| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Anna Chiarini, James Whitfield, Clara Bonafini, Balu Chakravarthy, Ubaldo Armato, Ilaria Dal Pr\\xc3\\xa. Amyloid-\\xce\\xb2(25-35), an amyloid-\\xce\\xb2(1-42) surrogate, and proinflammatory cytokines stimulate VEGF-A secretion by cultured, early passage, normoxic adult human cerebral astrocytes. Journal of Alzheimer\'s disease : JAD. vol 21. issue 3. 2011-01-18. PMID:20634577.' |
indeed, vegf-a gene upregulation, with increased vegf-a protein content of reactive astrocytes and microglia, occurs in load brains, and neovascularization was observed one week after injecting amyloid-β (aβ)(1-42) into rat hippocampus. |
2011-01-18 |
2023-08-12 |
human |
| Jinpyo Hong, Ik-Hyun Cho, Kyung Il Kwak, Eun Cheng Suh, Jinsoo Seo, Hyun Jung Min, Se-Young Choi, Chong-Hyun Kim, Seung Hwa Park, Eun-Kyeong Jo, Soojin Lee, Kyung Eun Lee, Sung Joong Le. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20923777. |
tlr2 expression was up-regulated in microglia in the ipsilateral hippocampus of kainic acid (ka)-injected mice. |
2011-01-10 |
2023-08-12 |
mouse |
| Jinpyo Hong, Ik-Hyun Cho, Kyung Il Kwak, Eun Cheng Suh, Jinsoo Seo, Hyun Jung Min, Se-Young Choi, Chong-Hyun Kim, Seung Hwa Park, Eun-Kyeong Jo, Soojin Lee, Kyung Eun Lee, Sung Joong Le. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20923777. |
these data demonstrate conclusively that tlr2 signaling in microglia contributes to ka-mediated innate immune responses and hippocampal excitotoxicity. |
2011-01-10 |
2023-08-12 |
mouse |
| Martine M Mirrione, Dorothy K Konomos, Iordanis Gravanis, Stephen L Dewey, Adriano Aguzzi, Frank L Heppner, Stella E Tsirk. Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice. Neurobiology of disease. vol 39. issue 1. 2010-12-14. PMID:20382223. |
we found that unilateral ablation of microglia from the dorsal hippocampus did not alter acute seizure sensitivity. |
2010-12-14 |
2023-08-12 |
mouse |
| Sheyla Montori, Severiano Dos-Anjos, Beatriz Martínez-Villayandre, Marta M Regueiro-Purriños, José M Gonzalo-Orden, Diego Ruano, Arsenio Fernández-Lópe. Age and meloxicam attenuate the ischemia/reperfusion-induced down-regulation in the NMDA receptor genes. Neurochemistry international. vol 56. issue 8. 2010-11-29. PMID:20350575. |
we quantified the mrna levels of the n-methyl-d-aspartate receptor (nmdar) subunits and those of the astroglia (glial fibrilar acidic protein, gfap) and microglia (cd11b) markers using real time pcr on the cerebral cortex and hippocampus of 3- and 18-month-old sprague-dawley rats. |
2010-11-29 |
2023-08-12 |
rat |
| Greg J Norman, Ning Zhang, John S Morris, Kate Karelina, Gary G Berntson, A Courtney DeVrie. Social interaction modulates autonomic, inflammatory, and depressive-like responses to cardiac arrest and cardiopulmonary resuscitation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 37. 2010-10-28. PMID:20805484. |
furthermore, socially isolated animals exposed to the ca/cpr procedure displayed significantly higher levels of neuronal cell death and microglia staining within the hippocampus at 7 d following surgery. |
2010-10-28 |
2023-08-12 |
mouse |
| Choong Hyun Lee, Ki-Yeon Yoo, Jung Hoon Choi, Ok Kyu Park, In Koo Hwang, Sung Koo Kim, Il-Jun Kang, Young-Myeong Kim, Moo-Ho Wo. Neuronal damage is much delayed and microgliosis is more severe in the aged hippocampus induced by transient cerebral ischemia compared to the adult hippocampus. Journal of the neurological sciences. vol 294. issue 1-2. 2010-10-21. PMID:20471038. |
activation of astrocytes and microglia in the post-ischemic hippocampus has been investigated using ischemia models. |
2010-10-21 |
2023-08-12 |
Not clear |
| Anibal G Armien, Shuxian Hu, Morgan R Little, Nicholas Robinson, James R Lokensgard, Walter C Low, Maxim C-J Cheera. Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis. Brain pathology (Zurich, Switzerland). vol 20. issue 4. 2010-10-19. PMID:20002440. |
the chronic lymphocytic infiltrate, cytokine production, and activated microglia were associated with the loss of cortical neuropile in the entorhinal cortex and hippocampus. |
2010-10-19 |
2023-08-12 |
Not clear |
| Naoko Kuzumaki, Daigo Ikegami, Satoshi Imai, Michiko Narita, Rie Tamura, Marie Yajima, Atsuo Suzuki, Kazuhiko Miyashita, Keiichi Niikura, Hideyuki Takeshima, Takayuki Ando, Toshikazu Ushijima, Tsutomu Suzuki, Minoru Narit. Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse (New York, N.Y.). vol 64. issue 9. 2010-10-19. PMID:20336624. |
in the present study, we investigated whether aging decreases neurogenesis accompanied by the activation of microglia and astrocytes, which increases the expression of il-1beta in the hippocampus, and whether in vitro treatment with il-1beta in neural stem cells directly impairs neurogenesis. |
2010-10-19 |
2023-08-12 |
mouse |
| Naoko Kuzumaki, Daigo Ikegami, Satoshi Imai, Michiko Narita, Rie Tamura, Marie Yajima, Atsuo Suzuki, Kazuhiko Miyashita, Keiichi Niikura, Hideyuki Takeshima, Takayuki Ando, Toshikazu Ushijima, Tsutomu Suzuki, Minoru Narit. Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse (New York, N.Y.). vol 64. issue 9. 2010-10-19. PMID:20336624. |
ionized calcium-binding adaptor molecule 1 (iba1)-positive microglia and glial fibrillary acidic protein (gfap)-positive astrocytes were increased in the dentate gyrus of the hippocampus of 28-month-old mice. |
2010-10-19 |
2023-08-12 |
mouse |
| Naoko Kuzumaki, Daigo Ikegami, Satoshi Imai, Michiko Narita, Rie Tamura, Marie Yajima, Atsuo Suzuki, Kazuhiko Miyashita, Keiichi Niikura, Hideyuki Takeshima, Takayuki Ando, Toshikazu Ushijima, Tsutomu Suzuki, Minoru Narit. Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse (New York, N.Y.). vol 64. issue 9. 2010-10-19. PMID:20336624. |
these findings suggest that aging may decrease hippocampal neurogenesis via epigenetic modifications accompanied by the activation of microglia and astrocytes with the increased expression of il-1beta in the hippocampus. |
2010-10-19 |
2023-08-12 |
mouse |
| Holly M Brothers, Yannick Marchalant, Gary L Wen. Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neuroscience letters. vol 480. issue 2. 2010-10-19. PMID:20541589. |
caffeine attenuated the number of activated microglia within the hippocampus of animals with lps-induced and age-related inflammation. |
2010-10-19 |
2023-08-12 |
rat |
| Saebyeol Jang, Ryan N Dilger, Rodney W Johnso. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. The Journal of nutrition. vol 140. issue 10. 2010-10-19. PMID:20685893. |
aged mice fed control diet exhibited deficits in spatial working memory and expression of inflammatory markers in the hippocampus indicative of increased microglial cell activity. |
2010-10-19 |
2023-08-12 |
mouse |
| Jing Ding, Qin-Ying Li, Xin Wang, Chang-Hai Sun, Chuan-Zhen Lu, Bao-Guo Xia. Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20882700. |
the administration of fasudil inhibited the activity of rock in brain tissue and cultured microglia, and protected hippocampal neurons against h/r injury. |
2010-10-19 |
2023-08-12 |
mouse |
| Eun-A Kim, Hoh-Gyu Hahn, Tae Ue Kim, Soo Young Choi, Sung-Woo Ch. Attenuation of beta-amyloid-induced neuroinflammation by KHG21834 in vivo. BMB reports. vol 43. issue 6. 2010-10-07. PMID:20587331. |
in vivo intracerebroventricular infusion of khg21834 leads to decreases in the numbers of activated astrocytes and microglia and level of proinflammatory cytokines such as interleukin- 1beta and tumor necrosis factor-alpha induced by abeta in the hippocampus. |
2010-10-07 |
2023-08-12 |
Not clear |
| Matthew G Frank, Ruth M Barrientos, Linda R Watkins, Steven F Maie. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. Journal of neuroimmunology. vol 226. issue 1-2. 2010-10-06. PMID:20537730. |
aging sensitizes rapidly isolated hippocampal microglia to lps ex vivo. |
2010-10-06 |
2023-08-12 |
rat |
| Matthew G Frank, Ruth M Barrientos, Linda R Watkins, Steven F Maie. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. Journal of neuroimmunology. vol 226. issue 1-2. 2010-10-06. PMID:20537730. |
the present study tested whether aging sensitizes hippocampal microglia to a pro-inflammatory challenge ex vivo. |
2010-10-06 |
2023-08-12 |
rat |
| Matthew G Frank, Ruth M Barrientos, Linda R Watkins, Steven F Maie. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. Journal of neuroimmunology. vol 226. issue 1-2. 2010-10-06. PMID:20537730. |
hippocampal microglia from 3 and 24 mo old male f344 x bn f1 rats were exposed to lps (0, 0.1, 1, 10 and 100 ng/ml) ex vivo. |
2010-10-06 |
2023-08-12 |
rat |
| Matthew G Frank, Ruth M Barrientos, Linda R Watkins, Steven F Maie. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. Journal of neuroimmunology. vol 226. issue 1-2. 2010-10-06. PMID:20537730. |
the present results demonstrate that aging sensitizes hippocampal microglia to pro-inflammatory challenges. |
2010-10-06 |
2023-08-12 |
rat |
| Staci D Bilb. Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline. Neurobiology of learning and memory. vol 94. issue 1. 2010-09-29. PMID:20388544. |
neonatally-infected rats also exhibited greater aging-induced increases in glial markers (cd11b and mhcii on microglia, and gfap on astrocytes), as well as selective changes in nmda receptor subunit expression within the hippocampus, but not in amygdala or parietal cortex compared to controls. |
2010-09-29 |
2023-08-12 |
rat |