessica A Babb, Keith A Strand, Debra Berkelhammer, Heidi E W Day, Steven F Maier, Linda R Watkin. Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats. Psychoneuroendocrinology. vol 37. issue 10. 2013-02-01. PMID:22497984. |
lps-induced il-1β mrna was attenuated by e2 in female but not male adult hippocampal microglia. |
2013-02-01 |
2023-08-12 |
rat |
| Hui Young Lee, Joon Ha Park, Choong Hyun Lee, Bingchun Yan, Ji Hyeon Ahn, Young Joo Lee, Chan Woo Park, Jun Hwi Cho, Soo Young Choi, Moo-Ho Wo. Changes of ribosomal protein S3 immunoreactivity and its new expression in microglia in the mice hippocampus after lipopolysaccharide treatment. Cellular and molecular neurobiology. vol 32. issue 4. 2013-01-31. PMID:22274408. |
changes of ribosomal protein s3 immunoreactivity and its new expression in microglia in the mice hippocampus after lipopolysaccharide treatment. |
2013-01-31 |
2023-08-12 |
mouse |
| Seung-Tae Kim, Ah-Reum Doo, Seung-Nam Kim, Song-Yi Kim, Yoon Young Kim, Jang-Hyun Kim, Hyejung Lee, Chang Shik Yin, Hi-Joon Par. Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus. The journal of physiological sciences : JPS. vol 62. issue 5. 2013-01-18. PMID:22773088. |
twenty-four hours after the ka injection, neuronal cell survival, the activations of microglia and astrocytes, and mrna expression of two proinflammatory cytokines, interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α), were measured in the hippocampus. |
2013-01-18 |
2023-08-12 |
mouse |
| Yolanda Diz-Chaves, Olga Pernía, Paloma Carrero, Luis M Garcia-Segur. Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22520439. |
prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice. |
2013-01-17 |
2023-08-12 |
mouse |
| Tobias Engel, Alba Jimenez-Pacheco, Maria Teresa Miras-Portugal, Miguel Diaz-Hernandez, David C Henshal. P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. International journal of physiology, pathophysiology and pharmacology. vol 4. issue 4. 2013-01-16. PMID:23320131. |
activation of the p2x7 receptor has been found to modulate neuronal excitability in the hippocampus and it has also been linked to microglia activation and neuroinflammatory responses. |
2013-01-16 |
2023-08-12 |
mouse |
| Eric S Wohleb, Ashley M Fenn, Ann M Pacenta, Nicole D Powell, John F Sheridan, Jonathan P Godbou. Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology. vol 37. issue 9. 2013-01-14. PMID:22386198. |
last, lps-induced microglia activation was most evident in the hippocampus of socially defeated mice. |
2013-01-14 |
2023-08-12 |
mouse |
| Yan Zhou, Yanxin Zhang, Junquan Li, Fengyue Lv, Yongmei Zhao, Deyi Duan, Qunyuan X. A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957701. |
microglia were activated in the hippocampus and striatum at 4 weeks, and in the sn at 24 weeks. |
2013-01-10 |
2023-08-12 |
rat |
| Tooru Nakamura-Hirota, Keiichi Kadoyama, Masaoki Takano, Mieko Otani, Shogo Matsuyam. The expression changes of EphA3 receptor during synaptic plasticity in mouse hippocampus through activation of nicotinic acetylcholine receptor. Neuroreport. vol 23. issue 13. 2013-01-03. PMID:22811059. |
epha3 receptor was localized in neuronal cells but not astrocytes or microglia of hippocampus. |
2013-01-03 |
2023-08-12 |
mouse |